Myofibroblastic stromal reaction and lymph node status in invasive breast carcinoma: Possible role of the TGF-β1/TGF-βR1 pathway

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Catteau, Xavier ^a,b   Simon, Philippe ^b   Noël, Jean Christophe ^b  

^a INSTITUTE OF PATHOLOGY AND GENETICS   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Breast carcinoma; CD34; Fibrocytes; Lymph node; Metastasis; Myofibroblasts; SMA; TGF ; Tumor microenvironment

Indexed keywords

SMOOTH MUSCLE ACTIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; ACTIN; CD34 ANTIGEN; PROTEIN SERINE THREONINE KINASE; TGF-BETA TYPE I RECEPTOR; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; AUTOCRINE EFFECT; BREAST CARCINOMA; BREAST FIBROCYTE; CANCER GRADING; CELL CONTACT; CELL TRANSFORMATION; CELL TYPE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MIDDLE AGED; MOLECULAR DYNAMICS; MYOFIBROBLAST; MYOFIBROBLASTIC STROMAL REACTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; STROMA CELL; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR VOLUME; BREAST TUMOR; CYTOLOGY; METABOLISM; PAGET NIPPLE DISEASE; PATHOLOGY; SIGNAL TRANSDUCTION; VERY ELDERLY;

ACTINS; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD34; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; FEMALE; HUMANS; LYMPHATIC METASTASIS; MIDDLE AGED; MYOFIBROBLASTS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; STROMAL CELLS; TRANSFORMING GROWTH FACTOR BETA1; TUMOR MICROENVIRONMENT;

EID: 84903858769     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-499     Document Type: Article

References (32)

