Genetic aspects of preeclampsia and the hellp syndrome

Journal of Pregnancy

Volumn 2014, Issue , 2014, Pages

  Haram, Kjell ^a   Mortensen, Jan Helge ^b   Nagy, Bálint ^c  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

^c SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

FEMALE; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HELLP SYNDROME; HUMAN; METABOLISM; PLACENTA; PREECLAMPSIA; PREGNANCY; REVIEW;

FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HELLP SYNDROME; HUMANS; PLACENTA; POLYMORPHISM, GENETIC; PRE-ECLAMPSIA; PREGNANCY;

EID: 84903648083     PISSN: 20902727     EISSN: 20902735     Source Type: Journal    
DOI: 10.1155/2014/910751     Document Type: Review

References (95)

1. Dekker G. A., Sibai B. M., Etiology and pathogenesis of preeclampsia: current concepts. American Journal of Obstetrics and Gynecology 1998 179 5 1359 1375 2-s2.0-0031752789 (Pubitemid 28533800)
2. Sagen N., Koller O., Haram K., Haemoconcentration in severe pre-eclampsia. British Journal of Obstetrics and Gynaecology 1982 89 10 802 805 2-s2.0-0019992383 (Pubitemid 12030359)
3. Sibai B., Dekker G., Kupferminc M., Pre-eclampsia. The Lancet 2005 365 9461 785 799 2-s2.0-14644412849 10.1016/S0140-6736(05)17987-2 (Pubitemid 40311367)
4. Haram K., Svendsen E., Abildgaard U., The HELLP syndrome: clinical issues and management. A review. BMC Pregnancy and Childbirth 2009 9, article 8 2-s2.0-62949156421 10.1186/1471-2393-9-8
5. Roberts J. M., Hubel C. A., The two stage model of preeclampsia: variations on the theme. Placenta 2009 30 32 37 2-s2.0-60249089098 10.1016/j.placenta.2008.11.009
6. Franzas B., Hydatidiform mole and pre-eclampsia. Annales Chirurgiae et Gynaecologiae Fenniae 1958 47 81 11 16 2-s2.0-70449244177
7. Borzychowski A. M., Sargent I. L., Redman C. W. G., Inflammation and pre-eclampsia. Seminars in Fetal and Neonatal Medicine 2006 11 5 309 316 2-s2.0-33745846457 10.1016/j.siny.2006.04.001 (Pubitemid 44038703)
8. Redman C. W., Sargent I. L., Latest advances in understanding preeclampsia. Science 2005 308 5728 1592 1594 2-s2.0-20444409135 10.1126/science.1111726 (Pubitemid 40807500)
9. Martin J. N. Jr., Rose C. H., Briery C. M., Understanding and managing HELLP syndrome: the integral role of aggressive glucocorticoids for mother and child. American Journal of Obstetrics and Gynecology 2006 195 4 914 934 2-s2.0-33748125067 10.1016/j.ajog.2005.08.044 (Pubitemid 44415627)
10. Oudejans C. B. M., van Dijk M., Placental gene expression and pre-eclampsia. Placenta 2008 29 78 82 2-s2.0-40749152784 10.1016/j.placenta. 2007.09.005 (Pubitemid 351380364)
11. Abildgaard U., Heimdal K., Pathogenesis of the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP): a review. European Journal of Obstetrics and Gynecology and Reproductive Biology 2013 166 117 123 10.1016/j.ejogrb.2012.09.026
12. Sep S., Smits L., Prins M., Peeters L., Prediction tests for recurrent hypertensive disease in pregnancy, a systematic review. Hypertension in Pregnancy 2010 29 2 206 230 2-s2.0-77950812724 10.3109/10641950902968668
13. Fitzpatrick K. E., Hinshaw K., Kurinczuk J. J., Knight M., Risk factors, management, and outcomes of hemolysis, elevated liver enzymes, and low platelets syndrome and elevated liver enzymes, low platelets syndrome. Obstetrics and Gynecolog 2014 123 3 618 627 10.1097/AOG.0000000000000140
14. Dekker G., Robillard P. Y., Roberts C., The etiology of preeclampsia: the role of the father. Journal of Reproductive Immunology 2011 89 2 126 132 2-s2.0-79956126940 10.1016/j.jri.2010.12.010
