LC-MS/MS method for simultaneous determination of valproic acid and major metabolites in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 21, 2011, Pages 1939-1944

  Gao, Shouhong ^a   Miao, Haijun ^a   Tao, Xia ^a   Jiang, Bo ^a   Xiao, Ying ^a   Cai, Fei ^a   Yun, Yunlei ^a   Li, Jingxian ^a   Chen, Wansheng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Epileptic patients; Human plasma; Liquid chromatography tandem mass spectroscopy; Metabolites; Valproic acid

Indexed keywords

ACCURACY AND PRECISION; AMMONIUM ACETATE; ANALYTES; ANALYTICAL METHOD; CORRELATION COEFFICIENT; EPILEPTIC PATIENTS; HUMAN PLASMAS; INTERNAL STANDARDS; ISOCRATIC MOBILE PHASE; LC-MS/MS; LOWER LIMIT OF QUANTIFICATIONS; MASS SPECTROSCOPY; PLASMA CONCENTRATION; QUANTITATIVE DETERMINATIONS; RUNTIMES; SENSITIVE METHOD; SIMULTANEOUS DETERMINATIONS; SOLID-PHASE EXTRACTION; VALPROIC ACID;

AMMONIUM COMPOUNDS; BIOMOLECULES; COLUMN CHROMATOGRAPHY; EXTRACTION; FORMIC ACID; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; METHANOL; PLASMA (HUMAN);

PLASMAS;

AMMONIUM ACETATE; DRUG METABOLITE; FORMIC ACID; METHANOL; VALPROIC ACID;

ADULT; ARTICLE; DRUG DETERMINATION; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

ADULT; ANALYSIS OF VARIANCE; ANTICONVULSANTS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FEMALE; HUMANS; LEAST-SQUARES ANALYSIS; MALE; METHANOL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; VALPROIC ACID;

EID: 79959360889     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.05.022     Document Type: Article

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