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Volumn 66, Issue 6, 2013, Pages 361-368

Treatment strategies for recurrent Clostridium difficile infection

Author keywords

Fidaxomicin; Literature review; Metronidazole; Recurrent Clostridium difficile infection; Relapse; Vancomycin

Indexed keywords

FIDAXOMICIN; METRONIDAZOLE; PROBIOTIC AGENT; RIFAMPICIN; RIFAXIMIN; VANCOMYCIN;

EID: 84903772113     PISSN: 00084123     EISSN: 19202903     Source Type: Journal    
DOI: 10.4212/cjhp.v66i6.1301     Document Type: Review
Times cited : (29)

References (54)
  • 1
    • 77951026738 scopus 로고    scopus 로고
    • Clinical practice guidelines for Clostridium difficile infection in adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)
    • Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol. 2010;31(5):431-55.
    • (2010) Infect Control Hosp Epidemiol , vol.31 , Issue.5 , pp. 431-455
    • Cohen, S.H.1    Gerding, D.N.2    Johnson, S.3    Kelly, C.P.4    Loo, V.G.5    McDonald, L.C.6
  • 3
    • 23944507069 scopus 로고    scopus 로고
    • Treatment of Clostridium difficile-associated disease: Old therapies and new strategies
    • DOI 10.1016/S1473-3099(05)70215-2, PII S1473309905702152
    • Aslam S, Hamill RJ, Musher DM. Treatment of Clostridium difficile-associated disease: old therapies and new strategies. Lancet Infect Dis. 2005;5(9):549-57. (Pubitemid 41196754)
    • (2005) Lancet Infectious Diseases , vol.5 , Issue.9 , pp. 549-557
    • Aslam, S.1    Hamill, R.J.2    Musher, D.M.3
  • 4
    • 77952564778 scopus 로고    scopus 로고
    • Economic healthcare costs of Clostridium difficile infection: A systematic review
    • Ghantoji SS, Sail K, Lairson DR, DuPont HL, Garey KW. Economic healthcare costs of Clostridium difficile infection: a systematic review. J Hosp Infect. 2010;74(4):309-18.
    • (2010) J Hosp Infect , vol.74 , Issue.4 , pp. 309-318
    • Ghantoji, S.S.1    Sail, K.2    Lairson, D.R.3    DuPont, H.L.4    Garey, K.W.5
  • 5
    • 0036129083 scopus 로고    scopus 로고
    • Morbidity, mortality, and healthcare burden of nosocomial Clostridium difficile-associated diarrhea in Canadian hospitals
    • Miller MA, Hyland M, Ofner-Agostini M, Gourdeau M, Ishak M; Canadian Hospital Epidemiology Committee. Morbidity, morality, and healthcare burden of nosocomial Clostridium difficile-associated diarrhea in Canadian hospitals. Infect Control Hosp Epidemiol. 2002;23(3):137-40. (Pubitemid 34246541)
    • (2002) Infection Control and Hospital Epidemiology , vol.23 , Issue.3 , pp. 137-140
    • Miller, M.A.1    Hyland, M.2    Ofner-Agostini, M.3    Gourdeau, M.4    Ishak, M.5
  • 7
    • 84858126738 scopus 로고    scopus 로고
    • Clostridium difficile infection: The scope of the problem
    • Dubberke E. Clostridium difficile infection: the scope of the problem. J Hosp Med. 2012;7(Suppl 3):S1-4.
    • (2012) J Hosp Med , vol.7 , Issue.SUPPL. 3
    • Dubberke, E.1
  • 8
    • 0025352241 scopus 로고
    • Nosocomial Clostridium difficile colonisation and disease
    • DOI 10.1016/0140-6736(90)91605-A
    • Johnson S, Clabots CR, Linn FV, Olson MM, Peterson LR, Gerding DN. Nosocomial Clostridium difficile colonisation and disease. Lancet. 1990; 336(8707):97-100. (Pubitemid 20222816)
    • (1990) Lancet , vol.336 , Issue.8707 , pp. 97-100
    • Johnson, S.1    Clabots, C.R.2    Linn, F.V.3    Olson, M.M.4    Peterson, L.R.5    Gerding, D.N.6
  • 9
    • 84859363607 scopus 로고    scopus 로고
    • A multicenter study of Clostirium difficile infection-related colectomy, 2000-2006
    • Centers for Disease Control and Prevention Epicenters Program
    • Kasper AM, Nyazee HA, Yokoe DS, Mayer J, Mangino JE, Khan YM, et al.; Centers for Disease Control and Prevention Epicenters Program. A multicenter study of Clostirium difficile infection-related colectomy, 2000-2006. Infect Control Hosp Epidemiol. 2012;33(5):470-6.
