Relief of pain induced by varicella-zoster virus in a rat model of post-herpetic neuralgia using a herpes simplex virus vector expressing enkephalin

Gene Therapy

Volumn 21, Issue 7, 2014, Pages 694-702

  Guedon, J M G ^a   Zhang, M ^a   Glorioso, J C ^a   Goins, W F ^a   Kinchington, P R ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PREPROENKEPHALIN; VIRUS VECTOR; ENKEPHALIN;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; GANGLION; GENE TARGETING; HERPES SIMPLEX VIRUS; LOW DRUG DOSE; MALE; NOCICEPTION; NONHUMAN; POSTHERPETIC NEURALGIA; PRIORITY JOURNAL; RAT; VARICELLA ZOSTER VIRUS; ADMINISTRATION AND DOSAGE; ANIMAL; DISEASE MODEL; FOOT; GANGLION CYST; GENE THERAPY; GENE VECTOR; GENETICS; HUMAN; METABOLISM; NEURALGIA, POSTHERPETIC; SIMPLEXVIRUS; SPINAL CORD; SPRAGUE DAWLEY RAT; TUMOR CELL LINE; VIROLOGY;

HERPES ZOSTER; HUMAN HERPESVIRUS 3; RATTUS; SIMPLEXVIRUS;

ANIMALS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; ENKEPHALINS; FOOT; GANGLION CYSTS; GENETIC THERAPY; GENETIC VECTORS; HUMANS; MALE; NEURALGIA, POSTHERPETIC; RATS; RATS, SPRAGUE-DAWLEY; SIMPLEXVIRUS; SPINAL CORD;

EID: 84903884815     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2014.43     Document Type: Article

References (51)

