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Volumn 41, Issue 4, 2012, Pages 763-779

The Role of Probiotics in the Prevention and Treatment of Antibiotic-Associated Diarrhea and Clostridium Difficile Colitis

Author keywords

Antibiotic; Diarrhea; Leukocytosis; Probiotics

Indexed keywords

ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; BACITRACIN; BACTERIAL VACCINE; BACTERIOCIN; CLAVULANIC ACID; CLOSTRIDIUM DIFFICILE TOXOID VACCINE; ERYTHROMYCIN; FIDAXOMICIN; FUSIDIC ACID; GUAIAC; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 10; METRONIDAZOLE; MUCIN; NITAZOXANIDE; PLACEBO; PROBIOTIC AGENT; PROTON PUMP INHIBITOR; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; RIFAXIMIN; TEICOPLANIN; TOLEVAMER; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VANCOMYCIN; YOGHURT;

EID: 84867949871     PISSN: 08898553     EISSN: 15581942     Source Type: Journal    
DOI: 10.1016/j.gtc.2012.08.002     Document Type: Review
Times cited : (27)

References (51)
  • 1
    • 55449090398 scopus 로고    scopus 로고
    • Antibiotic-associated diarrhea: epidemiology, trends and treatment
    • McFarland L.V. Antibiotic-associated diarrhea: epidemiology, trends and treatment. Future Microbiol 2008, 3(5):563-578.
    • (2008) Future Microbiol , vol.3 , Issue.5 , pp. 563-578
    • McFarland, L.V.1
  • 2
    • 53149129896 scopus 로고    scopus 로고
    • Probiotics for prevention of antibiotic-associated diarrhea
    • Doron S.I., Hibberd P.L., Gorbach S.L. Probiotics for prevention of antibiotic-associated diarrhea. J Clin Gastroenterol 2008, 42(Suppl 2):S58-S63.
    • (2008) J Clin Gastroenterol , vol.42 , Issue.SUPPL 2
    • Doron, S.I.1    Hibberd, P.L.2    Gorbach, S.L.3
  • 3
    • 1542513850 scopus 로고    scopus 로고
    • Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota
    • Young V.B., Schmidt T.M. Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota. J Clin Microbiol 2004, 42(3):1203-1206.
    • (2004) J Clin Microbiol , vol.42 , Issue.3 , pp. 1203-1206
    • Young, V.B.1    Schmidt, T.M.2
  • 4
    • 53149128432 scopus 로고    scopus 로고
    • Role of probiotics in antibiotic-associated diarrhea, clostridium difficile associated diarrhea and recurrent clostridium difficile-associated diarrhea
    • Surawicz C.M. Role of probiotics in antibiotic-associated diarrhea, clostridium difficile associated diarrhea and recurrent clostridium difficile-associated diarrhea. J Clin Gastroenterol 2008, 42(Suppl 2):S64-S70.
    • (2008) J Clin Gastroenterol , vol.42 , Issue.SUPPL 2
    • Surawicz, C.M.1
  • 5
    • 34347263800 scopus 로고    scopus 로고
    • Use of probiotics in pediatrics: rationale, mechanisms of action, and practical aspects
    • Saavedra J.M. Use of probiotics in pediatrics: rationale, mechanisms of action, and practical aspects. Nutr Clin Pract 2007, 22:351-365.
    • (2007) Nutr Clin Pract , vol.22 , pp. 351-365
    • Saavedra, J.M.1
  • 6
    • 0001964638 scopus 로고    scopus 로고
    • The discovery of lactobacillus GG
    • Gorbach S.L. The discovery of lactobacillus GG. Nutr Today 1996, 31:25-45.
    • (1996) Nutr Today , vol.31 , pp. 25-45
    • Gorbach, S.L.1
  • 7
    • 84907113294 scopus 로고
    • Saccharomyces boulardii: a review of an innovative biotherapeutic agent
    • McFarland L.V., Bernasconi P. Saccharomyces boulardii: a review of an innovative biotherapeutic agent. Microb Ecol Health Dis 1993, 6:157-171.