15. Saftlas A. F., Rubenstein L., Prater K., Harland K. K., Field E., Triche E. W., Cumulative exposure to paternal seminal fluid prior to conception and subsequent risk of preeclampsia. Journal of Reproductive Immunology 2014 101-102 104 110 10.1016/j.jri.2013.07.006
16. Saftlas A. F., Levine R. J., Klebanoff M. A., Martz K. L., Ewell M. G., Morris C. D., Sibai B. M., Abortion, changed paternity, and risk of preeclampsia in nulliparous women. American Journal of Epidemiology 2003 157 12 1108 1114 2-s2.0-0038315165 10.1093/aje/kwg101 (Pubitemid 36682302)
17. Oudejans C. B. M., Dijk M., Oosterkamp M., Lachmeijer A., Blankenstein M. A., Genetics of preeclampsia: paradigm shifts. Human Genetics 2007 120 5 607 612 2-s2.0-33845619984 10.1007/s00439-006-0259-1 (Pubitemid 44942844)
18. Roberts J. M., Gammill H. S., Preeclampsia: recent insights. Hypertension 2005 46 6 1243 1249 2-s2.0-31944436638 10.1161/01.HYP.0000188408.49896.c5 (Pubitemid 43189714)
19. Aardema M. W., Oosterhof H., Timmer A., van Rooy I., Aarnoudse J. G., Uterine artery Doppler flow and uteroplacental vascular pathology in normal pregnancies and pregnancies complicated by pre-eclampsia and small for gestational age fetuses. Placenta 2001 22 5 405 411 2-s2.0-0034992906 10.1053/plac.2001.0676 (Pubitemid 32519790)
20. Roberts J. M., Hubel C. A., Is oxidative stress the link in the two-stage model of pre-eclampsia? The Lancet 1999 354 9181 788 789 2-s2.0-0033523435 10.1016/S0140-6736(99)80002-6 (Pubitemid 29415578)
21. Roberts J. M., Lain K. Y., Recent insights into the pathogenesis of pre-eclampsia. Placenta 2002 23 5 359 372 2-s2.0-0036579918 10.1053/plac.2002. 0819 (Pubitemid 41110499)
22. Roberts J. M., Hubel C. A., The two stage model of preeclampsia: variations on the theme. Placenta 2009 30 S32 S37 2-s2.0-60249089098 10.1016/j.placenta.2008.11.009
23. Buimer M., Keijser R., Jebbink J. M., Wehkamp D., van Kampen A. H. C., Boer K., van der Post J. A. M., Ris-Stalpers C., Seven placental transcripts characterize HELLP-syndrome. Placenta 2008 29 5 444 453 2-s2.0-43049128783 10.1016/j.placenta.2008.02.007
24. Roberts J. M., Preeclampsia: what we know and what we do not know. Seminars in Perinatology 2000 24 1 24 28 2-s2.0-0034088851 (Pubitemid 30115266)
25. Huppertz B., Placental origins of preeclampsia: challenging the current hypothesis. Hypertension 2008 51 4 970 975 2-s2.0-40849096217 10.1161/HYPERTENSIONAHA.107.107607 (Pubitemid 351398986)
26. Sibai B. M., The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing? American Journal of Obstetrics and Gynecology 1990 162 2 311 316 2-s2.0-0025173837 (Pubitemid 20068487)
27. Chappell S., Morgan L., Searching for genetic clues to the causes of pre-eclampsia. Clinical Science 2006 110 4 443 458 2-s2.0-33645574663 10.1042/CS20050323
28. Lie R. T., Rasmussen S., Brunborg H., Gjessing H. K., Lie-Nielsen E., Irgens L. M., Fetal and maternal contributions to risk of pre-eclampsia: population based study. British Medical Journal 1998 316 7141 1343 1347 2-s2.0-0032474219 (Pubitemid 28195872)
29. Skjærven R., Vatten L. J., Wilcox A. J., Rønning T., Irgens L. M., Lie R. T., Recurrence of pre-eclampsia across generations: exploring fetal and maternal genetic components in a population based cohort. British Medical Journal 2005 331 7521 877 879 2-s2.0-26944457027 10.1136/bmj.38555. 462685.8F (Pubitemid 41502710)
30. Morgan T., Ward K., New insights into the genetics of preeclampsia. Seminars in Perinatology 1999 23 1 14 23 2-s2.0-0033041759 (Pubitemid 29095582)
