Reduced carnitine level causes death from hypoglycemia: Possible involvement of suppression of hypothalamic orexin expression during weaning period

Endocrine Journal

Volumn 54, Issue 6, 2007, Pages 911-925

  Kuwajima, Masamichi ^a   Fujihara, Hiroaki ^b   Sei, Hiroyoshi ^a   Umehara, Asako ^c   Sei, Masako ^a   Tsuda, Tomi T ^c   Sukeno, Akiko ^a   Okamoto, Tatsuya ^a   Inubushi, Akiko ^a   Ueta, Yoichi ^b   Doi, Toshio ^a   Kido, Hiroshi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

Carnitine; Death; Orexin

Indexed keywords

3 HYDROXYBUTYRIC ACID; CARNITINE; CELLULOSE; GLUCOSE; LACTOSE; MESSENGER RNA; OREXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; CARNITINE DEFICIENCY; CAUSE OF DEATH; CONTROLLED STUDY; DIET; DRY WEIGHT; HYPOGLYCEMIA; HYPOTHALAMUS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PUERPERIUM; STOMACH CONTENT; SURVIVAL; WEANING;

3-HYDROXYBUTYRIC ACID; ANIMALS; BEHAVIOR, ANIMAL; BLOOD GLUCOSE; CARNITINE; CELLULOSE; DARKNESS; FEMALE; HYPOGLYCEMIA; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LACTOSE; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEUROPEPTIDE Y; NEUROPEPTIDES; NUCLEIC ACID HYBRIDIZATION; PREGNANCY; PRO-OPIOMELANOCORTIN; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 40449085262     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.K07-044     Document Type: Article

References (46)

