Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes

Human Heredity

Volumn 63, Issue 1, 2007, Pages 1-16

  Goddard, Katrina A B ^a   Tromp, Gerard ^b   Romero, Roberto ^c   Olson, Jane M ^a   Lu, Qing ^a   Xu, Zhiying ^a   Parimi, Neeta ^a   Nien, Jyh Kae ^c   Gomez, Ricardo ^c,d   Behnke, Ernesto ^d   Solari, Margarita ^d   Espinoza, Jimmy ^c   Santolaya, Joaquin ^c   Chaiworapongsa, Tinnakorn ^c   Lenk, Guy M ^b   Volkenant, Kimberly ^b   Anant, Madan Kumar ^e   Salisbury, Benjamin A ^e   Carr, Janet ^e   Lee, Min Soeb ^e   Vovis, Gerald F ^e   Kuivaniemi, Helena ^b   more..

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^e Clinical Data Inc   (United States)

Author keywords

Genetic association study; Haplotype analysis; Hispanic population; Interleukin 1; Maternal fetal interaction; Type I collagen

Indexed keywords

DNA;

ADULT; ALGORITHM; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DEATH; DNA SEQUENCE; FEMALE; GENE LOCUS; GENETIC REGULATION; GENOTYPE; HAPLOTYPE; HOSPITAL BASED CASE CONTROL STUDY; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; PREECLAMPSIA; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

ADULT; CASE-CONTROL STUDIES; CHILE; COLLAGEN TYPE I; FEMALE; GENOTYPE; HUMANS; INFANT, NEWBORN; INTERLEUKIN-1ALPHA; MALE; MATERNAL-FETAL EXCHANGE; MODELS, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PRE-ECLAMPSIA; PREGNANCY; RECEPTORS, CELL SURFACE;

EID: 33846691503     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000097926     Document Type: Article

References (130)