    • (1993) Microb Ecol Health Dis , vol.6 , pp. 157-171
    • McFarland, L.V.1    Bernasconi, P.2
  • 8
    • 34447630803 scopus 로고    scopus 로고
    • Use of probiotic lactobacillus preparation to prevent diarrhea associated with antibiotics: randomized double blind placebo controlled trial
    • Hickson M., D'Souza A.L., Muthu N., et al. Use of probiotic lactobacillus preparation to prevent diarrhea associated with antibiotics: randomized double blind placebo controlled trial. BMJ 2007, 335:80.
    • (2007) BMJ , vol.335 , pp. 80
    • Hickson, M.1    D'Souza, A.L.2    Muthu, N.3
  • 9
    • 77954424086 scopus 로고    scopus 로고
    • Dose-response efficacy of a proprietary probiotic formula of lactobacillus acidophilus CL1285 and lactobacillus casei LBC8oR for antibiotic-associated diarrhea and clostridium difficile-associated diarrhea prophylaxis in adult patients
    • Gao X.W., Mubasher M., Fang C.Y., et al. Dose-response efficacy of a proprietary probiotic formula of lactobacillus acidophilus CL1285 and lactobacillus casei LBC8oR for antibiotic-associated diarrhea and clostridium difficile-associated diarrhea prophylaxis in adult patients. Am J Gastroenterol 2010, 105:1636-1641.
    • (2010) Am J Gastroenterol , vol.105 , pp. 1636-1641
    • Gao, X.W.1    Mubasher, M.2    Fang, C.Y.3
  • 10
    • 38649108836 scopus 로고    scopus 로고
    • Effect of a fermented milk combining lactobacillus acidophilus CL1285 and lactobacillus casei in the prevention of antibiotic-associated diarrhea: a randomized, double-blind, placebo-controlled trial
    • Beausoleil M., Fortier N., Guenette S., et al. Effect of a fermented milk combining lactobacillus acidophilus CL1285 and lactobacillus casei in the prevention of antibiotic-associated diarrhea: a randomized, double-blind, placebo-controlled trial. Can J Gastroenterol 2007, 21(11):732-736.
    • (2007) Can J Gastroenterol , vol.21 , Issue.11 , pp. 732-736
    • Beausoleil, M.1    Fortier, N.2    Guenette, S.3
  • 11
    • 33747877529 scopus 로고    scopus 로고
    • Probiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials
    • Szajewska H., Ruszczynski M., Radzkowski A. Probiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials. J Pediatr 2006, 149:367-372.
    • (2006) J Pediatr , vol.149 , pp. 367-372
    • Szajewska, H.1    Ruszczynski, M.2    Radzkowski, A.3
  • 12
    • 84860863711 scopus 로고    scopus 로고
    • Probiotics for the prevention of pediatric antibiotic-associated diarrhea
    • CD004827
    • Johnston B.C., Goldenberg J.Z., Vandvik P.O., et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev 2011, (11). CD004827. 10.1002/14651858.CD004827p.pub3.
    • (2011) Cochrane Database Syst Rev , Issue.11
    • Johnston, B.C.1    Goldenberg, J.Z.2    Vandvik, P.O.3
  • 13
    • 0037042674 scopus 로고    scopus 로고
    • Probiotics in prevention of antibiotic-associated diarrhea: meta-analysis
    • D'Souza A.I., Rajkumar C., Cooke J., et al. Probiotics in prevention of antibiotic-associated diarrhea: meta-analysis. BMJ 2002, 324:1-6.
    • (2002) BMJ , vol.324 , pp. 1-6
    • D'Souza, A.I.1    Rajkumar, C.2    Cooke, J.3
  • 14
    • 0036668707 scopus 로고    scopus 로고
    • Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhea
    • Cremonini F., Di Caro S., Nista E.C., et al. Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhea. Aliment Pharmacol Ther 2002, 16:1461-1467.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1461-1467
    • Cremonini, F.1    Di Caro, S.2    Nista, E.C.3
  • 15
    • 33645455337 scopus 로고    scopus 로고
    • Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of clostridium difficile disease
    • McFarland L.V. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of clostridium difficile disease. Am J Gastroenterol 2006, 101:812-822.
    • (2006) Am J Gastroenterol , vol.101 , pp. 812-822
    • McFarland, L.V.1
  • 16
    • 77952615260 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of Saccharomyces boulardii in Adult Patients
    • McFarland L.V. Systematic review and meta-analysis of Saccharomyces boulardii in Adult Patients. World J Gastroenterol 2010, 16:2202-2222.
