ApoA-I or ABCA1 expression suppresses fatty acid synthesis by reducing 27-hydroxycholesterol levels

Biochimie

Volumn 103, Issue 1, 2014, Pages 101-108

  Ma, Donglin ^a   Liu, Wei ^a   Wang, Yutong ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Apolipoprotein A I; ATP binding cassette transporter; Liver X receptor; Non alcoholic steatohepatitis

Indexed keywords

26 HYDROXYCHOLESTEROL; ABC TRANSPORTER A1; ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 1; ADENOVIRUS VECTOR; APOLIPOPROTEIN A1; CHOLESTEROL; CHOLINE; FATTY ACID; FATTY ACID SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; METHIONINE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; 27-HYDROXYCHOLESTEROL; CHOLESTEROL DERIVATIVE; FAS ANTIGEN; FAS PROTEIN, MOUSE; LIVER X RECEPTOR; ORPHAN NUCLEAR RECEPTOR;

ANIMAL CELL; ARTICLE; CHOLESTEROL METABOLISM; FATTY ACID SYNTHESIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIPID LIVER LEVEL; LIPID TRANSPORT; LIVER CELL; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; GENE EXPRESSION; GENETICS; METABOLISM;

MUS;

ACETYL-COA CARBOXYLASE; ANIMALS; ANTIGENS, CD95; APOLIPOPROTEIN A-I; ATP BINDING CASSETTE TRANSPORTER 1; CELL LINE; FATTY ACIDS; GENE EXPRESSION; HEPATOCYTES; HUMANS; HYDROXYCHOLESTEROLS; MALE; MICE; MICE, INBRED C57BL; ORPHAN NUCLEAR RECEPTORS; RNA, MESSENGER;

EID: 84903702526     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2014.04.010     Document Type: Article

References (29)