31. Cnattingius S., Reilly M., Pawitan Y., Lichtenstein P., Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based swedish cohort study. American Journal of Medical Genetics 2004 130 4 365 371 2-s2.0-7444238608 10.1002/ajmg.a.30257 (Pubitemid 39441611)
32. Salonen R. H., Lichtenstein P., Lipworth L., Cnattingius S., Genetic effects on the liability of developing pre-eclampsia and gestational hypertension. American Journal of Medical Genetics 2000 91 4 256 260 (Pubitemid 30191247)
33. Habli M., Eftekhari N., Wiebracht E., Bombrys A., Khabbaz M., How H., Sibai B., Long-term maternal and subsequent pregnancy outcomes 5 years after hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. American Journal of Obstetrics and Gynecology 2009 201 4 385.e1 385.e5 2-s2.0-70349312358 10.1016/j.ajog.2009.06.033
34. Hupuczi P., Rigó B., Sziller I., Szabó G., Szigeti Z., Papp Z., Follow-up analysis of pregnancies complicated by HELLP syndrome. Fetal Diagnosis and Therapy 2006 21 6 519 522 2-s2.0-33751326541 10.1159/000095665 (Pubitemid 44804591)
35. Lachmeijer A. M. A., Arngrímsson R., Bastiaans E. J., Frigge M. L., Pals G., Sigurdardóttir S., Stéfansson H., Pálsson B., Nicolae D., Kong A., Aarnoudse J. G., Gulcher J. R., Dekker G. A., Ten Kate L. P., Stéfansson K., A genome-wide scan for preeclampsia in the Netherlands. European Journal of Human Genetics 2001 9 10 758 764 2-s2.0-0034748125 10.1038/sj.ejhg.5200706 (Pubitemid 33014588)
36. Arngrímsson R., Sigurõardóttir S., Frigge M. L., A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. Human Molecular Genetics 1999 8 9 1799 1805 10.1093/hmg/8.9.1799 (Pubitemid 29423892)
37. Johnson M. P., Roten L. T., Dyer T. D., East C. E., Forsmo S., Blangero J., Brennecke S. P., Austgulen R., Moses E. K., The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. Human Genetics 2009 126 5 655 666 2-s2.0-73949152236 10.1007/s00439-009-0714-x
38. Roten L. T., Johnson M. P., Forsmo S., Fitzpatrick E., Dyer T. D., Brennecke S. P., Blangero J., Moses E. K., Austgulen R., Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study). European Journal of Human Genetics 2009 17 2 250 257 2-s2.0-58349118696 10.1038/ejhg.2008.158
39. Goddard K. A. B., Tromp G., Romero R., Olson J. M., Lu Q., Xu Z., Parimi N., Nien J. K., Gomez R., Behnke E., Solari M., Espinoza J., Santolaya J., Chaiworapongsa T., Lenk G. M., Volkenant K., Anant M. K., Salisbury B. A., Carr J., Lee M. S., Vovis G. F., Kuivaniemi H., Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes. Human Heredity 2007 63 1 1 16 2-s2.0-33846691503 10.1159/000097926 (Pubitemid 46192725)
40. Frendo J.-L., Olivier D., Cheynet V., Blond J.-L., Bouton O., Vidaud M., Rabreau M., Evain-Brion D., Mallet F., Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation. Molecular and Cellular Biology 2003 23 10 3566 3574 2-s2.0-0037627414 10.1128/MCB.23.10.3566- 3574.2003 (Pubitemid 36539189)
41. Burton G. J., Charnock-Jones D. S., Jauniaux E., Regulation of vascular growth and function in the human placenta. Reproduction 2009 138 6 895 902 2-s2.0-72949090384 10.1530/REP-09-0092
42. Goldman-Wohl D. S., Yagel S., Examination of distinct fetal and maternal molecular pathways suggests a mechanism for the development of preeclampsia. Journal of Reproductive Immunology 2007 76 1-2 54 60 2-s2.0-36048934271 10.1016/j.jri.2007.03.012 (Pubitemid 350100879)
43. Nagy B., Hupuczi P., Papp Z., High frequency of methylenetetrahydrofolate reductase 677TT genotype in Hungarian HELLP syndrome patients determined by quantitative real-time PCR. Journal of Human Hypertension 2007 21 2 154 158 2-s2.0-33847067499 10.1038/sj.jhh.1002122