1. Dekker GA, Sibai BM: Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 1998;179:1359-1375.
2. Higgins JR, Brennecke SP: Pre-eclampsia - still a disease of theories? Curr Opin Obstet Gynecol 1998;10:129-133.
3. Redman CW, Sargent IL: Latest advances in understanding preeclampsia. Science 2005;308:1592-1594.
4. Roberts JM, Taylor RN, Goldfien A: Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia. Am J Hypertens 1991;4:700-708.
5. Kaunitz AM, Hughes JM, Grimes DA, Smith JC, Rochat RW, Kafrissen ME: Causes of maternal mortality in the United States. Obstet Gynecol 1985;65:605-612.
6. Ogden E, Hildebrand GJ, Page EW: Rise of blood pressure during ischemia of the gravid uterus. Proceedings Soc Exp Biol Med 1940;43:49-51.
7. Gyongyossy A, Kelentey B: An experimental study of the effect of ischaemia of the pregnant uterus on the blood pressure. J Obstet Gynaecol Br Emp 1958;65:617-624.
8. Benjamin F, Craig CJT: Uterine distension and pre-eclamptic toxemia. J Obstet Gynaecol Br Emp 1961;68:827-830.
9. Page EW: The relation between hybrid moles, relative Ischemia of the gravid uterus, and the placental origin of eclampsia. Am J Obstet Gynecol 1938;37:293.
10. Robertson WB, Brosens I, Landells WN: Abnormal placentation. Obstet Gynecol Annu 1985;14:411-426.
11. Fisher SJ: The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia. Reprod Biol Endocrinol 2004;2:53.
12. Landells JW: Fine-needle-aspiration biopsies. Ethiop Med J 1985;23:133-134.
13. Khong TY, De Wolf F, Robertson WB, Brosens I: Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-forgestational age infants. Br J Obstet Gynaecol 1986;93:1049-1059.
14. Kupferminc MJ: Thrombophilia and pregnancy. Reprod Biol Endocrinol 2003;1:111.
15. Redman CW, Sargent IL: Pre-eclampsia, the placenta and the maternal systemic inflammatory response - a review. Placenta 2003;24 Suppl A:S21-S27.
16. Faas MM, Schuiling GA: Pre-eclampsia and the inflammatory response. Eur J Obstet Gynecol Reprod Biol 2001;95:213-217.
17. Redman CW, Sacks GP, Sargent IL: Pre-eclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999;180:499-506.
18. Hubel CA: Oxidative stress in the pathogenesis of preeclampsia. Proc Soc Exp Biol Med 1999;222:222-235.
19. Myatt L, Cui X: Oxidative stress in the placenta. Histochem Cell Biol 2004;122:369-382.
20. Chaiworapongsa T, Yoshimatsu J, Espinoza J, Kim YM, Berman S, Edwin S, Yoon BH, Romero R: Evidence of in vivo generation of thrombin in patients with small-for-gestational-age fetuses and pre-eclampsia. J Matern Fetal Neonatal Med 2002;11:362-367.
21. Cadroy Y, Grandjean H, Pichon J, Desprats R, Berrebi A, Fournie A, Boneu B: Evaluation of six markers of haemostatic system in normal pregnancy and pregnancy complicated by hypertension or pre-eclampsia. Br J Obstet Gynaecol 1993;100:416-420.
22. Reinthaller A, Mursch-Edlmayr G, Tatra G: Thrombin-antithrombin III complex levels in normal pregnancy with hypertensive disorders and after delivery. Br J Obstet Gynaecol 1990;97:506-510.
23. Terao T, Maki M, Ikenoue T, Gotoh K, Murata M, Iwasaki H, Shibata J, Nakabayashi M, Muraoka M, Takeda Y: The relationship between clinical signs and hypercoagulable state in toxemia of pregnancy. Gynecol Obstet Invest 1991;31:74-85.
24. Schjetlein R, Abdelnoor M, Haugen G, Husby H, Sandset PM, Wisloff F: Hemostatic variables as independent predictors for fetal growth retardation in preeclampsia. Acta Obstet Gynecol Scand 1999;78:191-197.
25. Schjetlein R, Haugen G, Wisloff F: Markers of intravascular coagulation and fibrinolysis in preeclampsia: association with intrauterine growth retardation. Acta Obstet Gynecol Scand 1997;76:541-546.
26. Halligan A, Bonnar J, Sheppard B, Darling M, Walshe J: Haemostatic, fibrinolytic and endothelial variables in normal pregnancies and pre-eclampsia. Br J Obstet Gynaecol 1994;101:488-492.
27. Shah DM: Role of the renin-angiotensin system in the pathogenesis of preeclampsia. Am J Physiol Renal Physiol 2005;288:F614-F625.
