Loss of P2Y14 results in an arresting response to hematological stress

Journal of Clinical Investigation

Volumn 124, Issue 7, 2014, Pages 2846-2848

  Garrison, Brian S ^a,b,c   Rossi, Derrick J ^a,b,c,d  

^a Harvard University   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y14 RECEPTOR; UNCLASSIFIED DRUG; P2RY14 PROTEIN, MOUSE;

CELL DIFFERENTIATION; CELL POLARITY; CELL POPULATION; CELLULAR STRESS RESPONSE; DNA METHYLATION; HEMATOPOIETIC STEM CELL; HISTONE MODIFICATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; REVIEW; SENESCENCE; ANIMAL; FEMALE; MALE; METABOLISM; NOTE; PREGNANCY; RADIATION EXPOSURE;

ANIMALS; FEMALE; HEMATOPOIETIC STEM CELLS; MALE; PREGNANCY; RECEPTORS, PURINERGIC P2Y;

EID: 84903770642     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI76626     Document Type: Review

References (22)

1. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25:585-621.
2. Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007;8(9):729-740. (Pubitemid 47312822)
3. Kuilman T, Michaloglou C, Mooi WJ, Peeper DS. The essence of senescence. Genes Dev. 2010; 24(22):2463-2479.
4. Salama R, Sadaie M, Hoare M, Narita M. Cellular senescence and its effector programs. Genes Dev. 2014;28(2):99-114.
5. Rossi DJ, et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A. 2005;102(26):9194-9199. (Pubitemid 40923540)
6. Dykstra B, Olthof S, Schreuder J, Ritsema M, de Haan G. Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. J Exp Med. 2011;208(13):2691-2703.
7. Beerman I, et al. Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci U S A. 2010; 107(12):5465-5470.
8. Pang WW, et al. Human bone marrow hematopoietic stem cells are increased in frequency and myeloidbiased with age. Proc Natl Acad Sci U S A. 2011; 108(50):20012-20017.
9. Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature. 2007; 447(7145):725-729. (Pubitemid 46889729)
10. Beerman I, Seita J, Inlay MA, Weissman IL, Rossi DJ. Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle. Cell Stem Cell. 2014;pii:S1934-5909(14)00153-2.
11. Florian MC, et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell. 2012;10(5):520-530.
12. Beerman I, et al. Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. Cell Stem Cell. 2013; 12(4):413-425.
13. Sun D, et al. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell. 2014; 14(5):673-688.
14. Sperka T, Wang J, Rudolph KL. DNA damage checkpoints in stem cells, ageing and cancer. Nat Rev Mol Cell Biol. 2012;13(9):579-590.
15. Attema JL, Pronk CJ, Norddahl GL, Nygren JM, Bryder D. Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence. Oncogene. 2009;28(22):2238-2243.
16. Janzen V, et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature. 2006;443(7110):421-426. (Pubitemid 44477274)
17. Cho J, et al. Purinergic P2Y14 receptor modulates stress-induced hematopoietic stem/progenitor cell senescence. J Clin Invest. 2014;124(7):3159-3171.
18. Ito K, et al. Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes. J Immunol. 2007; 178(1):103-110. (Pubitemid 46039661)
19. Tothova Z, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 2007;128(2):325-339. (Pubitemid 46137992)
20. Miyamoto K, et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell. 2007;1(1):101-112. (Pubitemid 46865800)
21. Yalcin S, et al. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem. 2008;283(37):25692-25705.
22. Shao L, et al. Total body irradiation causes longterm mouse BM injury via induction of HSC premature senescence in an Ink4a-and Arf-independent manner. Blood. 2014;123(20):3105-3115.