44. Scholz C., Toth B., Santoso L., Kuhn C., Franz M., Mayr D., Jeschke U., Friese K., Schiessl B., Distribution and maturity of dendritic cells in diseases of insufficient placentation. American Journal of Reproductive Immunology 2008 60 3 238 245 2-s2.0-50149083700 10.1111/j.1600-0897.2008.00619.x
45. Benedetto C., Marozio L., Salton L., Maulà V., Chieppa G., Massobrio M., Factor V Leiden and factor II G20210A in preeclampsia and HELLP syndrome. Acta Obstetricia et Gynecologica Scandinavica 2002 81 12 1095 1100 2-s2.0-0036901330 10.1034/j.1600-0412.2002.811201.x (Pubitemid 35454356)
46. Weed S., Bastek J. A., Anton L., Elovitz M. A., Parry S., Srinivas S. K., Examining the correlation between placental and serum placenta growth factor in preeclampsia. American Journal of Obstetrics and Gynecology 2012 207 2 140 146
47. Vincenti V., Cassano C., Rocchi M., Persico M. G., Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. Circulation 1996 93 8 1493 1495 2-s2.0-0029868465 (Pubitemid 26115412)
48. de Jong C. L. D., Dekker G. A., Sibai B. M., The renin-angiotensin- aldosterone system in preeclampsia: a review. Clinics in Perinatology 1991 18 4 683 711 2-s2.0-0025720204
49. Zusterzeel P. L. M., Peters W. H. M., Visser W., Hermsen K. J. M., Roelofs H. M. J., Steegers E. A. P., A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia. Journal of Medical Genetics 2001 38 4 234 237 2-s2.0-0035061382 (Pubitemid 32324505)
50. Kauma S. W., Huff T. F., Hayes N., Nilkaeo A., Placental Fas ligand expression is a mechanism for maternal immune tolerance to the fetus. Journal of Clinical Endocrinology and Metabolism 1999 84 6 2188 2194 2-s2.0-0033304910 (Pubitemid 30647053)
51. Sziller I., Hupuczi P., Normand N., Halmos A., Papp Z., Witkin S. S., Fas (TNFRSF6) gene polymorphism in pregnant women with hemolysis, elevated liver enzymes, and low platelets and in their neonates. Obstetrics and Gynecology 2006 107 3 582 587 2-s2.0-33646772180 10.1097/01.AOG.0000195824.51919.81
52. van Rijn B. B., Franx A., Steegers E. A. P., de Groot C. J. M., Bertina R. M., Pasterkamp G., Voorbij H. A. M., Bruinse H. W., Roest M., Maternal TLR4 and NOD2 gene variants, pro-inflammatory phenotype and susceptibility to early-onset preeclampsia and HELLP syndrome. PLoS ONE 2008 3 4 2-s2.0-44849130837 10.1371/journal.pone.0001865 e1865 (Pubitemid 351943835)
53. Anim-Nyame N., Sooranna S. R., Steer P. J., Johnson M. R., Longitudinal analysis of maternal plasma leptin concentrations during normal pregnancy and pre-eclampsia. Human Reproduction 2000 15 9 2033 2036 2-s2.0-0033812095
54. Rigó J. Jr., Szendei G., Rosta K., Fekete A., Bögi K., Molvarec A., Rónai Z., Vér Á., Leptin receptor gene polymorphisms in severely pre-eclamptic women. Gynecological Endocrinology 2006 22 9 521 525 2-s2.0-33750456996 10.1080/01674820600915502 (Pubitemid 44657949)
55. van Dijk M., Drewlo S., Oudejans C. B. M., Differential methylation of STOX1 in human placenta. Epigenetics 2010 5 8 736 742 2-s2.0-79952462560
56. Berends A. L., Bertoli-Avella A. M., de Groot C. J. M., van Duijn C. M., Oostra B. A., Steegers E. A. P., STOX1 gene in pre-eclampsia and intrauterine growth restriction. BJOG 2007 114 9 1163 1167 2-s2.0-34547850904 10.1111/j.1471-0528.2007.01414.x (Pubitemid 47247024)
57. Iglesias-Platas I., Monk D., Jebbink J., Buimer M., Boer K., van der Post J., Hills F., Apostolidou S., Ris-Stalpers C., Stanier P., Moore G. E., STOX1 is not imprinted and is not likely to be involved in preeclampsia. Nature Genetics 2007 39 3 279 280 2-s2.0-33847295115 10.1038/ng0307-279 (Pubitemid 46328474)
