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Volumn 24, Issue 4, 2014, Pages 112-118

Transcriptional and epigenetic control of IGF1R gene expression: Implications in metabolism and cancer

Author keywords

Cancer; IGF1R; IGF1R promoter; Transcription factors; Tumor suppressors

Indexed keywords

BINDING PROTEIN; HIGH MOBILITY GROUP A1 PROTEIN; KRUPPEL LIKE FACTOR 6; RNA BINDING PROTEIN EWS; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN; WT1 PROTEIN;

EID: 84903710324     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2014.03.006     Document Type: Review
Times cited : (50)

References (70)
  • 2
    • 0026744876 scopus 로고
    • Cloning and characterization of the human insulin-like growth factor-I receptor gene 5'-flanking region
    • Mamula P.W., Goldfine I.D. Cloning and characterization of the human insulin-like growth factor-I receptor gene 5'-flanking region. DNA Cell Biol. 1992, 11:43-50.
    • (1992) DNA Cell Biol. , vol.11 , pp. 43-50
    • Mamula, P.W.1    Goldfine, I.D.2
  • 3
    • 0026801581 scopus 로고
    • Structural and functional analysis of the insulin-like growth factor I receptor gene promoter
    • Werner H., Bach M.A., Stannard B., Roberts C.T., LeRoith D. Structural and functional analysis of the insulin-like growth factor I receptor gene promoter. Mol. Endocrinol. 1992, 6:1545-1558.
    • (1992) Mol. Endocrinol. , vol.6 , pp. 1545-1558
    • Werner, H.1    Bach, M.A.2    Stannard, B.3    Roberts, C.T.4    LeRoith, D.5
  • 4
    • 0025337031 scopus 로고
    • Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene
    • Werner H., Stannard B., Bach M.A., LeRoith D., Roberts C.T. Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene. Biochem. Biophys. Res. Commun. 1990, 169:1021-1027.
    • (1990) Biochem. Biophys. Res. Commun. , vol.169 , pp. 1021-1027
    • Werner, H.1    Stannard, B.2    Bach, M.A.3    LeRoith, D.4    Roberts, C.T.5
  • 5
    • 0026342613 scopus 로고
    • An analysis of vertebrate mRNA sequences: intimations of translational control
    • Kozak M. An analysis of vertebrate mRNA sequences: intimations of translational control. J. Cell Biol. 1991, 115:887-903.
    • (1991) J. Cell Biol. , vol.115 , pp. 887-903
    • Kozak, M.1
  • 6
    • 84861682298 scopus 로고    scopus 로고
    • Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer
    • Werner H. Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer. Oncogene 2012, 31:2703-2714.
    • (2012) Oncogene , vol.31 , pp. 2703-2714
    • Werner, H.1
  • 7
    • 0031028245 scopus 로고    scopus 로고
    • Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis
    • O'Connor R., Kauffmann-Zeh A., Liu Y., Lehar S., Evan G.I., Baserga R., Blattler W.A. Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis. Mol. Cell. Biol. 1997, 17:427-435.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 427-435
    • O'Connor, R.1    Kauffmann-Zeh, A.2    Liu, Y.3    Lehar, S.4    Evan, G.I.5    Baserga, R.6    Blattler, W.A.7
  • 9
    • 0033604523 scopus 로고    scopus 로고
    • The IGF-I receptor in cancer research
    • Baserga R. The IGF-I receptor in cancer research. Exp. Cell Res. 1999, 253:1-6.
    • (1999) Exp. Cell Res. , vol.253 , pp. 1-6
    • Baserga, R.1
  • 10
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat. Rev. Cancer 2008, 8:915-928.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 11
    • 33846874575 scopus 로고    scopus 로고
    • The role of the IGF system in cancer growth and metastasis: overview and recent insights
    • Samani A.A., Yakar S., LeRoith D., Brodt P. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr. Rev. 2007, 28:20-47.
