메뉴 건너뛰기




Volumn 12, Issue , 2012, Pages

TH1/TH2 Cytokine profile in relapsing-remitting multiple sclerosis patients treated with Glatiramer acetate or Natalizumab

Author keywords

Cytokines; Glatiramer acetate; Multiple sclerosis; Natalizumab; Th1; Th2

Indexed keywords

GAMMA INTERFERON; GLATIRAMER; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; NATALIZUMAB; TUMOR NECROSIS FACTOR ALPHA;

EID: 84866306371     PISSN: None     EISSN: 14712377     Source Type: Journal    
DOI: 10.1186/1471-2377-12-95     Document Type: Article
Times cited : (108)

References (39)
  • 1
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • 10.1146/annurev.immunol.23.021704.115707, 15771584
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005, 23:683-747. 10.1146/annurev.immunol.23.021704.115707, 15771584.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 2
    • 5344228374 scopus 로고    scopus 로고
    • Multiple sclerosis is an inflammatory T-cell-mediated autoimmune disease
    • 10.1001/archneur.61.10.1613, 15477521
    • Weiner HL. Multiple sclerosis is an inflammatory T-cell-mediated autoimmune disease. Arch Neurol 2004, 61:1613-1615. 10.1001/archneur.61.10.1613, 15477521.
    • (2004) Arch Neurol , vol.61 , pp. 1613-1615
    • Weiner, H.L.1
  • 3
    • 54849131500 scopus 로고    scopus 로고
    • Therapeutic targeting of chemokine signaling in Multiple Sclerosis
    • 10.1016/j.jns.2008.07.005, 18706659
    • Hamann I, Zipp F, Infante-Duarte C. Therapeutic targeting of chemokine signaling in Multiple Sclerosis. J Neurol Sci 2008, 274:31-38. 10.1016/j.jns.2008.07.005, 18706659.
    • (2008) J Neurol Sci , vol.274 , pp. 31-38
    • Hamann, I.1    Zipp, F.2    Infante-Duarte, C.3
  • 4
    • 30344437881 scopus 로고    scopus 로고
    • The expression and function of chemokines involved in CNS inflammation
    • 10.1016/j.tips.2005.11.002, 16310865
    • Ubogu EE, Cossoy MB, Ransohoff RM. The expression and function of chemokines involved in CNS inflammation. Trends Pharmacol Sci 2006, 27:48-55. 10.1016/j.tips.2005.11.002, 16310865.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 48-55
    • Ubogu, E.E.1    Cossoy, M.B.2    Ransohoff, R.M.3
  • 5
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • 10.1038/nri954, 12461566
    • Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nat Rev Immunol 2002, 2:933-944. 10.1038/nri954, 12461566.
    • (2002) Nat Rev Immunol , vol.2 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 6
    • 0038243261 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis: cytokines, effector T cells, and antigen-presenting cells in a prototypical Th1-mediated autoimmune disease
    • 10.1007/s11882-003-0017-6, 12543000
    • Segal BM. Experimental autoimmune encephalomyelitis: cytokines, effector T cells, and antigen-presenting cells in a prototypical Th1-mediated autoimmune disease. Curr Allergy Asthma Rep 2003, 3:86-93. 10.1007/s11882-003-0017-6, 12543000.
    • (2003) Curr Allergy Asthma Rep , vol.3 , pp. 86-93
    • Segal, B.M.1
  • 7
    • 0029410743 scopus 로고
    • Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis
    • 2230017, 8612196
    • Vartanian T, Li Y, Zhao M, Stefansson K. Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis. Mol Med 1995, 1:732-743. 2230017, 8612196.
    • (1995) Mol Med , vol.1 , pp. 732-743
    • Vartanian, T.1    Li, Y.2    Zhao, M.3    Stefansson, K.4
  • 8
    • 0025773147 scopus 로고
    • Association between tumor necrosis factor-alpha and disease progression in patients with multiple sclerosis
    • 10.1056/NEJM199108153250704, 1852181
    • Sharief MK, Hentges R. Association between tumor necrosis factor-alpha and disease progression in patients with multiple sclerosis. N Engl J Med 1991, 325:467-472. 10.1056/NEJM199108153250704, 1852181.
