Proteome-based systems biology analysis of the diabetic mouse aorta reveals major changes in fatty acid biosynthesis as potential hallmark in diabetes mellitus-associated vascular disease

Circulation: Cardiovascular Genetics

Volumn 7, Issue 2, 2014, Pages 161-170

  Husi, Holger ^a   Van Agtmael, Tom ^a   Mullen, William ^a   Bahlmann, Ferdinand H ^b   Schanstra, Joost P ^c   Vlahou, Antonia ^d,e   Delles, Christian ^a   Perco, Paul ^f   Mischak, Harald ^a,g  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b SAARLAND UNIVERSITY   (Germany)

^c Departments of Clinical Biochemistry and Sports Medicine   (France)

^d BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^e UNIVERSITY OF PLYMOUTH   (United Kingdom)

^f Emergentec Biodevelopment GmbH   (Austria)

^g MOSAIQUES DIAGNOSTICS GMBH   (Germany)

Author keywords

Aorta; Blood supply; Diabetes mellitus; Ketone bodies; Muscles; Proteomics; Smooth muscle; Systems biology

Indexed keywords

ALCOHOL DERIVATIVE; AMINO ACID; ASPARTATE AMINOTRANSFERASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP DEPENDENT PROTEIN KINASE; FATTY ACID; FILAMIN A; GLUCAGON; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYACID OXOACID TRANSHYDROGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KETONE BODY; LACTIC ACID; MYOSIN II; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; PERIPHERIN; PROTEOME; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA INTIMA; ARTICLE; BIOINFORMATICS; CITRIC ACID CYCLE; CONTROLLED STUDY; DIABETIC ANGIOPATHY; DISEASE ASSOCIATION; DOWN REGULATION; ENERGY METABOLISM; FATTY ACID SYNTHESIS; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPERTENSION; HYPERTROPHY; MALE; MOUSE; MUSCLE DEVELOPMENT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; SYSTEMS BIOLOGY; UPREGULATION; VASCULARIZATION; ANIMAL; AORTA; ATHEROSCLEROSIS; BIOSYNTHESIS; C57BL MOUSE; CHEMISTRY; COMPLICATION; EXPERIMENTAL DIABETES MELLITUS; GENETICS; HUMAN; METABOLISM; PROTEOMICS;

ANIMALS; AORTA; ATHEROSCLEROSIS; DIABETES MELLITUS, EXPERIMENTAL; FATTY ACIDS; HUMANS; KETONE BODIES; MALE; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, INBRED C57BL; PROTEOME; PROTEOMICS; SYSTEMS BIOLOGY;

EID: 84903635065     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.113.000196     Document Type: Article

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