    • (2007) Endocr. Rev. , vol.28 , pp. 20-47
    • Samani, A.A.1    Yakar, S.2    LeRoith, D.3    Brodt, P.4
  • 12
    • 0028332092 scopus 로고
    • Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts
    • Sell C., Dumenil G., Deveaud C., Miura M., Coppola D., DeAngelis T., Rubin R., Efstratiadis A., Baserga R. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol. Cell. Biol. 1994, 14:3604-3612.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3604-3612
    • Sell, C.1    Dumenil, G.2    Deveaud, C.3    Miura, M.4    Coppola, D.5    DeAngelis, T.6    Rubin, R.7    Efstratiadis, A.8    Baserga, R.9
  • 13
    • 0027366338 scopus 로고
    • Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor
    • Sell C., Rubini M., Rubin R., Liu J.P., Efstratiadis A., Baserga R. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:11217-11221.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 11217-11221
    • Sell, C.1    Rubini, M.2    Rubin, R.3    Liu, J.P.4    Efstratiadis, A.5    Baserga, R.6
  • 14
    • 79952266417 scopus 로고    scopus 로고
    • Identification of IGF-IR gene promoter binding proteins in estrogen receptor positive and ER-depleted breast cancer cells
    • Sarfstein R., Belfiore A., Werner H. Identification of IGF-IR gene promoter binding proteins in estrogen receptor positive and ER-depleted breast cancer cells. Cancers 2010, 2:233-261.
    • (2010) Cancers , vol.2 , pp. 233-261
    • Sarfstein, R.1    Belfiore, A.2    Werner, H.3
  • 15
    • 0029142836 scopus 로고
    • Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT element
    • Beitner-Johnson D., Werner H., Roberts C.T., LeRoith D. Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT element. Mol. Endocrinol. 1995, 9:1147-1156.
    • (1995) Mol. Endocrinol. , vol.9 , pp. 1147-1156
    • Beitner-Johnson, D.1    Werner, H.2    Roberts, C.T.3    LeRoith, D.4
  • 16
    • 33846846385 scopus 로고    scopus 로고
    • Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1
    • Maor S., Mayer D., Yarden R.I., Lee A.V., Sarfstein R., Werner H., Papa M.Z. Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1. J. Endocrinol. 2006, 191:605-612.
    • (2006) J. Endocrinol. , vol.191 , pp. 605-612
    • Maor, S.1    Mayer, D.2    Yarden, R.I.3    Lee, A.V.4    Sarfstein, R.5    Werner, H.6    Papa, M.Z.7
  • 17
    • 23844476254 scopus 로고    scopus 로고
    • The WT1 Wilms' tumor suppressor gene product interacts with estrogen receptor-alpha and regulates IGF-I receptor gene transcription in breast cancer cells
    • Reizner N., Maor S., Sarfstein R., Abramovitch S., Welshons W.V., Curran E.M., Lee A.V., Werner H. The WT1 Wilms' tumor suppressor gene product interacts with estrogen receptor-alpha and regulates IGF-I receptor gene transcription in breast cancer cells. J. Mol. Endocrinol. 2005, 35:135-144.
    • (2005) J. Mol. Endocrinol. , vol.35 , pp. 135-144
    • Reizner, N.1    Maor, S.2    Sarfstein, R.3    Abramovitch, S.4    Welshons, W.V.5    Curran, E.M.6    Lee, A.V.7    Werner, H.8
  • 20
    • 3843050225 scopus 로고    scopus 로고
    • Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53
    • Rubinstein M., Idelman G., Plymate S.R., Narla G., Friedman S.L., Werner H. Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53. Endocrinology 2004, 145:3769-3777.
    • (2004) Endocrinology , vol.145 , pp. 3769-3777
    • Rubinstein, M.1    Idelman, G.2    Plymate, S.R.3    Narla, G.4    Friedman, S.L.5    Werner, H.6
  • 22
    • 33750920705 scopus 로고    scopus 로고
    • Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis
    • DeGregori J., Johnson D.G. Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis. Curr. Mol. Med. 2006, 6:739-748.
    • (2006) Curr. Mol. Med. , vol.6 , pp. 739-748
    • DeGregori, J.1    Johnson, D.G.2
  • 25
    • 32044435126 scopus 로고    scopus 로고
    • Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
    • Levine A.J., Feng Z., Mak T.W., You H., Jin S. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev. 2006, 20:267-275.
