Antioxidant and anti-inflammatory effects of yam (dioscorea batatas decne.) on azoxymethane-induced colonic aberrant Crypt Foci in F344 Rats

Preventive Nutrition and Food Science

Volumn 19, Issue 2, 2014, Pages 82-88

  Son, In Suk ^a   Lee, Jeong Soon ^a   Lee, Ju Yeon ^a   Kwon, Chong Suk ^a  

^a Andong National University   (South Korea)

Author keywords

Antioxidant enzymes; Azoxymethane; Inflammatory mediators; Yam (Dioscorea batatas Decne.)

Indexed keywords

EID: 84903792130     PISSN: 22871098     EISSN: 22878602     Source Type: Journal    
DOI: 10.3746/pnf.2014.19.2.082     Document Type: Article

References (40)

1. Jemal A, Siegel R, Ward E., Murray T, Xu J, Smigal C., Thun MJ. 2006. Cancer statistics, 2006. CA Cancer J Clin 56: 106-130.
2. National Cancer Information Center: Cancer statistics. http://www.cancer.go.kr/mbs/cancer/subview (accessed March 15, 2014).
3. Sung JJ, Lau JY, Goh K.L., Leung WK, Asia Pacific Working Group on Colorectal Cancer. 2005. Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol 6: 871-876. (Pubitemid 41614799)
4. Stone WL, Papas AM 1997. Tocopherols and the etiology of colon cancer. J Natl Cancer Inst 89: 1006-1014. (Pubitemid 27327865)
5. Schatzkin A, Kelloff G. 1995. Chemo- and dietary prevention of colorectal cancer. Eur J Cancer 31: 1198-1204.
6. Valko M, Leibfritz D, Moncol J., Cronin MT, Mazur M, Telser J. 2007. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39: 44-84. (Pubitemid 44566469)
7. Ji LL, Gomez-Cabrera MC, Vina J. 2007. Role of nuclear factor kB and mitogen-activated protein kinase signaling in exercise-induced antioxidant enzyme adaptation. Appl Physiol Nutr Metab 32: 930-935.
8. Ray G, Husain SA 2002. Oxidants, antioxidants and carcin-ogenesis. Indian J Exp Biol 40: 1213-1232.
9. Poli G, Leonarduzzi G, Biasi F., Chiarpotto E. 2004. Oxidative stress and cell signaling. Curr Med Chem 11: 1163-1182.
10. Surh YJ, Chun KS, Cha H.H., Han SS, Keum YS, Park KK, Lee SS 2001. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kB activation. Mutat Res 480-481: 243-268. (Pubitemid 32744832)
11. Lappas M, Permezel M, Georgiou H.M., Rice GE 2002. Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitro. Biol Reprod 67: 668-673. (Pubitemid 34803959)
12. Shen HM, Tergaonkar V. 2009. NFkappaB signaling in carcinogenesis and as a potential molecular target for cancer therapy. Apoptosis 14: 348-363.
13. Ohta T, Takahashi M, Ochiai A. 2006. Increased protein expression of both inducible nitric oxide synthase and cyclooxygenase-2 in human colon cancers. Cancer Lett 239: 246-253. (Pubitemid 43974868)
14. Yang MH, Yoon KD, Chin Y.W., Kim JW 2009. Phyto-chemical and pharmacological profiles of Dioscorea species in Korea, China and Japan. Kor J Pharmacogn 40: 257-279.
15. Jin M, Suh SJ, Yang J.H., Lu Y., Kim SJ, Kwon SY, Jo TH, Kim J.W., Park YI, Ahn GW, Lee CK, Kim CH, Son JK, Son KH, Chang HW. 2010. Anti-inflammatory activity of bark of Dioscorea batatas DECNE through the inhibition of iNOS and COX-2 expressions in RAW264.7 cells via NF-kB and ERK1/2 inactivation. Food Chem Toxicol 48: 3073-3079.
16. Lu Y, Jin M, Park S.J., Son KH, Son JK, Chang HW 2011. Batatasin I, a naturally occurring phenanthrene derivative, isolated from tuberous roots of Dioscorea batatas suppresses eicosanoids generation and degranulation in bone marrow derived-mast cells. Biol Pharm Bull 34: 1021-1025.
17. 4 production in mouse bone marrow-derived mast cells. Arch Pharm Res 34: 1495-1501.
18. Chiu CS, Deng JS, Chang H.Y., Chen YC, Lee MM, Hou WC, Lee C.Y., Hunag SS, Huang GJ. 2013. Antioxidant and anti-inflammatory properties of Taiwanese yam (Dioscorea japonica Thunb. var. pseudojaponica (Hayata) Yamam.) and its reference compounds. Food Chem 141: 1087-1096.