28. Ward K, Hata A, Jeunemaitre X, Helin C, Nelson L, Namikawa C, Farrington PF, Ogasawara M, Suzumori K, Tomoda S: A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet 1993;4:59-61.
29. Cnattingius S, Reilly M, Pawitan Y, Lichtenstein P: Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia:a population-based Swedish cohort study. Am J Med Genet A 2004;130:365-371.
30. Salonen RH, Lichtenstein P, Lipworth L, Cnattingius S: Genetic effects on the liability of developing pre-eclampsia and gestational hypertension. Am J Med Genet 2000;91:256-260.
31. Morgan T, Ward K: New insights into the genetics of preeclampsia. Semin Perinatol 1999;23:14-23.
32. Esplin MS, Fausett MB, Fraser A, Kerber R, Mineau G, Carrillo J, Varner MW: Paternal and maternal components of the predisposition to preeclampsia. N Engl J Med 2001;344:867-872.
33. Dudding TE, Attia J: The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: A meta-analysis. Thromb Haemost 2004;91:700-711.
34. Kosmas IP, Tatsioni A, Ioannidis JP: Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene with hypertension in pregnancy and pre-eclampsia: a meta-analysis. J Hypertens 2004;22:1655-1662.
35. Lin J, August P: Genetic thrombophilias and preeclampsia: a meta-analysis. Obstet Gynecol 2005;105:182-192.
36. Zusterzeel PL, Visser W, Blom HJ, Peters WH, Heil SG, Steegers EA: Methylenetetrahydrofolate reductase polymorphisms in preeclampsia and the HELLP syndrome. Hypertens Pregnancy 2000;19:299-307.
37. Arngrimsson R, Hayward C, Nadaud S, Baldursdottir A, Walker JJ, Liston WA, Bjarnadottir RI, Brock DJ, Geirsson RT, Connor JM, Soubrier F: Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region. Am J Hum Genet 1997;61:354-362.
38. Lewis I, Lachmeijer G, Downing S, Dekker G, Glazebrook C, Clayton D, Morris NH, O'Shaughnessy KM: Failure to detect linkage of preeclampsia to the region of the NOS3 locus on chromosome 7q. Am J Hum Genet 1999;64:310-313.
39. Laivuori H, Lahermo P, Ollikainen V, Widen E, Haiva-Mallinen L, Sundstrom H, Laitinen T, Kaaja R, Ylikorkala O, Kere J: Susceptibility loci for preeclampsia on chromosomes 2p25 and 9p13 in Finnish families. Am J Hum Genet 2003;72:168-177.
40. Moses EK, Lade JA, Guo G, Wilton AN, Grehan M, Freed K, Borg A, Terwilliger JD, North R, Cooper DW, Brennecke SP: A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2. Am J Hum Genet 2000;67:1581-1585.
41. Arngrimsson R, Sigurdardottir S, Frigge ML, Bjarnadottir RI, Jonsson T, Stefansson H, Baldursdottir A, Einarsdottir AS, Palsson B, Snorradottir S, Lachmeijer AM, Nicolae D, Kong A, Bragason BT, Gulcher JR, Geirsson RT, Stefansson K: A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. Hum Mol Genet 1999;8:1799-1805.
42. Harrison GA, Humphrey KE, Jones N, Badenhop R, Guo G, Elakis G, Kaye JA, Turner RJ, Grehan M, Wilton AN, Brennecke SP, Cooper DW: A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q. Am J Hum Genet 1997;60:1158-1167.
43. Atwood LD, Samollow PB, Hixson JE, Stern MP, MacCluer JW: Genome-wide linkage analysis of blood pressure in Mexican Americans. Genet Epidemiol 2001;20:373-382.
44. Hsueh WC, Mitchell BD, Schneider JL, Wagner MJ, Bell CJ, Nanthakumar E, Shuldiner AR: QTL influencing blood pressure maps to the region of PPH1 on chromosome 2q31-34 in Old Order Amish. Circulation 2000;101:2810-2816.
45. Kristjansson K, Manolescu A, Kristinsson A, Hardarson T, Knudsen H, Ingason S, Thorleifsson G, Frigge ML, Kong A, Gulcher JR, Stefansson K: Linkage of essential hypertension to chromosome 18q. Hypertension 2002;39:1044-1049.
46. Levy D, DeStefano AL, Larson MG, O'Donnell CJ, Lifton RP, Gavras H, Cupples LA, Myers RH: Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study. Hypertension 2000;36:477-483.
47. Perola M, Kainulainen K, Pajukanta P, Terwilliger JD, Hiekkalinna T, Ellonen P, Kaprio J, Koskenvuo M, Kontula K, Peltonen L: Genome-wide scan of predisposing loci for increased diastolic blood pressure in Finnish siblings. J Hypertens 2000;18:1579-1585.