    • (2006) Genes Dev. , vol.20 , pp. 267-275
    • Levine, A.J.1    Feng, Z.2    Mak, T.W.3    You, H.4    Jin, S.5
  • 26
  • 27
    • 0029757120 scopus 로고    scopus 로고
    • Wild type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene
    • Werner H., Karnieli E., Rauscher F.J., LeRoith D. Wild type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:8318-8323.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 8318-8323
    • Werner, H.1    Karnieli, E.2    Rauscher, F.J.3    LeRoith, D.4
  • 28
    • 0037474216 scopus 로고    scopus 로고
    • WT1-p53 interactions in IGF-I receptor gene regulation
    • Idelman G., Glaser T., Roberts C.T., Werner H. WT1-p53 interactions in IGF-I receptor gene regulation. J. Biol. Chem. 2003, 278:3474-3482.
    • (2003) J. Biol. Chem. , vol.278 , pp. 3474-3482
    • Idelman, G.1    Glaser, T.2    Roberts, C.T.3    Werner, H.4
  • 29
    • 0031769052 scopus 로고    scopus 로고
    • P53 regulates IGF-I receptor expression and IGF-I induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1
    • Ohlsson C., Kley N., Werner H., LeRoith D. p53 regulates IGF-I receptor expression and IGF-I induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. Endocrinology 1998, 139:1101-1107.
    • (1998) Endocrinology , vol.139 , pp. 1101-1107
    • Ohlsson, C.1    Kley, N.2    Werner, H.3    LeRoith, D.4
  • 30
    • 0031036879 scopus 로고    scopus 로고
    • The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal
    • Prisco M., Hongo A., Rizzo M.G., Sacchi A., Baserga R. The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal. Mol. Cell. Biol. 1997, 17:1084-1092.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1084-1092
    • Prisco, M.1    Hongo, A.2    Rizzo, M.G.3    Sacchi, A.4    Baserga, R.5
  • 31
    • 84862026329 scopus 로고    scopus 로고
    • P53 regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed targeted therapy
    • Attias-Geva Z., Bentov I., Kidron D., Amichay K., Sarfstein R., Fishman A., Bruchim I., Werner H. p53 regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed targeted therapy. Eur. J. Cancer 2012, 48:1570-1580.
    • (2012) Eur. J. Cancer , vol.48 , pp. 1570-1580
    • Attias-Geva, Z.1    Bentov, I.2    Kidron, D.3    Amichay, K.4    Sarfstein, R.5    Fishman, A.6    Bruchim, I.7    Werner, H.8
  • 33
    • 0029881592 scopus 로고    scopus 로고
    • Regulation of insulin-like growth factor II P3 promoter by p53: a potential mechanism for tumorigenesis
    • Zhang L., Kashanchi F., Zhan Q., Zhan S., Brady J.N., Fornace A.J., Seth P., Helman L.J. Regulation of insulin-like growth factor II P3 promoter by p53: a potential mechanism for tumorigenesis. Cancer Res. 1996, 56:1367-1373.
    • (1996) Cancer Res. , vol.56 , pp. 1367-1373
    • Zhang, L.1    Kashanchi, F.2    Zhan, Q.3    Zhan, S.4    Brady, J.N.5    Fornace, A.J.6    Seth, P.7    Helman, L.J.8
  • 34
    • 0033552595 scopus 로고    scopus 로고
    • Regulation of p53 in response to DNA damage
    • Lakin N.D., Jackson S.P. Regulation of p53 in response to DNA damage. Oncogene 1999, 18:7644-7655.
    • (1999) Oncogene , vol.18 , pp. 7644-7655
    • Lakin, N.D.1    Jackson, S.P.2
  • 35
    • 0037013230 scopus 로고    scopus 로고
    • Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage
    • Heron-Milhavet L., LeRoith D. Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage. J. Biol. Chem. 2002, 277:15600-15606.
    • (2002) J. Biol. Chem. , vol.277 , pp. 15600-15606
    • Heron-Milhavet, L.1    LeRoith, D.2
  • 36
    • 0037816235 scopus 로고    scopus 로고
    • Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor
    • Girnita L., Girnita A., Larsson O. Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:8247-8252.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 8247-8252
    • Girnita, L.1    Girnita, A.2    Larsson, O.3
  • 37
    • 0031987277 scopus 로고    scopus 로고
    • Regulation of p53 downstream genes
    • el-Deiry W.S. Regulation of p53 downstream genes. Semin. Cancer Biol 1998, 8:345-357.
