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Volumn 9, Issue 7, 2014, Pages

L-carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model with upregulation of mitochondrial pathway

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALPHA TOCOPHEROL; CARNITINE; CYTOKINE; FERRITIN; LONG CHAIN FATTY ACID; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; FAT INTAKE; VITAMIN B COMPLEX;

EID: 84903697534     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100627     Document Type: Article
Times cited : (68)

References (41)
  • 1
    • 84875679556 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: An emerging threat to obese and diabetic individuals
    • Masuoka HC, Chalasani N (2013) Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals. Ann N Y Acad Sci 1281: 106-122.
    • (2013) Ann N Y Acad Sci , vol.1281 , pp. 106-122
    • Masuoka, H.C.1    Chalasani, N.2
  • 2
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis. Mayo Clinic experiences with a hitherto unnamed disease
    • Ludwig J, Viggiano TR, McGill DB, Oh BJ (1980) Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 55: 434-438. (Pubitemid 10057164)
    • (1980) Mayo Clinic Proceedings , vol.55 , Issue.7 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3    Ott, B.J.4
  • 3
    • 84861230299 scopus 로고    scopus 로고
    • Role of mitochondria in nonalcoholic fatty liver disease-from origin to propagation
    • Grattagliano I, de Bari O, Bernardo TC, Oliveira PJ, Wang DQ, et al. (2012) Role of mitochondria in nonalcoholic fatty liver disease-from origin to propagation. Clin Biochem 45: 610-618.
    • (2012) Clin Biochem , vol.45 , pp. 610-618
    • Grattagliano, I.1    De Bari, O.2    Bernardo, T.C.3    Oliveira, P.J.4    Wang, D.Q.5
  • 6
    • 84861591910 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
    • Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, et al. (2012) The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 142: 1592-1609.
    • (2012) Gastroenterology , vol.142 , pp. 1592-1609
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3    Diehl, A.M.4    Brunt, E.M.5
  • 7
    • 43049180323 scopus 로고    scopus 로고
    • Why have antioxidants failed in clinical trials?
    • Steinhubl SR (2008) Why have antioxidants failed in clinical trials? Am J Cardiol 101: 14D-19D.
    • (2008) Am J Cardiol , vol.101
    • Steinhubl, S.R.1
  • 8
    • 10644280659 scopus 로고    scopus 로고
    • Carnitine in type 2 diabetes
    • Mingrone G (2004) Carnitine in type 2 diabetes. Ann N Y Acad Sci 1033: 99-107.
    • (2004) Ann N Y Acad Sci , vol.1033 , pp. 99-107
    • Mingrone, G.1
  • 10
    • 0025285225 scopus 로고
    • Isolation of a malonyl-CoA-sensitive CPT/beta-oxidation enzyme complex from heart mitochondria
    • DOI 10.1021/bi00470a010
    • Kerner J, Bieber L (1990) Isolation of a malonyl-CoA-sensitive CPT/beta-oxidation enzyme complex from heart mitochondria. Biochemistry 29: 4326-4334. (Pubitemid 20153632)
    • (1990) Biochemistry , vol.29 , Issue.18 , pp. 4326-4334
    • Kerner, J.1    Bieber, L.2
  • 11
    • 11944275346 scopus 로고    scopus 로고
    • L-carnitine inhibits hepatocarcinogenesis via protection of mitochondria
    • DOI 10.1002/ijc.20636
    • Chang B, Nishikawa M, Nishiguchi S, Inoue M (2005) L-carnitine inhibits hepatocarcinogenesis via protection of mitochondria. Int J Cancer 113: 719-729. (Pubitemid 40101252)
    • (2005) International Journal of Cancer , vol.113 , Issue.5 , pp. 719-729
    • Chang, B.1    Nishikawa, M.2    Nishiguchi, S.3    Inoue, M.4
  • 12
    • 84884594542 scopus 로고    scopus 로고
    • A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma
    • Fujii M, Shibazaki Y, Wakamatsu K, Honda Y, Kawauchi Y, et al. (2013) A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma. Med Mol Morphol 46: 141-152.