48. Rice T, Rankinen T, Province MA, Chagnon YC, Perusse L, Borecki IB, Bouchard C, Rao DC: Genome-wide linkage analysis of systolic and diastolic blood pressure: the Quebec Family Study. Circulation 2000;102:1956-1963.
49. Zhu DL, Wang HY, Xiong MM, He X, Chu SL, Jin L, Wang GL, Yuan WT, Zhao GS, Boerwinkle E, Huang W: Linkage of hypertension to chromosome 2q14-q23 in Chinese families. J Hypertens 2001;19:55-61.
50. Lachmeijer AM, Arngrimsson R, Bastiaans EJ, Frigge ML, Pals G, Sigurdardottir S, Stefansson H, Palsson B, Nicolae D, Kong A, Aarnoudse JG, Gulcher JR, Dekker GA, ten Kate LP, Stefansson K: A genome-wide scan for preeclampsia in the Netherlands. Eur J Hum Genet 2001;9:758-764.
51. Wilson ML, Goodwin TM, Pan VL, Ingles SA: Molecular epidemiology of preeclampsia. Obstet Gynecol Survey 2002;58:39.
52. Stephens JC, Schneider JA, Tanguay DA, Choi J, Acharya T, Stanley SE, Jiang R, Messer CJ, Chew A, Han JH, Duan J, Carr JL, Lee MS, Koshy B, Kumar AM, Zhang G, Newell WR, Windemuth A, Xu C, Kalbfleisch TS, Shaner SL, Arnold K, Schulz V, Drysdale CM, Nandabalan K, Judson RS, Ruano G, Vovis GF: Haplotype variation and linkage disequilibrium in 313 human genes. Science 2001;293:489-493.
53. Judson R, Salisbury B, Schneider J, Windemuth A, Stephens JC: How many SNPs does a genome-wide haplotype map require? Pharmacogenomics 2002;3:379-391.
54. Kuivaniemi H, Yoon S, Shibamura H, Skunca M, Vongpunsawad S, Tromp G: Primer-extension preamplified DNA is a reliable template for genotyping. Clin Chem 2002;48:1601-1604.
55. Winkelman BR, Hoffmann MM, Nauck M, Kumar AM, Nandabalan K, Judson RS, Boehm BO, Tall AR, Ruano G, Marz W: Haplotypes of the cholesteryl ester transfer protein gene predict lipid-modifying response to statin therapy. Pharmacogenomics J 2003;3:284-296.
56. Olson JM: Relationship estimation by Markov-process models in a sib-pair linkage study. Am J Hum Genet 1999;64:1464-1472.
57. Boehnke M, Cox NJ: Accurate inference of relationships in sib-pair linkage studies. Am J Hum Genet 1997;61:423-429.
58. Epstein MP, Duren WL, Boehnke M: Improved inference of relationship for pairs of individuals. Am J Hum Genet 2000;67:1219-1231.
59. Abecasis GR, Cherny SS, Cookson WO, Cardon LR: GRR: graphical representation of relationship errors. Bioinformatics 2001;17:742-743.
60. Goring HH, Ott J: Relationship estimation in affected sib pair analysis of late-onset diseases. Eur J Hum Genet 1997;5:69-77.
61. Douglas JA, Skol AD, Boehnke M: Probability of detection of genotyping errors and mutations as inheritance inconsistencies in nuclear-family data. Am J Hum Genet 2002;70:487-495.
62. Lee WC: Detecting population stratification using a panel of single nucleotide polymorphisms. Int J Epidemiol 2003;32:1120.
63. Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, Dormishian F, Domingo R Jr, Ellis MC, Fullan A, Hinton LM, Jones NL, Kimmel BE, Kronmal GS, Lauer P, Lee VK, Loeb DB, Mapa FA, McClelland E, Meyer NC, Mintier GA, Moeller N, Moore T, Morikang E, Wolff RK: A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996;13:399-408.
64. Nielsen DM, Ehm MG, Weir BS: Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus. Am J Hum Genet 1998;63:1531-1540.
65. Wittke-Thompson JK, Pluzhnikov A, Cox NJ: Rational inferences about departures from Hardy-Weinberg equilibrium. Am J Hum Genet 2005;76:967-986.
66. Trikalinos TA, Salanti G, Khoury MJ, Ioannidis JP: Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations. Am J Epidemiol 2006;163:300-309.
67. Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA: Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002;70:425-434.
68. Devlin B, Roeder K: Genomic control for association studies. Biometrics 1999;55:997-1004.
69. Pritchard JK, Stephens M, Donnelly P: Inference of population structure using multilocus genotype data. Genetics 2000;155:945-959.
70. Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. Royal Stat Soc Ser B 1995;57:289-300.
