Myocardial deletion of transcription factor CHF1/Hey2 results in altered myocyte action potential and mild conduction system expansion but does not alter conduction system function or promote spontaneous arrhythmias

FASEB Journal

Volumn 28, Issue 7, 2014, Pages 3007-3015

  Hartman, Matthew E ^a   Liu, Yonggang ^a   Zhu, Wei Zhong ^b   Chien, Wei Ming ^a   Weldy, Chad S ^a   Fishman, Glenn I ^c   Laflamme, Michael A ^b   Chin, Michael T ^a,b  

^a Division of Cardiology   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brugada syndrome; Electro physiology; Heart rate variability; Notch signaling

Indexed keywords

ATROPINE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CACNA1C CHANNEL; CALCIUM ACTIVATED POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; ION CHANNEL; PROPRANOLOL; SODIUM CHANNEL NAV1.5; TRANSCRIPTION FACTOR CHF1; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; ELECTROCARDIOGRAPHY MONITORING; FEMALE; GENE DELETION; GENE EXPRESSION; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; HEART MUSCLE POTENTIAL; HEART RATE VARIABILITY; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SPONTANEOUS ARRHYTHMIA;

BRUGADA SYNDROME; ELECTROPHYSIOLOGY; HEART RATE VARIABILITY; NOTCH SIGNALING;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; HEART CONDUCTION SYSTEM; HEART RATE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIUM; MYOCYTES, CARDIAC; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

EID: 84903709011     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-251728     Document Type: Article

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