    • (1991) N Engl J Med , vol.325 , pp. 467-472
    • Sharief, M.K.1    Hentges, R.2
  • 9
    • 2642514600 scopus 로고    scopus 로고
    • Bio-markers of disease activity and response to therapy in multiple sclerosis
    • 10.1016/j.clineuro.2004.02.008, 15177778
    • Miller A, Glass-Marmor L, Abraham M, Grossman I, Shapiro S, Galboiz Y. Bio-markers of disease activity and response to therapy in multiple sclerosis. Clin Neurol Neurosurg 2004, 106:249-254. 10.1016/j.clineuro.2004.02.008, 15177778.
    • (2004) Clin Neurol Neurosurg , vol.106 , pp. 249-254
    • Miller, A.1    Glass-Marmor, L.2    Abraham, M.3    Grossman, I.4    Shapiro, S.5    Galboiz, Y.6
  • 10
    • 18044382584 scopus 로고    scopus 로고
    • Cytokines in multiple sclerosis: from bench to bedside
    • 10.1016/j.pharmthera.2004.11.007, 15866318
    • Imitola J, Chitnis T, Khoury SJ. Cytokines in multiple sclerosis: from bench to bedside. Pharmacol Ther 2005, 106:163-177. 10.1016/j.pharmthera.2004.11.007, 15866318.
    • (2005) Pharmacol Ther , vol.106 , pp. 163-177
    • Imitola, J.1    Chitnis, T.2    Khoury, S.J.3
  • 11
    • 0035045852 scopus 로고    scopus 로고
    • Antigen specific immunotherapy of multiple sclerosis
    • 10.1023/A:1011020225433, 11332658
    • Steinman L, Conlon P. Antigen specific immunotherapy of multiple sclerosis. J Clin Immunol 2001, 21:93-98. 10.1023/A:1011020225433, 11332658.
    • (2001) J Clin Immunol , vol.21 , pp. 93-98
    • Steinman, L.1    Conlon, P.2
  • 12
    • 0029082566 scopus 로고
    • Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. The Copolymer 1 Multiple Sclerosis Study Group
    • 10.1212/WNL.45.7.1268, 7617181
    • Johnson KP, Brooks BR, Cohen JA, Ford CC, Goldstein J, Lisak RP, Myers LW, Panitch HS, Rose JW, Schiffer RB. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. The Copolymer 1 Multiple Sclerosis Study Group. Neurology 1995, 45:1268-1276. 10.1212/WNL.45.7.1268, 7617181.
    • (1995) Neurology , vol.45 , pp. 1268-1276
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3    Ford, C.C.4    Goldstein, J.5    Lisak, R.P.6    Myers, L.W.7    Panitch, H.S.8    Rose, J.W.9    Schiffer, R.B.10
  • 14
    • 3042753839 scopus 로고    scopus 로고
    • Time-dependent cytokine deviation toward the Th2 side in Japanese multiple sclerosis patients with interferon beta-1b
    • 10.1016/j.jns.2004.04.012, 15240198
    • Ochi H, Feng-Jun M, Osoegawa M, Minohara M, Murai H, Taniwaki T, Kira J. Time-dependent cytokine deviation toward the Th2 side in Japanese multiple sclerosis patients with interferon beta-1b. J Neurol Sci 2004, 222:65-73. 10.1016/j.jns.2004.04.012, 15240198.
