Doubling of muscle carnosine concentration does not improve laboratory 1-Hr cycling time-trial performance

International Journal of Sport Nutrition and Exercise Metabolism

Volumn 24, Issue 3, 2014, Pages 315-324

  Chung, Weiliang ^a   Baguet, Audrey ^a   Bex, Tine ^a   Bishop, David J ^b   Derave, Wim ^a  

^a GHENT UNIVERSITY   (Belgium)

^b VICTORIA UNIVERSITY   (Australia)

Author keywords

Beta alanine; Buffering; Exercise performance; Magnetic resonance spectroscopy; Supplement

Indexed keywords

BETA ALANINE; CARNOSINE; LACTIC ACID; PLACEBO; PROTON;

ACIDOSIS; ARTICLE; ATHLETE; CONTROLLED STUDY; CYCLING; DOUBLE BLIND PROCEDURE; ENDURANCE; EXERCISE; GASTROCNEMIUS MUSCLE; HUMAN; LABORATORY; MALE; MUSCLE; MUSCLE CELL; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; SOLEUS MUSCLE; SUPPLEMENTATION; ATHLETIC PERFORMANCE; BLOOD; DIET SUPPLEMENTATION; DRUG EFFECTS; METABOLISM; PH; PHYSIOLOGY; SKELETAL MUSCLE;

ACIDOSIS; ATHLETIC PERFORMANCE; BETA-ALANINE; BICYCLING; CARNOSINE; DIETARY SUPPLEMENTS; EXERCISE; HUMANS; HYDROGEN-ION CONCENTRATION; LACTIC ACID; MALE; MUSCLE, SKELETAL; PHYSICAL ENDURANCE; PHYSICAL EXERTION;

EID: 84903774374     PISSN: 1526484X     EISSN: 15432742     Source Type: Journal    
DOI: 10.1123/ijsnem.2013-0125     Document Type: Article

References (33)