    • (2010) World J Gastroenterol , vol.16 , pp. 2202-2222
    • McFarland, L.V.1
  • 17
    • 29244491643 scopus 로고    scopus 로고
    • Efficacy and safety of Saccharomyces boulardii in prevention of antibiotic-associated diarrhea due to Helicobacter pylori eradication
    • Duman D.G., Bor S., Qzutemiz O., et al. Efficacy and safety of Saccharomyces boulardii in prevention of antibiotic-associated diarrhea due to Helicobacter pylori eradication. Eur J Gastroenterol Hepatol 2005, 17:1357-1361.
    • (2005) Eur J Gastroenterol Hepatol , vol.17 , pp. 1357-1361
    • Duman, D.G.1    Bor, S.2    Qzutemiz, O.3
  • 18
    • 34547569295 scopus 로고    scopus 로고
    • Efficacy and safety of Saccharomyces boulardii in the 14-day triple anti-Helicobacter pylori therapy: a prospective randomized placebo-controlled double-blind study
    • Cindoruk M., Erkan G., Karakan T., et al. Efficacy and safety of Saccharomyces boulardii in the 14-day triple anti-Helicobacter pylori therapy: a prospective randomized placebo-controlled double-blind study. Helicobacter 2007, 12:309-316.
    • (2007) Helicobacter , vol.12 , pp. 309-316
    • Cindoruk, M.1    Erkan, G.2    Karakan, T.3
  • 19
    • 0036840803 scopus 로고    scopus 로고
    • Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study
    • Cremonini F., DiCaro S., Dovino M., et al. Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol 2002, 97:2744-2749.
    • (2002) Am J Gastroenterol , vol.97 , pp. 2744-2749
    • Cremonini, F.1    DiCaro, S.2    Dovino, M.3
  • 20
    • 84861201441 scopus 로고    scopus 로고
    • Meta-analysis: probiotics in antibiotic-associated diarrhea
    • Videlock E.J., Cremonini F. Meta-analysis: probiotics in antibiotic-associated diarrhea. Aliment Pharmacol Ther 2012, 10.1111/j.1365-2036.2012.05104.x.
    • (2012) Aliment Pharmacol Ther
    • Videlock, E.J.1    Cremonini, F.2
  • 21
    • 0037204196 scopus 로고    scopus 로고
    • Antibiotic-associated diarrhea
    • Bartlett J.G. Antibiotic-associated diarrhea. N Engl J Med 2002, 346(5):334-338.
    • (2002) N Engl J Med , vol.346 , Issue.5 , pp. 334-338
    • Bartlett, J.G.1
  • 22
    • 56849106496 scopus 로고    scopus 로고
    • The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing
    • Dethlefsen L., Huse S., Sogin M.L., et al. The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol 2008, 6(11):e280. 10.1371/journal.pbio.0060280.
    • (2008) PLoS Biol , vol.6 , Issue.11
    • Dethlefsen, L.1    Huse, S.2    Sogin, M.L.3
  • 23
    • 79953170241 scopus 로고    scopus 로고
    • Effect of antibiotic treatment on the intestinal metabolome
    • Caetano L., Antunes M., Han J., et al. Effect of antibiotic treatment on the intestinal metabolome. Antimicrob Agents Chemother 2011, 55(4):1494-1503. 10.1128/AAC.01664-10.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.4 , pp. 1494-1503
    • Caetano, L.1    Antunes, M.2    Han, J.3
  • 24
    • 33847618667 scopus 로고    scopus 로고
    • Narrative review: the new epidemic of clostridium difficile-associated enteric disease
    • Bartlett J.G. Narrative review: the new epidemic of clostridium difficile-associated enteric disease. Ann Intern Med 2006, 145:758-764.
    • (2006) Ann Intern Med , vol.145 , pp. 758-764
    • Bartlett, J.G.1
  • 25
    • 28844441314 scopus 로고    scopus 로고
    • A predominant clonal multi-institutional outbreak of clostridium difficile-associated diarrhea with high morbidity and mortality
    • Loo V.G., Poirier L., Miller M.A., et al. A predominant clonal multi-institutional outbreak of clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005, 353:2442-2449.