    • (2004) J Neurol Sci , vol.222 , pp. 65-73
    • Ochi, H.1    Feng-Jun, M.2    Osoegawa, M.3    Minohara, M.4    Murai, H.5    Taniwaki, T.6    Kira, J.7
  • 16
    • 46849101948 scopus 로고    scopus 로고
    • Increased IL-10 mRNA and IL-23 mRNA expression in multiple sclerosis: interferon-beta treatment increases IL-10 mRNA expression while reducing IL-23 mRNA expression
    • 10.1177/1352458507087136, 18424480
    • Krakauer M, Sorensen P, Khademi M, Olsson T, Sellebjerg F. Increased IL-10 mRNA and IL-23 mRNA expression in multiple sclerosis: interferon-beta treatment increases IL-10 mRNA expression while reducing IL-23 mRNA expression. Mult Scler 2008, 14:622-630. 10.1177/1352458507087136, 18424480.
    • (2008) Mult Scler , vol.14 , pp. 622-630
    • Krakauer, M.1    Sorensen, P.2    Khademi, M.3    Olsson, T.4    Sellebjerg, F.5
  • 17
    • 34447529095 scopus 로고    scopus 로고
    • Glatiramer acetate: mechanisms of action in multiple sclerosis
    • 10.1016/j.autrev.2007.02.003, 17643935
    • Schrempf W, Ziemssen T. Glatiramer acetate: mechanisms of action in multiple sclerosis. Autoimmun Rev 2007, 6:469-475. 10.1016/j.autrev.2007.02.003, 17643935.
    • (2007) Autoimmun Rev , vol.6 , pp. 469-475
    • Schrempf, W.1    Ziemssen, T.2
  • 18
    • 2642521060 scopus 로고    scopus 로고
    • IFN-beta1a and IFN-beta1b have different patterns of influence on cytokines
    • 10.1016/j.clineuro.2004.02.010, 15177779
    • Sega S, Wraber B, Mesec A, Horvat A, Ihan A. IFN-beta1a and IFN-beta1b have different patterns of influence on cytokines. Clin Neurol Neurosurg 2004, 106:255-258. 10.1016/j.clineuro.2004.02.010, 15177779.
    • (2004) Clin Neurol Neurosurg , vol.106 , pp. 255-258
    • Sega, S.1    Wraber, B.2    Mesec, A.3    Horvat, A.4    Ihan, A.5
  • 19
    • 0034041863 scopus 로고    scopus 로고
    • Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis
    • 10.1172/JCI8970, 377485, 10749576
    • Duda PW, Schmied MC, Cook SL, Krieger JI, Hafler DA. Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. J Clin Invest 2000, 105:967-976. 10.1172/JCI8970, 377485, 10749576.
    • (2000) J Clin Invest , vol.105 , pp. 967-976
    • Duda, P.W.1    Schmied, M.C.2    Cook, S.L.3    Krieger, J.I.4    Hafler, D.A.5
  • 20
    • 23744480760 scopus 로고    scopus 로고
    • Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action
    • 10.1016/S1474-4422(05)70167-8, 16109363
    • Farina C, Weber MS, Meinl E, Wekerle H, Hohlfeld R. Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action. Lancet Neurol 2005, 4:567-575. 10.1016/S1474-4422(05)70167-8, 16109363.
    • (2005) Lancet Neurol , vol.4 , pp. 567-575
    • Farina, C.1    Weber, M.S.2    Meinl, E.3    Wekerle, H.4    Hohlfeld, R.5
  • 21
    • 0034691165 scopus 로고    scopus 로고
    • Multiple sclerosis: comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells
    • 10.1073/pnas.97.13.7452, 16566, 10861011
    • Neuhaus O, Farina C, Yassouridis A, Wiendl H, Then BF, Dose T, Wekerle H, Hohlfeld R. Multiple sclerosis: comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells. Proc Natl Acad Sci USA 2000, 97:7452-7457. 10.1073/pnas.97.13.7452, 16566, 10861011.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7452-7457
    • Neuhaus, O.1    Farina, C.2    Yassouridis, A.3    Wiendl, H.4    Then, B.F.5    Dose, T.6    Wekerle, H.7    Hohlfeld, R.8
  • 22
    • 0037406714 scopus 로고    scopus 로고
    • Glatiramer acetate (copolymer-1, copaxone) promotes Th2 cell development and increased IL-10 production through modulation of dendritic cells
    • Vieira PL, Heystek HC, Wormmeester J, Wierenga EA, Kapsenberg ML. Glatiramer acetate (copolymer-1, copaxone) promotes Th2 cell development and increased IL-10 production through modulation of dendritic cells. J Immunol 2003, 170:4483-4488.
