Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: Functional independence of ATPase activity and chaperone function

Free Radical Biology and Medicine

Volumn 73, Issue , 2014, Pages 411-420

  Galligan, James J ^a   Fritz, Kristofer S ^b   Backos, Donald S ^b   Shearn, Colin T ^b   Smathers, Rebecca L ^b   Jiang, Hua ^c   Maclean, Kenneth N ^c   Reigan, Philip R ^b   Petersen, Dennis R ^b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c Children's Hospital Colorado   (United States)

Author keywords

4 HNE; 4 ONE; Alcoholic liver disease; Electrophile; Free radicals; HSP; Protein oxidation

Indexed keywords

4 HYDROXYNONENAL; ADENOSINE TRIPHOSPHATASE; ALDEHYDE; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; 4-HYDROXY-2-NONENAL; 4-OXO-2-NONENAL; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; PROTEIN BINDING;

ADDUCTION; ALCOHOL LIVER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENETICS; HUMAN; INFLAMMATION; LIVER DISEASES, ALCOHOLIC; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; UNFOLDED PROTEIN RESPONSE;

ADENOSINE TRIPHOSPHATASES; ALDEHYDES; AMINO ACID SEQUENCE; ANIMALS; COMPUTER SIMULATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HEAT-SHOCK PROTEINS; HUMANS; INFLAMMATION; LIVER DISEASES, ALCOHOLIC; MALE; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; UNFOLDED PROTEIN RESPONSE;

EID: 84903692152     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.06.002     Document Type: Article

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