    • (2005) N Engl J Med , vol.353 , pp. 2442-2449
    • Loo, V.G.1    Poirier, L.2    Miller, M.A.3
  • 26
    • 28844494086 scopus 로고    scopus 로고
    • An epidemic, toxin gene-variant strain of clostridium difficile
    • McDonald L.C., Killfore G.E., Thompson A., et al. An epidemic, toxin gene-variant strain of clostridium difficile. N Engl J Med 2005, 353:2433-2441.
    • (2005) N Engl J Med , vol.353 , pp. 2433-2441
    • McDonald, L.C.1    Killfore, G.E.2    Thompson, A.3
  • 27
    • 34848846245 scopus 로고    scopus 로고
    • Asymptomatic arriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents
    • Riggs M.M., Sethi A.K., Zabarsky T.F., et al. Asymptomatic arriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents. Clin Infect Dis 2007, 45:992.
    • (2007) Clin Infect Dis , vol.45 , pp. 992
    • Riggs, M.M.1    Sethi, A.K.2    Zabarsky, T.F.3
  • 28
    • 77951026738 scopus 로고    scopus 로고
    • Clinical practice guidelines for clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the infectious Diseases Society of America (DSA)
    • Cohen S.H., Gerding K.N., Johnson S., et al. Clinical practice guidelines for clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the infectious Diseases Society of America (DSA). Infect Control Hosp Epidemiol 2010, 31(5):431-455.
    • (2010) Infect Control Hosp Epidemiol , vol.31 , Issue.5 , pp. 431-455
    • Cohen, S.H.1    Gerding, K.N.2    Johnson, S.3
  • 29
    • 66249121680 scopus 로고    scopus 로고
    • Fulminant Clostridium difficile Colitis
    • Sallhamer E.A., Carson K., Chang Y., et al. Fulminant Clostridium difficile Colitis. Arch Surg 2009, 144(5):433-439.
    • (2009) Arch Surg , vol.144 , Issue.5 , pp. 433-439
    • Sallhamer, E.A.1    Carson, K.2    Chang, Y.3
  • 30
    • 80055115172 scopus 로고    scopus 로고
    • Antibiotic treatment in clostridium difficile-associated diarrhea in adults
    • CD004610
    • Nelson R.L., Kelsey P., Leeman H., et al. Antibiotic treatment in clostridium difficile-associated diarrhea in adults. Cochrane Database Syst Rev 2011, (9). CD004610. 10.1002/14651858.CD004610pub4.
    • (2011) Cochrane Database Syst Rev , Issue.9
    • Nelson, R.L.1    Kelsey, P.2    Leeman, H.3
  • 31
    • 0030056217 scopus 로고    scopus 로고
    • Comparison of vancomycin, teicoplanin, metronidazole and fusidic acid for the treatment of clostridium difficile-associated diarrhea
    • Wenisch C., Parschalk B., Hasenhundl M., et al. Comparison of vancomycin, teicoplanin, metronidazole and fusidic acid for the treatment of clostridium difficile-associated diarrhea. Clin Infect Dis 1996, 22:813-818.
    • (1996) Clin Infect Dis , vol.22 , pp. 813-818
    • Wenisch, C.1    Parschalk, B.2    Hasenhundl, M.3
  • 32
    • 79551527297 scopus 로고    scopus 로고
    • Fidaxomicin versus vancomycin for clostridium difficile infection
    • Louie T.J., Miller M.A., Mullane K.M., et al. Fidaxomicin versus vancomycin for clostridium difficile infection. N Engl J Med 2011, 364(5):422-431.
    • (2011) N Engl J Med , vol.364 , Issue.5 , pp. 422-431
    • Louie, T.J.1    Miller, M.A.2    Mullane, K.M.3
  • 33
    • 33746656237 scopus 로고    scopus 로고
    • Tolevamer, a novel nonantibiotic polymer compared with vancomycin in the treatment of mild to moderately severe Clostridium dificile associated diarrhea
    • Louie T.J., Peppe J., Watt C.K., et al. Tolevamer, a novel nonantibiotic polymer compared with vancomycin in the treatment of mild to moderately severe Clostridium dificile associated diarrhea. Clin Infect Dis 2006, 43:411-420.
    • (2006) Clin Infect Dis , vol.43 , pp. 411-420
    • Louie, T.J.1    Peppe, J.2    Watt, C.K.3
  • 34
    • 55249105923 scopus 로고    scopus 로고
    • Clostridium difficile - more difficult than ever
    • Kelly C.P., LaMont J.T. Clostridium difficile - more difficult than ever. N Engl J Med 2008, 359:1932-1940.
