APOE and BDNF Val66Met polymorphisms combine to influence episodic memory function in older adults

Behavioural Brain Research

Volumn 271, Issue , 2014, Pages 309-315

  Ward, David D ^a   Summers, Mathew J ^a   Saunders, Nichole L ^a   Janssen, Pierce ^a   Stuart, Kimberley E ^a   Vickers, James C ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

Author keywords

Aging; APOE; BDNF; Episodic memory; Older adult; Polymorphism

Indexed keywords

APOLIPOPROTEIN E; BRAIN DERIVED NEUROTROPHIC FACTOR;

ADULT; AGED; APOE GENE; ARTICLE; BDNF GENE; COGNITION; EPISODIC MEMORY; EXECUTIVE FUNCTION; FEMALE; GENE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; LANGUAGE PROCESSING; MALE; NORMAL HUMAN; POST HOC ANALYSIS; PRIORITY JOURNAL; PROTEIN INTERACTION; WORKING MEMORY; AGING; GENETICS; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGY; RISK FACTOR; SHORT TERM MEMORY;

AGED; AGING; APOLIPOPROTEINS E; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION; FEMALE; HUMANS; MALE; MEMORY, EPISODIC; MEMORY, SHORT-TERM; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 84903643736     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2014.06.022     Document Type: Article

References (55)

