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Volumn 5, Issue JUN, 2014, Pages

Getting to the edge: Protein dynamical networks as a new frontier in plant-microbe interactions

Author keywords

Edgetics; Functional modules; Network dynamics; Plant pathogen interactions; Protein protein interactions; Regulatory network; Systems biology

Indexed keywords


EID: 84903723588     PISSN: None     EISSN: 1664462X     Source Type: Journal    
DOI: 10.3389/fpls.2014.00312     Document Type: Review
Times cited : (42)

References (48)
  • 1
    • 33745588546 scopus 로고    scopus 로고
    • The limits of reductionism in medicine: Could systems biology offer an alternative?
    • doi: 10.1371/journal.pmed.0030208
    • Ahn, A. C., Tewari, M., Poon, C. S., and Phillips, R. S. (2006). The limits of reductionism in medicine: could systems biology offer an alternative? PLoS Med. 3:e208. doi: 10.1371/journal.pmed.0030208
    • (2006) PLoS Med. , vol.3
    • Ahn, A.C.1    Tewari, M.2    Poon, C.S.3    Phillips, R.S.4
  • 2
    • 84857780876 scopus 로고    scopus 로고
    • Evidence for network evolution in an Arabidopsis interactome map
    • Arabidopsis Interactome Mapping Consortium, doi: 10.1126/science.1203877
    • Arabidopsis Interactome Mapping Consortium. (2011). Evidence for network evolution in an Arabidopsis interactome map. Science 333, 601-607. doi: 10.1126/science.1203877
    • (2011) Science , vol.333 , pp. 601-607
  • 3
    • 79952643760 scopus 로고    scopus 로고
    • Network news: Innovations in 21st century systems biology
    • doi: 10.1016/j.cell.2011.03.008
    • Arkin, A. P., and Schaffer, D. V. (2011). Network news: innovations in 21st century systems biology. Cell 144, 844-849. doi: 10.1016/j.cell.2011.03.008
    • (2011) Cell , vol.144 , pp. 844-849
    • Arkin, A.P.1    Schaffer, D.V.2
  • 4
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: A network-based approach to human disease
    • doi: 10.1038/nrg2918
    • Barabasi, A. L., Gulbahce, N., and Loscalzo, J. (2011). Network medicine: a network-based approach to human disease. Nat. Rev. Genet. 12, 56-68. doi: 10.1038/nrg2918
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 56-68
    • Barabasi, A.L.1    Gulbahce, N.2    Loscalzo, J.3
  • 5
    • 84885420310 scopus 로고    scopus 로고
    • Universality in network dynamics
    • doi: 10.1038/nphys2741
    • Barzel, B., and Barabasi, A. L. (2013). Universality in network dynamics. Nat. Phys. 9, 673-681. doi: 10.1038/nphys2741
    • (2013) Nat. Phys. , vol.9 , pp. 673-681
    • Barzel, B.1    Barabasi, A.L.2
  • 6
    • 84880509682 scopus 로고    scopus 로고
    • Plant-pathogen interactions: Disease resistance in modern agriculture
    • doi: 10.1016/j.tig.2012.10.011
    • Boyd, L. A., Ridout, C., O'Sullivan, D. M., Leach, J. E., and Leung, H. (2013). Plant-pathogen interactions: disease resistance in modern agriculture. Trends Genet. 29, 233-240. doi: 10.1016/j.tig.2012.10.011
    • (2013) Trends Genet. , vol.29 , pp. 233-240
    • Boyd, L.A.1    Ridout, C.2    O'Sullivan, D.M.3    Leach, J.E.4    Leung, H.5
  • 8
    • 85040021215 scopus 로고    scopus 로고
    • Integrating domain similarity to improve protein complexes identification in TAP-MS data
    • doi: 10.1186/1477-5956-11-S1-S2
    • Cai, B., Wang, H., Zheng, H., and Wang, H. (2013). Integrating domain similarity to improve protein complexes identification in TAP-MS data. Proteome Sci. 11:S2. doi: 10.1186/1477-5956-11-S1-S2
    • (2013) Proteome Sci. , vol.11