    • (2012) Infect Control Hosp Epidemiol , vol.33 , Issue.5 , pp. 470-476
    • Kasper, A.M.1    Nyazee, H.A.2    Yokoe, D.S.3    Mayer, J.4    Mangino, J.E.5    Khan, Y.M.6
  • 10
    • 0035915688 scopus 로고    scopus 로고
    • Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea
    • DOI 10.1016/S0140-6736(00)03592-3
    • Kyne L, Warny M, Qamar A, Kelly CP. Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea. Lancet. 2001;357(9251):189-93. (Pubitemid 32108091)
    • (2001) Lancet , vol.357 , Issue.9251 , pp. 189-193
    • Kyne, L.1    Warny, M.2    Qamar, A.3    Kelly, C.P.4
  • 12
    • 0037204196 scopus 로고    scopus 로고
    • Clinical practice. Antibiotic-associated diarrhea
    • Bartlett JG. Clinical practice. Antibiotic-associated diarrhea. N Engl J Med. 2002;346(5):334-9.
    • (2002) N Engl J Med , vol.346 , Issue.5 , pp. 334-339
    • Bartlett, J.G.1
  • 13
    • 43249103183 scopus 로고    scopus 로고
    • Vancomycin for the treatment of Clostridium difficile infection: For whom is this expensive bullet really magic?
    • DOI 10.1086/587656
    • Pepin J. Vancomycin for the treatment of Clostridium difficile infection: For whom is this expensive bullet really magic? Clin Infect Dis. 2008;46(10):1493-8. (Pubitemid 351706728)
    • (2008) Clinical Infectious Diseases , vol.46 , Issue.10 , pp. 1493-1498
    • Pepin, J.1
  • 17
    • 27544511378 scopus 로고    scopus 로고
    • Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec
    • DOI 10.1503/cmaj.050978
    • Pépin J, Valiquette L, Cossette B. Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec. CMAJ. 2005;173(9):1037-41. (Pubitemid 41546690)
    • (2005) Canadian Medical Association Journal , vol.173 , Issue.9 , pp. 1037-1041
    • Pepin, J.1    Valiquette, L.2    Cossette, B.3
  • 19
    • 73649139991 scopus 로고    scopus 로고
    • Health care-associated Clostiridium difficile infection in Canada: Patient age and infecting strain type are highly predictive of severe outcome and mortality
    • Miller M, Gravel D, Mulvey M, Taylor G, Boyd D, Simor A, et al. Health care-associated Clostiridium difficile infection in Canada: patient age and infecting strain type are highly predictive of severe outcome and mortality. Clin Infect Dis. 2010;50(2):194-201.