    • (2013) Med Mol Morphol , vol.46 , pp. 141-152
    • Fujii, M.1    Shibazaki, Y.2    Wakamatsu, K.3    Honda, Y.4    Kawauchi, Y.5
  • 14
    • 77952347780 scopus 로고    scopus 로고
    • Dietary alpha-tocopherol and neuromuscular health: Search for optimal dose and molecular mechanisms continues!
    • Gohil K, Vasu VT, Cross CE (2010) Dietary alpha-tocopherol and neuromuscular health: search for optimal dose and molecular mechanisms continues! Mol Nutr Food Res 54: 693-709.
    • (2010) Mol Nutr Food Res , vol.54 , pp. 693-709
    • Gohil, K.1    Vasu, V.T.2    Cross, C.E.3
  • 15
    • 33749317535 scopus 로고    scopus 로고
    • 8-Hydroxy-2′-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures
    • DOI 10.1007/s00420-006-0106-7
    • Pilger A, Rudiger HW (2006) 8-Hydroxy-2′-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures. Int Arch Occup Environ Health 80: 1-15. (Pubitemid 44489988)
    • (2006) International Archives of Occupational and Environmental Health , vol.80 , Issue.1 , pp. 1-15
    • Pilger, A.1    Rudiger, H.W.2
  • 16
    • 0347297590 scopus 로고    scopus 로고
    • Application of new primer-enzyme combinations to terminal restriction fragment length polymorphism profiling of bacterial populations in human feces
    • DOI 10.1128/AEM.69.2.1251-1262.2003
    • Nagashima K, Hisada T, Sato M, Mochizuki J (2003) Application of new primer-enzyme combinations to terminal restriction fragment length polymorphism profiling of bacterial populations in human feces. Appl Environ Microbiol 69: 1251-1262. (Pubitemid 36204859)
    • (2003) Applied and Environmental Microbiology , vol.69 , Issue.2 , pp. 1251-1262
    • Nagashima, K.1    Hisada, T.2    Sato, M.3    Mochizuki, J.4
  • 17
    • 84885911965 scopus 로고    scopus 로고
    • Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)
    • Takaki A, Kawai D, Yamamoto K (2013) Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH). Int J Mol Sci 14: 20704-20728.
    • (2013) Int J Mol Sci , vol.14 , pp. 20704-20728
    • Takaki, A.1    Kawai, D.2    Yamamoto, K.3
  • 18
    • 79952702137 scopus 로고    scopus 로고
    • Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver
    • Begriche K, Massart J, Robin MA, Borgne-Sanchez A, Fromenty B (2011) Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver. J Hepatol 54: 773-794.
    • (2011) J Hepatol , vol.54 , pp. 773-794
    • Begriche, K.1    Massart, J.2    Robin, M.A.3    Borgne-Sanchez, A.4    Fromenty, B.5
  • 19
    • 32844458032 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it
    • Begriche K, Igoudjil A, Pessayre D, Fromenty B (2006) Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion 6: 1-28.
    • (2006) Mitochondrion , vol.6 , pp. 1-28
    • Begriche, K.1    Igoudjil, A.2    Pessayre, D.3    Fromenty, B.4
  • 21
    • 79251532050 scopus 로고    scopus 로고
    • Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease
    • Nelson JE, Wilson L, Brunt EM, Yeh MM, Kleiner DE, et al. (2011) Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease. Hepatology 53: 448-457.
    • (2011) Hepatology , vol.53 , pp. 448-457
    • Nelson, J.E.1    Wilson, L.2    Brunt, E.M.3    Yeh, M.M.4    Kleiner, D.E.5
  • 22
    • 77953229020 scopus 로고    scopus 로고
    • L-carnitine supplementation to diet: A new tool in treatment of nonalcoholic steatohepatitis - A randomized and controlled clinical trial
    • Malaguarnera M, Gargante MP, Russo C, Antic T, Vacante M, et al. (2010) L-carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitis-a randomized and controlled clinical trial. Am J Gastroenterol 105: 1338-1345.