1. C.A. Matteoni, Z.M. Younossi, T. Gramlich, N. Boparai, Y.C. Liu, and A.J. McCullough Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity Gastroenterology 116 1999 1413 1419
2. M. Okamoto, Y. Takeda, Y. Yoda, K. Kobayashi, M.A. Fujino, and Z. Yamagata The association of fatty liver and diabetes risk J. Epidemiol. 13 2003 15 21
3. M. Hamaguchi, T. Kojima, N. Takeda, T. Nakagawa, H. Taniguchi, K. Fujii, T. Omatsu, T. Nakajima, H. Sarui, M. Shimazaki, T. Kato, J. Okuda, and K. Ida The metabolic syndrome as a predictor of nonalcoholic fatty liver disease Ann. Intern. Med. 143 2005 722 728
4. J. Ludwig, T.R. Viggiano, D.B. McGill, and B.J. Oh Nonalcoholic steatohepatitis: Mayo clinic experiences with a hitherto unnamed disease Mayo Clin. Proc. 55 1980 434 438
5. C.P. Day, and O.F. James Steatohepatitis: a tale of two "hits" Gastroenterology 114 1998 842 845
6. W. Youssef, and A.J. McCullough Diabetes mellitus, obesity, and hepatic steatosis Semin. Gastrointest. Dis. 13 2002 17 30
7. C. Joyce, L. Freeman, H.B. Brewer Jr., and S. Santamarina-Fojo Study of ABCA1 function in transgenic mice Arterioscler. Thromb. Vasc. Biol. 23 2003 965 971
8. J.F. Oram, and J.W. Heinecke ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease Physiol. Rev. 85 2005 1343 1372
9. C.L. Wellington, E.K. Walker, A. Suarez, A. Kwok, N. Bissada, and R. Singaraja et al. ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation Lab. Invest. 82 2002 273 283
10. L.O. Martinez, B. Agerholm-Larsen, N. Wang, W. Chen, and A.R. Tall Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I J. Biol. Chem. 278 2003 37368 37374
11. E.M. Rubin, R.M. Krauss, E.A. Spangler, J.G. Verstuyft, and S.M. Clift Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI Nature 353 1991 265 267
12. P.J. Willy, K. Umesono, E.S. Ong, R.M. Evans, R.A. Heyman, and D.J. Mangelsdorf LXR, a nuclear receptor that defines a distinct retinoid response pathway Genes. Dev. 9 1995 1033 1045
13. J.J. Repa, and D.J. Mangelsdorf The role of orphan nuclear receptors in the regulation of cholesterol homeostasis Annu. Rev. Cell. Dev. Biol. 16 2000 459 481
14. P.A. Edwards, M.A. Kennedy, and P.A. Mak LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis Vasc. Pharmacol. 38 2002 249 256
15. B.A. Janowski, P.J. Willy, T.R. Devi, J.R. Falck, and D.J. Mangelsdorf An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha Nature 383 1996 728 731
16. X. Fu, J.G. Menke, Y. Chen, G. Zhou, K.L. MacNaul, S.D. Wright, C.P. Sparrow, and E.G. Lund 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells J. Biol. Chem. 276 2001 38378 38387
17. S. Bellosta, A. Corsini, F. Bernini, A. Granata, G. Didoni, M. Mazzotti, and R. Fumagalli 27-Hydroxycholesterol modulation of low density lipoprotein metabolism in cultured human hepatic and extrahepatic cells FEBS Lett. 332 1993 115 118
18. R. Brauner, C. Johannes, F. Ploessl, F. Bracher, and R.L. Lorenz Phytosterols reduce cholesterol absorption by inhibition of 27- hydroxycholesterol generation, liver X receptor α activation, and expression of the basolateral sterol exporter ATP-binding cassette A1 in Caco-2 enterocytes J. Nutr. 142 2012 981 989
19. Y. Yang, Y. Jiang, Y. Wang, and W. An Suppression of ABCA1 by unsaturated fatty acids leads to lipid accumulation in HepG2 cells Biochimie 92 2010 958 963
20. W. Liu, L. Qin, H. Yu, F. Lv, and Y. Wang ApoA-I and ABCA1 expression alleviates lipid accumulation in hepatocytes J. Gastroenterol. Hepatol. 29 2014 614 622
21. J.F. Oram, R.M. Lawn, M.R. Garvin, and D.P. Wade ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages J. Biol. Chem. 275 2000 34508 34511
22. J. Folch, M. Lees, and G.H. Sloane Stanley A simple method for the isolation and purification of total lipides from animal tissues J. Biol. Chem. 226 1957 497 509
23. C.W. Joyce, E.M. Wagner, F. Basso, M.J. Amar, L.A. Freeman, R.D. Shamburek, C.L. Knapper, J. Syed, J. Wu, B.L. Vaisman, J. Fruchart-Najib, E.M. Billings, B. Paigen, A.T. Remaley, S. Santamarina-Fojo, and H.B. Brewer Jr. ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis J. Biol. Chem. 281 2006 33053 33065
24. S. Talukdar, and F.B. Hillgartner The mechanism mediating the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317 J. Lipid Res. 47 2006 2451 2461
25. B.B. Kahn, and J.S. Flier Obesity and insulin resistance J. Clin. Invest. 106 2000 473 481
26. D.J. Peet, S.D. Turley, W. Ma, B.A. Janowski, J.M. Lobaccaro, R.E. Hammer, and D.J. Mangelsdorf Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha Cell 93 1998 693 704
27. D.W. Russell Oxysterol biosynthetic enzymes Biochim. Biophys. Acta 1529 2000 126 135
28. W. Chen, G. Chen, D.L. Head, D.J. Mangelsdorf, and D.W. Russell Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice Cell Metab. 5 2007 73 79
29. P.S. Pannu, S. Allahverdian, and G.A. Francis Oxysterol generation and liver X receptor-dependent reverse cholesterol transport: not all roads lead to Rome Mol. Cell. Endocrinol. 368 2013 99 107