Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin

Archives of Dermatological Research

Volumn 306, Issue 5, 2014, Pages 447-454

  Reisman, Scott A ^a   Lee, Chun Yue I ^a   Meyer, Colin J ^a   Proksch, Joel W ^a   Ward, Keith W ^a  

^a Reata Pharmaceuticals Inc   (United States)

Author keywords

Nrf2; Oxidative stress; RTA 408; Skin; Synthetic triterpenoid

Indexed keywords

RTA 408; TRANSCRIPTION FACTOR NRF2; TRITERPENOID; UNCLASSIFIED DRUG; GLUTATHIONE; N-(11-CYANO-2,2,6A,6B,9,9,12A-HEPTMETHYL-10,14-DIOXO-1,3,4,5,6A,6B,7,8,8A,9,10,12A,14,14A,14B-HEXADECAHYDRO-2H-PICEN-4A-YL)-2-2-DIFLUOROPROPIONAMIDE; NFE2L2 PROTEIN, RAT; NQO1 PROTEIN, RAT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG PENETRATION; GENE TARGETING; MALE; NONHUMAN; OXIDATIVE STRESS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SKIN CELL; ANIMAL; BIOSYNTHESIS; BLOOD; DRUG EFFECTS; INTRADERMAL DRUG ADMINISTRATION; SKIN; SKIN ABSORPTION; SKIN DISEASES; SPRAGUE DAWLEY RAT;

ADMINISTRATION, CUTANEOUS; ANIMALS; CYTOPROTECTION; GLUTATHIONE; MALE; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SKIN ABSORPTION; SKIN DISEASES; TRITERPENES;

EID: 84903739616     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-013-1433-7     Document Type: Article

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