    • (1998) Semin. Cancer Biol , vol.8 , pp. 345-357
    • el-Deiry, W.S.1
  • 38
    • 28044468153 scopus 로고    scopus 로고
    • The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells
    • Nahor I., Abramovitch S., Engeland K., Werner H. The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells. Growth Hormon. IGF Res. 2005, 15:388-396.
    • (2005) Growth Hormon. IGF Res. , vol.15 , pp. 388-396
    • Nahor, I.1    Abramovitch, S.2    Engeland, K.3    Werner, H.4
  • 39
    • 84870202214 scopus 로고    scopus 로고
    • IGF-1 and BRCA1 signalling pathways in familial cancer
    • Werner H., Bruchim I. IGF-1 and BRCA1 signalling pathways in familial cancer. Lancet Oncol. 2012, 13:e537-e544.
    • (2012) Lancet Oncol. , vol.13
    • Werner, H.1    Bruchim, I.2
  • 40
    • 33745211914 scopus 로고    scopus 로고
    • Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer
    • Sarfstein R., Maor S., Reizner N., Abramovitch S., Werner H. Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer. Mol. Cell. Endocrinol. 2006, 252:241-246.
    • (2006) Mol. Cell. Endocrinol. , vol.252 , pp. 241-246
    • Sarfstein, R.1    Maor, S.2    Reizner, N.3    Abramovitch, S.4    Werner, H.5
  • 41
    • 0037464450 scopus 로고    scopus 로고
    • BRCA1-Sp1 interactions in transcriptional regulation of the IGF-IR gene
    • Abramovitch S., Glaser T., Ouchi T., Werner H. BRCA1-Sp1 interactions in transcriptional regulation of the IGF-IR gene. FEBS Lett. 2003, 541:149-154.
    • (2003) FEBS Lett. , vol.541 , pp. 149-154
    • Abramovitch, S.1    Glaser, T.2    Ouchi, T.3    Werner, H.4
  • 42
    • 0034033970 scopus 로고    scopus 로고
    • BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: potential interaction between BRCA1 and Sp1
    • Maor S.B., Abramovitch S., Erdos M.R., Brody L.C., Werner H. BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: potential interaction between BRCA1 and Sp1. Mol. Genet. Metab. 2000, 69:130-136.
    • (2000) Mol. Genet. Metab. , vol.69 , pp. 130-136
    • Maor, S.B.1    Abramovitch, S.2    Erdos, M.R.3    Brody, L.C.4    Werner, H.5
  • 43
    • 35148841175 scopus 로고    scopus 로고
    • Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations
    • Maor S., Yosepovich A., Papa M.Z., Yarden R.I., Mayer D., Friedman E., Werner H. Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations. Cancer Lett. 2007, 257:236-243.
    • (2007) Cancer Lett. , vol.257 , pp. 236-243
    • Maor, S.1    Yosepovich, A.2    Papa, M.Z.3    Yarden, R.I.4    Mayer, D.5    Friedman, E.6    Werner, H.7
  • 44
    • 0347986569 scopus 로고    scopus 로고
    • Functional and physical interactions between BRCA1 and p53 in transcriptional regulation of the IGF-IR gene
    • Abramovitch S., Werner H. Functional and physical interactions between BRCA1 and p53 in transcriptional regulation of the IGF-IR gene. Horm. Metab. Res. 2003, 35:758-762.
    • (2003) Horm. Metab. Res. , vol.35 , pp. 758-762
    • Abramovitch, S.1    Werner, H.2
  • 45
    • 84863667602 scopus 로고    scopus 로고
    • BRCA1 is expressed in uterine serous carcinoma (USC) and controls insulin-like growth factor I receptor (IGF-IR) gene expression in USC cell lines
    • Amichay K., Kidron D., Attias-Geva Z., Schayek H., Sarfstein R., Fishman A., Werner H., Bruchim I. BRCA1 is expressed in uterine serous carcinoma (USC) and controls insulin-like growth factor I receptor (IGF-IR) gene expression in USC cell lines. Int. J. Gynecol. Cancer 2012, 22:748-754.
