Meal and beta-alanine coingestion enhances muscle carnosine loading

Medicine and Science in Sports and Exercise

Volumn 45, Issue 8, 2013, Pages 1478-1485

  Stegen, Sanne ^a   Blancquaert, Laura ^a   Everaert, Inge ^a   Bex, Tine ^a   Taes, Youri ^b   Calders, Patrick ^a   Achten, Eric ^b   Derave, Wim ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

beta alanine metabolization; Beta alanine retention; carnosine synthase; ergogenic supplements

Indexed keywords

BETA ALANINE; CARNOSINE;

ADOLESCENT; ADULT; ARTICLE; DIET SUPPLEMENTATION; DRUG EFFECT; FEMALE; HUMAN; MALE; MEAL; METABOLISM; SKELETAL MUSCLE; YOUNG ADULT;

ADOLESCENT; ADULT; BETA-ALANINE; CARNOSINE; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; MEALS; MUSCLE, SKELETAL; YOUNG ADULT;

EID: 84880572257     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e31828ab073     Document Type: Article

References (35)

1. Baguet A, Bourgois J, Vanhee L, Achten E, Derave W. Important role of muscle carnosine in rowing performance. J Appl Physiol. 2010;109:1096-101.
2. Baguet A, Reyngoudt H, Pottier A, et al. Carnosine loading and washout in human skeletal muscles. J Appl Physiol. 2009;106: 837-42.
3. Bakardjiev A, Bauer K. Transport of beta-alanine and biosynthesis of carnosine by skeletal muscle cells in primary culture. Eur J Biochem. 1994;225:617-23.
4. Boldyrev AA. Carnosine: new concept for the function of an old molecule. Biochemistry (Mosc.). 2012;77:313-26.
5. Clausen T. Na+-K+ pump regulation and skeletal muscle contractility. Physiol Rev. 2003;83:1269-324.
6. De Biase D, Barra D, Simmaco M, John RA, Bossa F. Primary structure and tissue distribution of human 4-aminobutyrate aminotransferase. Eur J Biochem. 1995;227:476-80.
7. Decombaz J, Beaumont M, Vuichoud J, Bouisset F, Stellingwerff T. Effect of slow-release beta-alanine tablets on absorption kinetics and paresthesia. Amino Acids. 2012;43:67-76.
8. del Favero S, Roschel H, Solis MY, et al. Beta-alanine (Carnosyn) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacity. Amino Acids. 2012;43:49-56.
9. Derave W, Everaert I, Beeckman S, Baguet A. Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and training. Sports Med. 2010;40:247-63.
10. Derave W, Ozdemir MS, Harris RC, et al. beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters. J Appl Physiol. 2007;103:1736-43.
11. Everaert I, De Naeyer H, Taes Y, Derave W. Gene expression of carnosine-related enzymes and transporters in skeletal muscle. Eur J Appl Physiol. 2013;113(5):1169-79.
12. Flancbaum L, Fitzpatrick JC, Brotman DN, Marcoux AM, Kasziba E, Fisher H. The presence and significance of carnosine in histamine-containing tissues of several mammalian species. Agents Actions. 1990;31:190-6.
13. Green AL, Hultman E, Macdonald IA, Sewell DA, Greenhaff PL. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol. 1996;271:E821-6.
14. Green AL, Simpson EJ, Littlewood JJ, Macdonald IA, Greenhaff PL. Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Acta Physiol Scand. 1996;158:195-202.
15. Greenwood M, Kreider R, Earnest C, Rasmussen C, Altuntas Y. Differences in creatine retention among three nutritional formulations of oral creatine supplements. J Exerc Physiol. 2003;6: 37-43.
16. Griffith OW. Beta-amino acids: mammalian metabolism and utility as alpha-amino acid analogues. Annu Rev Biochem. 1986;55: 855-78.
17. Gualano B, Everaert I, Stegen S, et al. Reduced muscle carnosine content in type 2, but not in type 1 diabetic patients. Amino Acids. 2012;43:21-4.
18. Harding J, Margolis FL. Denervation in the primary olfactory pathway of mice. III. Effect on enzymes of carnosine metabolism. Brain Res. 1976;110:351-60.
19. Harris RC, Marlin DJ, Dunnett M, Snow DH, Hultman E. Muscle buffering capacity and dipeptide content in the thoroughbred horse, greyhound dog and man. Comp Biochem Physiol A Comp Physiol. 1990; 97:249-51.
20. Harris RC, Soderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Lond). 1992;83:367-74.
21. Harris RC, Tallon MJ, Dunnett M, et al. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids. 2006;30:279-89.
22. Hill CA. Beta-alanine supplementation and high intensity exercise performance [dissertation]. Unites Kingdom: University of Chichester; 2007. 226 p.
23. Hill CA, Harris RC, Kim HJ, et al. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids. 2007;32:225-33.
24. Ito S, Ohyama T, Kontani Y, Matslida K, Sakata SF, Tamaki N. Influence of dietary protein levels on beta-alanine aminotransferase expression and activity in rats. J.Nutr Sci Vitaminol (Tokyo). 2001;47:275-82.
25. Jackson MC, Lenney JF. The distribution of carnosine and related dipeptides in rat and human tissues. Inflamm Res. 1996;45:132-5.
26. James DE, Jenkins AB, Kraegen EW. Heterogeneity of insulin action in individual muscles in vivo: euglycemic clamp studies in rats. Am J Physiol. 1985;248:E567-74.
27. Jeukendrup A, Gleeson M. Fuel Sources for Muscle and Exercise Metabolism. Sport Nutrition. Champaign: Human Kinetics; 2010. pp. 48-77.
28. Lavoie L, Roy D, Ramlal T, et al. Insulin-induced translocation of Na+-K+-ATPase subunits to the plasma membrane is muscle fiber type specific. Am J Physiol. 1996;270:C1421-9.
29. Steenge GR, Lambourne J, Casey A, Macdonald IA, Greenhaff PL. Stimulatory effect of insulin on creatine accumulation in human skeletal muscle. Am J Physiol. 1998;275:E974-9.
30. Steenge GR, Simpson EJ, Greenhaff PL. Protein-and carbohydrateinduced augmentation of whole body creatine retention in humans. J Appl Physiol. 2000;89:1165-71.
31. Stellingwerff T, Anwander H, Egger A, et al. Effect of two betaalanine dosing protocols on muscle carnosine synthesis and washout. Amino Acids. 2012;42:2461-72.
32. Stephens FB, Constantin-Teodosiu D, Laithwaite D, Simpson EJ, Greenhaff PL. A threshold exists for the stimulatory effect of insulin on plasma L-carnitine clearance in humans. Am J Physiol Endocrinol Metab. 2007;292:E637-41.
33. Stephens FB, Evans CE, Constantin-Teodosiu D, Greenhaff PL. Carbohydrate ingestion augments L-carnitine retention in humans. J Appl Physiol. 2007;102:1065-70.
34. Sweeney G, Klip A. Regulation of the Na+/K+-ATPase by insulin: why and how? Mol Cell Biochem. 1998;182:121-33.
35. Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL. Chronic oral ingestion of Lcarnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. J Physiol. 2011;589:963-73.