1. Shibuya K, Mathers CD, Boschi-Pinto C, Lopez AD, Murray CJ. Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000. BMC Cancer 2002, 2:37. 10.1186/1471-2407-2-37, 149364, 12502432.
2. Place AE, Jin Huh S, Polyak K. The microenvironment in breast cancer progression: biology and implications for treatment. Breast Cancer Res 2011, 13:227. 10.1186/bcr2912, 3326543, 22078026.
3. Weinberg R, Mihich E. Eighteenth annual pezcoller symposium: tumor microenvironment and heterotypic interactions. Cancer Res 2006, 66:11550-11553. 10.1158/0008-5472.CAN-06-3149, 17158190.
4. Barth PJ, Ebrahimsade S, Ramaswamy A, Moll R. CD34+ fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ, and benign breast lesions. Virchows Arch 2002, 440:298-303. 10.1007/s004280100530, 11889601.
5. Barth PJ, Moll R, Ramaswamy A. Stromal remodeling and SPARC (secreted protein acid rich in cysteine) expression in invasive ductal carcinomas of the breast. Virchows Arch 2005, 446:532-536. 10.1007/s00428-005-1256-9, 15838642.
6. Faler BJ, Macsata RA, Plummer D, Mishra L, Sidawy AN. Transforming growth factor-beta and wound healing. Perspect Vasc Surg Endovasc Ther 2006, 18:55-62. 10.1177/153100350601800123, 16628336.
7. O'Kane S, Ferguson MW. Transforming growth factor beta s and wound healing. Int J Biochem Cell Biol 1997, 29:63-78. 10.1016/S1357-2725(96)00120-3, 9076942.
8. Wahl SM. Transforming growth factor-beta: innately bipolar. Curr Opin Immunol 2007, 19:55-62. 10.1016/j.coi.2006.11.008, 17137775.
9. Fleisch MC, Maxwell CA, Barcellos-Hoff MH. The pleiotropic roles of transforming growth factor beta in homeostasis and carcinogenesis of endocrine organs. Endocr Relat Cancer 2006, 13:379-400. 10.1677/erc.1.01112, 16728569.
10. Ronnov-Jessen L, Petersen OW. Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia. Lab Invest 1993, 68:696-707.
11. Sieuwerts AM, Klijn JG, Henzen-Logmans SC, Foekens JA. Cytokine-regulated urokinase-type-plasminogen-activator (uPA) production by human breast fibroblasts in vitro. Breast Cancer Res Treat 1999, 55:9-20. 10.1023/A:1006190729866, 10472775.
12. Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, Liotta LA, Falanga V, Kehrl JH. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A 1986, 83:4167-4171. 10.1073/pnas.83.12.4167, 323692, 2424019.
13. Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 1991, 19:403-410. 10.1111/j.1365-2559.1991.tb00229.x, 1757079.
14. Goulding H, Pinder S, Cannon P, Pearson D, Nicholson R, Snead D, Bell J, Elston CWE, Robertson JF, Blamey RW, Ellis IO. A new immunohistochemical antibody for the assessment of estrogen receptor status on routine formalin-fixed tissue samples. Hum Pathol 1995, 26:291-294. 10.1016/0046-8177(95)90060-8, 7890280.
15. Bissell MJ, Kenny PA, Radisky DC. Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes. Cold Spring Harb Symp Quant Biol 2005, 70:343-356. 10.1101/sqb.2005.70.013, 3004779, 16869771.
16. Tlsty TD, Hein PW. Know thy neighbor: stromal cells can contribute oncogenic signals. Curr Opin Genet Dev 2001, 11:54-59. 10.1016/S0959-437X(00)00156-8, 11163151.
17. De Wever O, Demetter P, Mareel M, Bracke M. Stromal myofibroblasts are drivers of invasive cancer growth. Int J Cancer 2008, 123:2229-2238. 10.1002/ijc.23925, 18777559.
18. Catteau X, Simon P, Vanhaeverbeek M, Noel JC. Variable stromal periductular expression of CD34 and smooth muscle actin (SMA) in intraductal carcinoma of the breast. PLoS One 2013, 8:e57773. 10.1371/journal.pone.0057773, 3585862, 23469238.
19. Abe R, Donnelly SC, Peng T, Bucala R, Metz CN. Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol 2001, 166:7556-7562. 10.4049/jimmunol.166.12.7556, 11390511.
20. Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, Porter D, Hu M, Chin L, Richardson A, Schnitt S, Sellers WR, Polyak K. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 2004, 6:17-32. 10.1016/j.ccr.2004.06.010, 15261139.
21. Espana EM, Kawakita T, Liu CY, Tseng SC. CD-34 expression by cultured human keratocytes is downregulated during myofibroblast differentiation induced by TGF-beta1. Invest Ophthalmol Vis Sci 2004, 45:2985-2991. 10.1167/iovs.04-0201, 15326111.
22. Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, West AB. Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol 1999, 277:C1-C9.
23. Orimo A, Tomioka Y, Shimizu Y, Sato M, Oigawa S, Kamata K, Nogi Y, Inoue S, Takahashi M, Hata T, Muramatsu M. Cancer-associated myofibroblasts possess various factors to promote endometrial tumor progression. Clin Cancer Res 2001, 7:3097-3105.
24. De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol 2003, 200:429-447. 10.1002/path.1398, 12845611.
25. Liang X, Huuskonen J, Hajivandi M, Manzanedo R, Predki P, Amshey JR, Pope RM. Identification and quantification of proteins differentially secreted by a pair of normal and malignant breast-cancer cell lines. Proteomics 2009, 9:182-193. 10.1002/pmic.200700957, 19053080.
26. Sircar K, Hewlett BR, Huizinga JD, Chorneyko K, Berezin I, Riddell RH. Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. Am J Surg Pathol 1999, 23:377-389. 10.1097/00000478-199904000-00002, 10199467.
27. Suster S, Fisher C. Immunoreactivity for the human hematopoietic progenitor cell antigen (CD34) in lipomatous tumors. Am J Surg Pathol 1997, 21:195-200. 10.1097/00000478-199702000-00009, 9042286.
28. Jedeszko C, Victor BC, Podgorski I, Sloane BF. Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ. Cancer Res 2009, 69:9148-9155. 10.1158/0008-5472.CAN-09-1043, 2789178, 19920187.
29. Tyan SW, Kuo WH, Huang CK, Pan CC, Shew JY, Chang KJ, Lee EY, Lee WH. Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis. PLoS One 2011, 6:e15313. 10.1371/journal.pone.0015313, 3020942, 21249190.
30. Opdenakker G, Van Damme J. Chemotactic factors, passive invasion and metastasis of cancer cells. Immunol Today 1992, 13:463-464. 10.1016/0167-5699(92)90079-M, 1298279.
31. Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986, 315:1650-1659. 10.1056/NEJM198612253152606, 3537791.
32. Satish L, Gallo PH, Baratz ME, Johnson S, Kathju S. Reversal of TGF-beta1 stimulation of alpha-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren's-derived fibroblasts. BMC Musculoskelet Disord 2011, 12:113. 10.1186/1471-2474-12-113, 3125251, 21612641.