71. Benjamini Y, Drai D, Elmer G, Kafkafi N, Golani I: Controlling the false discovery rate in behavior genetics research. Behav Brain Res 2001;125:279-284.
72. Mardones F, Rioseco A, Ocqueteau M, Urrutia MT, Javet L, Rojas I, Villarroel dL: [Anemia in pregnant women from the community of Puente Alto, Chile]. Rev Med Chil 2003;131:520-525.
73. Vio del Rio F, Albala C, Salinas J, Mardones F, Truffello I: [Influence of the smoking habit on breast feeding]. Rev Med Chil 1987;115:611-615.
74. Haggerty CL, Ferrell RE, Hubel CA, Markovic N, Harger G, Ness RB: Association between allelic variants in cytokine genes and preeclampsia. Am J Obstet Gynecol 2005;193:209-215.
75. Rinehart BK, Terrone DA, Lagoo-Deenadayalan S, Barber WH, Hale EA, Martin JN Jr, Bennett WA: Expression of the placental cytokines tumor necrosis factor alpha, interleukin 1beta, and interleukin 10 is increased in preeclampsia. Am J Obstet Gynecol 1999;181:915-920.
76. Kocyigit Y, Atamer Y, Atamer A, Tuzcu A, Akkus Z: Changes in serum levels of leptin, cytokines and lipoprotein in pre-eclamptic and normotensive pregnant women. Gynecol Endocrinol 2004;19:267-273.
77. Lachmeijer AM, Nosti-Escanilla MP, Bastiaans EB, Pals G, Sandkuijl LA, Kostense PJ, Aarnoudse JG, Crusius JB, Pena AS, Dekker GA, Arngrimsson R, ten Kate LP: Linkage and association studies of IL1B and IL1RN gene polymorphisms in preeclampsia. Hypertens Pregnancy 2002;21:23-38.
78. Opsjon SL, Austgulen R, Waage A: Interleukin-1, interleukin-6 and tumor necrosis factor at delivery in preeclamptic disorders. Acta Obstet Gynecol Scand 1995;74:19-26.
79. Kupferminc MJ, Peaceman AM, Dollberg S, Socol ML: Tumor necrosis factor-alpha is decreased in the umbilical cord plasma of patients with severe preeclampsia. Am J Perinatol 1999;16:203-208.
80. Saleh AA, Bottoms SF, Welch RA, Ali AM, Mariona FG, Mammen EF: Preeclampsia, delivery, and the hemostatic system. Am J Obstet Gynecol 1987;157:331-336.
81. GOPEC Consortium: Disentangling fetal and maternal susceptibility for pre-eclampsia: A British multicenter candidate-gene study. Am J Hum Genet 2005;77:127-131.
82. Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M: Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia. Mol Hum Reprod 2005;11:437-440.
83. Bauer S, Pollheimer J, Hartmann J, Husslein P, Aplin JD, Knofler M: Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures. J Clin Endocrinol Metab 2004;89:812-822.
84. Liu J, Chakraborty C, Graham CH, Barbin YP, Dixon SJ, Lala PK: Noncatalytic domain of uPA stimulates human extravillous trophoblast migration by using phospholipase C, phosphatidylinositol 3-kinase and mitogen-activated protein kinase. Exp Cell Res 2003;286:138-151.
85. Taylor RN: Review: immunobiology of pre-eclampsia. Am J Reprod Immunol 1997;37:79-86.
86. Galewska Z, Bankowski E, Romanowicz L, Gogiel T, Wolanska M, Jaworski S: Pre-eclampsia-associated reduction of cathepsin D activity in the umbilical cord. Clin Chim Acta 2005;351:177-184.
87. Gorzelak M, Darmochwal-Kolarz D, Jablonski M, Rolinski J, Leszczynska-Gorzelak B, Modrzewski K, Oleszczuk J: The concentrations of osteocalcin and degradation products of type I collagen in pregnant women with pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 2001;98:23-27.
88. Sun F, Flanders WD, Yang Q, Khoury MJ: Transmission disequilibrium test (TDT) when only one parent is available: the 1-TDT. Am J Epidemiol 1999;150:97-104.
89. Bacanu SA, Devlin B, Roeder K: The power of genomic control. Am J Hum Genet 2000;66:1933-1944.
90. Pritchard JK, Rosenberg NA: Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet 1999;65:220-228.
91. Llop E, Harb Z, Moreno R, Rothhammer F: Genetic marker variation in coastal populations of Chile. Homo 2002;53:170-177.
92. Rosenberg NA, Pritchard JK, Weber JL, Cann HM, Kidd KK, Zhivotovsky LA, Feldman MW: Genetic structure of human populations. Science 2002;298:2381-2385.
93. Rosenberg NA, Li LM, Ward R, Pritchard JK: Informativeness of genetic markers for inference of ancestry. Am J Hum Genet 2003;73:1402-1422.