    • (2010) Am J Gastroenterol , vol.105 , pp. 1338-1345
    • Malaguarnera, M.1    Gargante, M.P.2    Russo, C.3    Antic, T.4    Vacante, M.5
  • 23
    • 81055124193 scopus 로고    scopus 로고
    • L-carnitine ameliorated fatty liver in high-calorie diet/STZ-induced type 2 diabetic mice by improving mitochondrial function
    • Xia Y, Li Q, Zhong W, Dong J, Wang Z, et al. (2011) L-carnitine ameliorated fatty liver in high-calorie diet/STZ-induced type 2 diabetic mice by improving mitochondrial function. Diabetol Metab Syndr 3: 31.
    • (2011) Diabetol Metab Syndr , vol.3 , pp. 31
    • Xia, Y.1    Li, Q.2    Zhong, W.3    Dong, J.4    Wang, Z.5
  • 24
    • 79953174586 scopus 로고    scopus 로고
    • Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: A randomized, double-blind, placebo-controlled study
    • Malaguarnera M, Vacante M, Giordano M, Pennisi G, Bella R, et al. (2011) Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Am J Clin Nutr 93: 799-808.
    • (2011) Am J Clin Nutr , vol.93 , pp. 799-808
    • Malaguarnera, M.1    Vacante, M.2    Giordano, M.3    Pennisi, G.4    Bella, R.5
  • 26
    • 0031983188 scopus 로고    scopus 로고
    • Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat
    • DOI 10.1016/S0016-5085(98)70644-4
    • Sokol RJ, McKim JM, Jr., Goff MC, Ruyle SZ, Devereaux MW, et al. (1998) Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat. Gastroenterology 114: 164-174. (Pubitemid 28020966)
    • (1998) Gastroenterology , vol.114 , Issue.1 , pp. 164-174
    • Sokol, R.J.1    McKim Jr., J.M.2    Goff, M.C.3    Ruyle, S.Z.4    Devereaux, M.W.5    Han, D.6    Packer, L.7    Everson, G.8
  • 27
    • 84880796530 scopus 로고    scopus 로고
    • Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal
    • Selman C, McLaren JS, Collins AR, Duthie GG, Speakman JR (2013) Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal. Biol Lett 9: 20130432.
    • (2013) Biol Lett , vol.9 , pp. 20130432
    • Selman, C.1    McLaren, J.S.2    Collins, A.R.3    Duthie, G.G.4    Speakman, J.R.5
  • 29
    • 79955446251 scopus 로고    scopus 로고
    • Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: The TONIC randomized controlled trial
    • Lavine JE, Schwimmer JB, Van Natta ML, Molleston JP, Murray KF, et al. (2011) Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA 305: 1659-1668.
    • (2011) JAMA , vol.305 , pp. 1659-1668
    • Lavine, J.E.1    Schwimmer, J.B.2    Van Natta, M.L.3    Molleston, J.P.4    Murray, K.F.5
  • 30
    • 84881317939 scopus 로고    scopus 로고
    • Effects of vitamin E on stroke subtypes: Meta-analysis of randomised controlled trials
    • Schurks M, Glynn RJ, Rist PM, Tzourio C, Kurth T (2010) Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ 341: c5702.
    • (2010) BMJ , vol.341
    • Schurks, M.1    Glynn, R.J.2    Rist, P.M.3    Tzourio, C.4    Kurth, T.5
  • 31
    • 33847378451 scopus 로고    scopus 로고
    • Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis
    • DOI 10.1001/jama.297.8.842
    • Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C (2007) Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297: 842-857. (Pubitemid 46333949)
    • (2007) Journal of the American Medical Association , vol.297 , Issue.8 , pp. 842-857
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 33
    • 79959990093 scopus 로고    scopus 로고
    • The many faces of the octahedral ferritin protein
    • Watt RK (2011) The many faces of the octahedral ferritin protein. Biometals 24: 489-500.
