Intestinal drug transport: Ex vivo evaluation of the interactions between ABC transporters and anthelmintic molecules

Journal of Veterinary Pharmacology and Therapeutics

Volumn 37, Issue 4, 2014, Pages 332-337

  Ballent, M ^a   Mate L ^a   Virkel, G ^a   Sallovitz, J ^a   Viviani, P ^a   Lanusse, C ^a   Lifschitz, A ^a  

^a UNIVERSIDAD NACIONAL DEL CENTRO DE LA PROVINCIA DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; CLOSANTEL; DANOFLOXACIN; IVERMECTIN; MOXIDECTIN; MULTIDRUG RESISTANCE PROTEIN; PANTOPRAZOLE; RHODAMINE 123; ANTHELMINTIC AGENT; FLUORESCENT DYE; QUINOLONE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DIFFUSION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG TRANSPORT; EX VIVO STUDY; ILEUM; INTESTINE ABSORPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; CHEMISTRY; HUMAN; INTESTINE; MALE; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

RATTUS;

ANIMALS; ANTHELMINTICS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; FLUORESCENT DYES; FLUOROQUINOLONES; HUMANS; INTESTINES; MALE; RATS; RATS, WISTAR; RHODAMINE 123;

EID: 84903817156     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/jvp.12112     Document Type: Article

References (35)

