Clinical pharmacology for development of topical dermatological products: Present and future opportunities for safety and efficacy

Clinical Pharmacology and Therapeutics

Volumn 89, Issue 2, 2011, Pages 167-169

  Cho, S ^a   Bashaw, E D ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; PREDNISONE; TIMOLOL; TOPICAL AGENT;

ANALYTIC METHOD; ATRIOVENTRICULAR BLOCK; CLINICAL PHARMACOLOGY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG EFFICACY; DRUG EXPOSURE; DRUG SAFETY; DRUG TISSUE LEVEL; HUMAN; MICRODIALYSIS; PRIORITY JOURNAL; REVIEW; RISK BENEFIT ANALYSIS; SKIN DISEASE; TREATMENT RESPONSE;

ADMINISTRATION, TOPICAL; DERMATOLOGIC AGENTS; DRUG DISCOVERY; HUMANS; PHARMACOLOGY, CLINICAL; SKIN; SKIN DISEASES;

EID: 78951469690     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2010.283     Document Type: Review

References (5)

1. Dehkharghani, S., Bible, J., Chen, J.G., Feldman, S.R. & Fleischer, A.B. The economic burden of skin disease in the United States. J. Am. Acad. Dermatol. 48, 592-599 (2003).
2. Babu, R.J. et al. Percutaneous absorption and anti-inflammatory effect of a substance P receptor antagonist: spantide II. Pharm. Res. 21, 108-113 (2004).
3. McClain, R.W., Yentzer, B.A. & Feldman, S.R. Comparison of skin concentrations following topical versus oral corticosteroid treatment: reconsidering the treatment of common inflammatory dermatoses. J. Drugs Dermatol. 8, 1076-1079 (2009).
4. Herkenne, C. et al. In vivo methods for the assessment of topical drug bioavailability. Pharm. Res. 25, 87-103 (2008).
5. Brunner, M. & Langer, O. Microdialysis versus other techniques for the clinical assessment of in vivo tissue drug distribution. AAPS J. 8, E263-271 (2006).