Impact of protein and ligand impurities on ITC-derived protein-ligand thermodynamics

Biochimica et Biophysica Acta - General Subjects

Volumn 1840, Issue 9, 2014, Pages 2843-2850

  Grüner, Stefan ^a,c   Neeb, Manuel ^a   Barandun, Luzi Jakob ^b   Sielaff, Frank ^a   Hohn, Christoph ^b   Kojima, Shun ^b   Steinmetzer, Torsten ^a   Diederich, François ^b   Klebe, Gerhard ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b ETH ZURICH   (Switzerland)

^c MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

Author keywords

Dynamic light scattering; Enthalpy; Gibbs free energy; Impurities; Isothermal titration calorimetry

Indexed keywords

GLYCOSYLTRANSFERASE; QUEUINE TRANSFER RIBONUCLEIC ACID RIBOSYLTRANSFERASE; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENTHALPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTHERMAL TITRATION CALORIMETRY; LIGHT SCATTERING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; STOICHIOMETRY; THERMODYNAMICS;

DYNAMIC LIGHT SCATTERING; ENTHALPY; GIBBS FREE ENERGY; IMPURITIES; ISOTHERMAL TITRATION CALORIMETRY;

ANIMALS; CALORIMETRY; CATTLE; LIGANDS; PENTOSYLTRANSFERASES; THERMODYNAMICS; TRYPSIN;

EID: 84903649557     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2014.04.018     Document Type: Article

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