Rapid and quantitative screening method for 43 benzodiazepines and their metabolites, zolpidem and zopiclone in human plasma by liquid chromatography/mass spectrometry with a small particle column

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 25, 2009, Pages 2652-2657

  Ishida, Tomomi ^a,b   Kudo, Keiko ^a   Hayashida, Makiko ^c   Ikeda, Noriaki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b EISAI CO LTD   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Benzodiazepines; Drug screening; Focus ; LC MS; UPLC

Indexed keywords

AVERAGE RECOVERY; BENZODIAZEPINES; CALIBRATION CURVES; CONCENTRATION RANGES; CORRELATION COEFFICIENT; DRUG SCREENING; DRUG-FACILITATED SEXUAL ASSAULT; HUMAN PLASMAS; LC/MS; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; QUANTITATIVE SCREENING; SMALL PARTICLES; TOXICOLOGICAL ANALYSIS; UPLC;

LIQUIDS; METABOLISM; METABOLITES; PLASMAS; SEMICONDUCTOR SWITCHES; SPECTROMETRY;

PLASMA (HUMAN);

4 HYDROXYALPRAZOLAM; 4 HYDROXYTRIAZOLAM; 7 AMINO 1,3 DIHYDRO 5 PHENYL 2H 1,4 BENZODIAZEPIN 2 ONE; ALPHA HYDROXYBROTIZOLAM; ALPHA HYDROXYTRIAZOLAM; ALPRAZOLAM; BENZODIAZEPINE DERIVATIVE; BROMAZEPAM; BROTIZOLAM; CHLORDIAZEPOXIDE; CLONAZEPAM; CLOTIAZEPAM; CLOXAZOLAM; ESTAZOLAM; FLUDIAZEPAM; FLUMAZENIL; FLUNITRAZEPAM; FLURAZEPAM; LORAZEPAM; LORMETAZEPAM; MEDAZEPAM; MIDAZOLAM; NIMETAZEPAM; NITRAZEPAM; OXAZEPAM; TEMAZEPAM; TRIAZOLAM; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZOLPIDEM; ZOPICLONE;

ACCURACY; ARTICLE; CALIBRATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HUMAN EXPERIMENT; ION MONITORING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

AZABICYCLO COMPOUNDS; BENZODIAZEPINES; CHROMATOGRAPHY, LIQUID; HUMANS; MASS SPECTROMETRY; PIPERAZINES; PYRIDINES;

EID: 67651173100     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.05.008     Document Type: Article

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