    • Cai, B.1    Wang, H.2    Zheng, H.3    Wang, H.4
  • 10
    • 84879951956 scopus 로고    scopus 로고
    • Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis
    • doi: 10.7554/eLife.00675
    • Chang, K. N., Zhong, S., Weirauch, M. T., Hon, G., Pelizzola, M., Li, H., et al. (2013). Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis. Elife 2:e00675. doi: 10.7554/eLife.00675
    • (2013) Elife , vol.2
    • Chang, K.N.1    Zhong, S.2    Weirauch, M.T.3    Hon, G.4    Pelizzola, M.5    Li, H.6
  • 11
    • 80054761046 scopus 로고    scopus 로고
    • Protein-protein interactions and networks: Forward and reverse edgetics
    • doi: 10.1007/978-1-61779-173-4_12
    • Charloteaux, B., Zhong, Q., Dreze, M., Cusick, M. E., Hill, D. E., and Vidal, M. (2011). Protein-protein interactions and networks: forward and reverse edgetics. Methods Mol. Biol. 759, 197-213. doi: 10.1007/978-1-61779-173-4_12
    • (2011) Methods Mol. Biol. , vol.759 , pp. 197-213
    • Charloteaux, B.1    Zhong, Q.2    Dreze, M.3    Cusick, M.E.4    Hill, D.E.5    Vidal, M.6
  • 12
    • 84889032390 scopus 로고    scopus 로고
    • Exploring mechanisms of human disease through structurally resolved protein interactome networks
    • doi: 10.1039/c3mb70225a
    • Das, J., Fragoza, R., Lee, H. R., Cordero, N. A., Guo, Y., Meyer, M. J., et al. (2014a). Exploring mechanisms of human disease through structurally resolved protein interactome networks. Mol. Biosyst. 10, 9-17. doi: 10.1039/c3mb70225a
    • (2014) Mol. Biosyst. , vol.10 , pp. 9-17
    • Das, J.1    Fragoza, R.2    Lee, H.R.3    Cordero, N.A.4    Guo, Y.5    Meyer, M.J.6
  • 13
    • 84898815256 scopus 로고    scopus 로고
    • Elucidating common structural features of human pathogenic variations using large-scale atomic-resolution protein networks
    • doi: 10.1002/humu.22534
    • Das, J., Lee, H. R., Sagar, A., Fragoza, R., Liang, J., Wei, X., et al. (2014b). Elucidating common structural features of human pathogenic variations using large-scale atomic-resolution protein networks. Hum. Mutat. 35, 585-593. doi: 10.1002/humu.22534
    • (2014) Hum. Mutat. , vol.35 , pp. 585-593
    • Das, J.1    Lee, H.R.2    Sagar, A.3    Fragoza, R.4    Liang, J.5    Wei, X.6
  • 14
    • 38949210153 scopus 로고    scopus 로고
    • Dynamic simulation of regulatory networks using SQUAD
    • doi: 10.1186/1471-2105-8-462
    • Di Cara, A., Garg, A., De Micheli, G., Xenarios, I., and Mendoza, L. (2007). Dynamic simulation of regulatory networks using SQUAD. BMC Bioinformatics 8:462. doi: 10.1186/1471-2105-8-462
    • (2007) BMC Bioinformatics , vol.8 , pp. 462
    • Di Cara, A.1    Garg, A.2    De Micheli, G.3    Xenarios, I.4    Mendoza, L.5
  • 16
    • 37349040712 scopus 로고    scopus 로고
    • Prediction of protein-ligand complex structure by docking software guided by other complex structures
    • doi: 10.1016/j.jmgm.2007.07.001
    • Fukunishi, Y., and Nakamura, H. (2008). Prediction of protein-ligand complex structure by docking software guided by other complex structures. J. Mol. Graph. Model. 26, 1030-1033. doi: 10.1016/j.jmgm.2007.07.001
    • (2008) J. Mol. Graph. Model. , vol.26 , pp. 1030-1033
    • Fukunishi, Y.1    Nakamura, H.2
  • 17
    • 84873392956 scopus 로고    scopus 로고
    • Linking the signaling cascades and dynamic regulatory networks controlling stress responses
    • doi: 10.1101/gr.138628.112