    • (2003) J Immunol , vol.170 , pp. 4483-4488
    • Vieira, P.L.1    Heystek, H.C.2    Wormmeester, J.3    Wierenga, E.A.4    Kapsenberg, M.L.5
  • 26
    • 17644398787 scopus 로고    scopus 로고
    • Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale
    • 10.1212/01.WNL.0000158329.30470.D0, 15851719
    • Rice GP, Hartung HP, Calabresi PA. Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale. Neurology 2005, 64:1336-1342. 10.1212/01.WNL.0000158329.30470.D0, 15851719.
    • (2005) Neurology , vol.64 , pp. 1336-1342
    • Rice, G.P.1    Hartung, H.P.2    Calabresi, P.A.3
  • 27
    • 76449087805 scopus 로고    scopus 로고
    • Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid
    • 10.1177/1352458509355068, 20007431
    • Mellergard J, Edstrom M, Vrethem M, Ernerudh J, Dahle C. Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid. Mult Scler 2010, 16:208-217. 10.1177/1352458509355068, 20007431.
    • (2010) Mult Scler , vol.16 , pp. 208-217
    • Mellergard, J.1    Edstrom, M.2    Vrethem, M.3    Ernerudh, J.4    Dahle, C.5
  • 28
    • 80555150830 scopus 로고    scopus 로고
    • Treatment with natalizumab in relapsing-remitting multiple sclerosis patients induces changes in inflammatory mechanism
    • 10.1007/s10875-011-9522-x, 3155864, 21491095
    • Ramos-Cejudo J, Oreja-Guevara C, Stark AL, de Rodriguez AL, Chamorro B, Diez-Tejedor E. Treatment with natalizumab in relapsing-remitting multiple sclerosis patients induces changes in inflammatory mechanism. J Clin Immunol 2011, 31:623-631. 10.1007/s10875-011-9522-x, 3155864, 21491095.
    • (2011) J Clin Immunol , vol.31 , pp. 623-631
    • Ramos-Cejudo, J.1    Oreja-Guevara, C.2    Stark, A.L.3    de Rodriguez, A.L.4    Chamorro, B.5    Diez-Tejedor, E.6
  • 30
    • 0035049725 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with Copaxone (COP): Elispot assay detects COP-induced interleukin-4 and interferon-gamma response in blood cells
    • 10.1093/brain/124.4.705, 11287371
    • Farina C, Then BF, Albrecht H, Meinl E, Yassouridis A, Neuhaus O, Hohlfeld R. Treatment of multiple sclerosis with Copaxone (COP): Elispot assay detects COP-induced interleukin-4 and interferon-gamma response in blood cells. Brain 2001, 124:705-719. 10.1093/brain/124.4.705, 11287371.
    • (2001) Brain , vol.124 , pp. 705-719
    • Farina, C.1    Then, B.F.2    Albrecht, H.3    Meinl, E.4    Yassouridis, A.5    Neuhaus, O.6    Hohlfeld, R.7
  • 31
    • 34447536807 scopus 로고    scopus 로고
    • Clinical response to glatiramer acetate correlates with modulation of IFN-gamma and IL-4 expression in multiple sclerosis
    • 10.1177/1352458506074510, 17613604
    • Valenzuela RM, Costello K, Chen M, Said A, Johnson KP, Dhib-Jalbut S. Clinical response to glatiramer acetate correlates with modulation of IFN-gamma and IL-4 expression in multiple sclerosis. Mult Scler 2007, 13:754-762. 10.1177/1352458506074510, 17613604.
