Inflammation and pre-eclampsia

Seminars in Fetal and Neonatal Medicine

Volumn 11, Issue 5, 2006, Pages 309-316

  Borzychowski, A M ^a   Sargent, I L ^a   Redman, C W G ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Endothelium; Oxidative stress; Placental debris; Pre eclampsia; Systemic inflammatory response

Indexed keywords

ACETYLCYSTEINE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CORTICOSTEROID; NEUTRALIZING ANTIBODY; PROTEIN TYROSINE KINASE; VASCULOTROPIN ANTIBODY; VASCULOTROPIN RECEPTOR;

ARTICLE; CANCER; CARDIOVASCULAR DISEASE; CELL ACTIVATION; CLINICAL TRIAL; DIABETES MELLITUS; DISEASE PREDISPOSITION; EDEMA; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; HELLP SYNDROME; HUMAN; HYPERTENSION; INFLAMMATION; INNATE IMMUNITY; LEUKOCYTE; MATERNAL HYPERTENSION; MEDICAL RESEARCH; METABOLISM; NONHUMAN; OXIDATIVE STRESS; PLACENTA; PLACENTA CIRCULATION; PREECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATION; PROTEINURIA; SYNCYTIOTROPHOBLAST; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; VASCULARIZATION;

ENDOTHELIUM; FEMALE; HUMANS; INFLAMMATION; OXIDATIVE STRESS; PLACENTA; PLACENTAL CIRCULATION; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY OUTCOME;

EID: 33745846457     PISSN: 1744165X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.siny.2006.04.001     Document Type: Article

References (63)