    • Gitter, A., Carmi, M., Barkai, N., and Bar-Joseph, Z. (2013). Linking the signaling cascades and dynamic regulatory networks controlling stress responses. Genome Res. 23, 365-376. doi: 10.1101/gr.138628.112
    • (2013) Genome Res. , vol.23 , pp. 365-376
    • Gitter, A.1    Carmi, M.2    Barkai, N.3    Bar-Joseph, Z.4
  • 18
    • 84864053752 scopus 로고    scopus 로고
    • Viral perturbations of host networks reflect disease etiology
    • doi: 10.1371/journal.pcbi.1002531
    • Gulbahce, N., Yan, H., Dricot, A., Padi, M., Byrdsong, D., Franchi, R., et al. (2012). Viral perturbations of host networks reflect disease etiology. PLoS Comput. Biol. 8:e1002531. doi: 10.1371/journal.pcbi.1002531
    • (2012) PLoS Comput. Biol. , vol.8
    • Gulbahce, N.1    Yan, H.2    Dricot, A.3    Padi, M.4    Byrdsong, D.5    Franchi, R.6
  • 21
    • 77953224209 scopus 로고    scopus 로고
    • Mapping plant interactomes using literature curated and predicted protein-protein interaction data sets
    • doi: 10.1105/tpc.109.072736
    • Lee, K., Thorneycroft, D., Achuthan, P., Hermjakob, H., and Ideker, T. (2010). Mapping plant interactomes using literature curated and predicted protein-protein interaction data sets. Plant Cell 22, 997-1005. doi: 10.1105/tpc.109.072736
    • (2010) Plant Cell , vol.22 , pp. 997-1005
    • Lee, K.1    Thorneycroft, D.2    Achuthan, P.3    Hermjakob, H.4    Ideker, T.5
  • 22
    • 84878858665 scopus 로고    scopus 로고
    • INstruct: A database of high-quality 3D structurally resolved protein interactome networks
    • doi: 10.1093/bioinformatics/btt181
    • Meyer, M. J., Das, J., Wang, X., and Yu, H. (2013). INstruct: a database of high-quality 3D structurally resolved protein interactome networks. Bioinformatics 29, 1577-1579. doi: 10.1093/bioinformatics/btt181
    • (2013) Bioinformatics , vol.29 , pp. 1577-1579
    • Meyer, M.J.1    Das, J.2    Wang, X.3    Yu, H.4
  • 23
    • 84884397652 scopus 로고    scopus 로고
    • Integrative approaches for finding modular structure in biological networks
    • doi: 10.1038/nrg3552
    • Mitra, K., Carvunis, A. R., Ramesh, S. K., and Ideker, T. (2013). Integrative approaches for finding modular structure in biological networks. Nat. Rev. Genet. 14, 719-732. doi: 10.1038/nrg3552
    • (2013) Nat. Rev. Genet. , vol.14 , pp. 719-732
    • Mitra, K.1    Carvunis, A.R.2    Ramesh, S.K.3    Ideker, T.4
  • 24
    • 84891718169 scopus 로고    scopus 로고
    • From experimental systems to evolutionary biology: An impossible journey?
    • Morange, M. (2013). From experimental systems to evolutionary biology: an impossible journey? Hist. Philos. Life Sci. 35, 27-32.
    • (2013) Hist. Philos. Life Sci. , vol.35 , pp. 27-32
    • Morange, M.1
  • 25
    • 84883270109 scopus 로고    scopus 로고
    • Engineering NLR immune receptors for broad-spectrum disease resistance
    • doi: 10.1016/j.tplants.2013.08.005
    • Mukhtar, M. S. (2013). Engineering NLR immune receptors for broad-spectrum disease resistance. Trends Plant Sci. 18, 469-472. doi: 10.1016/j.tplants.2013.08.005
    • (2013) Trends Plant Sci. , vol.18 , pp. 469-472
    • Mukhtar, M.S.1
  • 26
    • 79960957705 scopus 로고    scopus 로고
    • Independently evolved virulence effectors converge onto hubs in a plant immune system network
    • doi: 10.1126/science.1203659
    • Mukhtar, M. S., Carvunis, A. R., Dreze, M., Epple, P., Steinbrenner, J., Moore, J., et al. (2011). Independently evolved virulence effectors converge onto hubs in a plant immune system network. Science 333, 596-601. doi: 10.1126/science.1203659