    • (2007) Mult Scler , vol.13 , pp. 754-762
    • Valenzuela, R.M.1    Costello, K.2    Chen, M.3    Said, A.4    Johnson, K.P.5    Dhib-Jalbut, S.6
  • 34
    • 39149138486 scopus 로고    scopus 로고
    • Induction of systemic TNFalpha in natalizumab-treated multiple sclerosis
    • 10.1111/j.1468-1331.2007.02037.x, 18190511
    • Khademi M, Stol D, Olsson T, Wallstrom E. Induction of systemic TNFalpha in natalizumab-treated multiple sclerosis. Eur J Neurol 2008, 15:309-312. 10.1111/j.1468-1331.2007.02037.x, 18190511.
    • (2008) Eur J Neurol , vol.15 , pp. 309-312
    • Khademi, M.1    Stol, D.2    Olsson, T.3    Wallstrom, E.4
  • 35
    • 62849098757 scopus 로고    scopus 로고
    • The effects of natalizumab on inflammatory mediators in multiple sclerosis: prospects for treatment-sensitive biomarkers
    • 10.1111/j.1468-1331.2009.02532.x, 19220425
    • Khademi M, Bornsen L, Rafatnia F, Andersson M, Brundin L, Piehl F, Sellebjerg F, Olsson T. The effects of natalizumab on inflammatory mediators in multiple sclerosis: prospects for treatment-sensitive biomarkers. Eur J Neurol 2009, 16:528-536. 10.1111/j.1468-1331.2009.02532.x, 19220425.
    • (2009) Eur J Neurol , vol.16 , pp. 528-536
    • Khademi, M.1    Bornsen, L.2    Rafatnia, F.3    Andersson, M.4    Brundin, L.5    Piehl, F.6    Sellebjerg, F.7    Olsson, T.8
  • 36
    • 67650032747 scopus 로고    scopus 로고
    • Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells
    • 10.1212/WNL.0b013e3181a8266f, 2690969, 19487650
    • Kivisakk P, Healy BC, Viglietta V, Quintana FJ, Hootstein MA, Weiner HL, Khoury SJ. Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells. Neurology 2009, 72:1922-1930. 10.1212/WNL.0b013e3181a8266f, 2690969, 19487650.
    • (2009) Neurology , vol.72 , pp. 1922-1930
    • Kivisakk, P.1    Healy, B.C.2    Viglietta, V.3    Quintana, F.J.4    Hootstein, M.A.5    Weiner, H.L.6    Khoury, S.J.7
  • 37
    • 22844445230 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy in a patient treated with natalizumab
    • 10.1056/NEJMoa051847, 15947078
    • Langer-Gould A, Atlas SW, Green AJ, Bollen AW, Pelletier D. Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med 2005, 353:375-381. 10.1056/NEJMoa051847, 15947078.
    • (2005) N Engl J Med , vol.353 , pp. 375-381
    • Langer-Gould, A.1    Atlas, S.W.2    Green, A.J.3    Bollen, A.W.4    Pelletier, D.5
  • 38
    • 41549130359 scopus 로고    scopus 로고
    • Postwithdrawal rebound increase in T2 lesional activity in natalizumab-treated MS patients
    • Vellinga MM, Castelijns JA, Barkhof F, Uitdehaag BM, Polman CH. Postwithdrawal rebound increase in T2 lesional activity in natalizumab-treated MS patients. Neurology 2008, 70:1150-1151.
    • (2008) Neurology , vol.70 , pp. 1150-1151
    • Vellinga, M.M.1    Castelijns, J.A.2    Barkhof, F.3    Uitdehaag, B.M.4    Polman, C.H.5
  • 39
    • 61549089098 scopus 로고    scopus 로고
    • Natalizumab: bound to rebound?
    • 10.1212/01.wnl.0000341783.33962.5b, 19188569
    • Schiess N, Calabresi PA. Natalizumab: bound to rebound?. Neurology 2009, 72:392-393. 10.1212/01.wnl.0000341783.33962.5b, 19188569.
    • (2009) Neurology , vol.72 , pp. 392-393
    • Schiess, N.1    Calabresi, P.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.