Complement C3a binding to its receptor as a negative modulator of Th2 response in liver injury in trichloroethylene-sensitized mice

Toxicology Letters

Volumn 229, Issue 1, 2014, Pages 229-239

  Wang, Feng ^a   Zha, Wan sheng ^a   Zhang, Jia xiang ^a   Li, Shu long ^a   Wang, Hui ^a   Ye, Liang ping ^a   Shen, Tong ^a   Wu, Chang hao ^b   Zhu, Qi xing ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

C3a; C3aR; Liver injury; Th2 cell; Trichloroethylene

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C3A RECEPTOR; COMPLEMENT COMPONENT C5B; COMPLEMENT RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 4; RECEPTOR BLOCKING AGENT; SB 290157; TRICHLOROETHYLENE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; KUPFFER CELL; LIVER FUNCTION; LIVER INJURY; LIVER NECROSIS; MOUSE; MOUSE MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; SKIN SENSITIZATION; SPLEEN; TH2 CELL; UPREGULATION;

C3A; C3AR; LIVER INJURY; TH2 CELL; TRICHLOROETHYLENE;

ANIMALS; ARGININE; BENZHYDRYL COMPOUNDS; COMPLEMENT ACTIVATION; COMPLEMENT C3A; COMPLEMENT C5B; DRUG-INDUCED LIVER INJURY; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOHISTOCHEMISTRY; INTERFERON-GAMMA; INTERLEUKIN-4; LIVER; LIVER FUNCTION TESTS; MICE; MICE, INBRED BALB C; RECEPTORS, COMPLEMENT; SKIN; SOLVENTS; TH2 CELLS; TRICHLOROETHYLENE;

EID: 84903639807     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.06.841     Document Type: Article

References (38)