19. Miyoshi N, Nagasawa T, Mabuchi R., Yasui Y, Wakabayashi K, Tanaka T., Ohshima H. 2011. Chemoprevention of azoxy-methane/dextran sodium sulfate-induced mouse colon carci-nogenesis by freeze-dried yam sanyaku and its constituent diosgenin. Cancer Prev Res 4: 924-934.
20. Bird RP. 1987. Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett 37: 147-151. (Pubitemid 17157833)
21. -δδCT method. Methods 25: 402-408. (Pubitemid 34164012)
22. McLellan EA, Medline A, Bird RP 1991. Dose response and proliferative characteristics of aberrant crypt foci: putative preneoplastic lesions in rat colon. Carcinogenesis 12: 2093-2098.
23. Bird RP. 1995. Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 93: 55-71.
24. Alrawi SJ, Schiff M, Carroll R.E., Dayton M., Gibbs JF, Kulavlat M, Tan D, Berman K., Stoler DL, Anderson GR. 2006. Aberrant crypt foci. Anticancer Res 26: 107-119. (Pubitemid 43206067)
25. Kurata M, Suzuki M, Agar NS 1993. Antioxidant systems and erythrocyte life-span in mammals. Comp Biochem Physiol B 106: 477-487. (Pubitemid 23310844)
26. Nagai T, Nagashima T. 2006. Functional properties of dioscorin, a soluble viscous protein from Japanese yam (Dioscorea opposita Thunb.) tuber mucilage tororo. Z Naturforsch C 61: 792-798. (Pubitemid 46159131)
27. Lin SY, Liu HY, Lu Y.L., Hou WC 2005. Antioxidant activities of mucilages from different Taiwanese yam cultivars. Bot Bull Acad Sin 46: 183-188.
28. Bhandari MR, Kawabata J. 2004. Organic acid, phenolic content and antioxidant activity of wild yam (Dioscorea spp.) tubers of Nepal. Food Chem 88: 163-168. (Pubitemid 38887354)
29. Fiala ES. 1977. Investigations into the metabolism and mode of action of the colon carcinogens 1, 2-dimethylhydrazine and azoxymethane. Cancer 40: 2436-2445. (Pubitemid 8237744)
30. Szatrowski TP, Nathan CF 1991. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 51: 794-798.
31. Storz P. 2005. Reactive oxygen species in tumor progression. Front Biosci 10: 1881-1896. (Pubitemid 40529044)
32. Ozen T, Korkmaz H. 2003. Modulatory effect of Urtica dioica L (Urticaceae) leaf extract on biotransformation of enzyme systems, antioxidant enzymes, LDH and lipid peroxidation in mice. Phytomedicine 10: 405-415. (Pubitemid 36745164)
33. Umesalma S, Sudhandiran G. 2010. Chemomodulation of the antioxidative enzymes and peroxidative damage in the colon of 1, 2-dimethyl hydrazine-induced rats by ellagicacid. Phytother Res 24: S114-S119.
34. Rajeshkumar NV, Kuttan R. 2003. Modulation of carcinogenic response and antioxidant enzymes of rats administered with 1, 2-dimethylhydrazine by Picroliv. Cancer Lett 191: 137-143. (Pubitemid 36255598)
35. Chandel NS, Trzyna WC, McClintock D.S., Schumacker PT 2000. Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. J Immunol 165: 1013-1021. (Pubitemid 30484771)
36. Escárcega R.O., Fuentes-Alexandro S, García-Carrasco M, Gatica A, Zamora A. 2007. The transcription factor nuclear factor-kappa B and cancer. Clin Oncol 19: 154-161. (Pubitemid 46172840)
37. Maihöfner C., Charalambous MP, Bhambra U, Lightfoot T., Geisslinger G, Gooderham NJ; Colorectal Cancer Group. 2003. Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. Carcinogenesis 24: 665-671. (Pubitemid 36592401)
38. Tak PP, Firestein GS 2001. NF-kB: a key role in inflammatory diseases. J Clin Invest 107: 7-11. (Pubitemid 32047405)
39. Moore RJ, Owens DM, Stamp G, Arnott C., Burke F, East N, Holdsworth H., Turner L, Rollins B, Pasparakis M, Kollias G, Balkwill F. 1999. Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nat Med 5: 828-831. (Pubitemid 29318619)
40. Rao CV, Kawamori T, Hamid R., Reddy BS 1999. Chemo-prevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor. Carcinogenesis 20: 641-644. (Pubitemid 29151301)