58. Kivinen K., Peterson H., Hiltunen L., Laivuori H., Heino S., Tiala I., Knuutila S., Rasi V., Kere J., Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample. European Journal of Human Genetics 2007 15 4 494 497 2-s2.0-33947669482 10.1038/sj.ejhg.5201788 (Pubitemid 46487705)
59. Rigourd V., Chauvet C., Chelbi S. T., Rebourcet R., Mondon F., Letourneur F., Mignot T.-M., Barbaux S., Vaiman D., STOX1 overexpression in choriocarcinoma cells mimics transcriptional alterations observed in preeclamptic placentas. PLoS ONE 2008 3 12 2-s2.0-57749199677 10.1371/journal.pone.0003905 e3905
60. van Dijk M., van Bezu J., van Abel D., Dunk C., Blankenstein M. A., Oudejans C. B. M., Lye S. J., The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by α -T-catenin upregulation. Human Molecular Genetics 2010 19 13 2658 2667 2-s2.0-77954162320 10.1093/hmg/ddq152
61. van Dijk M., Oudejans C. B. M., STOX1: key player in trophoblast dysfunction underlying early onset preeclampsia with growth retardation. Journal of Pregnancy 2011 2011 7 521826 10.1155/2011/521826
62. Blond J.-L., Lavillette D., Cheynet V., Bouton O., Oriol G., Chapel-Fernandes S., Mandrand B., Mallet F., Cosset F.-L., An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor. Journal of Virology 2000 74 7 3321 3329 2-s2.0-0034053834 10.1128/JVI.74.7.3321- 3329.2000 (Pubitemid 30143757)
63. Sha M., Lee X., Li X.-P., Veldman G. M., Finnerty H., Racie L., LaVallie E., Tang X.-Y., Edouard P., Howes S., Keith J. C. Jr., McCoy J. M., Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 2000 403 6771 785 789 2-s2.0-0342545919 10.1038/35001608 (Pubitemid 30111841)
64. Than N. G., Abdul Rahman O., Magenheim R., Nagy B., Fule T., Hargitai B., Sammar M., Hupuczi P., Tarca A. L., Szabo G., Kovalszky I., Meiri H., Sziller I., Rigo J. Jr., Romero R., Papp Z., Placental protein 13 (galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm pre-eclampsia and HELLP syndrome. Virchows Archiv 2008 453 4 387 400 2-s2.0-52649148045 10.1007/s00428-008-0658-x
65. Knerr I., Beinder E., Rascher W., Syncytin, a novel human endogenous retroviral gene in human placenta: evidence for its dysregulation in preeclampsia and HELLP syndrome. American Journal of Obstetrics and Gynecology 2002 186 2 210 213 2-s2.0-0036178377 10.1067/mob.2002.119636 (Pubitemid 34165435)
66. Langbein M., Strick R., Strissel P. L., Vogt N., Parsch H., Beckmann M. W., Schild R. L., Impaired cytotrophoblast cell-cell fusion is associated with reduced syncytin and increased apoptosis in patients with placental dysfunction. Molecular Reproduction and Development 2008 75 1 175 183 2-s2.0-36849053912 10.1002/mrd.20729 (Pubitemid 350225582)
67. Sziller I., Babula O., Hupuczi P., Nagy B., Rigó B., Szabó G., Papp Z., Linhares I. M., Witkin S. S., Mannose-binding lectin (MBL) codon 54 gene polymorphism protects against development of pre-eclampsia, HELLP syndrome and pre-eclampsia-associated intrauterine growth restriction. Molecular Human Reproduction 2007 13 4 281 285 2-s2.0-34147187301 10.1093/molehr/gam003 (Pubitemid 46554746)
68. Lin J., August P., Genetic thrombophilias and preeclampsia: a meta-analysis. Obstetrics and Gynecology 2005 105 1 182 192 2-s2.0-13244271259 (Pubitemid 40189930)
69. Muetze S., Leeners B., Ortlepp J. R., Kuse S., Tag C. G., Weiskirchen R., Gressner A. M., Rudnik-Schoeneborn S., Zerres K., Rath W., Maternal factor V Leiden mutation is associated with HELLP syndrome in Caucasian women. Acta Obstetricia et Gynecologica Scandinavica 2008 87 6 635 642 2-s2.0-45849144786 10.1080/00016340802112740 (Pubitemid 351882489)