    • (2008) N Engl J Med , vol.359 , pp. 1932-1940
    • Kelly, C.P.1    LaMont, J.T.2
  • 35
    • 0033766160 scopus 로고    scopus 로고
    • Treatment of recurrent clostridium difficile-associated diarrhea by administration of donated stool directly through a colonoscope
    • Persky S.E., Brandt L. Treatment of recurrent clostridium difficile-associated diarrhea by administration of donated stool directly through a colonoscope. Am J Gastroenterol 2000, 95:3283-3285.
    • (2000) Am J Gastroenterol , vol.95 , pp. 3283-3285
    • Persky, S.E.1    Brandt, L.2
  • 36
    • 77951026738 scopus 로고    scopus 로고
    • Clinical practice guidelines for clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the infectious Diseases Society of America (IDSA)
    • Cohen S.H., Gerding D.N., Johnson S., et al. Clinical practice guidelines for clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 2010, 31(5):431-455.
    • (2010) Infect Control Hosp Epidemiol , vol.31 , Issue.5 , pp. 431-455
    • Cohen, S.H.1    Gerding, D.N.2    Johnson, S.3
  • 37
    • 74849098405 scopus 로고    scopus 로고
    • Treatment with monoclonal antibodies against clostridium difficile toxins
    • Lowy I., Molrine D.C., Leav B.A., et al. Treatment with monoclonal antibodies against clostridium difficile toxins. N Engl J Med 2010, 362:197-205.
    • (2010) N Engl J Med , vol.362 , pp. 197-205
    • Lowy, I.1    Molrine, D.C.2    Leav, B.A.3
  • 38
    • 0025727765 scopus 로고
    • Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxin
    • Leung D.Y., Kelly C.P., Boguniewicz M., et al. Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxin. J Pediatr 1991, 118:633-637.
    • (1991) J Pediatr , vol.118 , pp. 633-637
    • Leung, D.Y.1    Kelly, C.P.2    Boguniewicz, M.3
  • 39
    • 20244383137 scopus 로고    scopus 로고
    • Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea
    • Sougioultzis S., Kyne L., Drudy D., et al. Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea. Gastroenterology 2005, 128:764-770.
    • (2005) Gastroenterology , vol.128 , pp. 764-770
    • Sougioultzis, S.1    Kyne, L.2    Drudy, D.3
  • 40
    • 0037373020 scopus 로고    scopus 로고
    • Recurrent clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube
    • Aas J., Gessert C.E., Bakken J.S. Recurrent clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube. Clin Infect Dis 2003, 36:580-585.
    • (2003) Clin Infect Dis , vol.36 , pp. 580-585
    • Aas, J.1    Gessert, C.E.2    Bakken, J.S.3
  • 41
    • 70350018031 scopus 로고    scopus 로고
    • Hand hygiene with soap and water is superior to alcohol rub and antiseptic wipes for removal of clostridium difficile
    • Oughton M.T., Loo V.G., Dendukuri N., et al. Hand hygiene with soap and water is superior to alcohol rub and antiseptic wipes for removal of clostridium difficile. Infect Control Hosp Epidemiol 2009, 30:939-944.
    • (2009) Infect Control Hosp Epidemiol , vol.30 , pp. 939-944
    • Oughton, M.T.1    Loo, V.G.2    Dendukuri, N.3
  • 42
    • 79958827058 scopus 로고    scopus 로고
    • Cumulative antibiotic exposures over time and the risk of clostridium difficile infection
    • Stevens V., Dumyata G., Fine L.S., et al. Cumulative antibiotic exposures over time and the risk of clostridium difficile infection. Clin Infect Dis 2011, 53:42.
    • (2011) Clin Infect Dis , vol.53 , pp. 42
    • Stevens, V.1    Dumyata, G.2    Fine, L.S.3
  • 43
    • 34548267536 scopus 로고    scopus 로고
    • Impact of a reduction in the use of high risk antibiotics in the course of an epidemic of clostridium difficile-associated disease caused by the hyper virulent NAP1/027 strain
    • Valiquette L., Cossette B., Garant L.P., et al. Impact of a reduction in the use of high risk antibiotics in the course of an epidemic of clostridium difficile-associated disease caused by the hyper virulent NAP1/027 strain. Clin Infect Dis 2007, 45(Suppl 2):S112-S121.