    • (2011) Science , vol.333 , pp. 596-601
    • Mukhtar, M.S.1    Carvunis, A.R.2    Dreze, M.3    Epple, P.4    Steinbrenner, J.5    Moore, J.6
  • 27
    • 65849291758 scopus 로고    scopus 로고
    • NPR1 in plant defense: It's not over 'til it's turned over
    • doi: 10.1016/j.cell.2009.05.010
    • Mukhtar, M. S., Nishimura, M. T., and Dangl, J. (2009). NPR1 in plant defense: it's not over 'til it's turned over. Cell 137, 804-806. doi: 10.1016/j.cell.2009.05.010
    • (2009) Cell , vol.137 , pp. 804-806
    • Mukhtar, M.S.1    Nishimura, M.T.2    Dangl, J.3
  • 28
    • 84863084720 scopus 로고    scopus 로고
    • Integrated systems view on networking by hormones in Arabidopsis immunity reveals multiple crosstalk for cytokinin
    • doi: 10.1105/tpc.112.098335
    • Naseem, M., Philippi, N., Hussain, A., Wangorsch, G., Ahmed, N., and Dandekar, T. (2012). Integrated systems view on networking by hormones in Arabidopsis immunity reveals multiple crosstalk for cytokinin. Plant Cell 24, 1793-1814. doi: 10.1105/tpc.112.098335
    • (2012) Plant Cell , vol.24 , pp. 1793-1814
    • Naseem, M.1    Philippi, N.2    Hussain, A.3    Wangorsch, G.4    Ahmed, N.5    Dandekar, T.6
  • 29
    • 84880786504 scopus 로고    scopus 로고
    • Tell me more: Roles of NPRs in plant immunity
    • doi: 10.1016/j.tplants.2013.04.004
    • Pajerowska-Mukhtar, K. M., Emerine, D. K., and Mukhtar, M. S. (2013). Tell me more: roles of NPRs in plant immunity. Trends Plant Sci. 18, 402-411. doi: 10.1016/j.tplants.2013.04.004
    • (2013) Trends Plant Sci. , vol.18 , pp. 402-411
    • Pajerowska-Mukhtar, K.M.1    Emerine, D.K.2    Mukhtar, M.S.3
  • 30
    • 84876861024 scopus 로고    scopus 로고
    • Post-docking optimization and analysis of protein-ligand interactions of estrogen receptor alpha using AMMOS software
    • Pencheva, T., Jereva, D., Miteva, M. A., and Pajeva, I. (2013). Post-docking optimization and analysis of protein-ligand interactions of estrogen receptor alpha using AMMOS software. Curr. Comput. Aided Drug Des. 9, 83-94.
    • (2013) Curr. Comput. Aided Drug Des. , vol.9 , pp. 83-94
    • Pencheva, T.1    Jereva, D.2    Miteva, M.A.3    Pajeva, I.4
  • 31
    • 79952041528 scopus 로고    scopus 로고
    • A systems biology perspective on plant-microbe interactions: Biochemical and structural targets of pathogen effectors
    • doi: 10.1016/j.plantsci.2010.12.008
    • Pritchard, L., and Birch, P. (2011). A systems biology perspective on plant-microbe interactions: biochemical and structural targets of pathogen effectors. Plant Sci. 180, 584-603. doi: 10.1016/j.plantsci.2010.12.008
    • (2011) Plant Sci. , vol.180 , pp. 584-603
    • Pritchard, L.1    Birch, P.2
  • 32
    • 84868246018 scopus 로고    scopus 로고
    • A synthetic biology approach to understanding cellular information processing
    • doi: 10.1021/sb300044r
    • Riccione, K. A., Smith, R. P., Lee, A. J., and You, L. (2012). A synthetic biology approach to understanding cellular information processing. ACS Synth. Biol. 1, 389-402. doi: 10.1021/sb300044r
    • (2012) ACS Synth. Biol. , vol.1 , pp. 389-402
    • Riccione, K.A.1    Smith, R.P.2    Lee, A.J.3    You, L.4
  • 33
    • 77957654501 scopus 로고    scopus 로고
    • Network modeling reveals prevalent negative regulatory relationships between signaling sectors in Arabidopsis immune signaling
    • doi: 10.1371/journal.ppat.1001011
