Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) procedure for screening of urine specimens for 100 analytes relevant in drug-facilitated crime (DFC)

Analytical and Bioanalytical Chemistry

Volumn 406, Issue 18, 2014, Pages 4411-4424

  Remane, Daniela ^a   Wetzel, Diana ^a   Peters, Frank T ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

Drug facilitated assault; Drug facilitated crime; LC MS MS; Matrix effects; Urine; Validation

Indexed keywords

BODY FLUIDS; CRIME; ELECTROSPRAY IONIZATION; INDUCTIVELY COUPLED PLASMA; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

DRUG-FACILITATED ASSAULT; DRUG-FACILITATED CRIMES; LC-MS/MS; MATRIX EFFECTS; URINE; VALIDATION;

DRUG DOSAGE;

BENZODIAZEPINE DERIVATIVE; DOXYLAMINE; DRONABINOL; DRUG; OXYBATE SODIUM; TETRAZEPAM;

CRIME; CRIME VICTIM; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; FORENSIC MEDICINE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; PROCEDURES; SEXUAL CRIME; TANDEM MASS SPECTROMETRY; URINALYSIS; URINE; VALIDATION STUDY; YOUNG ADULT;

BENZODIAZEPINES; CHROMATOGRAPHY, LIQUID; CRIME; CRIME VICTIMS; DOXYLAMINE; DRONABINOL; FEMALE; FORENSIC MEDICINE; HUMANS; MALE; PHARMACEUTICAL PREPARATIONS; SEX OFFENSES; SODIUM OXYBATE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; URINALYSIS; YOUNG ADULT;

EID: 84903783736     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-014-7841-5     Document Type: Article

References (36)