    • (2010) Clin Infect Dis , vol.50 , Issue.2 , pp. 194-201
    • Miller, M.1    Gravel, D.2    Mulvey, M.3    Taylor, G.4    Boyd, D.5    Simor, A.6
  • 20
    • 36549073638 scopus 로고    scopus 로고
    • Outcomes of Clostridium difficile-associated disease treated with metronidazole or vancomycin before and after the emergence of NAP1/027
    • DOI 10.1111/j.1572-0241.2007.01539.x
    • Pépin J, Valiquette L, Gagnon S, Routhier S, Brazeau I. Outcomes of Clostridium difficile-associated disease treated with metronidazole or vancomycin before and after the emergence of NAP1/027. Am J Gastroenterol. 2007;102(12):2781-8. (Pubitemid 350179349)
    • (2007) American Journal of Gastroenterology , vol.102 , Issue.12 , pp. 2781-2788
    • Pepin, J.1    Valiquette, L.2    Gagnon, S.3    Routhier, S.4    Brazeau, I.5
  • 21
    • 36048950259 scopus 로고    scopus 로고
    • Outcome of metronidazole therapy for Clostridium difficile disease and correlation with a scoring system
    • DOI 10.1016/j.jinf.2007.09.015, PII S0163445307007840
    • Belmares J, Gerding DN, Parada JP, Miskevics S, Weaver F, Johnson S. Outcome of metronidazole therapy for Clostridium difficile disease and correlation with a scoring system. J Infect. 2007;55(6):495-501. (Pubitemid 350082477)
    • (2007) Journal of Infection , vol.55 , Issue.6 , pp. 495-501
    • Belmares, J.1    Gerding, D.N.2    Parada, J.P.3    Miskevics, S.4    Weaver, F.5    Johnson, S.6
  • 22
    • 46249102186 scopus 로고    scopus 로고
    • Comparison of clinical and microbiological response to treatment of Clostridium difficile-associated disease with metronidazole and vancomycin
    • DOI 10.1086/588293
    • Al-Nassir WN, Sethi AK, Nerandzic MM, Bobulsky GS, Jump RL, Donskey CJ. Comparison of clinical and microbiological response to treatment of Clostridium difficile-associated disease with metronidazole and vancomycin. Clin Infect Dis. 2008;47(1):56-62. (Pubitemid 351920588)
    • (2008) Clinical Infectious Diseases , vol.47 , Issue.1 , pp. 56-62
    • Al-Nassir, W.N.1    Sethi, A.K.2    Nerandzic, M.M.3    Bobulsky, G.S.4    Jump, R.L.P.5    Donskey, C.J.6
  • 23
    • 34547133720 scopus 로고    scopus 로고
    • A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity
    • DOI 10.1086/519265
    • Zar FA, Bakkanagari SR, Moorthi KMLST, Davis MB. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis. 2007;45(3):302-7. (Pubitemid 47101025)
    • (2007) Clinical Infectious Diseases , vol.45 , Issue.3 , pp. 302-307
    • Zar, F.A.1    Bakkanagari, S.R.2    Moorthi, K.M.L.S.T.3    Davis, M.B.4
  • 24
    • 4344559215 scopus 로고    scopus 로고
    • Factors associated with failure of metronidazole in Clostridium difficile-associated disease
    • Fernandez A, Anand G, Riedenberg F. Factors associated with failure of metronidazole in Clostridium difficile-associated disease. J Clin Gastroenterol. 2004;38(5):414-8.
    • (2004) J Clin Gastroenterol , vol.38 , Issue.5 , pp. 414-418
    • Fernandez, A.1    Anand, G.2    Riedenberg, F.3
  • 25
    • 0021038539 scopus 로고
    • Prospective randomised trial of metronidazole versus vancomycin for clostridium-difficile-associated diarrhoea and colitis
    • Teasley DG, Gerding DN, Olson MM, Peterson LR, Gebhard RL, Schwartz MJ, et al. Prospective randomised trial of metronidazole versus vancomycin for Clostridium difficile-associated diarrhoea and colitis. Lancet. 1983;2(8358):1043-6. (Pubitemid 14235361)
    • (1983) Lancet , vol.2 , Issue.8358 , pp. 1043-1046
    • Teasley, D.G.1    Gerding, D.N.2    Olson, M.M.3
  • 26
    • 0037105769 scopus 로고    scopus 로고
    • Adjunctive intracolonic vancomycin for severe Clostridium difficile colitis: Case series and review of the literature
    • DOI 10.1086/342334
    • Apisarnthanarak A, Razavi B, Mundy LM. Adjunctive intracolonic vancomycin for severe Clostridium difficile colitis: case series and review of the literature. Clin Infect Dis. 2002;35(6):690-6. (Pubitemid 35024729)
    • (2002) Clinical Infectious Diseases , vol.35 , Issue.6 , pp. 690-696
    • Apisarnthanarak, A.1    Razavi, B.2    Mundy, L.M.3
  • 27
    • 0022491104 scopus 로고
    • Faecal metronidazole concentrations during oral and intravenous therapy for antibiotic associated colitis due to Clostridium difficile
    • Bolton RP, Culshaw MA. Faecal metronidazole concentrations during oral and intravenous therapy for antibiotic associated colitis due to Clostridium difficile. Gut. 1986;27(10):1169-72. (Pubitemid 16002615)
    • (1986) Gut , vol.27 , Issue.10 , pp. 1169-1172
    • Bolton, R.P.1    Culshaw, M.A.2
  • 28
    • 84858627904 scopus 로고    scopus 로고
    • Prospective observational study comparing three different treatment regimes in patients with Clostridium difficile infection
    • Wenisch JM, Schmid D, Kuo HW, Allerberger F, Michl V, Tesik P, et al. Prospective observational study comparing three different treatment regimes in patients with Clostridium difficile infection. Antimicrob Agents Chemother. 2012;56(4):1974-8.
