Statistical allosteric coupling to the active site indole ring flip equilibria in the FK506-binding domain

Biophysical Chemistry

Volumn 192, Issue , 2014, Pages 41-48

  Anderson, Janet S ^a   Mustafi, Sourajit M ^b   Hernández, Griselda ^b,c   Lemaster, David M ^b,c  

^a UNION COLLEGE   (United States)

^b WADSWORTH CENTER   (United States)

^c STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Allostery; Concerted transition; FKBP12; Molecular simulation; NMR; Statistical coupling

Indexed keywords

FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 51; FK 506 BINDING PROTEIN 52; INDOLE DERIVATIVE; NITROGEN; UNCLASSIFIED DRUG; INDOLE; TACROLIMUS; TACROLIMUS BINDING PROTEIN 5;

ALLOSTERISM; ALPHA HELIX; ARTICLE; BINDING SITE; CONFORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; HYDROGEN BOND; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN STRUCTURE; SIMULATION; WILD TYPE; CHEMISTRY; ENZYME ACTIVE SITE; HUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN TERTIARY STRUCTURE; STATISTICAL ANALYSIS;

CATALYTIC DOMAIN; DATA INTERPRETATION, STATISTICAL; HUMANS; INDOLES; MOLECULAR DYNAMICS SIMULATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, TERTIARY; TACROLIMUS; TACROLIMUS BINDING PROTEIN 1A; TACROLIMUS BINDING PROTEINS;

EID: 84903863906     PISSN: 03014622     EISSN: 18734200     Source Type: Journal    
DOI: 10.1016/j.bpc.2014.06.004     Document Type: Article

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