1. Baguet, A., Bourgois, J., Vanhee, L., Achten, E., & Derave, W. (2010). Important role of muscle carnosine in rowing performance. Journal of Applied Physiology, 109(4), 1096-1101. PubMed doi:10.1152/japplphysiol.00141. 2010
2. Baguet, A., Everaert, I., De Naeyer, H., Reyngoudt, H., Stegen, S., Beeckman, S., . . . Derave, W. (2011a). Effects of sprint training combined with vegetarian or mixed diet on muscle carnosine content and buffering capacity. European Journal of Applied Physiology, 111(10), 2571-2580. PubMed doi:10.1007/s00421-011-1877-4
3. Baguet, A., Everaert, I., Hespel, P., Petrovic, M., Achten, E., & Derave, W. (2011b). A new method for non-invasive estimation of human muscle fiber type composition. PLoS ONE, 6(7), e21956. PubMed doi:10.1371/journal.pone. 0021956
4. Baguet, A., Koppo, K., Pottier, A., & Derave, W. (2010). Betaalanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise. European Journal of Applied Physiology, 108(3), 495-503. PubMed doi:10.1007/s00421-009-1225-0
5. Baguet, A., Reyngoudt, H., Pottier, A., Everaert, I., Callens, S., Achten, E., & Derave, W. (2009). Carnosine loading and washout in human skeletal muscles. Journal of Applied Physiology, 106(3), 837-842. PubMed doi:10.1152/japplphysiol.91357.2008
6. Bex, T., Chung, W., Baguet, A., Stegen, S., Stautemas, J., Achten, E., & Derave, W. (2014). Muscle carnosine loading by beta-alanine supplementation is more pronounced in trained vs. untrained muscles. Journal of Applied Physiology, 116(2), 204-209.
7. Boldyrev, A.A., Aldini, G., & Derave, W. (2013).Physiology and pathophysiology of carnosine. Physiological Reviews. 93(4), 1803-1845. PubMed
8. Borg, G.A. (1982). Psychophysical bases of perceived exertion. Medicine and Science in Sports and Exercise, 14(5), 377-381. PubMed doi:10.1249/00005768- 198205000-00012
9. Chung, W., Shaw, G., Anderson, M.E., Pyne, D.B., Saunders, P.U., Bishop, D.J., & Burke, L.M. (2012). Effect of 10 week beta-alanine supplementation on competition and training performance in elite swimmers. Nutrients, 4(10), 1441-1453. PubMed doi:10.3390/nu4101441
10. del Favero, S., Roschel, H., Solis, M.Y., Hayashi, A.P., Artioli, G.G., Otaduy, M.C., . . . Gualano, B. (2012). Beta-alanine (Carnosyn) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacity. Amino Acids, 43(1), 49-56. PubMed doi:10.1007/s00726-011- 1190-x
11. Derave, W., Everaert, I., Beeckman, S., & Baguet, A. (2010). Muscle carnosine metabolism and β-alanine supplementation in relation to exercise and training. Sports Medicine (Auckland, N.Z.), 40 (3), 247-263. PubMed doi:10.2165/11530310-000000000-00000
12. Derave, W., Özdemir, M.S., Harris, R.C., Pottier, A., Reyngoudt, H., Koppo, K., . . . Achten, E. (2007). β-alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters. Journal of Applied Physiology, 103(5), 1736-1743. PubMed doi:10.1152/japplphysiol.00397.2007
13. Ducker, K.B, Dawson, B., & Wallman, K.E. (2013).Effect of beta-alanine supplementation on 2000 m rowing ergometer performance. International Journal of Sport Nutrition and Exercise Metabolism. 23(4):336-343. PubMed
14. Dutka, T.L., & Lamb, G.D. (2004). Effect of carnosine on excitation-contraction coupling in mechanically-skinned rat skeletal muscle. Journal of Muscle Research and Cell Motility, 25 (3), 203-213. PubMed doi:10.1023/B:JURE.0000038265.37022.c5
15. Dutka, T. L., Lamboley, C. R., McKenna, M. J., Murphy, R. M., & Lamb, G. D. (2012). Effects of carnosine on contractile apparatus Ca(2)(+) sensitivity and sarcoplasmic reticulum Ca(2)(+) release in human skeletal muscle fibers. Journal of Applied Physiology, 112(5), 728-736.
16. Everaert, I., Stegen, S., Vanheel, B., Taes, Y., & Derave, W. (2013). Effect of beta-alanine and carnosine supplementation on muscle contractility in mice. Medicine and Science in Sports and Exercise, 45(1), 43-51. PubMed doi:10.1249/MSS.0b013e31826cdb68
17. Harris, R.C., Marlin, D.J., Dunnett, M., Snow, D.H., & Hultman, E. (1990). Muscle buffering capacity and dipeptide content in the thoroughbred horse, greyhound dog and man. Comparative Biochemistry and Physiology. A, Comparative Physiology, 97(2), 249-251. PubMed doi:10.1016/0300-9629(90)90180-Z
18. Harris, R.C., Tallon, M.J., Dunnett, M., Boobis, L., Coakley, J., Kim, H.J., . . . Wise, J.A. (2006). The absorption of orally supplied b-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids, 30(3), 279-289. PubMed doi:10.1007/s00726-006-0299-9
19. Hill, C.A., Harris, R.C., Kim, H.J., Harris, B.D., Sale, C., Boobis, L.H., . . . Wise, J.A. (2007). Influence of b-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids, 32(2), 225-233. PubMed doi:10.1007/s00726-006-0364-4
20. Hobson, R.M., Saunders, B., Ball, G., Harris, R., & Sale, C. (2012). Effects of â-alanine supplementation on exercise performance: a meta-analysis. Amino Acids, 43(1), 25-37. PubMed doi:10.1007/s00726-011-1200-z
21. Jeukendrup, A., Saris, W.H., Brouns, F., & Kester, A.D. (1996). A new validated endurance performance test. Medicine and Science in Sports and Exercise, 28(2), 266-270. PubMed doi:10.1097/00005768-199602000-00017
22. Kuipers, H., Keizer, H.A., Brouns, F., & Saris, W.H.M. (1987). Carbohydrate feeding and glycogen synthesis during exercise in man. Pflugers Archiv, 410(6), 652-656 (European Journal of Physiology). PubMed doi:10.1007/BF00581327
23. Lamont, C., & Miller, D.J. (1992). Calcium sensitizing action of carnosine and other endogenous imidazoles in chemically skinned striated muscle. The Journal of Physiology, 454(1), 421-434. PubMed
24. Ozdemir, M.S., Reyngoudt, H., De Deene, Y., Sazak, H.S., Fieremans, E., Delputte, S., . . . Achten, E. (2007). Absolute quantification of carnosine in human calf muscle by proton magnetic resonance spectroscopy. Physics in Medicine and Biology, 52(23), 6781-6794. PubMed doi:10.1088/0031-9155/52/23/001
25. de Salles Painelli, V., Roschel, H., de Jesus, F., Sale, C., Harris, R.C., Solis, M.Y., . . . Artioli, G.G. (2013). The ergogenic effect of beta-alanine combined with sodium bicarbonate on high-intensity swimming performance. Applied Physiology, Nutrition, and Metabolism, 38(5), 525-532. PubMed doi:10.1139/apnm-2012-0286
26. Parkhouse, W.S., McKenzie, D.C., Hochachka, P.W., & Ovalle, W.K. (1985). Buffering capacity of deproteinized human vastus lateralis muscle. Journal of Applied Physiology, 58(1), 14-17. PubMed (Pubitemid 15054372)
27. Sewell, D.A., Harris, R.C., Marlin, D.J., & Dunnett, M. (1992). Estimation of the carnosine content of different fibre types in the middle gluteal muscle of the thoroughbred horse. The Journal of Physiology, 455(1), 447-453. PubMed
28. Stegen, S., Blancquaert, L., Everaert, I., Bex, T., Taes, Y., Calders, P., . . . Derave, W. (2013). Meal and beta-alanine coingestion enhances muscle carnosine loading. Medicine and Science in Sports and Exercise, 45(8), 1478-1485. PubMed doi:10.1249/MSS.0b013e31828ab073
29. Stellingwerff, T., Anwander, H., Egger, A., Buehler, T., Kreis, R., Decombaz, J., & Boesch, C. (2012). Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout. Amino Acids, 42(6), 2461-2472. PubMed doi:10.1007/s00726-011-1054-4
30. Stephens, T.J., McKenna, M.J., Canny, B.J., Snow, R.J., & McConell, G.K. (2002). Effect of sodium bicarbonate on muscle metabolism during intense endurance cycling. Medicine and Science in Sports and Exercise, 34(4), 614-621. PubMed doi:10.1097/00005768-200204000-00009
31. Stout, J.R., Cramer, J.T., Zoeller, R.F., Torok, D., Costa, P., Hoffman, J.R., . . . O'Kroy, J. (2007). Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. Amino Acids, 32(3), 381-386. PubMed doi:10.1007/s00726-006-0474-z
32. Van Thienen, R., Van Proeyen, K., Eynde, B.V., Pyuype, J., Lefere, T., & Hespel, P. (2009). b-alanine improves sprint performance in endurance cycling. Medicine and Science in Sports and Exercise, 41(4), 898-903. PubMed doi:10.1249/MSS.0b013e31818db708
33. Zoeller, R.F., Stout, J.R., O'Kroy J.A., Torok, D.J., & Mielke, M. (2007). Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion. Amino Acids, 33(3), 505-510. PubMed doi:10.1007/s00726-006-0399-6