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.4 , pp. 1974-1978
    • Wenisch, J.M.1    Schmid, D.2    Kuo, H.W.3    Allerberger, F.4    Michl, V.5    Tesik, P.6
  • 29
    • 0020582752 scopus 로고
    • Comparative pharmacokinetics of metronidazole and tinidazole as influenced by administration route
    • Mattila J, Männistö PT, Mäntylä R, Nykänen S, Lamminsivu U. Comparative pharmacokinetics of metronidazole and tinidazole as influenced by administration route. Antimicrob Agents Chemother. 1983;23(5):721-5. (Pubitemid 13087010)
    • (1983) Antimicrobial Agents and Chemotherapy , vol.23 , Issue.5 , pp. 721-725
    • Mattila, J.1    Mannisto, P.T.2    Mantyla, R.3
  • 30
    • 0021251983 scopus 로고
    • Metronidazole kinetics and bioavailability in patients undergoing gastrointestinal surgery
    • Thiercelin JF, Diquet B, Levesque C, Ghesquiére F, Simon P, Viars P. Metronidazole kinetics and bioavailability in patients undergoing ganstrointestinal surgery. Clin Pharmacol Ther. 1984;35(4):510-9. (Pubitemid 14133492)
    • (1984) Clinical Pharmacology and Therapeutics , vol.35 , Issue.4 , pp. 510-519
    • Thiercelin, J.F.1    Diquet, B.2    Levesque, C.3
  • 31
    • 81955161936 scopus 로고    scopus 로고
    • Metronidazole-induced central nervous system toxicity: A systematic review
    • Kuriyama A, Jackson JL, Doi A, Kamiya T. Metronidazole-induced central nervous system toxicity: a systematic review. Clin Neuropharmacol. 2011;34(6):241-7.
    • (2011) Clin Neuropharmacol , vol.34 , Issue.6 , pp. 241-247
    • Kuriyama, A.1    Jackson, J.L.2    Doi, A.3    Kamiya, T.4
  • 32
    • 0036311186 scopus 로고    scopus 로고
    • Breaking the cycle: Treatment strategies for 163 cases of recurrent Clostridium difficile disease
    • DOI 10.1016/S0002-9270(02)04195-3
    • McFarland LV, Elmer GW, Surawicz CM. Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease. Am J Gastroenterol. 2002;97(7):1769-75. (Pubitemid 34761404)
    • (2002) American Journal of Gastroenterology , vol.97 , Issue.7 , pp. 1769-1775
    • McFarland, L.V.1    Elmer, G.W.2    Surawicz, C.M.3
  • 33
    • 2942516215 scopus 로고    scopus 로고
    • Simple solution to a common statistical problem: Interpreting multiple tests
    • DOI 10.1016/S0149-2918(04)90078-1
    • Gordi T, Khamis H. Simple solution to a common statistical problem: interpreting multiple tests. Clin Ther. 2004;26(5):780-6. (Pubitemid 38736968)
    • (2004) Clinical Therapeutics , vol.26 , Issue.5 , pp. 780-786
    • Gordi, T.1    Khamis, H.2
  • 34
    • 84924657714 scopus 로고    scopus 로고
    • Control number 151086. Ottawa (ON): Health Canada; Oct 30 [cited 2013 Nov 13]. Available from
    • Summary basis of decision (SBD) for DIFICIDTM. Control number 151086. Ottawa (ON): Health Canada; 2012 Oct 30 [cited 2013 Nov 13]. Available from: www.hc-sc.gc.ca/dhp-mps/prodpharma/sbd-smd/drug-med/sbd-smd-2012-dificid-151086- eng.php
    • (2012) Summary Basis of Decision (SBD) for DIFICIDTM
  • 35
    • 84905848265 scopus 로고    scopus 로고
    • Toronto (ON): Optimer Pharmaceuticals Canada Inc; revised Jun 4
    • DIFICID® (fidaxomicin) [product monograph]. Toronto (ON): Optimer Pharmaceuticals Canada Inc; revised 2012 Jun 4.
