Neonatal peripheral immune challenge activates microglia and inhibits neurogenesis in the developing murine hippocampus

Developmental Neuroscience

Volumn 36, Issue 2, 2014, Pages 119-131

  Smith, Peter L P ^a   Hagberg, Henrik ^a,c   Naylor, Andrew S ^a,b   Mallard, Carina ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Hippocampal development; Lipopolysaccharide; Lys EGFP ki mice; M1; M2; Microglia activation; Microglia proliferation; Microglial phenotype

Indexed keywords

LIPOPOLYSACCHARIDE; BACTERIUM LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; BRAIN BLOOD VESSEL; CELL COUNT; CELL DENSITY; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION; GRANULOCYTE; HIPPOCAMPUS; IMMUNOREACTIVITY; IMMUNOSTIMULATION; INFLAMMATION; MACROPHAGE; MALE; MICROGLIA; MONOCYTE; MOUSE; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NEWBORN PERIOD; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; UPREGULATION; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; CHEMICALLY INDUCED; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NERVE CELL; STEM CELL; ANIMAL CELL; ANIMAL TISSUE; CELL ACTIVATION; CELL INFILTRATION; CENTRAL NERVOUS SYSTEM; NEWBORN; POSTNATAL DEVELOPMENT; PROVOCATION TEST; REGULATORY MECHANISM;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; HIPPOCAMPUS; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE, INBRED C57BL; MICROGLIA; NEURAL STEM CELLS; NEUROGENESIS; NEURONS; STEM CELLS;

EID: 84903647196     PISSN: 03785866     EISSN: 14219859     Source Type: Journal    
DOI: 10.1159/000359950     Document Type: Article

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