    • Sato, M., Tsuda, K., Wang, L., Coller, J., Watanabe, Y., Glazebrook, J., et al. (2010). Network modeling reveals prevalent negative regulatory relationships between signaling sectors in Arabidopsis immune signaling. PLoS Pathog. 6:e1001011. doi: 10.1371/journal.ppat.1001011
    • (2010) PLoS Pathog. , vol.6
    • Sato, M.1    Tsuda, K.2    Wang, L.3    Coller, J.4    Watanabe, Y.5    Glazebrook, J.6
  • 34
    • 84864921682 scopus 로고    scopus 로고
    • DREM 2.0: Improved reconstruction of dynamic regulatory networks from time-series expression data
    • doi: 10.1186/1752-0509-6-104
    • Schulz, M. H., Devanny, W. E., Gitter, A., Zhong, S., Ernst, J., and Bar-Joseph, Z. (2012). DREM 2.0: improved reconstruction of dynamic regulatory networks from time-series expression data. BMC Syst. Biol. 6:104. doi: 10.1186/1752-0509-6-104
    • (2012) BMC Syst. Biol. , vol.6 , pp. 104
    • Schulz, M.H.1    Devanny, W.E.2    Gitter, A.3    Zhong, S.4    Ernst, J.5    Bar-Joseph, Z.6
  • 35
    • 79952689290 scopus 로고    scopus 로고
    • SnapShot: Protein-protein interaction networks
    • doi: 10.1016/j.cell.2011.02.025
    • Seebacher, J., and Gavin, A. C. (2011). SnapShot: protein-protein interaction networks. Cell 144, 1000:1001. e1. doi: 10.1016/j.cell.2011.02.025
    • (2011) Cell , vol.144
    • Seebacher, J.1    Gavin, A.C.2
  • 36
    • 71549141289 scopus 로고    scopus 로고
    • Deterministic and stochastic models of genetic regulatory networks
    • doi: 10.1016/S0076-6879(09)67013-67010
    • Shmulevich, I., and Aitchison, J. D. (2009). Deterministic and stochastic models of genetic regulatory networks. Methods Enzymol. 467, 335-356. doi: 10.1016/S0076-6879(09)67013-67010
    • (2009) Methods Enzymol. , vol.467 , pp. 335-356
    • Shmulevich, I.1    Aitchison, J.D.2
  • 37
    • 84880324632 scopus 로고    scopus 로고
    • Evolutionary systems biology: What it is and why it matters
    • doi: 10.1002/bies.201300029
    • Soyer, O. S., and O'Malley, M. A. (2013). Evolutionary systems biology: what it is and why it matters. Bioessays 35, 696-705. doi: 10.1002/bies.201300029
    • (2013) Bioessays , vol.35 , pp. 696-705
    • Soyer, O.S.1    O'Malley, M.A.2
  • 38
    • 78651344377 scopus 로고    scopus 로고
    • 3did: Identification and classification of domain-based interactions of known three-dimensional structure
    • doi: 10.1093/nar/gkq962
    • Stein, A., Ceol, A., and Aloy, P. (2011). 3did: identification and classification of domain-based interactions of known three-dimensional structure. Nucleic Acids Res. 39, D718-D723. doi: 10.1093/nar/gkq962
    • (2011) Nucleic Acids Res. , vol.39
    • Stein, A.1    Ceol, A.2    Aloy, P.3
  • 39
    • 84875381367 scopus 로고    scopus 로고
    • Interactome mapping: Using protein microarray technology to reconstruct diverse protein networks
    • doi: 10.1016/j.gpb.2012.12.005
    • Uzoma, I., and Zhu, H. (2013). Interactome mapping: using protein microarray technology to reconstruct diverse protein networks. Genomics Proteomics Bioinformatics 11, 18-28. doi: 10.1016/j.gpb.2012.12.005
    • (2013) Genomics Proteomics Bioinformatics , vol.11 , pp. 18-28
    • Uzoma, I.1    Zhu, H.2
  • 41
    • 79953743545 scopus 로고    scopus 로고
    • The Protein Data Bank in Europe (PDBe): Bringing structure to biology
    • doi: 10.1107/S090744491004117X
    • Velankar, S., and Kleywegt, G. J. (2011). The Protein Data Bank in Europe (PDBe): bringing structure to biology. Acta Crystallogr. D. Biol. Crystallogr. 67, 324-330. doi: 10.1107/S090744491004117X