70. Lin J., August P., Genetic thrombophilias and preeclampsia: a meta-analysis. Obstetrics and Gynecology 2005 105 1 182 192 2-s2.0-13244271259 (Pubitemid 40189930)
71. Lin J., August P., Genetic thrombophilias and preeclampsia: a meta-analysis. Obstetrics & Gynecology 2005 105 1 182 192 10.1097/01.AOG.0000146250.85561.e9 (Pubitemid 40189930)
72. Sgambati E., Marini M., Zappoli Thyrion G. D., Parretti E., Mello G., Orlando C., Simi L., Tricarico C., Gheri G., Brizzi E., VEGF expression in the placenta from pregnancies complicated by hypertensive disorders. BJOG 2004 111 6 564 570 2-s2.0-2942571100 10.1111/j.1471-0528.2004.00143.x (Pubitemid 38746240)
73. Muy-Rivera M., Ning Y., Frederick I. O., Vadachkoria S., Luthy D. A., Williams M. A., Leptin, soluble leptin receptor and leptin gene polymorphism in relation to preeclampsia risk. Physiological Research 2005 54 2 167 174 2-s2.0-18844404908 (Pubitemid 40686263)
74. Perez-Sepulveda A., Espana-Perrot P. P., Fernandez X. B., Levels of key enzymes of methionine-homocysteine metabolism in preeclampsia. BioMed Research International 2013 2013 8 731962 10.1155/2013/731962
75. Poort S. R., Rosendaal F. R., Reitsma P. H., Bertina R. M., A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996 88 10 3698 3703 2-s2.0-0029850530 (Pubitemid 26383091)
76. Kupferminc M. J., Eldor A., Steinman N., Many A., Bar-Am A., Jaffa A., Fait G., Lessing J. B., Increased frequency of genetic thrombophilia in women with complications of pregnancy. The New England Journal of Medicine 1999 340 1 9 13 2-s2.0-0033531184 10.1056/NEJM199901073400102 (Pubitemid 29024678)
77. Nagy B., Savli H., Molvarec A., Várkonyi T., Rigó B., Hupuczi P., Rigó J. Jr., Vascular endothelial growth factor (VEGF) polymorphisms in HELLP syndrome patients determined by quantitative real-time PCR and melting curve analyses. Clinica Chimica Acta 2008 389 1-2 126 131 2-s2.0-38649114682 10.1016/j.cca.2007.12.003
78. Zeeman G. G., Dekker G. A., Pathogenesis of preeclampsia: a hypothesis. Clinical Obstetrics and Gynecology 1992 35 2 317 337 2-s2.0-0026772438
79. Mello G., Parretti E., Gensini F., Sticchi E., Mecacci F., Scarselli G., Genuardi M., Abbate R., Fatini C., Maternal-fetal flow, negative events, and preeclampsia: role of ACE I/D polymorphism. Hypertension 2003 41 4 932 937 2-s2.0-0037390270 10.1161/01.HYP.0000063146.40351.AD (Pubitemid 36418468)
80. Bertalan R., Patocs A., Nagy B., Derzsy Z., Gullai N., Szappanos A., Rigo J. Jr., Racz K., Overrepresentation of BclI polymorphism of the glucocorticoid receptor gene in pregnant women with HELLP syndrome. Clinica Chimica Acta 2009 405 1-2 148 152 2-s2.0-67349192662 10.1016/j.cca.2009.03.046
81. Yeon M. K., Romero R., Seo Y. O., Chong J. K., Kilburn B. A., Armant D. R., Jyh K. N., Gomez R., Mazor M., Saito S., Abrahams V. M., Mor G., Toll-like receptor 4: a potential link between "danger signals," the innate immune system, and preeclampsia? American Journal of Obstetrics and Gynecology 2005 193 supplement 3 921.e1 921.e8 2-s2.0-24644491788 10.1016/j.ajog.2005.07. 076 (Pubitemid 41285471)
82. 4+ CD25bright regulatory T cells in pre-eclampsia. Clinical and Experimental Immunology 2007 149 1 139 145 2-s2.0-34250182084 10.1111/j.1365-2249.2007.03397.x (Pubitemid 46897107)
83. Bełtowski J., Role of leptin in blood pressure regulation and arterial hypertension. Journal of Hypertension 2006 24 5 789 801 2-s2.0-33646360219 10.1097/01.hjh.0000222743.06584.66 (Pubitemid 43670444)