1. Abbas A.K., Murphy K.M., Sher A. Functional diversity of helper T lymphocytes. Nature 1996, 383(6603):787-793.
2. Ames R.S., Lee D., Foley J.J., Jurewicz A.J., Tornetta M.A., Bautsch W., Settmacher B., Klos A., Erhard K.F., Cousins R.D., Sulpizio A.C., Hieble J.P., Mccafferty G., Ward K.W., Adams J.L., Bondinell W.E., Underwood D.C., Osborn R.R., Badger A.M., Sarau H.M. Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. J. Immunol. 2001, 166(10):6341-6348.
3. Baldwin W.M., Ota H., Rodriguez E.R. Complement in transplant rejection: diagnostic and mechanistic considerations. Springer Semin. Immunopathol. 2003, 25:181-197.
4. Bao L., Osawe I., Haas M., Quigg R.J. Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis. J. Immunol. 2005, 175(3):1947-1955.
5. Cai P., Konig R., Boor P.J., Kondraganti S., Kaphalia B.S., Khan M.F., Ansari G.A. Chronic exposure to trichloroethene causes early onset of SLE-like disease in female MRL+/+ mice. Toxicol. Appl. Pharmacol. 2008, 228(1):68-75.
6. Dillard P., Wetsel R.A., Drouin S.M. Complement C3a regulates Muc5ac expression by airway Clara cells independently of Th2 responses. Am. J. Respir. Crit. Care Med. 2007, 175(12):1250-1258.
7. Drouin S.M., Corry D.B., Hollman T.J., Kildsgaard J., Wetsel R.A. Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy. J. Immunol. 2002, 169(10):5233-5926.
8. Ducruet A.F., Hassid B.G., Mack W.J., Sosunov S.A., Otten M.L., Fusco D.J., Hickman Z.L., Kim G.H., Komotar R.J., Mocco J., Connolly E.S. C3a receptor modulation of granulocyte infiltration after murine focal cerebral ischemia is reperfusion dependent. J. Cereb. Blood Flow Metab. 2008, 28(5):1048-1058.
9. + T cell activation caused by trichloroethylene exposure. Toxicol. Sci. 2012, 127(1):169-178.
10. Gilbert K.M., Przybyla B., Pumford N.R., Han T., Fuscoe J., Schnackenberg L.K., Holland R.D., Doss J.C., MacMillan-Crow L.A., Blossom S.J. Delineating liver events in trichloroethylene-induced autoimmune hepatitis. Chem. Res. Toxicol. 2009, 22(4):626-632.
11. Goon A.T., Lee L.T., Tay Y.K., Yosipovitch G., Ng S.K., Giam Y.C. A case of trichloroethylene hypersen-sitivity syndrome. Arch. Dermatol. 2001, 137(3):274-276.
12. + T-cell activation and induction of autoimmune hepatitis following trichloroethylene treatment in MRL+/+ mice. Toxicol. Sci. 2000, 57(2):345-352.
13. Hartmann K., Henz B.M., Kruger-Krasagakes S., Kohl J., Burger R., Guhl S., Haase I., Lippert U., Zuberbier T. C3a and C5a stimulate chemotaxis of human mast cells. Blood 1997, 89(8):2863-2870.
14. Kocamemi B.A., Cecen F. Biological removal of the xenobiotic trichloroethylene (TCE) through cometabolism in nitrifying systems. Bioresour. Technol. 2010, 101(1):430-433.
15. Kwan W.H., van der Touw W., Heeger P.S. Complement regulation of T cell immunity. Immunol. Res. 2012, 54(1-3):247-253.
16. Lang J.T., Badea T.C., Wade R., Shin M.L. Sublytic terminal complement attack on myotubes decreases the expression of mRNAs encoding muscle-specific proteins. J. Neurochem. 1997, 68(4):1581-1589.
17. Legler D.F., Loetscher M., Jones S.A., Dahinden C.A., Arock M., Moser B. Expression of high- and low-affinity receptors for C3a on the human mast cell line, HMC-1. Eur. J. Immunol. 1996, 26(4):753-758.
18. Mamane Y., Chung Chan C., Lavallee G., Morin N., Xu L.J., Huang J., Gordon R., Thomas W., Lamb J., Schadt E.E., Kennedy B.P., Mancini J.A. The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation. Diabetes 2009, 58(9):2006-2017.
19. Markiewski M.M., Lambris J.D. The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am. J. Pathol. 2007, 171(3):715-727.
20. Nakajima T., Yamanoshita O., Kamijima M., Kishi R., Ichihara G. Generalized skin reactions in relation to trichloroethylene exposure: a review from the viewpoint of drug-metabolizing enzymes. J. Occup. Health 2003, 45(1):8-14.
21. Niebuhr M., Baumer W., Kietzmann M., Wichmann K., Heratizadeh A., Werfel T. Participation of complement 3a receptor (C3aR) in the sensitization phase of Th2 mediated allergic contact dermatitis. Exp. Dermatol. 2012, 21(1):52-56.
22. Nilsson G., Johnell M., Hammer C.H., Tiffany H.L., Nilsson K., Metcalfe D.D., Siegbahn A., Murphy P.M. C3a and C5a are chemotaxins for human mast-cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway. J. Immunol. 1996, 157(4):1693-1698.
23. Oreja-Guevara C., Ramos-Cejudo J., Aroeira L.S., Chamorro B., Diez-Tejedor E. TH1/TH2 cytokine profile in relapsing-remitting multiple sclerosis patients treated with Glatiramer acetate or Nataliumab. BMC Neurol. 2012, 12:95.
24. Pantucharoensri S., Boontee P., Likhitsan P., Padungtod C., Prasartsansoui S. Generalized eruption accompanied by hepatitis in two Thai metal cleaners exposed to trichloroethylene. Ind. Health 2004, 42(3):385-388.
25. Purdue M.P., Bakke B., Stewart P., De Roos A.J., Schenk M., Lynch C.F., Bernstein L., Morton L.M., Cerhan J.R., Severson R.K., Cozen W., Davis S., Rothman N., Hartge P., Colt J.S. A case-control study of occupational exposure to trichloroethylene and non-Hodgkin lymphoma. Environ. Health Perspect. 2011, 119(2):232-238.
26. Ratajczak J., Reca R., Kucia M., Majka M., Allendorf D.J., Baran J.T., Janowska-Wieczorek A., Wetsel R.A., Ross G.D., Ratajczak M.Z. Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow. Blood 2004, 103(6):2071-2078.
27. Ricklin D., Hajishengallis G., Yang K., Lambris J.D. Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 2010, 11(9):785-797.
28. Shen T., Zhu Q.X., Zhang H.F., Yang S., Zhang X.J. Trichloroethylene induced cutaneous irritation in BALB/c hairless mice: histopathological changes and oxidative damage. Toxicology 2008, 248(2-3):113-120.
29. Shirazi Y., Rus H.G., Macklin W.B., Shin M.L. Enhanced degradation of messenger RNA encoding myelin proteins by terminal complement complexes in oligodendrocytes. J. Immunol. 1993, 150(10):4581-4590.
30. Strey C.W., Markiewski M., Mastellos D., Tudoran R., Spruce L.A., Greenbaum L.E., Lambris J.D. The proinflammatory mediators C3a and C5a are essential for liver regeneration. J. Exp. Med. 2003, 198(6):913-923.
31. Tang X., Que B., Song X., Li S., Yang X., Wang H., Huang H., Kamijima M., Nakajima T., Lin Y., Li L. Characterization of liver injury associated with hypersensitive skin reactions induced by trichloroethylene in the guinea pig maximization test. J. Occup. Health 2008, 50(2):114-121.
32. Tegla C.A., Cudrici C., Patel S., Trippe 3rd R., Rus V., Niculescu F., Rus H. Membrane attack by complement: assembly and biology of terminal complement complexes. Immunol. Res. 2011, 51(1):45-60.
33. Wehner J., Morrell C.N., Reynolds T., Rodriguez E.R., Baldwin W.M. Antibody and complement in transplant vasculopathy. Circ. Res. 2007, 100(2):191-203.
34. Xu H., Zhu Q.X., Shen T., Yu J.F., Leng J. Changes in humoral immunity in sensitized guinea pigs exposed to trichloroethylene. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2012, 30(9):641-644.
35. Yu J.F., Leng J., Shen T., Zhou C.F., Xu H., Jiang T., Xu S.H., Zhu Q.X. Possible role of complement activation in renal impairment in trichloroethylene-sensitized guinea pigs. Toxicology 2012, 302(2-3):172-178.
36. Zhai Y., Busuttil R.W., Kupiec-Weglinski J.W. Liver ischemia and reperfusion injury: new insights into mechanisms of innate-adaptive immune-mediated tissue inflammation. Am. J. Transplant. 2011, 11(8):1563-1569.
37. Zhang J., Zha W., Wang F., Jiang T., Xu S., Yu J., Zhou C., Shen T., Wu C., Zhu Q. Complement activation and liver impairment in trichloroethylene-sensitized BALB/c mice. Int. J. Toxicol. 2013, 32(6):431-441.
38. Zhao N., Wang H.L., Yue F., Zeng Z.M., Li H.L., Huang Y.S., Chen R.T. Studying the changes of the related serum complement immune indexes in patients with occupational medicamentosa-like dermatitis induced by trichloroethylene and workers occupationally exposed to trichloroethylene. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2012, 30(4):284-288.