    • (2012) DIFICID® (Fidaxomicin) [Product Monograph]
  • 36
    • 79551527297 scopus 로고    scopus 로고
    • Fidaxomicin versus vancomycin for Clostridium difficile infection
    • OPT-80-003 Clinical Study Group
    • Louie TJ, Miller MA, Mullane KM, Weiss K, Lentnek A, Golan Y, et al.; OPT-80-003 Clinical Study Group. Fidaxomicin versus vancomycin for Clostridium difficile infection. N Engl J Med. 2011;364(5):422-31.
    • (2011) N Engl J Med , vol.364 , Issue.5 , pp. 422-431
    • Louie, T.J.1    Miller, M.A.2    Mullane, K.M.3    Weiss, K.4    Lentnek, A.5    Golan, Y.6
  • 37
    • 84859007390 scopus 로고    scopus 로고
    • Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: A double-blind, non-inferiority, randomised controlled trial
    • OPT-80-004 Clinical Study Group
    • Cornely OA, Crook DW, Esposito R, Poirier A, Somero MS, Weiss K, et al.; OPT-80-004 Clinical Study Group. Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial. Lancet Infect Dis. 2012;12(4):281-9.
    • (2012) Lancet Infect Dis , vol.12 , Issue.4 , pp. 281-289
    • Cornely, O.A.1    Crook, D.W.2    Esposito, R.3    Poirier, A.4    Somero, M.S.5    Weiss, K.6
  • 38
    • 84863676557 scopus 로고    scopus 로고
    • Treatment of first recurrence of Clostridium difficile infection: Fidaxomicin versus vancomycin
    • Cornely OA, Miller MA, Louie TJ, Crook DW, Gorbach SL. Treatment of first recurrence of Clostridium difficile infection: fidaxomicin versus vancomycin. Clin Infect Dis. 2012;55 Suppl 2:S154-61.
    • (2012) Clin Infect Dis , vol.55 , Issue.SUPPL. 2
    • Cornely, O.A.1    Miller, M.A.2    Louie, T.J.3    Crook, D.W.4    Gorbach, S.L.5
  • 39
    • 84905848266 scopus 로고    scopus 로고
    • The Canadian Press; Jul 5 [cited 2012 Aug 12]. Available from
    • New C. diff drug approved. The Canadian Press; 2012 Jul 5 [cited 2012 Aug 12]. Available from: www.thespec.com/print/article/755566
    • (2012) New C. Diff Drug Approved
  • 40
    • 0345025166 scopus 로고    scopus 로고
    • Toronto (ON): Ministry of Health and Long-Term Care; updated Aug 27 [cited 2012 Aug 31]. Available from
    • Ontario drug benefit formulary/comparative drug index. Toronto (ON): Ministry of Health and Long-Term Care; updated 2012 Aug 27 [cited 2012 Aug 31]. Available from: https://www.healthinfo.moh.gov.on.ca/formulary/index.jsp
    • (2012) Ontario Drug Benefit Formulary/comparative Drug Index
  • 43
    • 81855199757 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled pilot study to assess the ability of rifaximin to prevent recurrent diarrhoea in patients with Clostridium difficile infection
    • Garey KW, Ghantoji SS, Shah DN, Habib M, Arora V, Jiang ZD, et al. A randomized, double-blind, placebo-controlled pilot study to assess the ability of rifaximin to prevent recurrent diarrhoea in patients with Clostridium difficile infection. J Antimicrob Chemother. 2011;66(12):2850-5.
    • (2011) J Antimicrob Chemother , vol.66 , Issue.12 , pp. 2850-2855
    • Garey, K.W.1    Ghantoji, S.S.2    Shah, D.N.3    Habib, M.4    Arora, V.5    Jiang, Z.D.6
  • 44
    • 42449115458 scopus 로고    scopus 로고
    • Probiotics for treatment of Clostridium difficile-associated colitis in adults
    • Pillai A, Nelson RL. Probiotics for treatment of Clostridium difficile-associated colitis in adults. Cochrane Database Syst Rev. 2008;(1):CD004611.
