Insights into the human glycan receptor conformation of 1918 pandemic hemagglutinin-glycan complexes derived from nuclear magnetic resonance and molecular dynamics studies

Biochemistry

Volumn 53, Issue 25, 2014, Pages 4122-4135

  Elli, Stefano ^a   Macchi, Eleonora ^a   Rudd, Timothy R ^b   Raman, Rahul ^c   Sassaki, Guillherme ^d   Viswanathan, Karthik ^c   Yates, Edwin A ^e   Shriver, Zachary ^c   Naggi, Annamaria ^a   Torri, Giangiacomo ^a   Sasisekharan, Ram ^c   Guerrini, Marco ^a  

^a Istituto di Ricerche Chimiche e Biochimiche G Ronzoni   (Italy)

^b DIAMOND LIGHT SOURCE LTD   (United Kingdom)

^c Massachusetts Institute of Technology   (United States)

^d FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^e UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AEROSOLS; AMINO ACIDS; BINDING SITES; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; POLYSACCHARIDES; VIRUSES;

CHARACTERISTIC SIGNATURE; CONFORMATIONAL CONSTRAINTS; CONFORMATIONAL SPACE; HIGH AFFINITY BINDING; NUCLEAR MAGNETIC RESONANCE(NMR); RECEPTOR BINDING SITE; STRINGENT CONSTRAINTS; STRUCTURAL CONSTRAINTS;

CONFORMATIONS;

GLYCAN; GLYCOSAMINOGLYCAN; INFLUENZA VIRUS HEMAGGLUTININ;

ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL STRUCTURE; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PANDEMIC INFLUENZA; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR BINDING;

ANIMALS; BIRDS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS; INFLUENZA PANDEMIC, 1918-1919; MOLECULAR DYNAMICS SIMULATION; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; POLYSACCHARIDES; PROTEIN CONFORMATION; RECEPTORS, VIRUS; SIALIC ACIDS;

EID: 84903728263     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi500338r     Document Type: Article

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