1. Hall JA, Moore CB (2008) Drug facilitated sexual assault - a review. J Forensic Legal Med 15(5):291-297. doi: 10.1016/j.jflm.2007.12.005
2. Madea B, Musshoff F (2009) Knock-out drugs: their prevalence, modes of action, and means of detection. Dtsch Arztebl Int 106(20):341-347. doi: 10.3238/arztebl.2009.0341
3. Goulle JP, Anger JP (2004) Drug-facilitated robbery or sexual assault: problems associated with amnesia. Ther Drug Monit 26(2):206-210
4. Scott-Ham M, Burton FC (2005) Toxicological findings in cases of alleged drug-facilitated sexual assault in the United Kingdom over a 3-year period. J Clin Forensic Med 12(4):175-186. doi: 10.1016/j.jcfm.2005.03.009
5. Madea B, Plieger S, Musshoff F (2008) Begutachtung in Fällen von drogenassoziierten Sexualdelikten. Aktuelle Beiträge zur Forensischen und Klinischen Toxikologie Bad Vilbel:116-124
6. Kauert GF (2008) Pharmakologisches Knocked Out. Ist das Bewusstlosigkeit oder was? Aktuelle Beiträge zur Forensischen und Klinischen Toxikologie Bad Vilbel:107-110
7. Beynon CM, McVeigh C, McVeigh J, Leavey C, Bellis MA (2008) The involvement of drugs and alcohol in drug-facilitated sexual assault: a systematic review of the evidence. Trauma Violence Abuse 9(3):178-188. doi: 10.1177/1524838008320221
8. Schwartz RH, Milteer R, LeBeau MA (2000) Drug-facilitated sexual assault ('date rape'). South Med J 93(6):558-561
9. Brown SD, Melton TC (2011) Trends in bioanalytical methods for the determination and quantification of club drugs: 2000-2010. Biomed Chromatogr: BMC 25(1-2):300-321. doi: 10.1002/bmc.1549
10. Kintz P (2007) Bioanalytical procedures for detection of chemical agents in hair in the case of drug-facilitated crimes. Anal Bioanal Chem 388(7):1467-1474. doi: 10.1007/s00216-007-1209-z
11. SOFT DFSA Committee (2012) Recommended minimum performance limits for common DFSA drugs and metabolites in urine samples. http://soft-tox.org/sites/ default/files/SOFT-DFSA-Rec-Det-Limits-3-2012.pdf. Accessed 22 May 2013
12. LeBeau MA (2008) Guidance for improved detection of drugs used to facilitate crimes. Ther Drug Monit 30(2):229-233. doi: 10.1097/FTD. 0b013e31816791d7
13. von Mach MA, Weber C, Meyer MR, Weilemann LS, Maurer HH, Peters FT (2007) Comparison of urinary on-site immunoassay screening and gas chromatography-mass spectrometry results of 111 patients with suspected poisoning presenting at an emergency department. Ther Drug Monit 29(1):27-39. doi: 10.1097/FTD. 0b013e31802bb2aa
14. Kintz P, Villain M, Dumestre-Toulet V, Ludes B (2005) Drug-facilitated sexual assault and analytical toxicology: the role of LC-MS/MS A case involving zolpidem. J Clin Forensic Med 12(1):36-41. doi: 10.1016/j.jcfm.2004.08.005
15. Deveaux M, Cheze M, Pepin G (2008) The role of liquid chromatography-tandem mass spectrometry (LC-MS/MS) to test blood and urine samples for the toxicological investigation of drug-facilitated crimes. Ther Drug Monit 30(2):225-228. doi: 10.1097/FTD.0b013e3181676186
16. Parkin MC, Turfus SC, Smith NW, Halket JM, Braithwaite RA, Elliott SP, Osselton MD, Cowan DA, Kicman AT (2008) Detection of ketamine and its metabolites in urine by ultra high pressure liquid chromatography-tandem mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 876(1):137-142. doi: 10.1016/j.jchromb.2008.09.036
17. Quintela O, Sauvage FL, Charvier F, Gaulier JM, Lachatre G, Marquet P (2006) Liquid chromatography-tandem mass spectrometry for detection of low concentrations of 21 benzodiazepines, metabolites, and analogs in urine: method with forensic applications. Clin Chem 52(7):1346-1355. doi: 10.1373/clinchem. 2005.065631
18. Birkler RI, Telving R, Ingemann-Hansen O, Charles AV, Johannsen M, Andreasen MF (2012) Screening analysis for medicinal drugs and drugs of abuse in whole blood using ultra-performance liquid chromatography time-of-flight mass spectrometry (UPLC-TOF-MS)-toxicological findings in cases of alleged sexual assault. Forensic Sci Int 222(1-3):154-161. doi: 10.1016/j.forsciint.2012.05.019
19. Vincenti M, Cavanna D, Gerace E, Pirro V, Petrarulo M, Di Corcia D, Salomone A (2012) Fast screening of 88 pharmaceutical drugs and metabolites in whole blood by ultrahigh-performance liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. doi: 10.1007/s00216-012-6403-y
20. Ishida T, Kudo K, Hayashida M, Ikeda N (2009) Rapid and quantitative screening method for 43 benzodiazepines and their metabolites, zolpidem and zopiclone in human plasma by liquid chromatography/mass spectrometry with a small particle column. J Chromatogr B Anal Technol Biomed Life Sci 877(25):2652-2657. doi: 10.1016/j.jchromb.2009.05.008
21. Adamowicz P, Kala M (2010) Simultaneous screening for and determination of 128 date-rape drugs in urine by gas chromatography-electron ionization-mass spectrometry. Forensic Sci Int 198(1-3):39-45. doi: 10.1016/j.forsciint.2010.02. 012
22. Juhascik M, Le NL, Tomlinson K, Moore C, Gaensslen RE, Negrusz A (2004) Development of an analytical approach to the specimens collected from victims of sexual assault. J Anal Toxicol 28(6):400-406
23. Martinez-Ramirez JA, Voigt K, Peters FT (2012) Studies on the metabolism of five model drugs by fungi colonizing cadavers using LC-ESI-MS/MS and GC-MS analysis. Anal Bioanal Chem. doi: 10.1007/s00216-012-6212-3
24. Paul LD, Musshoff F (2009) Richtilinie der GTFCh zur Qualitä tssicherung bei forensisch-toxikologischen Untersuchungen. Toxichem Krimtech 76(3):142-176
25. Wissenbach DK, Meyer MR, Remane D, Weber AA, Maurer HH (2011) Development of the first metabolite-based LC-MS(n) urine drug screening procedure-exemplified for antidepressants. Anal Bioanal Chem 400(1):79-88. doi: 10.1007/s00216-010-4398-9
26. Matuszewski BK, Constanzer ML, Chavez-Eng CM (2003) Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal Chem 75(13):3019-3030
27. Yeatman DT, Reid K (2003) A study of urinary endogenous gamma-hydroxybutyrate (GHB) levels. J Anal Toxicol 27(1):40-42
28. LeBeau MA, Montgomery MA, Morris-Kukoski C, Schaff JE, Deakin A, Levine B (2006) A comprehensive study on the variations in urinary concentrations of endogenous gamma-hydroxybutyrate (GHB). J Anal Toxicol 30(2):98-105
29. Salomone A, Di Corcia D, Gerace E, Vincenti M (2011) A fatal case of simultaneous ingestion of mirtazapine, escitalopram, and valproic acid. J Anal Toxicol 35(7):519-523
30. Gao S, Miao H, Tao X, Jiang B, Xiao Y, Cai F, Yun Y, Li J, Chen W (2011) LC-MS/MS method for simultaneous determination of valproic acid and major metabolites in human plasma. J Chromatogr B Anal Technol Biomed Life Sci 879(21):1939-1944. doi: 10.1016/j.jchromb.2011.05.022
31. Jain DS, Subbaiah G, Sanyal M, Shrivastav P (2007) A high throughput and selective method for the estimation of valproic acid an antiepileptic drug in human plasma by tandem LC-MS/MS. Talanta 72(1):80-88. doi: 10.1016/j.talanta. 2006.09.033
32. Kim KB, Seo KA, Kim SE, Bae SK, Kim DH, Shin JG (2011) Simple and accurate quantitative analysis of ten antiepileptic drugs in human plasma by liquid chromatography/tandem mass spectrometry. J Pharm Biomed Anal 56(4):771-777. doi: 10.1016/j.jpba.2011.07.019
33. Matsuura K, Ohmori T, Nakamura M, Itoh Y, Hirano K (2008) A simple and rapid determination of valproic acid in human plasma using a non-porous silica column and liquid chromatography with tandem mass spectrometric detection. Biomed Chromatogr 22(4):387-393. doi: 10.1002/bmc.944
34. Allen KR (2006) Interference by venlafaxine ingestion in the detection of tramadol by liquid chromatography linked to tandem mass spectrometry for the screening of illicit drugs in human urine. Clin Toxicol (Phila) 44(2):147-153
35. Donato JL, Koizumi F, Pereira AS, Mendes GD, De Nucci G (2012) Simultaneous determination of dextromethorphan, dextrorphan and doxylamine in human plasma by HPLC coupled to electrospray ionization tandem mass spectrometry: application to a pharmacokinetic study. J Chromatogr B Anal Technol Biomed Life Sci 899:46-56. doi: 10.1016/j.jchromb.2012.05.001
36. GTFCh (2009) Anhang B zur Richtlinie der GTFCh zur Qualitä tssicherung bei forensich-toxikologischen Untersuchenungen. Anforderungen an die Validierung von Analysenmethoden. http://www.gtfch.org/cms/images/stories/ files/GTFCh-Richtlinie-Anhang%20B-Validierung-Version%201.pdf. Accessed 22 Jun 2013