94. Turakulov R, Easteal S: Number of SNPS loci needed to detect population structure. Hum Hered 2003;55:37-45.
95. Bamshad MJ, Wooding S, Watkins WS, Ostler CT, Batzer MA, Jorde LB: Human population genetic structure and inference of group membership. Am J Hum Genet 2003;72:578-589.
96. Collins-Schramm HE, Chima B, Morii T, Wah K, Figueroa Y, Criswell LA, Hanson RL, Knowler WC, Silva G, Belmont JW, Seldin MF: Mexican American ancestry-informative markers: examination of population structure and marker characteristics in European Americans, Mexican Americans, Amerindians and Asians. Hum Genet 2004;114:263-271.
97. Gurdol F, Isbilen E, Yilmaz H, Isbir T, Dirican A: The association between preeclampsia and angiotensin-converting enzyme insertion/deletion polymorphism. Clin Chim Acta 2004;341:127-131.
98. Choi H, Kang JY, Yoon HS, Han SS, Whang CS, Moon IG, Shin HH, Park JB: Association of angiotensin-converting enzyme and angiotensinogen gene polymorphisms with preeclampsia. J Korean Med Sci 2004;19:253-257.
99. Bouba I, Makrydimas G, Kalaitzidis R, Lolis DE, Siamopoulos KC, Georgiou I: Interaction between the polymorphisms of the renin-angiotensin system in preeclampsia. Eur J Obstet Gynecol Reprod Biol 2003;110:8-11.
100. Kobashi G, Hata A, Shido K, Kato EH, Yamada H, Fujimoto S, Kishi R, Kondo K: Association of a variant of the angiotensinogen gene with pure type of hypertension in pregnancy in the Japanese: implication of a racial difference and significance of an age factor. Am J Med Genet 1999;86:232-236.
101. Kobashi G: [A case - control study of pregnancy - induced hypertension with a genetic predisposition: association of a molecular variant of angiotensinogen in the Japanese women]. Hokkaido Igaku Zasshi 1995;70:649-657.
102. Kobashi G, Hata A, Fujimoto S: [Association of pregnancy - induced hypertension with a molecular variant of angiotensinogen gene]. Nippon Sanka Fujinka Gakkai Zasshi 1995;47:497-498.
103. Plummer S, Tower C, Alonso P, Morgan L, Baker P, Broughton-Pipkin F, Kalsheker N: Haplotypes of the angiotensin II receptor genes AGTR1 and AGTR2 in women with normotensive pregnancy and women with preeclampsia. Hum Mutat 2004;24:14-20.
104. Ozkur M, Dogulu F, Ozkur A, Gokmen B, Inaloz SS, Aynacioglu AS: Association of the Gln27Glu polymorphism of the beta-2-adrenergic receptor with preterm labor. Int J Gynaecol Obstet 2002;77:209-215.
105. Laasanen J, Romppanen EL, Hiltunen M, Helisalmi S, Mannermaa A, Punnonen K, Heinonen S: Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia. Eur J Hum Genet 2002;10:569-573.
106. Zusterzeel PL, Peters WH, Visser W, Hermsen KJ, Roelofs HM, Steegers EA: A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia. J Med Genet 2001;38:234-237.
107. Camilleri RS, Peebles D, Portmann C, Everington T, Cohen H: -455G/A beta-fibrinogen gene polymorphism, factor V Leiden, prothrombin G20210A mutation and MTHFR C677T, and placental vascular complications. Blood Coagul Fibrinolysis 2004;15:139-147.
108. Hira B, Pegoraro RJ, Rom L, Moodley J: Absence of Factor V Leiden, thrombomodulin and prothrombin gene variants in Black South African women with pre-eclampsia and eclampsia. BJOG 2003;110:327-328.
109. Grandone E, Margaglione M, Colaizzo D, Cappucci G, Paladini D, Martinelli P, Montanaro S, Pavone G, Di MG: Factor V Leiden, C > T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thromb Haemost 1997;77:1052-1054.
110. Kim YJ, Williamson RA, Murray JC, Andrews J, Pietscher JJ, Peraud PJ, Merrill DC: Genetic susceptibility to preeclampsia: Roles of cytosine-to-thymine substitution at nucleotide 677 of the gene for methylenetetrahydrofolate reductase, 68-base pair insertion at nucleotide 844 of the gene for cystathionine beta-synthase, and factor V Leiden mutation. Am J Obstet Gynecol 2001;184:1211-1217.
111. Prasmusinto D, Skrablin S, Fimmers R, van der Ven K: Ethnic differences in the association of factor V Leiden mutation and the C677T methylenetetrahydrofolate reductase gene polymorphism with preeclampsia. Eur J Obstet Gynecol Reprod Biol 2004;112:162-169.