1. Redman C.W. Current topic: pre-eclampsia and the placenta. Placenta 12 (1991) 301-308
2. Ness R.B., and Roberts J.M. Heterogeneous causes constituting the single syndrome of preeclampsia: a hypothesis and its implications. Am J Obstet Gynecol 175 (1996) 1365-1370
3. Moffett-King A. Natural killer cells and pregnancy. Nat Rev Immunol 2 (2002) 656-663
4. Gabay C., and Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 340 (1999) 448-454
5. Pepys M.B., and Hirschfield G.M. C-reactive protein: a critical update. J Clin Invest 111 (2003) 1805-1812
6. Sethi J.K., and Hotamisligil G.S. The role of TNF alpha in adipocyte metabolism. Semin Cell Dev Biol 10 (1999) 19-29
7. Isomaa B. A major health hazard: the metabolic syndrome. Life Sci 73 (2003) 2395-2411
8. Yudkin J.S., Stehouwer C.D., Emeis J.J., and Coppack S.W. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?. Arterioscler Thromb Vasc Biol 19 (1999) 972-978
9. Hansson G.K., Libby P., Schonbeck U., and Yan Z.Q. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res 91 (2002) 281-291
10. Redman C.W., Sacks G.P., and Sargent I.L. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 180 (1999) 499-506
11. Gatti L., Tenconi P.M., Guarneri D., et al. Hemostatic parameters and platelet activation by flow-cytometry in normal pregnancy: a longitudinal study. Int J Clin Lab Res 24 (1994) 217-219
12. Halligan A., Bonnar J., Sheppard B., Darling M., and Walshe J. Haemostatic, fibrinolytic and endothelial variables in normal pregnancies and pre-eclampsia. Br J Obstet Gynaecol 101 (1994) 488-492
13. Haram K., Augensen K., and Elsayed S. Serum protein pattern in normal pregnancy with special reference to acute-phase reactants. Br J Obstet Gynaecol 90 (1983) 139-145
14. Studd J.W., Blainey J.D., and Bailey D.E. Serum protein changes in the pre-eclampsia-eclampsia syndrome. J Obstet Gynaecol Br Commonw 77 (1970) 796-801
15. Sacks G.P., Seyani L., Lavery S., and Trew G. Maternal C-reactive protein levels are raised at 4 weeks gestation. Hum Reprod 19 (2004) 1025-1030
16. Smarason A.K., Gunnarsson A., Alfredsson J.H., and Valdimarsson H. Monocytosis and monocytic infiltration of decidua in early pregnancy. J Clin Lab Immunol 21 (1986) 1-5
17. Barriga C., Rodriguez A.B., and Ortega E. Increased phagocytic activity of polymorphonuclear leukocytes during pregnancy. Eur J Obstet Gynecol Reprod Biol 57 (1994) 43-46
18. Greer I.A., Dawes J., Johnston T.A., and Calder A.A. Neutrophil activation is confined to the maternal circulation in pregnancy-induced hypertension. Obstet Gynecol 78 (1991) 28-32
19. Koumandakis E., Koumandaki I., Kaklamani E., Sparos L., Aravantinos D., and Trichopoulos D. Enhanced phagocytosis of mononuclear phagocytes in pregnancy. Br J Obstet Gynaecol 93 (1986) 1150-1154
20. Sacks G.P., Redman C.W., and Sargent I.L. Monocytes are primed to produce the Th1 type cytokine IL-12 in normal human pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells. Clin Exp Immunol 131 (2003) 490-497
21. Sacks G.P., Studena K., Sargent I.L., and Redman C.W. Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis. Am J Obstet Gynecol 179 (1998) 80-86
22. Austgulen R., Lien E., Liabakk N.B., Jacobsen G., and Arntzen K.J. Increased levels of cytokines and cytokine activity modifiers in normal pregnancy. Eur J Obstet Gynecol Reprod Biol 57 (1994) 149-155
23. Melczer Z., Banhidy F., Csomor S., et al. Influence of leptin and the TNF system on insulin resistance in pregnancy and their effect on anthropometric parameters of newborns. Acta Obstet Gynecol Scand 82 (2003) 432-438
24. Arntzen K.J., Liabakk N.B., Jacobsen G., Espevik T., and Austgulen R. Soluble tumor necrosis factor receptor in serum and urine throughout normal pregnancy and at delivery. Am J Reprod Immunol 34 (1995) 163-169
25. Morris J.M., Gopaul N.K., Endresen M.J., et al. Circulating markers of oxidative stress are raised in normal pregnancy and pre-eclampsia. Br J Obstet Gynaecol 105 (1998) 1195-1199
26. Stanley K., Fraser R., and Bruce C. Physiological changes in insulin resistance in human pregnancy: longitudinal study with the hyperinsulinaemic euglycaemic clamp technique. Br J Obstet Gynaecol 105 (1998) 756-759
27. Martin U., Davies C., Hayavi S., Hartland A., and Dunne F. Is normal pregnancy atherogenic?. Clin Sci (Lond) 96 (1999) 421-425
28. Barbour L.A., Shao J., Qiao L., et al. Human placental growth hormone causes severe insulin resistance in transgenic mice. Am J Obstet Gynecol 186 (2002) 512-517
29. Yura S., Sagawa N., Itoh H., et al. Resistin is expressed in the human placenta. J Clin Endocrinol Metab 88 (2003) 1394-1397
30. Roberts J.M., Taylor R.N., Musci T.J., Rodgers G.M., Hubel C.A., and McLaughlin M.K. Pre-eclampsia: an endothelial cell disorder. Am J Obstet Gynecol 161 (1989) 1200-1204
31. Mantovani A., and Dejana E. Cytokines as communication signals between leukocytes and endothelial cells. Immunol Today 10 (1989) 370-375
32. Hingorani A.D., Cross J., Kharbanda R.K., et al. Acute systemic inflammation impairs endothelium-dependent dilatation in humans. Circulation 102 (2000) 994-999
33. Faas M.M., Schuiling G.A., Baller J.F., Visscher C.A., and Bakker W.W. A new animal model for human preeclampsia: ultra-low-dose endotoxin infusion in pregnant rats. Am J Obstet Gynecol 171 (1994) 158-164
34. Alexander B.T., Cockrell K.L., Massey M.B., Bennett W.A., and Granger J.P. Tumor necrosis factor-alpha-induced hypertension in pregnant rats results in decreased renal neuronal nitric oxide synthase expression. Am J Hypertens 15 (2002) 170-175
