메뉴 건너뛰기




Volumn 6, Issue 4, 2014, Pages 871-878

Evaluation of cardiovascular parameters in cynomolgus monkeys following IV administration of LBR-101, a monoclonal antibody against calcitonin gene-related peptide

Author keywords

Antibody; Cardiovascular; CGRP; Hemodynamic; Migraine; Safety

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; LBR 101; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

EID: 84903783970     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.29242     Document Type: Article
Times cited : (36)

References (37)
  • 1
    • 0027509161 scopus 로고
    • The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats
    • PMID:8388188
    • Goadsby PJ, Edvinsson L. The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol 1993; 33:48-56; PMID:8388188; http://dx.doi.org/10.1002/ ana.410330109
    • (1993) Ann Neurol , vol.33 , pp. 48-56
    • Goadsby, P.J.1    Edvinsson, L.2
  • 2
    • 0025116298 scopus 로고
    • Extracerebral manifestations in migraine. A peptidergic involvement?
    • PMID:2266336
    • Edvinsson L, Goadsby PJ. Extracerebral manifestations in migraine. A peptidergic involvement? J Intern Med 1990; 228:299-304; PMID:2266336; http://dx.doi.org/10.1111/j.1365-2796.1990.tb00236.x
    • (1990) J Intern Med , vol.228 , pp. 299-304
    • Edvinsson, L.1    Goadsby, P.J.2
  • 3
    • 0025143541 scopus 로고
    • Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
    • PMID:1699472
    • Goadsby PJ, Edvinsson L, Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 1990; 28:183-7; PMID:1699472; http://dx.doi.org/10.1002/ana.410280213
    • (1990) Ann Neurol , vol.28 , pp. 183-187
    • Goadsby, P.J.1    Edvinsson, L.2    Ekman, R.3
  • 5
    • 57649233374 scopus 로고    scopus 로고
    • Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin generelated peptide receptor, compared with zolmitriptan for acute migraine: A randomised, placebo-controlled, parallel-treatment trial
    • PMID:19036425
    • Ho TW, Ferrari MD, Dodick DW, Galet V, Kost J, Fan X, Leibensperger H, Froman S, Assaid C, Lines C, et al. Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin generelated peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial. Lancet 2008; 372:2115-23; PMID:19036425; http://dx.doi.org/10.1016/S0140-6736(08)61626-8
    • (2008) Lancet , vol.372 , pp. 2115-2123
    • Ho, T.W.1    Ferrari, M.D.2    Dodick, D.W.3    Galet, V.4    Kost, J.5    Fan, X.6    Leibensperger, H.7    Froman, S.8    Assaid, C.9    Lines, C.10
  • 7
    • 1542346238 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine
    • BIBN 4096 BS Clinical Proof of Concept Study Group PMID:15014183
    • Olesen J, Diener HC, Husstedt IW, Goadsby PJ, Hall D, Meier U, Pollentier S, Lesko LM; BIBN 4096 BS Clinical Proof of Concept Study Group. Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine. N Engl J Med 2004; 350:1104-10; PMID:15014183; http://dx.doi.org/10. 1056/NEJMoa030505
    • (2004) N Engl J Med , vol.350 , pp. 1104-1110
    • Olesen, J.1    Diener, H.C.2    Husstedt, I.W.3    Goadsby, P.J.4    Hall, D.5    Meier, U.6    Pollentier, S.7    Lesko, L.M.8
  • 8
    • 84871261412 scopus 로고    scopus 로고
    • Emerging target-based paradigms to prevent and treat migraine
    • PMID:23212108
    • Silberstein SD. Emerging target-based paradigms to prevent and treat migraine. Clin Pharmacol Ther 2013; 93:78-85; PMID:23212108; http://dx.doi.org/10.1038/clpt.2012.198
    • (2013) Clin Pharmacol Ther , vol.93 , pp. 78-85
    • Silberstein, S.D.1
  • 9
    • 84857633644 scopus 로고    scopus 로고
    • New Agents for Acute Treatment of Migraine: CGRP Receptor Antagonists, iNOS Inhibitors
    • PMID:22090312
    • Hoffmann J, Goadsby PJ. New Agents for Acute Treatment of Migraine: CGRP Receptor Antagonists, iNOS Inhibitors. Curr Treat Options Neurol 2012; 14:50-9; PMID:22090312; http://dx.doi.org/10.1007/s11940-011-0155-4
    • (2012) Curr Treat Options Neurol , vol.14 , pp. 50-59
    • Hoffmann, J.1    Goadsby, P.J.2
  • 10
    • 17644413164 scopus 로고    scopus 로고
    • Humanized antibodies and their applications
    • PMID:15848069
    • Wu H, Dall'Acqua WF. Humanized antibodies and their applications. Methods 2005; 36:1-2; PMID:15848069; http://dx.doi.org/10.1016/j.ymeth.2005.02.001
    • (2005) Methods , vol.36 , pp. 1-2
    • Wu, H.1    Dall'Acqua, W.F.2
  • 11
    • 0031106389 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide and reperfusion injury
    • PMID:9167627
    • Allen DM, Chen LE, Seaber AV, Urbaniak JR. Calcitonin gene-related peptide and reperfusion injury. J Orthop Res 1997; 15:243-8; PMID:9167627; http://dx.doi.org/10.1002/jor.1100150213
    • (1997) J Orthop Res , vol.15 , pp. 243-248
    • Allen, D.M.1    Chen, L.E.2    Seaber, A.V.3    Urbaniak, J.R.4
  • 12
    • 0032076264 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide in myocardial ischaemia and reperfusion in the pig
    • PMID:9709411
    • Källner G, Gonon A, Franco-Cereceda A. Calcitonin gene-related peptide in myocardial ischaemia and reperfusion in the pig. Cardiovasc Res 1998; 38:493-9; PMID:9709411; http://dx.doi.org/10.1016/ S0008-6363(98)00016-9
    • (1998) Cardiovasc Res , vol.38 , pp. 493-499
    • Källner, G.1    Gonon, A.2    Franco-Cereceda, A.3
  • 13
    • 78650763344 scopus 로고    scopus 로고
    • Effect of calcitonin gene-related peptide receptor antagonism on the systemic blood pressure responses to mechanistically diverse vasomodulators in conscious rats
    • PMID:20729756
    • Lynch JJ Jr., Detwiler TJ, Kane SA, Regan CP. Effect of calcitonin gene-related peptide receptor antagonism on the systemic blood pressure responses to mechanistically diverse vasomodulators in conscious rats. J Cardiovasc Pharmacol 2010; 56:518-25; PMID:20729756; http://dx.doi.org/10.1097/ FJC.0b013e3181f5d414
    • (2010) J Cardiovasc Pharmacol , vol.56 , pp. 518-525
    • Lynch Jr., J.J.1    Detwiler, T.J.2    Kane, S.A.3    Regan, C.P.4
  • 14
    • 23944444767 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide and substance P contribute to reduced blood pressure in sympathectomized rats
    • PMID:15879482
    • Supowit SC, Ethridge RT, Zhao H, Katki KA, Dipette DJ. Calcitonin gene-related peptide and substance P contribute to reduced blood pressure in sympathectomized rats. Am J Physiol Heart Circ Physiol 2005; 289:H1169-75; PMID:15879482; http://dx.doi.org/10.1152/ajpheart.00973.2004
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Supowit, S.C.1    Ethridge, R.T.2    Zhao, H.3    Katki, K.A.4    Dipette, D.J.5
  • 16
    • 70350335038 scopus 로고    scopus 로고
    • Effects of the prototype serotonin 5-HT(1B/1D) receptor agonist sumatriptan and the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37) on myocardial reactive hyperemic response in conscious dogs
    • PMID:19766109
    • Lynch JJ, Shen YT, Pittman TJ, Anderson KD, Koblan KS, Gould RJ, Regan CP, Kane SA. Effects of the prototype serotonin 5-HT(1B/1D) receptor agonist sumatriptan and the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37) on myocardial reactive hyperemic response in conscious dogs. Eur J Pharmacol 2009; 623:96-102; PMID:19766109; http://dx.doi.org/10.1016/j.ejphar. 2009.09.018
    • (2009) Eur J Pharmacol , vol.623 , pp. 96-102
    • Lynch, J.J.1    Shen, Y.T.2    Pittman, T.J.3    Anderson, K.D.4    Koblan, K.S.5    Gould, R.J.6    Regan, C.P.7    Kane, S.A.8
  • 17
    • 79953840319 scopus 로고    scopus 로고
    • The potent calcitonin gene-related peptide receptor antagonist, telcagepant, does not affect nitroglycerin-induced vasodilation in healthy men
    • PMID:21480950
    • Van der Schueren BJ, Blanchard R, Murphy MG, Palcza J, De Lepeleire I, Van Hecken A, Depré M, de Hoon JN. The potent calcitonin gene-related peptide receptor antagonist, telcagepant, does not affect nitroglycerin-induced vasodilation in healthy men. Br J Clin Pharmacol 2011; 71:708-17; PMID:21480950; http://dx.doi.org/10.1111/j.1365-2125.2010.03869.x
    • (2011) Br J Clin Pharmacol , vol.71 , pp. 708-717
    • Van Der Schueren, B.J.1    Blanchard, R.2    Murphy, M.G.3    Palcza, J.4    De Lepeleire, I.5    Van Hecken, A.6    Depré, M.7    De Hoon, J.N.8
  • 19
    • 84884151958 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide (CGRP) and migraine current understanding and state of development
    • PMID:23848260
    • Bigal ME, Walter S, Rapoport AM. Calcitonin gene-related peptide (CGRP) and migraine current understanding and state of development. Headache 2013; 53:1230-44; PMID:23848260; http://dx.doi.org/10.1111/head.12179
    • (2013) Headache , vol.53 , pp. 1230-1244
    • Bigal, M.E.1    Walter, S.2    Rapoport, A.M.3
  • 20
    • 77957922955 scopus 로고    scopus 로고
    • CGRP and its receptors provide new insights into migraine pathophysiology
    • PMID:20820195
    • Ho TW, Edvinsson L, Goadsby PJ. CGRP and its receptors provide new insights into migraine pathophysiology. Nat Rev Neurol 2010; 6:573-82; PMID:20820195; http://dx.doi.org/10.1038/nrneurol.2010.127
    • (2010) Nat Rev Neurol , vol.6 , pp. 573-582
    • Ho, T.W.1    Edvinsson, L.2    Goadsby, P.J.3
  • 21
    • 84883259160 scopus 로고    scopus 로고
    • The pipeline in headache therapy
    • PMID:23839594
    • Vollbracht S, Rapoport AM. The pipeline in headache therapy. CNS Drugs 2013; 27:717-29; PMID:23839594; http://dx.doi.org/10.1007/s40263-013-0090-x
    • (2013) CNS Drugs , vol.27 , pp. 717-729
    • Vollbracht, S.1    Rapoport, A.M.2
  • 22
    • 0032810008 scopus 로고    scopus 로고
    • Recombinant human IgG molecules lacking Fcgamma receptor I binding and monocyte triggering activities
    • PMID:10458776
    • Armour KL, Clark MR, Hadley AG, Williamson LM. Recombinant human IgG molecules lacking Fcgamma receptor I binding and monocyte triggering activities. Eur J Immunol 1999; 29:2613-24; PMID:10458776; http://dx.doi.org/10.1002/(SICI) 1521-4141(199908)29: 08〈2613: :AIDIMMU2613〉3.0.CO;2-J
    • (1999) Eur J Immunol , vol.29 , pp. 2613-2624
    • Armour, K.L.1    Clark, M.R.2    Hadley, A.G.3    Williamson, L.M.4
  • 23
    • 56749176453 scopus 로고    scopus 로고
    • CGRP function-blocking antibodies inhibit neurogenic vasodilatation without affecting heart rate or arterial blood pressure in the rat
    • PMID:18776916
    • Zeller J, Poulsen KT, Sutton JE, Abdiche YN, Collier S, Chopra R, Garcia CA, Pons J, Rosenthal A, Shelton DL. CGRP function-blocking antibodies inhibit neurogenic vasodilatation without affecting heart rate or arterial blood pressure in the rat. Br J Pharmacol 2008; 155:1093-103; PMID:18776916; http://dx.doi.org/10.1038/bjp.2008.334
    • (2008) Br J Pharmacol , vol.155 , pp. 1093-1103
    • Zeller, J.1    Poulsen, K.T.2    Sutton, J.E.3    Abdiche, Y.N.4    Collier, S.5    Chopra, R.6    Garcia, C.A.7    Pons, J.8    Rosenthal, A.9    Shelton, D.L.10
  • 24
    • 0032979346 scopus 로고    scopus 로고
    • Pharmacology and safety assessment of humanized monoclonal antibodies for therapeutic use
    • PMID:10367664
    • Klingbeil C, Hsu DH. Pharmacology and safety assessment of humanized monoclonal antibodies for therapeutic use. Toxicol Pathol 1999; 27:1-3; PMID:10367664; http://dx.doi.org/10.1177/019262339902700101
    • (1999) Toxicol Pathol , vol.27 , pp. 1-3
    • Klingbeil, C.1    Hsu, D.H.2
  • 26
    • 84901046526 scopus 로고    scopus 로고
    • Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program
    • PMID:24366980
    • Bigal ME, Escandon R, Bronson M, Walter S, Sudworth M, Huggins JP, Garzone P. Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program. Cephalalgia 2013; 34:483-92; PMID:24366980; http://dx.doi.org/10.1177/ 0333102413517775
    • (2013) Cephalalgia , vol.34 , pp. 483-492