1. Leung J, Harpaz R, Molinari N A, Jumaan A, Zhou F. Herpes zoster incidence among insured persons in the United States, 1993-2006: Evaluation of impact of varicella vaccination. Clin Infect Dis 2011; 52: 332-340
2. Harpaz R, Ortega-Sanchez IR, Seward JF. Advisory Committee on Immunization Practices Centers for Disease, C. & Prevention. Prevention of herpes zoster: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. Recommendations and reports: Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control 2008; 57: 1-30
3. Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LD, et al. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med 2005; 352: 2271-2284
4. Gilden D, Cohrs RJ, Mahalingam R, Nagel MA. Neurological disease produced by varicella zoster virus reactivation without rash. Curr Top Microbiol Immunol 2010; 342: 243-253
5. Haanpaa M, Laippala P, Nurmikko T. Pain and somatosensory dysfunction in acute herpes zoster. Clin J Pain 1999; 15: 78-84
6. Kim SR, Khan F, Tyring SK. Varicella zoster: An update on current treatment options and future perspectives. Exp Opin Pharmacother 2014; 15: 61-71
7. Schmader K. Postherpetic neuralgia in immunocompetent elderly people. Vaccine 1998; 16: 1768-1770
8. Johnson RW, Bouhassira D, Kassianos G, Leplège A, Schmader KE, Weinke T. The impact of herpes zoster and post-herpetic neuralgia on quality-of-life. BMC Med 2010; 8: 37
9. Kinchington PR, Goins WF. Varicella zoster virus-induced pain and post-herpetic neuralgia in the human host and in rodent animal models. J Neurovirol 2011; 17: 590-599
10. Fleetwood-Walker SM, Quinn JP, Wallace C, Blackburn-Munro G, Kelly BG, Fiskerstrand CE, et al. Behavioural changes in the rat following infection with varicella-zoster virus. J Gen Virol 1999; 80 (Pt 9): 2433-2436
11. Garry EM, et al. Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs. Pain 2005; 118: 97-111
12. Hasnie FS, Breuer J, Parker S, Wallace V, Blackbeard J, Lever I, et al. Further characterization of a rat model of varicella zoster virus-Associated pain: Relationship between mechanical hypersensitivity and anxiety-related behavior, and the influence of analgesic drugs. Neuroscience 2007; 144: 1495-1508
13. Zhang GH, Lv MM, Wang S, Chen L, Qian NS, Tang Y, et al. Spinal astrocytic activation is involved in a virally-induced rat model of neuropathic pain. PLoS One 2011; 6: E23059
14. Dalziel RG, Bingham S, Sutton D, Grant D, Champion JM, Dennis SA, et al. Allodynia in rats infected with varicella zoster virus-A small animal model for post-herpetic neuralgia. Brain Res Brain Res Rev 2004; 46: 234-242
15. Zimmermann K. Science of Pain, by AI Basbaum and C Bushnell, 1st ed., Academic Press, 2009, 1088 pp., Reviewed by Katherine Zimmermann. Eur J Pain 2011; 15: 731
16. Yaksh TL. Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesthesiol Scand 1997; 41: 94-111
17. Mogil JS. Animal models of pain: Progress and challenges. Nat Rev Neurosci 2009; 10: 283-294
18. Takahashi M, Okuno Y, Otsuka T, Osame J, Takamizawa A. Development of a live attenuated varicella vaccine. Biken J 1975; 18: 25-33
19. Takahashi M, Otsuka T, Okuno Y, Asano Y, Yazaki T. Live vaccine used to prevent the spread of varicella in children in hospital. Lancet 1974; 2: 1288-1290
20. Yokoyama H, Oguchi T, Goins WF, Goss JR, Nishizawa O, de Groat WC, et al. Effects of herpes simplex virus vector-mediated enkephalin gene therapy on bladder overactivity and nociception. Hum Gene Therapy 2013; 24: 170-180
21. Nagel MA, Gilden D. Complications of varicella zoster virus reactivation. Curr Treat Options Neurol 2013; 15: 439-453
22. Gilden D, Nagel MA, Cohrs RJ, Mahalingam R. The variegate neurological manifestations of varicella zoster virus infection. Curr Neurol Neurosci Rep 2013; 13: 374
23. Wilson SP, Yeomans DC, Bender MA, Lu Y, Goins WF, Glorioso JC, et al. Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus. Proc Natl Acad Sci USA 1999; 96: 3211-3216
24. Braz J, Beaufour C, Coutaux A, Epstein A.L, Cesselin F, Hamon M, et al. Therapeutic efficacy in experimental polyarthritis of viral-driven enkephalin overproduction in sensory neurons. J Neurosci 2001; 21: 7881-7888
25. Lu Y, McNearney TA, Lin W, Wilson SP, Yeomans DC, Westlund KN. Treatment of inflamed pancreas with enkephalin encoding HSV-1 recombinant vector reduces inflammatory damage and behavioral sequelae. Mol Ther 2007; 15: 1812-1819