1. Bouchard T.J., McGue M. Familial studies of intelligence - a review. Science 1981, 212:1055-1059.
2. Haworth C.M.A., Wright M.J., Luciano M., Martin N.G., de Geus E.J.C., van Beijsterveldt C.E.M., et al. The heritability of general cognitive ability increases linearly from childhood to young adulthood. Mol Psychiatry 2010, 15:1112-1120.
3. Plomin R., Haworth C.M.A., Meaburn E.L., Price T.S., WTCCC 2, Davis O.S.P. Common DNA markers can account for more than half of the genetic influence on cognitive abilities. Psychol Sci 2013, 24:562-568.
4. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993, 261:921-923.
5. Bath K.G., Lee F.S. Variant BDNF (val66met) impact on brain structure and function. Cogn Affect Behav Neurosci 2006, 6:79-85.
6. Harris S.E., Deary I.J. The genetics of cognitive ability and cognitive ageing in healthy older people. Trends Cogn Sci 2011, 15:388-394.
7. Espeseth T., Westlye L.T., Fjell A.M., Walhovd K.B., Rootwelt H., Reinvang I. Accelerated age-related cortical thinning in healthy carriers of apolipoprotein E epsilon 4. Neurobiol Aging 2008, 29:329-340.
8. Kok E., Haikonen S., Luoto T., Huhtala H., Goebeler S., Haapasalo H., et al. Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age. Ann Neurol 2009, 65:650-657.
9. Ready R.E., Baran B., Chaudhry M., Schatz K., Gordon J., Spencer R.M.C. Apolipoprotein E-e4, processing speed, and white matter volume in a genetically enriched sample of midlife adults. Am J Alzheimers Dis Other Demen 2011, 26:463-468.
10. Suri S., Heise V., Trachtenberg A.J., Mackay C.E. The forgotten APOE allele: a review of the evidence and suggested mechanisms for the protective effect of APOE e2. Neurosci Biobehav Rev 2013, 37:2878-2886.
11. Summers M.J., Saunders N.L., Valenzuela M.J., Summers J.J., Ritchie K., Robinson A., et al. The Tasmanian Healthy Brain Project (THBP): a prospective longitudinal examination of the effect of university-level education in older adults in preventing age-related cognitive decline and reducing the risk of dementia. Int Psychogeriatr 2013, 25:1145-1155.
12. Jurica P.J., Leitten C.L., Mattis S. Dementia rating scale-2 (DRS-2): professional manual 2001, Psychological Assessment Resources, Odessa, RL.
13. Snaith R.P., Zigmond A.S. The hospital anxiety and depression scale (HADS): manual 1994, GL Assessment Ltd, London, UK.
14. The Psychological Corporation Wechsler test of adult reading 2001, Harcourt Assessment, San Antonio, TX.
15. Strauss E., Sherman E.M.S., Spreen O. A compendium of neuropsychological tests: administrations, norms, and commentary 2006, Oxford University Press, New York, NY. 3rd ed.
16. Wechsler D. Wechsler memory scale - third edition (WMS - III): administration and scoring manual 1997, The Psychological Corporation, San Antonio, TX.
17. Cambridge Cognition Ltd. CANTABeclipse 2004, Cambridge Cognition Ltd., Cambridge.
18. Wechsler D. Wechsler adult intelligence scale-third edition (WAIS-III): administration and scoring manual 1997, The Psychological Corporation.
19. Lezak M.D., Howieson D.B., Bigler E.D., Tranel D. Neuropsychological assessment 2012, Oxford University Press, Oxford. 5th ed.
20. Kaplan E., Goodglass H., Weintraub S. Boston naming test 1983, Lea & Febiger, Philadelphia, PA.
21. DNA Genotek Inc. Oragene-DNA (OG-500) data sheet 2012, DNA Genotek Inc. http://www.dnagenotek.com/ROW/pdf/PD-BR-017.pdf.
22. Donohoe G.G., Salomaki A., Lehtimaki T., Pulkki K., Kairisto V. Rapid identification of apolipoprotein E genotypes by multiplex amplification refractory mutation system PCR and capillary gel electrophoresis. Clin Chem 1999, 14:3-6.
23. Sheikha H., Hayden E., Kryski K., Smith H., Singha S. Genotyping the BDNF rs6265 polymorphism by one-step amplified refractory mutation system PCR. Psychiatr Genet 2011, 20:109-112.
24. Deary I.J., Whiteman M.C., Pattie A., Starr J.M., Hayward C., Wright A.F., et al. Apolipoprotein e gene variability and cognitive functions at age 79: a follow-up of the Scottish mental survey of 1932. Psychol Aging 2004, 19:367-371.
25. Wilson R.S., Schneider J.A., Barnes L.L., Beckett L.A., Aggarwal N.T., Cochran E.J., et al. The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period. Arch Neurol 2002, 59:1154-1160.
26. Wisdom N.M., Callahan J.L., Hawkins K.A. The effects of apolipoprotein E on non-impaired cognitive functioning: a meta-analysis. Neurobiol Aging 2011, 32:63-74.
27. Foster J.K., Albrecht M.A., Savage G., Lautenschlager N.T., Ellis K.A., Maruff P., et al. Lack of reliable evidence for a distinctive epsilon 4-related cognitive phenotype that is independent from clinical diagnostic status: findings from the Australian Imaging, Biomarkers and Lifestyle Study. Brain 2013, 136:2201-2216.
28. Quintas J.L., Souza V.C., Henriques A.D., Machado-Silva W., Toledo J.O., Córdova C., et al. Lack of association between apolipoprotein E genotypes and cognitive performance in the non-demented elderly. Psychogeriatrics 2013, 14:11-16.
29. Laukka E.J., Lövdén M., Herlitz A., Karlsson S., Ferencz B., Pantzar A., et al. Genetic effects on old-age cognitive functioning: a population-based study. Psychol Aging 2013, 28:262-274.
