Activation of Nrf2 protects against triptolide-induced hepatotoxicity

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Li, Jia ^a,b   Shen, Feihai ^a   Guan, Cuiwen ^a   Wang, Wenwen ^a   Sun, Xiaozhe ^a   Fu, Xinlu ^a   Huang, Min ^a   Jin, Jing ^a   Huang, Zhiying ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; TRIPTOLIDE; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; DITERPENE; EPOXIDE; ISOTHIOCYANIC ACID DERIVATIVE; NFE2L2 PROTEIN, HUMAN; NFE2L2 PROTEIN, MOUSE; PHENANTHRENE DERIVATIVE; SULFORAFAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CELL DAMAGE; CONTROLLED STUDY; GENE; GENE OVEREXPRESSION; GENE SILENCING; HEPG2 CELL LINE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; NRF2 GENE; OXIDATIVE STRESS; PROTEIN DEPLETION; PROTEIN EXPRESSION; REGULATORY MECHANISM; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; METABOLISM; PATHOLOGY;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; DITERPENES; DRUG-INDUCED LIVER INJURY; EPOXY COMPOUNDS; HEP G2 CELLS; HUMANS; ISOTHIOCYANATES; MICE; MICE, INBRED BALB C; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHENANTHRENES;

EID: 84903761622     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100685     Document Type: Article

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