1. Steiber A, Kerner J, Hoppel CL (2004) Carnitine: a nutritional, biosynthetic, and functional perspective. Mol Aspects Med 25: 455-473.
2. Bartlett K, Eaton S (2004) Mitochondrial β-oxidation. Eur J Biochem 271: 462-469.
3. Foster DW (2004) The role of the carnitine system in human metabolism. Ann NY Acad Sci 1033: 1-16.
4. Hoppel C (2003) The role of carnitine in normal and altered fatty acid metabolism. Am J Kidney Dis 41: S4-S12.
5. Olpin SE (2004) Implications of impaired ketogenesis in fatty acid oxidation disorders. Prostaglandins Leukot Essent Fatty Acids 70: 293-308.
6. Stanley CA (2004) Carnitine deficiency disorders in children. Ann NY Acad Sci 1033: 42-51.
7. Frayn KN (2003) The glucose-fatty acid cycle: a physiological perspective. Biochem Soc Trans 31: 1115-1119.
8. Kelley DE, Mandarino LJ (2000) Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 49: 677-683.
9. Kuwajima M, Kono N, Horiuchi M, Imamura Y, Ono A, Inui Y, Kawata S, Koizumi T, Hayakawa J, Saheki T, Tarui S (1991) Animal model of systemic carnitine deficiency: analysis in C3H-H-2° strain of mouse associated with juvenile visceral steatosis. Biochem Biophys Res Commun 174: 1090-1094.
10. Lu K, Nishimori H, Nakamura Y, Shima K, Kuwajima M (1998) A missense mutation of mouse OCTN2, a sodium-dependent carnitine cotransporter, in the juvenile visceral steatosis mouse. Biochem Biophys Res Commun 252: 590-594.
11. Lahjouji K, Mitchell GA, Qureshi IA (2001) Carnitine transport by organic cation transporters and systemic carnitine deficiency. Mol Genet Metab 73: 287-297.
12. Hotta K, Kuwajima M, Ono A, Nakajima H, Horikawa Y, Miyagawa J, Namba M, Hanafusa T, Horiuchi M, Nikaido H, Hayakawa J, Saheki T, Kono N, Noguchi T, Matsuzawa Y (1996) Disordered expression of glycolytic and gluconeogenic liver enzymes of juvenile visceral steatosis mice with systemic carnitine deficiency. Diabetes Res Clin Pract 32: 117-123.
13. Epstein AN, Teitelbaum P (1967) Specific loss of the hypoglycemic control of feeding in recovered lateral rats. Am J Physiol 213: 1159-1167.
14. Smith GP, Epstein AN (1969) Increased feeding in response to decreased glucose utilization in the rat and monkey. Am J Physiol 217: 1083-1087.
15. Ritter S, Taylor JS (1989) Capsaicin abolishes lipoprivic but not glucoprivic feeding in rats. Am J Physiol 256: R1232-R1239.
16. Scharrer E (1999) Control of food intake by fatty acid oxidation and ketogenesis. Nutrition 15: 704-714.
17. Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD, Kuhajda FP (2000) Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288: 2379-2381.
18. Obici S, Feng Z, Arduini A, Conti R, Rossetti L (2003) Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat Med 9: 756-761.
19. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404: 661-671.
20. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92: 573-585.
21. Clark JT, Kalra PS, Crowley WR, Kalra SP (1984) Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115: 427-429.
22. Shimizu H, Shargill NS, Bray GA, Yen TT, Gesellchen PD (1989) Effects of MSH on food intake, body weight and coat color of the yellow obese mouse. Life Sci 45: 543-552.
23. Suenaga M, Kuwajima M, Himeda T, Morokami K, Matsuura T, Ozaki K, Arakaki N, Shibata H, Higuti T (2004) Identification of the up- and down-regulated genes in the heart of juvenile visceral steatosis mice. Biol Pharm Bull 27: 496-503.
24. Kono N, Kuwajima M, Tarui S (1981) Alteration of glycolytic intermediary metabolism in erythrocytes during diabetic ketoacidosis and its recovery phase. Diabetes 30: 346-353.
25. Halliwell G, Halliwell N (1984) Cellulose. In Methods of Enzymatic Analysis, Third Edition. Vol. VI Metabolites 1: Carbohydrates. H.U. Bergmeyer, J. Bergmeyer, M. Graßl, eds. Weinheim·Deerfield Beach, Florida·Basel, Verlag Chemie p. 18-31.
26. Beutler HO (1984) Lactose and D-Galactose, UV-method. In Methods of Enzymatic Analysis, Third Edition. Vol. VI Metabolites 1: Carbohydrates. H.U. Bergmeyer, J. Bergmeyer, M. Graßl, eds. Weinheim·Deerfield Beach, Florida·Basel, Verlag Chemie p. 104-111.
27. Yamamoto Y, Ueta Y, Date Y, Nakazato M, Hara Y, Serino R, Nomura M, Shibuya I, Matsukura S, Yamashita H (1999) Down regulation of the preproorexin gene expression in genetically obese mice. Brain Res Mol Brain Res 65: 14-22.
28. Hanada R, Teranishi H, Pearson JT, Kurokawa M, Hosoda H, Fukushima N, Fukue Y, Serino R, Fujihara H, Ueta Y, Ikawa M, Okabe M, Murakami N, Shirai M, Yoshimatsu H, Kangawa K, Kojima M (2004) Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat Med 10: 1067-1073.
29. Uezu K, Sei H, Sano A, Toida K, Suzuki-Yamamoto T, Houtani T, Sugimoto T, Takeshima H, Ishimura K, Morita Y (2004) Lack of nociceptin receptor alters body temperature during resting period in mice. Neuroreport 15: 751-755.
30. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7: 947-953.
31. Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, Bihain BE, Lodish HF (2001) Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 98: 2005-2010.
32. Langhans W, Pantel K, Scharrer E (1985) Ketone kinetics and D-(-)-3-hydroxybutyrate-induced inhibition of feeding in rats. Physiol Behav 34: 579-582.
33. Krude H, Biebermann H, Luck W, Horn R, Brabant G, Grüters A (1998) Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19: 155-157.
34. Yamamoto Y, Ueta Y, Hara Y, Serino R, Nomura M, Shibuya I, Shirahata A, Yamashita H (2000) Postnatal development of orexin/hypocretin in rats. Brain Res Mol Brain Res 78: 108-119.
35. Redman RS, Sweney LR (1976) Changes in diet and patterns of feeding activity of developing rats. J Nutr 106: 615-626.
36. Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami K, Sugiyama F, Goto K, Yanagisawa M, Sakurai T (2003) Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 38: 701-713.
37. Matsuzaki I, Sakurai T, Kunii K, Nakamura T, Yanagisawa M, Goto K (2002) Involvement of the serotonergic system in orexin-induced behavioral alterations in rats. Regul Pept 104: 119-123.
38. Liu J, Head E, Kuratsune H, Cotman CW, Ames BN (2004) Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann NY Acad Sci 1033: 117-131.
39. Yoshida G, Li MX, Horiuchi M, Nakagawa S, Sakata M, Kuchiiwa S, Kuchiiwa T, Jalil MA, Begum L, Lu YB, Iijima M, Hanada T, Nakazato M, Huang ZL, Eguchi N, Kobayashi K, Saheki T (2006) Fasting-induced reduction in locomotor activity and reduced response of orexin neurons in carnitine-deficient mice. Neurosci Res 55: 78-86.
40. Higashi Y, Yokogawa K, Takeuchi N, Tamai I, Nomura M, Hashimoto N, Hayakawa JI, Miyamoto KI, Tsuji A (2001) Effect of γ-butyrobetaine on fatty liver in juvenile visceral steatosis mice. J Pharm Pharmacol 53: 527-533.
41. Shennan DB, Peaker M (2000) Transport of milk constituents by the mammary gland. Physiol Rev 80: 925-951.
42. Flynn TJ, Deshmukh DS, Pieringer RA (1977) Effects of altered thyroid function on galactosyl diacylglycerol metabolism in myelinating rat brain. J Biol Chem 252: 5864-5870.
43. Henning SJ (1981) Postnatal development: coordination of feeding, digestion, and metabolism. Am J Physiol 241: G199-G214.
44. Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98: 437-451.
45. Thannickal TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich M, Cornford M, Siegel JM (2000) Reduced number of hypocretin neurons in human narcolepsy. Neuron 27: 469-474.
46. Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E (2000) A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 6: 991-997.