Cancer-associated myofibroblasts possess various factors to promote endometrial tumor progression

Clinical Cancer Research

Volumn 7, Issue 10, 2001, Pages 3097-3105

  Orimo, Akira ^a,d   Sato, Miyuki ^a   Nogi, Yasuhisa ^a   Inoue, Satoshi ^a   Muramatsu, Masami ^a   Tomioka, Yasuhiro ^b   Oigawa, Satoko ^b   Hata, Toshio ^b   Shimizu, Yoshihiko ^b   Kamata, Koichi ^b   Takahashi, Masakazu ^a,c  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b Saitama Medical School ^*

^c SASAKI INSTITUTE   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS ANTIGEN; CYCLIN DEPENDENT KINASE; CYCLINE; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR ALPHA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; SOMATOMEDIN; VASCULOTROPIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CARCINOGENESIS; CELL INTERACTION; CELL INVASION; CELL PROLIFERATION; CLINICAL ARTICLE; ENDOMETRIUM CANCER; FEMALE; FROZEN SECTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERSTITIUM; MYOFIBROBLAST; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ADULT; AGED; CELL CYCLE PROTEINS; ENDOMETRIAL NEOPLASMS; ESTROGEN RECEPTOR ALPHA; FEMALE; GROWTH SUBSTANCES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MIDDLE AGED; MUSCLE, SMOOTH; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, ESTROGEN; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 0034787876     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. The HL-60 transforming sequence: A ras oncogene coexisting with altered myc genes in hematopoietic tumors
2. A genetic model for colorectal tumorigenesis
3. The hallmarks of cancer
4. Cellular changes involved in conversion of normal to malignant breast: Importance of the stromal reaction
5. Landscaping the cancer terrain
6. Tumorigenic conversion of immortal human keratinocytes through stromal cell activation
7. Transforming growth factor-β 1 induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
8. Fibroblasts, myofibroblasts, and wound contraction
9. The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells
10. DNA synthesis in prolyl 4-hydroxylase positive fibroblasts in situ in synovial tissue. An autoradiography-immunoperoxidase double labeling study
11. Fibroblast markers in labial salivary gland biopsies in progressive systemic sclerosis
12. Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions
13. Malignant breast epithelium selects for insulin-like growth factor II expression in breast stroma: Evidence for paracrine function
14. Fibroblasts can modulate the phenotype of malignant epithelial cells in vitro
15. Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: In vitro analysis of tumor-stromal interactions
16. Co-inoculation of tumorigenic rat prostate mesenchymal cells with non-tumorigenic epithelial cells results in the development of carcinosarcoma in syngeneic and athymic animals
17. Fibroblast-mediated acceleration of human epithelial tumor growth in vivo
18. A novel coculture technique demonstrates that normal human prostatic fibroblasts contribute to tumor formation of LNCaP cells by retarding cell death
19. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
20. A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas
21. Coexpression of stromelysin-3 and insulin-like growth factor II in tumors of ectodermal, mesodermal, and endodermal origin: Indicator of a fetal cell phenotype
22. Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen responsive finger protein (efp) gene, which is a direct target of estrogen receptor α (ER α)
23. Genomic binding-site cloning reveals a novel estrogen responsive gene that encodes a RING finger protein
24. Regulation of progesterone receptor gene expression and growth in the rat uterus: Modulation of estrogen actions by progesterone and sex steroid hormone antagonists
25. Know thy neighbor: Stromal cells can contribute oncogenic signals
26. Evaluation of criteria for distinguishing atypical endometrial hyperplasia from well-differentiated carcinoma
27. Smooth-muscle differentiation in stromal cells of malignant and non-malignant breast tissues
28. Participation of tenascin and transforming growth factor-β in reciprocal epithelial-mesenchymal interactions of MCF7 cells and fibroblasts
29. The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-β1
30. Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia
31. Expression of connective tissue growth factor mRNA in the fibrous stroma of mammary tumors
32. Epithelial-stromal interactions in basal cell cancer: The PDGF system
33. TGF β and bFGF synthesis and localization in Dupuytren's disease (nodular palmar fibromatosis) relative to cellular activity, myofibroblast phenotype and oncofetal variants of fibronectin
34. Risk factors for the development of diethylstilbestrol-associated clear cell adenocarcinoma: A case-control study
35. Low-potency oestrogen and risk of endometrial cancer: A case-control study
36. Myofibroblasts in the stroma of invasive and metastatic carcinoma: A possible host response to neoplasia
37. Matrix-bound thrombospondin promotes angiogenesis in vitro
38. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolasel: Involvement of HIF-1 in tumor progression
39. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
40. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer