High frequency of circulating follicular helper T cells in patients with bronchial asthma

Clinical Laboratory

Volumn 60, Issue 6, 2014, Pages 963-968

  Gong, Fang ^a   Su, Qiang ^a   Jiang, Dongling ^a   Chen, Jiang ^a   Pan, Yuhong ^a   Huang, Xuan ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Bronchial asthma; CXCR5; Follicular helper T

Indexed keywords

CHEMOKINE RECEPTOR CXCR5; IMMUNOGLOBULIN E; INTERLEUKIN 21; MESSENGER RNA; PROTEIN BCL 6;

ADULT; ARTICLE; ASTHMA; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FOLLICULAR HELPER T CELL; FORCED EXPIRATORY VOLUME; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; MALE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION;

ADULT; ANALYSIS OF VARIANCE; ASTHMA; DNA-BINDING PROTEINS; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN E; INTERLEUKINS; MALE; MIDDLE AGED; RECEPTORS, CXCR5; T-LYMPHOCYTES, HELPER-INDUCER; YOUNG ADULT;

EID: 84903783917     PISSN: 14336510     EISSN: None     Source Type: Journal    
DOI: 10.7754/Clin.Lab.2013.130427     Document Type: Article

References (26)

1. Boyce JA, Bochner B, Finkelman FD, Rothenberg ME. Advances in mechanisms of asthma, allergy, and immunology in 2011. J Allergy Clin Immunol 2012;129:335-41.
2. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-57. (Pubitemid 16136806)
3. Kips JC, Brusselle GG, Joos GF, et al. Importance of interleukin-4 4 interleukin-12 in allergen-induced airway changes in mice. Int Arch Allergy Immunol 1995;107:115-8.
4. Corry DB, Folkesson HG, Warnock ML, et al. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med 1996;183:109-17. (Pubitemid 26028750)
5. Wegmann M. Th2 cells as targets for therapeutic intervention in allergic bronchial asthma. Expert Rev Mol Diagn 2009;9:85-100.
6. Breitfeld D, Ohl L, Kremmer E, et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 2000;192:1545-52.
7. Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 2000;192:1553-62.
8. King C, Tangye SG, Mackay CR. T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol 2008;26:741-66. (Pubitemid 351600391)
9. Nurieva RI, Chung Y, Hwang D, et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1,2, or 17 cell lineages. Immunity 2008;29:138-49.
10. Ma CS, Deenick EK, Batten M, Tangye SG. The origins, function, and regulation of T follicular helper cells. J Exp Med 2012;209:1241-53.
11. Yusuf I, Kageyama R, Monticelli L, et al. Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol 2010;185:190-202.
12. Morita R, Schmitt N, Bentebibel SE, et al. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 2011;34:108-21.
13. Coraglia A, Felippo M, Schierloh P, Malbran A, de Bracco MM. CD4+ T Lymphocytes with follicular helper phenotype (T(FH)) in patients with SH2D1A deficiency (XLP). Clin Immunol 2011;141:357-64.
14. Feng J, Lu L, Hua C, et al. High frequency of CD4+ CXCR5+ TFH cells in patients with immune-active chronic hepatitis B. PLoS One 2011;6:e21698.
15. Li XY, Wu ZB, Ding J, et al. Role of the frequency of blood CD4(+) CXCR5(+) CCR6(+) T cells in autoimmunity in patients with Sjögren's syndrome. Biochem Biophys Res Commun 2012;422:238-44.
16. Ma J, Zhu C, Ma B, et al. Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis. Clin Dev Immunol 2012;2012:827480.
17. Bateman ED, Hurd SS, Barnes PJ, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008;31:143-78.
18. Johnston RJ, Poholek AC, DiToro D, et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 2009;325:1006-10.
19. Nurieva RI, Chung Y, Martinez GJ, et al. Bcl6 mediates the development of T follicular helper cells. Science 2009;325:1001-5.
20. Gauchat JF, Lebman DA, Coffman RL, Gascan H, de Vries JE. Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production. J Exp Med 1990;172:463-73. (Pubitemid 20248388)
21. Armitage RJ, Fanslow WC, Strockbine L, et al. Molecular and biological characterization of a murine ligand for CD40. Nature 1992;357:80-2.
22. Ozaki K, Spolski R, Feng CG, et al. A critical role for IL-21 in regulating immunoglobulin production. Science 2002;298:1630-4. (Pubitemid 35387203)
23. Shang XZ, Ma KY, Radewonuk J, et al. IgE isotype switch and IgE production are enhanced in IL-21-deficient but not IFN-gamma-deficient mice in a Th2-biased response. Cell Immunol 2006;241:66-74. (Pubitemid 44648023)
24. Hiromura Y, Kishida T, Nakano H, et al. IL-21 administration into the nostril alleviates murine allergic rhinitis. J Immunol 2007;179:7157-65.
25. Kobayashi S, Haruo N, Sugane K, Ochs HD, Agematsu K. Interleukin-21 stimulates B-cell immunoglobulin E synthesis in human beings concomitantly with activation-induced cytidine deaminase expression and differentiation into plasma cells. Hum Immunol 2009;70:35-40.
26. Avery DT, Ma CS, Bryant VL, et al. STAT3 is required for IL-21-induced secretion of IgE from human naive B cells. Blood 2008;112:1784-93.