    • (2012) Int. J. Gynecol. Cancer , vol.22 , pp. 748-754
    • Amichay, K.1    Kidron, D.2    Attias-Geva, Z.3    Schayek, H.4    Sarfstein, R.5    Fishman, A.6    Werner, H.7    Bruchim, I.8
  • 46
    • 63449121864 scopus 로고    scopus 로고
    • Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner
    • Schayek H., Haugk K., Sun S., True L.D., Plymate S.R., Werner H. Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner. Clin. Cancer Res. 2009, 15:1558-1565.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 1558-1565
    • Schayek, H.1    Haugk, K.2    Sun, S.3    True, L.D.4    Plymate, S.R.5    Werner, H.6
  • 49
    • 0025098654 scopus 로고
    • Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping
    • Gessler M., Poustka A., Cavenee W., Neve R.L., Orkin S.H., Bruns G.A. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature 1990, 343:774-778.
    • (1990) Nature , vol.343 , pp. 774-778
    • Gessler, M.1    Poustka, A.2    Cavenee, W.3    Neve, R.L.4    Orkin, S.H.5    Bruns, G.A.6
  • 51
    • 0029054127 scopus 로고
    • Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression
    • Werner H., Shen-Orr Z., Rauscher F.J., Morris J.F., Roberts C.T., LeRoith D. Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression. Mol. Cell. Biol. 1995, 15:3516-3522.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3516-3522
    • Werner, H.1    Shen-Orr, Z.2    Rauscher, F.J.3    Morris, J.F.4    Roberts, C.T.5    LeRoith, D.6
  • 52
    • 0141562167 scopus 로고    scopus 로고
    • The WT1 Wilms' tumor suppressor gene: a novel target for insulin-like growth factor-I action
    • Bentov I., LeRoith D., Werner H. The WT1 Wilms' tumor suppressor gene: a novel target for insulin-like growth factor-I action. Endocrinology 2003, 144:4276-4279.
    • (2003) Endocrinology , vol.144 , pp. 4276-4279
    • Bentov, I.1    LeRoith, D.2    Werner, H.3
  • 53
    • 34948858983 scopus 로고    scopus 로고
    • The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma
    • Yuen J.S., Cockman M.E., Sullivan M., Protheroe A., Turner G.D., Roberts I.S., Pugh C.W., Werner H., Macaulay V.M. The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma. Oncogene 2007, 26:6499-6508.
    • (2007) Oncogene , vol.26 , pp. 6499-6508
    • Yuen, J.S.1    Cockman, M.E.2    Sullivan, M.3    Protheroe, A.4    Turner, G.D.5    Roberts, I.S.6    Pugh, C.W.7    Werner, H.8    Macaulay, V.M.9
  • 54
    • 0028246185 scopus 로고
    • Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor
    • Ladanyi M., Gerald W.L. Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor. Cancer Res. 1994, 54:2837-2840.
    • (1994) Cancer Res. , vol.54 , pp. 2837-2840
    • Ladanyi, M.1    Gerald, W.L.2
  • 55
    • 85047698483 scopus 로고    scopus 로고
    • Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein
    • Finkeltov I., Kuhn S., Glaser T., Idelman G., Wright J.J., Roberts C.T., Werner H. Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein. Oncogene 2002, 21:1890-1898.
    • (2002) Oncogene , vol.21 , pp. 1890-1898
    • Finkeltov, I.1    Kuhn, S.2    Glaser, T.3    Idelman, G.4    Wright, J.J.5    Roberts, C.T.6    Werner, H.7
  • 56
    • 33845630749 scopus 로고    scopus 로고
    • A novel EWS-WT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene
    • Werner H., Idelman G., Rubinstein M., Pattee P., Nagalla S.R., Roberts C.T. A novel EWS-WT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene. Cancer Lett. 2007, 247:84-90.
    • (2007) Cancer Lett. , vol.247 , pp. 84-90
    • Werner, H.1    Idelman, G.2    Rubinstein, M.3    Pattee, P.4    Nagalla, S.R.5    Roberts, C.T.6
  • 60
    • 84876753599 scopus 로고    scopus 로고
    • Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transduction
    • Sarfstein R., Werner H. Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transduction. Endocrinology 2013, 154:1672-1679.
    • (2013) Endocrinology , vol.154 , pp. 1672-1679
    • Sarfstein, R.1    Werner, H.2
  • 61
    • 84864568833 scopus 로고    scopus 로고
    • Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cells
    • Wu Y.-C., Zhu M., Robertson D.M. Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cells. PLoS One 2012, 7(8):e42483.