1. Alvarez, A.I., Merino, G., Molina, A.J., Pulido, M.M., McKellar, Q.A. & Prieto, J.G. (2006) Role of ABC transporters in veterinary drug research and parasite resistance. Current Drug Delivery, 3, 199-206.
2. Ballent, M., Lifschitz, A., Virkel, G., Sallovitz, J.M. & Lanusse, C. (2007) Involvement of P-glycoprotein on ivermectin kinetic behaviour in sheep: itraconazole-mediated changes on gastrointestinal disposition. Journal of Veterinary Pharmacology and Therapeutics, 30, 242-248.
3. Ballent, M., Lifschitz, A., Virkel, G., Sallovitz, J., Maté, L. & Lanusse, C. (2012) In vivo and ex vivo assessment of the interaction between ivermectin and danofloxacin in sheep. The Veterinary Journal, 192, 422-427.
4. Craven, J., Bjørn, H., Hennessy, D.R. & Friis, C. (2002) The effects of body disposition on the pharmacokinetics of subcutaneous injected ivermectin and moxidectin in pigs. Journal of Veterinary Pharmacology and Therapeutics, 25, 227-232.
5. Cromie, L., Ferry, M., Couper, A., Fields, C. & Taylor, S.M. (2006) Pharmacokinetics of the novel closantel/ivermectin injection in cattle. Journal of Veterinary Pharmacology and Therapeutics, 29, 205-211.
6. Dupuy, J., Lespine, A., Sutra, J.F. & Alvinerie, M. (2006) The interaction between moxidectin and MDR transporters in primary cultures of rat hepatocytes. Journal of Veterinary Pharmacology and Therapeutics, 29, 107-111.
7. Dupuy, J., Alvinerie, M., Ménez, C. & Lespine, A. (2010) Interaction of anthelmintic drugs with P-glycoprotein in recombinant LLC-PK1-mdr1a cells. Chemic-Biological Interactions, 186, 280-286.
8. Garrigues, A., Loiseau, N., Delaforge, M., Ferté, J., Garrigos, M., André, F. & Orlowski, S. (2002) Characterization of two pharmacophores on the multidrug transporter P-glycoprotein. Molecular Pharmacology, 62, 1288-1298.
9. Gottesman, M.M. & Pastan, I. (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annual Review of Biochemistry, 62, 385-427.
10. Griffiths, N.M., Hirst, B.H. & Simmons, N.L. (1993) Active secretion of the fluoroquinolone ciprofloxacin by human intestinal epithelial Caco-2 cell layers. British Journal of Pharmacology, 108, 575-586.
11. Griffin, J., Fletcher, N., Clemence, R., Blanchflower, S. & Brayden, D.J. (2005) Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein. Journal of Veterinary Pharmacology and Therapeutics, 28, 257-265.
12. Ho, R.H. & Kim, R.B. (2005) Transporters and drug therapy: implications for drug disposition and disease. Clinical Pharmacology and Therapeutics, 78, 260-277.
13. Imperiale, F., Lifschitz, A., Sallovitz, J., Virkel, G. & Lanusse, C. (2004) Comparative depletion of ivermectin and moxidectin milk residues in dairy sheep after oral and subcutaneous administration. Journal of Dairy Research, 71, 427-433.
14. Kiki-Mvouaka, S., Ménez, C., Borin, C., Lyazrhi, F., Foucaud-Vignault, M., Dupuy, J., Collet, X., Alvinerie, M. & Lespine, A. (2010) Role of P-glycoprotein in the disposition of macrocyclic lactones: a comparison between ivermectin, eprinomectin and moxidectin in mice. Drug Metabolism and Disposition, 38, 573-580.
15. Laffont, C.M., Toutain, P., Alviniere, M. & Bousquet-Mélou, A. (2002) Intestinal secretion is a major route for parent ivermectin elimination in the rat. Drug Metabolism and Disposition, 30, 626-630.
16. Lanusse, C., Lifschitz, A., Virkel, G., Alvarez, L., Sánchez, S., Sutra, J.F., Galtier, P. & Alvinerie, M. (1997) Comparative plasma disposition kinetics of ivermectin, moxidectin and doramectin in cattle. Journal of Veterinary Pharmacology and Therapeutics, 20, 91-99.
17. Lennernäs, H. (1997) Human jejunal effective permeability and its correlation with preclinical drug absorption models. Journal of Pharmacy and Pharmacology, 49, 627-638.
18. Lespine, A., Dupuy, J., Orlowski, S., Nagy, T., Glavinas, H., Krajcsi, P. & Alvinerie, M. (2006) Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3). Chemico-Biological Interactions, 159, 169-179.
19. Lespine, A., Martin, S., Dupuy, J., Roulet, A., Pineau, T., Orlowski, S. & Alvinerie, M. (2007) Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship. European Journal of Pharmaceutical Sciences, 30, 84-94.
20. Lifschitz, A., Virkel, G., Sallovitz, J., Imperiale, F., Pis, A. & Lanusse, C. (2002) Loperamide-induced enhancement of moxidectin availability in cattle. Journal of Veterinary Pharmacology and Therapeutics, 25, 111-120.
21. Lifschitz, A., Virkel, G., Sallovitz, J., Imperiale, F., Pis, A. & Lanusse, C. (2004) Loperamide modifies the tissue disposition kinetics of ivermectin in rats. Journal of Pharmacy and Pharmacology, 56, 61-67.
22. Lifschitz, A., Suarez, V.H., Sallovitz, J., Cristel, S.L., Imperiale, F., Ahoussou, S., Schiavi, C. & Lanusse, C. (2010a) Cattle nematodes resistant to macrocyclic lactones: comparative effects of P-glycoprotein modulation on the efficacy and disposition kinetics of ivermectin and moxidectin. Experimental Parasitology, 125, 172-178.
23. Lifschitz, A., Entrocasso, C., Alvarez, L., Lloberas, M., Ballent, M., Manazza, G., Virkel, G., Borda, B. & Lanusse, C. (2010b) Interference with P-glycoprotein improves ivermectin activity against adult resistant nematodes in sheep. Veterinary Parasitology, 172, 291-298.
24. Lowes, S. & Simmons, N. (2002) Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-r) cells. British Journal of Pharmacology, 135, 1263-1275.
25. Marchetti, S., Mazzanti, R., Beijnen, J.H. & Schellens, J.H. (2007) Concise review: clinical relevance of drug-drug and herb-drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein). Oncologist, 12, 927-941.
26. Mealey, K.L., Waiting, D., Raunig, D.L., Schmidt, K.R. & Nelson, F.R. (2010) Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs. Journal of Veterinary Pharmacology and Therapeutics, 33, 453-460.
27. Merino, G., Alvarez, A.I., Pulido, M.M., Molina, A.J., Schinkel, A.H. & Prieto, J.G. (2006) Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion. Drug Metabolism and Disposition, 34, 690-695.
28. Muenster, U., Grieshop, B., Ickenroth, K. & Gnoth, M.J. (2008) Characterization of substrates and inhibitors for the in vitro assessment of Bcrp mediated drug-drug interactions. Pharmacology Research, 25, 2320-2326.
29. Perez, M., Blazquez, A.G., Real, R., Mendoza, G., Prieto, J.G., Merino, G. & Alvarez, A.I. (2009) In vitro and in vivo interaction of moxidectin with BCRP/ABCG2. Chemic-Biological Interactions, 180, 106-112.
30. Pouliot, J.F., L'Heureux, F., Liu, Z., Prochard, R.K. & Georges, E. (1997) Reversal P-glycoprotein-associated multidrug resistance by ivermectin. Biochemical Pharmacology, 53, 17-25.
31. Prichard, R., Ménez, C. & Lespine, A. (2012) Moxidectin and the avermectins: consanguinity but not identity. International Journal of Parasitology: Drugs and Drug Resistance, 2, 134-153.
32. Real, R., Egido, E., Pérez, M., González-Lobato, L., Barrera, B., Prieto, J.G., Alvarez, A.I. & Merino, G. (2011) Involvement of breast cancer resistance protein (BCRP/ABCG2) in the secretion of danofloxacin into milk: interaction with ivermectin. Journal of Veterinary Pharmacology and Therapeutics, 34, 313-321.
33. Schinkel, A.H. & Jonker, J.W. (2003) Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Advanced Drug Delivery Reviews, 55, 3-29.
34. Schrickx, J.A. & Fink-Gremmels, J. (2007) Danofloxacin-mesylate is a substrate for ATP-dependent efflux transporters. British Journal of Pharmacology, 150, 463-469.
35. Žakelj, S., Sturm, S. & Kristl, A. (2006) Ciprofloxacin permeability and its active secretion through rat small intestine in vitro. International Journal of Pharmaceutics, 313, 175-180.