84. Henson M. C., Swan K. F., O'Neil J. S., Expression of placental leptin and leptin receptor transcripts in early pregnancy and at term. Obstetrics and Gynecology 1998 92 6 1020 1028 2-s2.0-0032402324 10.1016/S0029-7844(98)00299-3 (Pubitemid 28536123)
85. Bushati N., Cohen S. M., MicroRNA functions. Annual Review of Cell and Developmental Biology 2007 23 175 205 2-s2.0-34547960488 10.1146/annurev. cellbio.23.090506.123406
86. Eisenberg I., Eran A., Nishino I., Moggio M., Lamperti C., Amato A. A., Lidov H. G., Kang P. B., North K. N., Mitrani-Rosenbaum S., Flanigan K. M., Neely L. A., Whitney D., Beggs A. H., Kohane I. S., Kunkel L. M., Distinctive patterns of microRNA expression in primary muscular disorders. Proceedings of the National Academy of Sciences of the United States of America 2007 104 43 17016 17021 2-s2.0-36749019110 10.1073/pnas.0708115104 (Pubitemid 350210983)
87. Zhu X.-M., Han T., Sargent I. L., Yin G.-W., Yao Y.-Q., Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies. American Journal of Obstetrics and Gynecology 2009 200 6 661.e1 661.e7 2-s2.0-67349233035 10.1016/j.ajog.2008.12.045
88. Farina A., Morano D., Arcelli D., de Sanctis P., Sekizawa A., Purwosunu Y., Zucchini C., Simonazzi G., Okai T., Rizzo N., Gene expression in chorionic villous samples at 11 weeks of gestation in women who develop preeclampsia later in pregnancy: implications for screening. Prenatal Diagnosis 2009 29 11 1038 1044 2-s2.0-70350457992 10.1002/pd.2344
89. Founds S. A., Conley Y. P., Lyons-Weiler J. F., Jeyabalan A., Allen Hogge W., Conrad K. P., Altered global gene expression in first trimester placentas of women destined to develop preeclampsia. Placenta 2009 30 1 15 24 2-s2.0-57749175087 10.1016/j.placenta.2008.09.015
90. Várkonyi T., Nagy B., Füle T., Tarca A. L., Karászi K., Schönléber J., Hupuczi P., Mihalik N., Kovalszky I., Rigó J. Jr., Meiri H., Papp Z., Romero R., Than N. G., Microarray profiling reveals that placental transcriptomes of early-onset HELLP syndrome and preeclampsia are similar. Placenta 2011 32 supplement 1 S21 S29 2-s2.0-79151481145 10.1016/j.placenta.2010.04.014
91. Islami D., Bischof P., Chardonnens D., Possible interactions between leptin, gonadotrophin-releasing hormone (GnRH-I and II) and human chorionic gonadotrophin (hCG). European Journal of Obstetrics Gynecology and Reproductive Biology 2003 110 2 169 175 2-s2.0-0037755598 10.1016/S0301-2115(03)00185-4 (Pubitemid 37101314)
92. Burton G. J., Woods A. W., Jauniaux E., Kingdom J. C. P., Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy. Placenta 2009 30 6 473 482 2-s2.0-67349192531 10.1016/j.placenta.2009.02.009
93. Bertalan R., Patocs A., Nagy B., Derzsy Z., Gullai N., Szappanos A., Rigo J. Jr., Racz K., Overrepresentation of BclI polymorphism of the glucocorticoid receptor gene in pregnant women with HELLP syndrome. Clinica Chimica Acta 2009 405 1-2 148 152 2-s2.0-67349192662 10.1016/j.cca.2009.03.046
94. de Groot C. J. M., Bloemenkamp K. W. M., Duvekot E. J., Helmerhorst F. M., Bertina R. M., van der Meer F., de Ronde H., Oei S. G., Kanhai H. H. H., Rosendaal F. R., Preeclampsia and genetic risk factors for thrombosis: a case-control study. American Journal of Obstetrics and Gynecology 1999 181 4 975 980 2-s2.0-0032740843 10.1016/S0002-9378(99)70335-2 (Pubitemid 29503626)
95. Prusac I. K., Zekic Tomas S., Roje D., Apoptosis, proliferation and Fas ligand expression in placental trophoblast from pregnancies complicated by HELLP syndrome or pre-eclampsia. Acta Obstetricia et Gynecologica Scandinavica 2011 90 10 1157 1163 2-s2.0-80052975064 10.1111/j.1600-0412.2011.01152.x