35. Sibai B.M., and Barton J.R. Dexamethasone to improve maternal outcome in women with hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Obstet Gynecol 193 (2005) 1587-1590
36. Terrone D.A., Rinehart B.K., May W.L., Moore A., Magann E.F., and Martin Jr. J.N. Leukocytosis is proportional to HELLP syndrome severity: evidence for an inflammatory form of preeclampsia. South Med J 93 (2000) 768-771
37. Haeger M., Unander M., Norder-Hansson B., Tylman M., and Bengtsson A. Complement, neutrophil, and macrophage activation in women with severe preeclampsia and the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Obstet Gynecol 79 (1992) 19-26
38. Perry Jr. K.G., and Martin Jr. J.N. Abnormal hemostasis and coagulopathy in preeclampsia and eclampsia. Clin Obstet Gynecol 35 (1992) 338-350
39. Konijnenberg A., Stokkers E.W., van der Post J.A., et al. Extensive platelet activation in preeclampsia compared with normal pregnancy: enhanced expression of cell adhesion molecules. Am J Obstet Gynecol 176 (1997) 461-469
40. Taylor R.N., Crombleholme W.R., Friedman S.A., Jones L.A., Casal D.C., and Roberts J.M. High plasma cellular fibronectin levels correlate with biochemical and clinical features of preeclampsia but cannot be attributed to hypertension alone. Am J Obstet Gynecol 165 (1991) 895-901
41. Gratacos E., Casals E., Deulofeu R., Caranach V., Alonso P.L., and Fortuny A. Lipid peroxide and vitamin E patterns in pregnant women with different types of hypertension in pregnancy. Am J Obstet Gynecol 178 (1998) 1072-1076
42. Hubel C.A. Dyslipidemia, iron, and oxidative stress in preeclampsia: assessment of maternal and feto-placental interactions. Semin Reprod Endocrinol 16 (1998) 75-92
43. Vince G.S., Starkey P.M., Austgalen R., Kwiatkowski D., and Redman C.W. Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia. Br J Obstet Gynaecol 102 (1995) 20-25
44. Greer I.A., Lyall F., Perera T., Boswell F., and Macara L.M. Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: a mechanism for endothelial dysfunction?. Obstet Gynecol 84 (1994) 937-940
45. Stallmach T., Hebisch G., Joller H., Kolditz P., and Engelmann M. Expression pattern of cytokines in the different compartments of the feto-maternal unit under various conditions. Reprod Fertil Dev 7 (1995) 1573-1580
46. Chappell L.C., Seed P.T., Briley A.L., et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 354 (1999) 810-816
47. Roes E.M., Raijmakers M.T., Boo T.M., et al. Oral N-acetylcysteine administration does not stabilise the process of established severe preeclampsia. Eur J Obstet Gynecol Reprod Biol (2005) [e-pub]
48. Raijmakers M.T., Dechend R., and Poston L. Oxidative stress and preeclampsia: rationale for antioxidant clinical trials. Hypertension 44 (2004) 374-380
49. Vitoratos N., Salamalekis E., Dalamaga N., Kassanos D., and Creatsas G. Defective antioxidant mechanisms via changes in serum ceruloplasmin and total iron binding capacity of serum in women with pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 84 (1999) 63-67
50. Johansen K.A., Williams J.H., and Stark J.M. Acute-phase C56-forming ability and concentrations of complement components in normotensive and hypertensive pregnancies. Br J Obstet Gynaecol 88 (1981) 504-512
51. Teran E., Escudero C., Moya W., Flores M., Vallance P., and Lopez-Jaramillo P. Elevated C-reactive protein and pro-inflammatory cytokines in Andean women with pre-eclampsia. Int J Gynaecol Obstet 75 (2001) 243-249
52. Maynard S.E., Min J.Y., Merchan J., et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111 (2003) 649-658
53. Kabbinavar F., Hurwitz H.I., Fehrenbacher L., et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 21 (2003) 60-65
54. Li H., Gu B., Zhang Y., Lewis D.F., and Wang Y. Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta. Placenta 26 (2005) 210-217
55. Felmeden D.C., Spencer C.G., Belgore F.M., Blann A.D., Beevers D.G., and Lip G.Y. Endothelial damage and angiogenesis in hypertensive patients: relationship to cardiovascular risk factors and risk factor management. Am J Hypertens 16 (2003) 11-20
56. Benyo D.F., Smarason A., Redman C.W., Sims C., and Conrad K.P. Expression of inflammatory cytokines in placentas from women with preeclampsia. J Clin Endocrinol Metab 86 (2001) 2505-2512
57. Knight M., Redman C.W., Linton E.A., and Sargent I.L. Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnancies. Br J Obstet Gynaecol 105 (1998) 632-640
58. Ishihara N., Matsuo H., Murakoshi H., Laoag-Fernandez J.B., Samoto T., and Maruo T. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol 186 (2002) 158-166
59. Levy R., Smith S.D., Chandler K., Sadovsky Y., and Nelson D.M. Apoptosis in human cultured trophoblasts is enhanced by hypoxia and diminished by epidermal growth factor. Am J Physiol Cell Physiol 278 (2000) C982-C988
60. Schrocksnadel H., Daxenbichler G., Artner E., Steckel-Berger G., and Dapunt O. Tumor markers in hypertensive disorders of pregnancy. Gynecol Obstet Invest 35 (1993) 204-208
61. Lo Y.M., Leung T.N., Tein M.S., et al. Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia. Clin Chem 45 (1999) 184-188
62. Rodie V.A., Freeman D.J., Satter N., and Greer I.A. Pre-eclampsia and cardiovascular disease: metabolic syndrome of pregnancy?. Atherosclerosis 175 (2004) 189-202
63. Sattar N., and Greer I.A. Pregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening?. Br Med J 325 (2002) 157-160