Structural-functional analysis of the third transmembrane domain of the corticotropin-releasing factor type 1 receptor role in activation and allosteric antagonism

Journal of Biological Chemistry

Volumn 289, Issue 27, 2014, Pages 18966-18977

  Spyridaki, Katerina ^a   Matsoukas, Minos Timotheos ^b   Cordomi, Arnau ^b   Gkountelias, Kostas ^a   Papadokostaki, Maria ^a   Mavromoustakos, Thomas ^c   Logothetis, Diomedes E ^d   Margioris, Andrew N ^a   Pardo, Leonardo ^b   Liapakis, George ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSITY OF ATHENS   (Greece)

^d VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIOLOGICAL MEMBRANES; CHEMICAL ACTIVATION;

CORTICOTROPIN-RELEASING FACTORS; MOLECULAR MECHANISM; NONPEPTIDE; RECEPTOR ACTIVATION; STRUCTURAL-FUNCTIONAL; TRANS-MEMBRANE DOMAINS;

MOLECULAR INTERACTIONS;

CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; GLYCINE; GUANINE NUCLEOTIDE BINDING PROTEIN; PHENYLALANINE;

ALLOSTERISM; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; EMBRYO; HEK293 CELL LINE; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; RECEPTOR UPREGULATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

7-HELIX RECEPTOR; CORTICOTROPIN-RELEASING FACTOR (CRF); G PROTEIN-COUPLED RECEPTOR (GPCR); PROTEIN DRUG INTERACTION; PROTEIN STRUCTURE; RECEPTOR STRUCTURE-FUNCTION; TYPE 1 CRF RECEPTOR (CRF1R);

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; CELL MEMBRANE; CONSERVED SEQUENCE; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; PYRROLES; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84903837647     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.544460     Document Type: Article

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