Decursin, an active compound isolated from angelica gigas, inhibits fat accumulation, reduces adipocytokine secretion and improves glucose tolerance in mice fed a high-fat diet

Phytotherapy Research

Volumn 26, Issue 5, 2012, Pages 633-638

  Hwang, Jin Taek ^a   Kim, Sung Hee ^a   Hur, Haeng Jeon ^a   Kim, Hyun Jin ^a   Park, Jae Ho ^a   Sung, Mi Jeong ^a   Yang, Hye Jeong ^a   Ryu, Shi Yong ^b   Kim, Young Sup ^b   Cha, Mi Ran ^b   Kim, Myung Sunny ^a   Kwon, Dae Young ^a  

^a Korea Food Research Institute   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

3T3 L1 adipocyte; adipocytokine; antidiabetes; antiobesity; decursin; high fat diet

Indexed keywords

ADIPOCYTOKINE; ANTIOBESITY AGENT; CHOLESTEROL; DECURSIN; FATTY ACID SYNTHASE; INTERLEUKIN 6; LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RESISTIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOCYTE; ANGELICA GIGAS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL SIZE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE RELEASE; DIET SUPPLEMENTATION; FOOD INTAKE; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; IN VITRO STUDY; INSULIN RESISTANCE; LIPID STORAGE; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; OBESITY; PREVENTION AND CONTROL; PROTEIN EXPRESSION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION;

3T3-L1 CELLS; ADIPOKINES; ADIPOSE TISSUE; ANGELICA; ANIMALS; ANTI-OBESITY AGENTS; BENZOPYRANS; BLOOD GLUCOSE; BODY WEIGHT; BUTYRATES; CHOLESTEROL; DIET, HIGH-FAT; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; OBESITY; WEIGHT GAIN;

ANGELICA GIGAS; MUS;

EID: 84859887923     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3612     Document Type: Article

References (29)

1. Abete I, Astrup A, Martinez JA, Thorsdottir I, Zulet MA,. 2010. Obesity and the metabolic syndrome: role of different dietary macronutrient distribution patterns and specific nutritional components on weight loss and maintenance. Nutr Rev 68: 214-231.
2. Adachi T, Toishi T, Wu H, Kamiya T, Hara H,. 2009. Expression of extracellular superoxide dismutase during adipose differentiation in 3T3-L1 cells. Redox Rep 14: 34-40.
3. Folch J, Lees M, Sloane Stanley GH,. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509.
4. Fortuno A, Bidegain J, Baltanas A, et al,. 2010. Is leptin involved in phagocytic NADPH oxidase overactivity in obesity? Potential clinical implications. J Hypertens 28: 1944-1950.
5. Han SB, Kim YH, Lee CW, et al,. 1998. Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai. Immunopharmacology 40: 39-48. (Pubitemid 28434952)
6. Hwang JT, Kwon DY, Yoon SH,. 2009. AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols. N Biotechnol 26: 17-22.
7. Jiang C, Lee HJ, Li GX, et al,. 2006. Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer. Cancer Res 66: 453-463. (Pubitemid 43166054)
8. Kamada Y, Takehara T, Hayashi N,. 2008. Adipocytokines and liver disease. J Gastroenterol 43: 811-822.
9. Kang SY, Kim YC,. 2007. Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicity. J Pharm Pharmacol 59: 863-870. (Pubitemid 47051099)
10. Ketonen J, Shi J, Martonen E, Mervaala E,. 2010. Periadventitial adipose tissue promotes endothelial dysfunction via oxidative stress in diet-induced obese C57Bl/6 mice. Circ J 74: 1479-1487.
11. Kim JH, Jeong JH, Jeon ST, et al,. 2006a. Decursin inhibits induction of inflammatory mediators by blocking nuclear factor-kappaB activation in macrophages. Mol Pharmacol 69: 1783-1790.
12. Kim JH, Jeong SJ, Kwon HY, Park SY, Lee HJ, Lee HJ,. 2010b. Decursin prevents cisplatin-induced apoptosis via the enhancement of antioxidant enzymes in human renal epithelial cells. Biol Pharm Bull 33: 1279-1284.
13. Kim WJ, Lee MY, Kim JH, Suk K, Lee WH,. 2010c. Decursinol angelate blocks transmigration and inflammatory activation of cancer cells through inhibition of PI3K, ERK and NF-kappaB activation. Cancer Lett 296: 35-42.
14. Kim WJ, Lee SJ, Choi YD, Moon SK,. 2010a. Decursin inhibits growth of human bladder and colon cancer cells via apoptosis, G1-phase cell cycle arrest and extracellular signal-regulated kinase activation. Int J Mol Med 25: 635-641.
15. Knight SF, Imig JD,. 2007. Obesity, insulin resistance, and renal function. Microcirculation 14: 349-362. (Pubitemid 47050027)
16. Lee SH, Lee YS, Jung SH, Shin KH, Kim BK, Kang SS,. 2003a. Antioxidant activities of decursinol angelate and decursin from Angelica gigas roots. Nat Prod Sci 9: 170-173. (Pubitemid 37254397)
17. Lee SH, Shin DS, Kim JS, Oh KB, Kang SS,. 2003b. Antibacterial coumarins from Angelica gigas roots. Arch Pharm Res 26: 449-452.
18. Mclnnis KJ,. 2000. Exercise and obesity. Coron Artery Dis 11: 111-116.
19. Ndisang JF,. 2010. Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity. Mediators Inflamm 2010: 1-18.
20. Nishihara R, Sugano N, Takano M, et al,. 2009. The effect of Porphyromonas gingivalis infection on cytokine levels in type 2 diabetic mice. J Periodontal Res 44: 305-310.
21. Odrowaz-Sypniewska G,. 2007. Markers of pro-inflammatory and pro-thrombotic state in the diagnosis of metabolic syndrome. Adv Med Sci 52: 246-250.
22. Ohshiro T, Namatame I, Lee EW, Kawagishi H, Tomoda H,. 2006. Molecular target of decursins in the inhibition of lipid droplet accumulation in macrophages. Biol Pharm Bull 29: 981-984.
23. Pausova Z,. 2006. From big fat cells to high blood pressure: a pathway to obesity-associated hypertension. Curr Opin Nephrol Hypertens 15: 173-178.
24. Sies H,. 2010. Polyphenols and health: update and perspectives. Arch Biochem Biophys 501: 2-5.
25. Singer G, Granger DN,. 2007. Inflammatory responses underlying the microvascular dysfunction associated with obesity and insulin resistance. Microcirculation 14: 375-387. (Pubitemid 47050029)
26. Son SH, Kim MJ, Chung WY, et al,. 2009. Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase. Cancer Lett 280: 86-92.
27. Teo CF, Wollaston-Hayden EE, Wells L,. 2010. Hexosamine flux, the O-GlcNAc modification, and the development of insulin resistance in adipocytes. Mol Cell Endocrinol 318: 44-53.
28. Yang EJ, Song GY, Lee JS, Yun CY, Kim IS,. 2009. A novel (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 2,2-dimethyl-8-oxo-3, 4-dihydro-2H,8H-pyrano[3,2-g]chromen-3-yl-ester, inhibits ovalbumin-induced lung inflammation in a mouse model of asthma. Biol Pharm Bull 32: 444-449.
29. Yin J, Zhang H, Ye J,. 2008. Traditional chinese medicine in treatment of metabolic syndrome. Endocr Metab Immune Disord Drug Targets 8: 99-111.