    • (2012) PLoS One , vol.7 , Issue.8
    • Wu, Y.-C.1    Zhu, M.2    Robertson, D.M.3
  • 62
    • 0028356544 scopus 로고
    • Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour
    • Steenman M.J., Rainier S., Dobry C.J., Grundy P., Horon I.L., Feinberg A.P. Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour. Nat. Genet. 1994, 7:433-439.
    • (1994) Nat. Genet. , vol.7 , pp. 433-439
    • Steenman, M.J.1    Rainier, S.2    Dobry, C.J.3    Grundy, P.4    Horon, I.L.5    Feinberg, A.P.6
  • 63
    • 0029931018 scopus 로고    scopus 로고
    • Alterations in the promoter-specific imprinting of the insulin-like growth factor-II gene in Wilms' tumor
    • Vu T.H., Hoffman A. Alterations in the promoter-specific imprinting of the insulin-like growth factor-II gene in Wilms' tumor. J. Biol. Chem. 1996, 271:9014-9023.
    • (1996) J. Biol. Chem. , vol.271 , pp. 9014-9023
    • Vu, T.H.1    Hoffman, A.2
  • 65
    • 77952891110 scopus 로고    scopus 로고
    • Progression to metastatic stage in a cellular model of prostate cancer is associated with methylation of the androgen receptor gene and transcriptional suppression of the insulin-like growth factor-I receptor gene
    • Schayek H., Bentov I., Sun S., Plymate S.R., Werner H. Progression to metastatic stage in a cellular model of prostate cancer is associated with methylation of the androgen receptor gene and transcriptional suppression of the insulin-like growth factor-I receptor gene. Exp. Cell Res. 2010, 316:1479-1488.
    • (2010) Exp. Cell Res. , vol.316 , pp. 1479-1488
    • Schayek, H.1    Bentov, I.2    Sun, S.3    Plymate, S.R.4    Werner, H.5
  • 66
    • 77952951956 scopus 로고    scopus 로고
    • Differential regulation of insulin-like growth factor-I receptor gene expression by wild type and mutant androgen receptor in prostate cancer cells
    • Schayek H., Seti H., Greenberg N.M., Sun S., Werner H., Plymate S.R. Differential regulation of insulin-like growth factor-I receptor gene expression by wild type and mutant androgen receptor in prostate cancer cells. Mol. Cell. Endocrinol. 2010, 323:239-245.
    • (2010) Mol. Cell. Endocrinol. , vol.323 , pp. 239-245
    • Schayek, H.1    Seti, H.2    Greenberg, N.M.3    Sun, S.4    Werner, H.5    Plymate, S.R.6
  • 67
    • 84862162985 scopus 로고    scopus 로고
    • Global methylation analysis identifies PITX2 as an upstream regulator of the androgen receptor and IGF-I receptor genes in prostate cancer
    • Schayek H., Bentov I., Jacob-Hirsch J., Yeung C., Khanna C., Helman L.J., Plymate S.R., Werner H. Global methylation analysis identifies PITX2 as an upstream regulator of the androgen receptor and IGF-I receptor genes in prostate cancer. Horm. Metab. Res. 2012, 44:511-519.
    • (2012) Horm. Metab. Res. , vol.44 , pp. 511-519
    • Schayek, H.1    Bentov, I.2    Jacob-Hirsch, J.3    Yeung, C.4    Khanna, C.5    Helman, L.J.6    Plymate, S.R.7    Werner, H.8
  • 68
    • 79954470614 scopus 로고    scopus 로고
    • Epigenetic DNA methylation in the promoters of the Igf1 receptor and insulin receptor genes in db/db mice
    • Nikoshkov A., Sunkari V., Savu O., Forsberg E., Sergiu-Bogdan C., Brismar K. Epigenetic DNA methylation in the promoters of the Igf1 receptor and insulin receptor genes in db/db mice. Epigenetics 2011, 6:405-409.
    • (2011) Epigenetics , vol.6 , pp. 405-409
    • Nikoshkov, A.1    Sunkari, V.2    Savu, O.3    Forsberg, E.4    Sergiu-Bogdan, C.5    Brismar, K.6
  • 69
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956, 123:309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.