112. Vefring H, Lie RT, Odegard R, Mansoor MA, Nilsen ST: Maternal and fetal variants of genetic thrombophilias and the risk of preeclampsia. Epidemiology 2004;15:317-322.
113. Watanabe H, Hamada H, Yamada N, Sohda S, Yamakawa-Kobayashi K, Yoshikawa H, Arinami T: Association analysis of nine missense polymorphisms in the coagulation factor V gene with severe preeclampsia in pregnant Japanese women. J Hum Genet 2002;47:131-135.
114. Zusterzeel PL, Visser W, Peters WH, Merkus HW, Nelen WL, Steegers EA: Polymorphism in the glutathione S-transferase P1 gene and risk for preeclampsia. Obstet Gynecol 2000;96:50-54.
115. Ohta K, Kobashi G, Hata A, Yamada H, Minakami H, Fujimoto S, Kondo K, Tamashiro H: Association between a variant of the glutathione S-transferase P1 gene (GSTP1) and hypertension in pregnancy in Japanese: interaction with parity, age, and genetic factors. Semin Thromb Hemost 2003;29:653-659.
116. Schneider K, Knutson F, Tamsen L, Sjoberg O: HLA antigen sharing in preeclampsia. Gynecol Obstet Invest 1994;37:87-90.
117. Liston WA, Kilpatrick DC: Is genetic susceptibility to pre-eclampsia conferred by homozygosity for the same single recessive gene in mother and fetus? Br J Obstet Gynaecol 1991;98:1079-1086.
118. Kilpatrick DC, Gibson F, Livingston J, Liston WA: Pre-eclampsia is associated with HLA-DR4 sharing between mother and fetus. Tissue Antigens 1990;35:178-181.
119. Kilpatrick DC, Liston WA, Gibson F, Livingstone J: Association between susceptibility to pre-eclampsia within families and HLA DR4. Lancet 1989;2:1063-1065.
120. Hylenius S, Andersen AM, Melbye M, Hviid TV: Association between HLA-G genotype and risk of pre-eclampsia: a case-control study using family triads. Mol Hum Reprod 2004;10:237-246.
121. De Groot CJ, Jansen MW, Bertina RM, Schonkeren JJ, Helmerhorst FM, Huizinga TW: Interleukin 10-2849AA genotype protects against pre-eclampsia. Genes Immun 2004;5:313-314.
122. Hubel CA, Roberts JM, Ferrell RE: Association of pre-eclampsia with common coding sequence variations in the lipoprotein lipase gene. Clin Genet 1999;56:289-296.
123. Watanabe H, Hamada H, Yamakawa-Kobayashi K, Yoshikawa H, Arinami T: Evidence for an association of the R485K polymorphism in the coagulation factor V gene with severe preeclampsia from screening 35 polymorphisms in 27 candidate genes. Thromb Haemost 2001;86:1594-1595.
124. Kobashi G, Yamada H, Ohta K, Kato E, Ebina Y, Fujimoto S: Endothelial nitric oxide synthase gene (NOS3) variant and hypertension in pregnancy. Am J Med Genet 2001;103:241-244.
125. Kupferminc MJ, Fait G, Many A, Gordon D, Eldor A, Lessing JB: Severe preeclampsia and high frequency of genetic thrombophilic mutations. Obstet Gynecol 2000;96:45-49.
126. Fabbro D, D'Elia AV, Spizzo R, Driul L, Barillari G, Di LC, Marchesoni D, Damante G: Association between plasminogen activator inhibitor 1 gene polymorphisms and preeclampsia. Gynecol Obstet Invest 2003;56:17-22.
127. Pegoraro RJ, Hira B, Rom L, Moodley J: Plasminogen activator inhibitor type 1 (PAI1) and platelet glycoprotein IIIa (PGIIIa) polymorphisms in Black South Africans with pre-eclampsia. Acta Obstet Gynecol Scand 2003;82:313-317.
128. Yamada N, Arinami T, Yamakawa-Kobayashi K, Watanabe H, Sohda S, Hamada H, Kubo T, Hamaguchi H: The 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene is associated with severe pre-eclampsia. J Hum Genet 2000;45:138-141.
129. Kachmeijer AM, Crusius JB, Pals G, Dekker GA, Arngrimsson R, ten Kate LP: Polymorphisms in the tumor necrosis factor and lymphotoxin-alpha gene region and pre-eclampsia. Obstet Gynecol 2001;98:612-619.
130. Shim SS, Jung N-Y, Lim JH, Shim J-Y, Park JS, Jun JK, Choi YM, Yoon BH, Syn HC: Polymorphism of promotor region of the angiotensinogen gene is a risk factor for elevation of blood pressure in women with hypertensive disorders of pregnancy. J Soc Gynecol Inv 2003;10:166A.