    • (2011) Acta Crystallogr. D. Biol. Crystallogr. , vol.67 , pp. 324-330
    • Velankar, S.1    Kleywegt, G.J.2
  • 42
    • 79952674000 scopus 로고    scopus 로고
    • Interactome networks and human disease
    • doi: 10.1016/j.cell.2011.02.016
    • Vidal, M., Cusick, M. E., and Barabasi, A. L. (2011). Interactome networks and human disease. Cell 144, 986-998. doi: 10.1016/j.cell.2011.02.016
    • (2011) Cell , vol.144 , pp. 986-998
    • Vidal, M.1    Cusick, M.E.2    Barabasi, A.L.3
  • 43
    • 84877312859 scopus 로고    scopus 로고
    • Reconstructing regulatory networks from the dynamic plasticity of gene expression by mutual information
    • doi: 10.1093/nar/gkt147
    • Wang, J., Chen, B., Wang, Y., Wang, N., Garbey, M., Tran-Son-Tay, R., et al. (2013). Reconstructing regulatory networks from the dynamic plasticity of gene expression by mutual information. Nucleic Acids Res. 41:e97. doi: 10.1093/nar/gkt147
    • (2013) Nucleic Acids Res. , vol.41
    • Wang, J.1    Chen, B.2    Wang, Y.3    Wang, N.4    Garbey, M.5    Tran-Son-Tay, R.6
  • 44
    • 84863010950 scopus 로고    scopus 로고
    • Three-dimensional reconstruction of protein networks provides insight into human genetic disease
    • doi: 10.1038/nbt.2106
    • Wang, X., Wei, X., Thijssen, B., Das, J., Lipkin, S. M., and Yu, H. (2012). Three-dimensional reconstruction of protein networks provides insight into human genetic disease. Nat. Biotechnol. 30, 159-164. doi: 10.1038/nbt.2106
    • (2012) Nat. Biotechnol. , vol.30 , pp. 159-164
    • Wang, X.1    Wei, X.2    Thijssen, B.3    Das, J.4    Lipkin, S.M.5    Yu, H.6
  • 45
    • 84871681271 scopus 로고    scopus 로고
    • Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0
    • doi: 10.1186/1752-0509-7-1
    • Weber, M., Henkel, S. G., Vlaic, S., Guthke, R., Van Zoelen, E. J., and Driesch, D. (2013). Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0. BMC Syst. Biol. 7:1. doi: 10.1186/1752-0509-7-1
    • (2013) BMC Syst. Biol. , vol.7 , pp. 1
    • Weber, M.1    Henkel, S.G.2    Vlaic, S.3    Guthke, R.4    Van Zoelen, E.J.5    Driesch, D.6
  • 46
    • 84864562602 scopus 로고    scopus 로고
    • NEXCADE: Perturbation analysis for complex networks
    • doi: 10.1371/journal.pone.0041827
    • Yadav, G., and Babu, S. (2012). NEXCADE: perturbation analysis for complex networks. PLoS ONE 7:e41827. doi: 10.1371/journal.pone.0041827
    • (2012) PLoS ONE , vol.7
    • Yadav, G.1    Babu, S.2
  • 47
    • 84867881743 scopus 로고    scopus 로고
    • Structure-based prediction of protein-protein interactions on a genome-wide scale
    • doi: 10.1038/nature11503
    • Zhang, Q. C., Petrey, D., Deng, L., Qiang, L., Shi, Y., Thu, C. A., et al. (2012). Structure-based prediction of protein-protein interactions on a genome-wide scale. Nature 490, 556-560. doi: 10.1038/nature11503
    • (2012) Nature , vol.490 , pp. 556-560
    • Zhang, Q.C.1    Petrey, D.2    Deng, L.3    Qiang, L.4    Shi, Y.5    Thu, C.A.6
  • 48
    • 72849142731 scopus 로고    scopus 로고
    • Edgetic perturbation models of human inherited disorders
    • doi: 10.1038/msb.2009.80
    • Zhong, Q., Simonis, N., Li, Q. R., Charloteaux, B., Heuze, F., Klitgord, N., et al. (2009). Edgetic perturbation models of human inherited disorders. Mol. Syst. Biol. 5:321. doi: 10.1038/msb.2009.80
    • (2009) Mol. Syst. Biol. , vol.5 , pp. 321
    • Zhong, Q.1    Simonis, N.2    Li, Q.R.3    Charloteaux, B.4    Heuze, F.5    Klitgord, N.6


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