    • (2011) Biometals , vol.24 , pp. 489-500
    • Watt, R.K.1
  • 34
    • 56649099169 scopus 로고    scopus 로고
    • Altered expression of iron regulatory genes in cirrhotic human livers: Clues to the cause of hemosiderosis?
    • Bergmann OM, Mathahs MM, Broadhurst KA, Weydert JA, Wilkinson N, et al. (2008) Altered expression of iron regulatory genes in cirrhotic human livers: clues to the cause of hemosiderosis? Lab Invest 88: 1349-1357.
    • (2008) Lab Invest , vol.88 , pp. 1349-1357
    • Bergmann, O.M.1    Mathahs, M.M.2    Broadhurst, K.A.3    Weydert, J.A.4    Wilkinson, N.5
  • 35
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, et al. (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482: 179-185.
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1    Elinav, E.2    Jin, C.3    Hao, L.4    Mehal, W.Z.5
  • 36
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, et al. (2013) Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 499: 97-101.
    • (2013) Nature , vol.499 , pp. 97-101
    • Yoshimoto, S.1    Loo, T.M.2    Atarashi, K.3    Kanda, H.4    Sato, S.5
  • 37
    • 79960245264 scopus 로고    scopus 로고
    • Oxidative stress is closely associated with tumor angiogenesis of hepatocellular carcinoma
    • Jo M, Nishikawa T, Nakajima T, Okada Y, Yamaguchi K, et al. (2011) Oxidative stress is closely associated with tumor angiogenesis of hepatocellular carcinoma. J Gastroenterol 46: 809-821.
    • (2011) J Gastroenterol , vol.46 , pp. 809-821
    • Jo, M.1    Nishikawa, T.2    Nakajima, T.3    Okada, Y.4    Yamaguchi, K.5
  • 38
    • 67049087682 scopus 로고    scopus 로고
    • Oxidative stress may enhance the malignant potential of human hepatocellular carcinoma by telomerase activation
    • Nishikawa T, Nakajima T, Katagishi T, Okada Y, Jo M, et al. (2009) Oxidative stress may enhance the malignant potential of human hepatocellular carcinoma by telomerase activation. Liver Int 29: 846-856.
    • (2009) Liver Int , vol.29 , pp. 846-856
    • Nishikawa, T.1    Nakajima, T.2    Katagishi, T.3    Okada, Y.4    Jo, M.5
  • 39
    • 84889884073 scopus 로고    scopus 로고
    • Increased hepatic oxidative DNA damage in patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma
    • Tanaka S, Miyanishi K, Kobune M, Kawano Y, Hoki T, et al. (2013) Increased hepatic oxidative DNA damage in patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma. J Gastroenterol 48: 1249-1258.
    • (2013) J Gastroenterol , vol.48 , pp. 1249-1258
    • Tanaka, S.1    Miyanishi, K.2    Kobune, M.3    Kawano, Y.4    Hoki, T.5
  • 40
    • 84863321158 scopus 로고    scopus 로고
    • Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell
    • Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, et al. (2012) Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell. Nat Commun 3: 883.
    • (2012) Nat Commun , vol.3 , pp. 883
    • Yae, T.1    Tsuchihashi, K.2    Ishimoto, T.3    Motohara, T.4    Yoshikawa, M.5
  • 41
    • 84868347619 scopus 로고    scopus 로고
    • L-carnitine is an endogenous HDAC inhibitor selectively inhibiting cancer cell growth in vivo and in vitro
    • Huang H, Liu N, Guo H, Liao S, Li X, et al. (2012) L-carnitine is an endogenous HDAC inhibitor selectively inhibiting cancer cell growth in vivo and in vitro. PLoS One 7: e49062.
    • (2012) PLoS One , vol.7
    • Huang, H.1    Liu, N.2    Guo, H.3    Liao, S.4    Li, X.5


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