    • (2007) Clin Infect Dis , vol.45 , Issue.SUPPL 2
    • Valiquette, L.1    Cossette, B.2    Garant, L.P.3
  • 44
    • 2942704185 scopus 로고    scopus 로고
    • Clostridium difficile pilot study: effects of probiotic supplementation in the incidence of C. difficile diarrhea
    • Plummer S., Weaver M.A., Harris J.C., et al. Clostridium difficile pilot study: effects of probiotic supplementation in the incidence of C. difficile diarrhea. Int Microbiol 2004, 7:59-62.
    • (2004) Int Microbiol , vol.7 , pp. 59-62
    • Plummer, S.1    Weaver, M.A.2    Harris, J.C.3
  • 45
    • 0034450738 scopus 로고    scopus 로고
    • The search for a better treatment for recurrent clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardii
    • Surawicz C.M., McFarland L.V., Greenberg R.N., et al. The search for a better treatment for recurrent clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardii. Clin Infect Dis 2000, 31:1012-1017.
    • (2000) Clin Infect Dis , vol.31 , pp. 1012-1017
    • Surawicz, C.M.1    McFarland, L.V.2    Greenberg, R.N.3
  • 46
    • 33745628389 scopus 로고    scopus 로고
    • Probiotic use in clinical practice: what are the risks?
    • Boyle R.J., Robins-Browne R.M., Tank Mimi L.K. Probiotic use in clinical practice: what are the risks?. Am J Clin Nutr 2006, 83:1256-1264.
    • (2006) Am J Clin Nutr , vol.83 , pp. 1256-1264
    • Boyle, R.J.1    Robins-Browne, R.M.2    Tank Mimi, L.K.3
  • 47
    • 79957623658 scopus 로고    scopus 로고
    • Economic impact of Clostridium difficile infection in a multihospital cohort of academic health centers
    • Pakyz A., Carroll N.V., Harpe S.E., et al. Economic impact of Clostridium difficile infection in a multihospital cohort of academic health centers. Pharmacotherapy 2011, 31(6):546-551.
    • (2011) Pharmacotherapy , vol.31 , Issue.6 , pp. 546-551
    • Pakyz, A.1    Carroll, N.V.2    Harpe, S.E.3
  • 48
    • 84857654786 scopus 로고    scopus 로고
    • The economic burden of clostridium difficile
    • McGlone S.M., Bailey R.R., Zimmer S.M., et al. The economic burden of clostridium difficile. Clin Microbiol Infect 2012, 18(3):282-289.
    • (2012) Clin Microbiol Infect , vol.18 , Issue.3 , pp. 282-289
    • McGlone, S.M.1    Bailey, R.R.2    Zimmer, S.M.3
  • 49
    • 77149140102 scopus 로고    scopus 로고
    • Clostridium difficile infection and inflammatory bowel disease
    • Musa S., Thomson S., Cowan M., et al. Clostridium difficile infection and inflammatory bowel disease. Scand J Gastroenterol 2010, 45(3):261-272.
    • (2010) Scand J Gastroenterol , vol.45 , Issue.3 , pp. 261-272
    • Musa, S.1    Thomson, S.2    Cowan, M.3
  • 50
    • 78650108131 scopus 로고    scopus 로고
    • Recurrence rate of clostridium difficile infection in hospitalized pediatric patients with inflammatory bowel disease
    • Kelsen J.R., Kim J., Latta D., et al. Recurrence rate of clostridium difficile infection in hospitalized pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis 2011, 17(1):50-55.
    • (2011) Inflamm Bowel Dis , vol.17 , Issue.1 , pp. 50-55
    • Kelsen, J.R.1    Kim, J.2    Latta, D.3
  • 51
    • 84860708876 scopus 로고    scopus 로고
    • Probiotics for the prevention and treatment of antibiotic-associated diarrhea
    • Hempel S., Newberry S.J., Maher A.R., et al. Probiotics for the prevention and treatment of antibiotic-associated diarrhea. JAMA 2012, 307(18):1959-1969.
    • (2012) JAMA , vol.307 , Issue.18 , pp. 1959-1969
    • Hempel, S.1    Newberry, S.J.2    Maher, A.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.