Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: A double-blind randomized controlled trial

Journal of Allergy and Clinical Immunology

Volumn 134, Issue 1, 2014, Pages

  Khalid, Saifudin ^a   Murdoch, Robert ^b   Newlands, Amy ^b   Smart, Kevin ^b   Kelsall, Angela ^a   Holt, Kimberley ^a   Dockry, Rachel ^a   Woodcock, Ashley ^a   Smith, Jaclyn A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

capsaicin; Cough; cough sounds; sensory nerves; transient receptor potential vanilloid 1

Indexed keywords

1 (2 BROMOPHENYL) 3 [1 (5 TRIFLUOROMETHYL 2 PYRIDINYL) 3 PYRROLIDINYL]UREA; CAPSAICIN; PLACEBO; VANILLOID RECEPTOR 1; ANTITUSSIVE AGENT; PYRROLIDINE DERIVATIVE; TRPV1 PROTEIN, HUMAN; UREA; VANILLOID RECEPTOR;

ADULT; AGED; ARTICLE; CHRONIC COUGH; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEMALE; FEVER; HEADACHE; HUMAN; MALE; PREDICTIVE VALUE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RECEPTOR BLOCKING; SINGLE DRUG DOSE; VISUAL ANALOG SCALE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; CHRONIC DISEASE; COUGH; GENE EXPRESSION; GENETICS; INHALATIONAL DRUG ADMINISTRATION; MIDDLE AGED; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; ADULT; AGED; ANIMALS; ANTITUSSIVE AGENTS; CAPSAICIN; CHRONIC DISEASE; COUGH; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; PYRROLIDINES; QUALITY OF LIFE; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; TRPV CATION CHANNELS; UREA;

EID: 84903709164     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.01.038     Document Type: Article

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