    • Bigal, M.E.1    Escandon, R.2    Bronson, M.3    Walter, S.4    Sudworth, M.5    Huggins, J.P.6    Garzone, P.7
  • 27
    • 0032868529 scopus 로고    scopus 로고
    • Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development
    • PMID:10532808
    • Lu JT, Son YJ, Lee J, Jetton TL, Shiota M, Moscoso L, Niswender KD, Loewy AD, Magnuson MA, Sanes JR, et al. Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development. Mol Cell Neurosci 1999; 14:99-120; PMID:10532808; http://dx.doi.org/10.1006/ mcne.1999.0767
    • (1999) Mol Cell Neurosci , vol.14 , pp. 99-120
    • Lu, J.T.1    Son, Y.J.2    Lee, J.3    Jetton, T.L.4    Shiota, M.5    Moscoso, L.6    Niswender, K.D.7    Loewy, A.D.8    Magnuson, M.A.9    Sanes, J.R.10
  • 30
    • 78649940547 scopus 로고    scopus 로고
    • Possible sites of action of the new calcitonin gene-related peptide receptor antagonists
    • PMID:21179597
    • Eftekhari S, Edvinsson L. Possible sites of action of the new calcitonin gene-related peptide receptor antagonists. Ther Adv Neurol Disord 2010; 3:369-78; PMID:21179597; http://dx.doi.org/10.1177/1756285610388343
    • (2010) Ther Adv Neurol Disord , vol.3 , pp. 369-378
    • Eftekhari, S.1    Edvinsson, L.2
  • 31
    • 84857084559 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide in migraine: Intersection of peripheral inflammation and central modulation
    • PMID:22123247
    • Raddant AC, Russo AF. Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation. Expert Rev Mol Med 2011; 13:e36; PMID:22123247; http://dx.doi.org/10.1017/S1462399411002067
    • (2011) Expert Rev Mol Med , vol.13
    • Raddant, A.C.1    Russo, A.F.2
  • 33
    • 84861584700 scopus 로고    scopus 로고
    • Central ventilatory and cardiovascular actions of calcitonin gene-related peptide in unanesthetized trout
    • PMID:22573772
    • Le Mével JC, Lancien F, Mimassi N, Kermorgant M, Conlon JM. Central ventilatory and cardiovascular actions of calcitonin gene-related peptide in unanesthetized trout. J Exp Biol 2012; 215:1930-7; PMID:22573772; http://dx.doi.org/10.1242/jeb.070177
    • (2012) J Exp Biol , vol.215 , pp. 1930-1937
    • Le Mével, J.C.1    Lancien, F.2    Mimassi, N.3    Kermorgant, M.4    Conlon, J.M.5
  • 34
    • 84871067431 scopus 로고    scopus 로고
    • Compensatory vasodilatation during hypoxic exercise: Mechanisms responsible for matching oxygen supply to demand
    • PMID:22988134
    • Casey DP, Joyner MJ. Compensatory vasodilatation during hypoxic exercise: mechanisms responsible for matching oxygen supply to demand. J Physiol 2012; 590:6321-6; PMID:22988134; http://dx.doi.org/10.1113/jphysiol.2012.242396
    • (2012) J Physiol , vol.590 , pp. 6321-6326
    • Casey, D.P.1    Joyner, M.J.2
  • 35
    • 0034718464 scopus 로고    scopus 로고
    • Practice parameter: Evidence-based guidelines for migraine headache (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology
    • PMID:10993991
    • Silberstein SD. Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2000; 55:754-62; PMID:10993991; http://dx.doi.org/10.1212/WNL.55.6.754
    • (2000) Neurology , vol.55 , pp. 754-762
    • Silberstein, S.D.1
  • 36
    • 0003633755 scopus 로고    scopus 로고
    • Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council
    • Guide for the Care and Use of Laboratory Animals. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, 1996.
    • (1996) Guide for the Care and Use of Laboratory Animals
  • 37
    • 79952477780 scopus 로고    scopus 로고
    • Henry Cuthbert Bazett (1885-1950) - The man behind the QT interval correction formula
    • PMID:21091739
    • Roguin A. Henry Cuthbert Bazett (1885-1950) - the man behind the QT interval correction formula. Pacing Clin Electrophysiol 2011; 34:384-8; PMID:21091739; http://dx.doi.org/10.1111/j.1540-8159.2010.02973.x
    • (2011) Pacing Clin Electrophysiol , vol.34 , pp. 384-388
    • Roguin, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.