    • (2008) Cochrane Database Syst Rev , Issue.1
    • Pillai, A.1    Nelson, R.L.2
  • 47
    • 24044452865 scopus 로고    scopus 로고
    • Probiotics for recurrent Clostridium difficile disease [1]
    • DOI 10.1099/jmm.0.46096-0
    • Lawrence SJ, Korzenik JR, Mundy LM. Probiotics for recurrent Clostridium difficile disease. J Med Microbiol. 2005;54(Pt 9):905-6. (Pubitemid 41216291)
    • (2005) Journal of Medical Microbiology , vol.54 , Issue.9 , pp. 905-906
    • Lawrence, S.J.1    Korzenik, J.R.2    Mundy, L.M.3
  • 48
    • 0042922857 scopus 로고    scopus 로고
    • Lactobacillus plantarum 299v for the treatment of recurrent clostridium difficile-associated diarrhoea: A double-blind, placebo-controlled trial
    • DOI 10.1080/00365540310010985
    • Wullt M, Hagslätt ML, Odenholt I. Lactobacillus plantarum 299v for the treatment of recurrent Clostridium difficile associated diarrhoea: a double-blind, placebo-controlled trial. Scand J Infect Dis. 2003;35(6-7):365-7. (Pubitemid 37038627)
    • (2003) Scandinavian Journal of Infectious Diseases , vol.35 , Issue.6-7 , pp. 365-367
    • Wullt, M.1    Hagslatt, M.-L.J.2    Odenholt, I.3
  • 49
    • 84871349683 scopus 로고    scopus 로고
    • Probiotics for the prevention of Clostridium difficile-associated diarrhea: A systematic review and meta-analysis
    • Johnston BC, Ma SS, Goldenberg JZ, Thorlund K, Vandvik PO, Loeb M, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. Ann Intern Med. 2012;157(12):878-88.
    • (2012) Ann Intern Med , vol.157 , Issue.12 , pp. 878-888
    • Johnston, B.C.1    Ma, S.S.2    Goldenberg, J.Z.3    Thorlund, K.4    Vandvik, P.O.5    Loeb, M.6
  • 50
    • 84867949871 scopus 로고    scopus 로고
    • The role of probiotics in the prevention and treatment of antibiotic-associated diarrhea and Clostirdium difficile colitis
    • Friedman G. The role of probiotics in the prevention and treatment of antibiotic-associated diarrhea and Clostirdium difficile colitis. Gastroenterol Clin North Am. 2012;41(4):763-79.
    • (2012) Gastroenterol Clin North Am , vol.41 , Issue.4 , pp. 763-779
    • Friedman, G.1
  • 51
    • 84875952542 scopus 로고    scopus 로고
    • Fecal microbiota transplantation for Clostridium difficile infection: Systematic review and meta-analysis
    • Kassam Z, Lee CH, Yuan Y, Hunt RH. Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysis. Am J Gastroenterol. 2013;108(4):500-8.
    • (2013) Am J Gastroenterol , vol.108 , Issue.4 , pp. 500-508
    • Kassam, Z.1    Lee, C.H.2    Yuan, Y.3    Hunt, R.H.4
  • 52
    • 84857640098 scopus 로고    scopus 로고
    • Fecal transplantation, through colonoscopy, is effective therapy for recurrent Clostridium difficile infection
    • Mattila E, Uusitalo-Seppälä R, Wuorela M, Lehtola L, Nurmi H, Ristikankare M, et al. Fecal transplantation, through colonoscopy, is effective therapy for recurrent Clostridium difficile infection. Gastroenterology. 2012;142(3):490-6.
    • (2012) Gastroenterology , vol.142 , Issue.3 , pp. 490-496
    • Mattila, E.1    Uusitalo-Seppälä, R.2    Wuorela, M.3    Lehtola, L.4    Nurmi, H.5    Ristikankare, M.6
  • 53
    • 84905848267 scopus 로고    scopus 로고
    • Letter to C. Richard Boland, American Gastroenterological Association. Rockville (MD): Department of Health and Human Services, Food and Drug Administration, Public Health Service; Apr 25 [cited 2013 Jun 27]. Available from
    • Midthun K. Letter to C. Richard Boland, American Gastroenterological Association. Rockville (MD): Department of Health and Human Services, Food and Drug Administration, Public Health Service; 2013 Apr 25 [cited 2013 Jun 27]. Available from: http://highroadsolution.com/file-upload-2/files/ fda+response+letter+to+fmt+inquiry.pdf
    • (2013)
    • Midthun, K.1


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