30. Frodl T., Schüle C., Schmitt G., Born C., Baghai T., Zill P., et al. Association of the brain-derived neurotrophic factor val66met polymorphism with reduced hippocampal volumes in major depression. Arch Gen Psychiatry 2007, 64:410-416.
31. Gong P., Zheng Z., Chi W., Lei X., Wu X., Chen D., et al. An association study of the genetic polymorphisms in 13 neural plasticity-related genes with semantic and episodic memories. J Mol Neurosci 2012, 46:352-361.
32. Houlihan L.M., Harris S.E., Luciano M., Gow A.J., Starr J.M., Visscher P.M., et al. Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936. Genes Brain Behav 2009, 8:238-247.
33. Stuart K., Summers M.J., Valenzuela M.J., Vickers J.C. BDNF and COMT polymorphisms have a limited association with episodic memory performance or engagement in complex cognitive activity in healthy older adults. Neurobiol Learn Mem 2014, 110:1-7.
34. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003, 112:257-269.
35. Hariri A.R., Goldberg T.E., Mattay V.S., Kolachana B.S., Callicott J.H., Egan M.F., et al. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 2003, 23:6690-6694.
36. Raz N., Rodrigue K.M., Kennedy K.M., Land S. Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE, and hypertension. Neuropsychology 2009, 23:105-116.
37. Casey B.J., Glatt C.E., Tottenham N., Soliman F., Bath K., Amso D., et al. BDNF as a model system for examining gene by environment interactions across development. Neuroscience 2009, 164:108-120.
38. Richter-Schmidinger T., Alexopoulos P., Horn M., Maus S., Reichel M., Rhein C., et al. Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults. J Neural Transm 2010, 118:249-257.
39. Kauppi K., Nilsson L.G., Persson J., Nyberg L. Additive genetic effect of APOE and BDNF on hippocampus activity. Neuroimage 2014, 89:306-313.
40. Adamczuk K., De Weer A.-S., Nelissen N., Chen K., Sleegers K., Bettens K., et al. Polymorphism of brain derived neurotrophic factor influences beta amyloid load in cognitively intact apolipoprotein E e4 carriers. Neuroimage Clin 2013, 2:512-520.
41. Hashimoto R., Hirata Y., Asada T., Yamashita F., Nemoto K., Mori T., et al. Effect of the brain-derived neurotrophic factor and the apolipoprotein E polymorphisms on disease progression in preclinical Alzheimer's disease. Genes Brain Behav 2009, 8:43-52.
42. Harrisberger F., Spalek K., Smieskova R., Schmidt A., Coynel D., Milnik A., et al. The association of the BDNF Val66Met polymorphism and the hippocampal volumes in healthy humans A joint meta-analysis of published and new data. Neurosci Biobehav Rev 2014, 42:267-278.
43. Brandys M.K., Kas M.J.H., Van Elburg A.A., Ophoff R., Slof-op't Landt M.C.T., Middledorp C.M., et al. The Val66Met polymorphism of the BDNF gene in anorexia nervosa: new data and a meta-analysis. World J Biol Psychiatry 2013, 14:441-451.
44. Egger G., Liang G., Aparicio A., Jones P.A. Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004, 429:457-463.
45. Davies G., Tenesa A., Payton A., Yang J., Harris S.E., Liewald D., et al. Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Mol Psychiatry 2011, 16:996-1005.
46. Farmer J., Zhao X., Van Praag H., Wodke K., Gage F.H., Christie B.R. Effects of voluntary exercise of synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience 2004, 124:71-79.
47. Mattson M.P., Maudsley S., Martin B. BDNF and 5-HT A dynamicdue in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 2004, 27:589-594.
48. Vaynman S., Ying Z., Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 2004, 20:2580-2590.
49. Noble E.E., Mavanji V., Little M.R., Billington C.J., Kotz C.M., Wang C.F. Exercise reduces diet-induced cognitive decline and increases hippocampal brain-derived neurotrophic factor in CA3 neurons. Neurobiol Learn Mem 2014, 114:40-50.
50. Castellano J.M., Kim J., Stewart F.R., Jiang H., DeMattos R.B., Patterson B.W., et al. Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance. Sci Transl Med 2011, 3:1-21.
51. Liu Y., Paajanen T., Westman E., Zhang Y., Wahlund L.-O., Simmons A., et al. APOE e{open}2 allele is associated with larger regional cortical thicknesses and volumes. Dement Geriatr Cogn Disord 2010, 30:229-237.
52. Jorm A.F., Mather K.A., Butterworth P., Anstey K.J., Christensen H., Easteal S. APOE genotype and cognitive functioning in a large age-stratified population sample. Neuropsychology 2007, 21:1-8.
53. Small B.J., Basun H., Bäckman L. Three-year changes in cognitive performance as a function of apolipoprotein E genotype: evidence from very old adults without dementia. Psychol Aging 1998, 13:80-87.
54. Lu B., Nagappan G., Guan X., Nathan P.J., Wren P. BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nat Rev Neurosci 2013, 14:401-416.
55. Laing K.R., Mitchell D., Wersching H., Czira M.E., Berger K., Baune B.T. Brain-derived neurotrophic factor (BDNF) gene: a gender-specific role in cognitive function during normal cognitive aging of the MEMO-Study?. Age 2011, 34:1011-1022.