26. Yeomans DC, Jones T, Laurito CE, Lu Y, Wilson SP. Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin. Mol Ther 2004; 9: 24-29
27. Yeomans DC, Lu Y, Laurito CE, Peters MC, Vota-Vellis G, Wilson SP, et al. Recombinant herpes vector-mediated analgesia in a primate model of hyperalgesia. Mol Ther 2006; 13: 589-597
28. Lu Y, McNearney T. A, Wilson SP, Yeomans DC, Westlund KN. Joint capsule treatment with enkephalin-encoding HSV-1 recombinant vector reduces inflammatory damage and behavioural sequelae in rat CFA monoarthritis. Eur J Neurosci 2008; 27: 1153-1165
29. Meunier A, Latrémolière A, Mauborgne A, Bourgoin S, Kayser V, Cesselin F, et al. Attenuation of pain-related behavior in a rat model of trigeminal neuropathic pain by viral-driven enkephalin overproduction in trigeminal ganglion neurons. Mol Ther 2005; 11: 608-616
30. Pinto M, Castro AR, Tshudy F, Wilson SP, Lima D, Tavares I. Opioids modulate pain facilitation from the dorsal reticular nucleus. Mol Cell Neurosci 2008; 39: 508-518
31. Goss J. R, Harley CF, Mata M, O'Malley ME, Goins WF, Hu X, et al. Herpes vectormediated expression of proenkephalin reduces bone cancer pain. Ann Neurol 2002; 52: 662-665
32. Goss J. R, Mata M, Goins WF, Wu HH, Glorioso JC, Fink DJ, et al. Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion. Gene Therapy 2001; 8: 551-556
33. Yokoyama H, Sasaki K, Franks ME, Goins WF, Goss JR, de Groat WC, et al. Gene therapy for bladder overactivity and nociception with herpes simplex virus vectors expressing preproenkephalin. Hum Gene Ther 2009; 20: 63-71
34. Yoshimura N, Franks M.E, Sasaki K, Goins W.F, Goss J, Yokoyama T, et al. Gene therapy of bladder pain with herpes simplex virus (HSV) vectors expressing preproenkephalin (PPE). Urology 2001; 57: 116
35. Hao S, Mata M, Goins W, Glorioso J. C, Fink D. J. Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain. Pain 2003; 102: 135-142
36. Yang H, McNearney TA, Chu R, Lu Y, Ren Y, Yeomans DC, et al. Enkephalinencoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model. Mol Pain 2008; 4: 8
37. Hao S, Wolfe D, Glorioso J. C, Mata M, Fink D. J. Effects of transgene-mediated endomorphin-2 in inflammatory pain. Eur J Pain 2009; 13: 380-386
38. Zou W, Guo Q, Chen C, Yang Y, Wang E. Intrathecal herpes simplex virus type 1 amplicon vector-mediated human proenkephalin reduces chronic constriction injury-induced neuropathic pain in rats. Mol Med Rep 2011; 4: 529-533
39. Wolfe D, Hao S, Hu J, Srinivasan R, Goss J, Mata M, et al. Engineering an endomorphin-2 gene for use in neuropathic pain therapy. Pain 2007; 133: 29-38
40. Liu J, Wolfe D, Hao S, Huang S, Glorioso J.C, Mata M, et al. Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain. Mol Ther 2004; 10: 57-66
41. Sun J, Liu S, Mata M, Fink DJ, Hao S. Transgene-mediated expression of tumor necrosis factor soluble receptor attenuates morphine tolerance in rats. Gene Therapy 2012; 19: 101-108
42. Huang W, Zheng W, Liu S, Zeng W, Levitt RC, Candiotti KA, et al. HSV-mediated p55TNFSR reduces neuropathic pain induced by HIV gp120 in rats through CXCR4 activity. Gene Therapy 2014; 21: 328-336
43. Hamza MA, Higgins DM, Ruyechan WT. Two alphaherpesvirus latency-Associated gene products influence calcitonin gene-related peptide levels in rat trigeminal neurons. Neurobiol Dis 2007; 25: 553-560
44. Kennedy PG, Montague P, Scott F, Grinfeld E, Ashrafi GH, Breuer J, et al. Varicella-zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line. PLoS One 2013; 8: E51570
45. Fink D. J, Wechuck J, Mata M, Glorioso JC, Goss J, Krisky D, et al. Gene therapy for pain: Results of a phase I clinical trial. Ann Neurol 2011; 70: 207-212
46. Erazo A, Yee MB, Osterrieder N, Kinchington PR. Varicella-zoster virus open reading frame 66 protein kinase is required for efficient viral growth in primary human corneal stromal fibroblast cells. J Virol 2008; 82: 7653-7665
47. Marconi P, Krisky D, Oligino T, Poliani PL, Ramakrishnan R, Goins WF, et al. Replication-defective herpes simplex virus vectors for gene transfer in vivo. Proc Natl Acad Sci USA 1996; 93: 11319-11320
48. Srinivasan R, Huang S, Chaudhry S, Sculptoreanu A, Krisky D, Cascio M, et al. An HSV vector system for selection of ligand-gated ion channel modulators. Nat Methods 2007; 4: 733-739
49. Dixon WJ. Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 1980; 20: 441-462
50. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994; 53: 55-63
51. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988; 32: 77-88.