Overexpression of FABP3 promotes apoptosis through inducing mitochondrial impairment in embryonic cancer cells

Journal of Cellular Biochemistry

Volumn 113, Issue 12, 2012, Pages 3701-3708

  Song, Gui Xian ^a   Shen, Ya Hui ^a   Liu, Yao Qiu ^a   Sun, Wei ^a   Miao, Li Ping ^a   Zhou, Li Juan ^a   Liu, Hai Lang ^a   Yang, Rong ^a   Kong, Xiang Qing ^a   Cao, Ke Jiang ^a   Qian, Ling Mei ^a   Sheng, Yan Hui ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

CONGENITAL HEART DISEASE; FABP3; MITOCHONDRION; P19 CELL

Indexed keywords

ADENOSINE TRIPHOSPHATE; FATTY ACID BINDING PROTEIN; FATTY ACID BINDING PROTEIN 3; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; EMBRYO CELL; GENE DOSAGE; GENE OVEREXPRESSION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SURVIVAL; DNA, MITOCHONDRIAL; EMBRYO, MAMMALIAN; EMBRYONAL CARCINOMA STEM CELLS; FATTY ACID-BINDING PROTEINS; GENE DOSAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL SIZE; OXIDATION-REDUCTION; PROTEIN STABILITY; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84867504485     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24243     Document Type: Article

References (31)

1. Andreyev AY, Kushnareva YE, Starkov AA,. 2005. Mitochondrial metabolism of reactive oxygen species. Biochemistry (Mosc) 70: 200-214.
2. Bajolle F, Zaffran S, Bonnet D,. 2009. Genetics and embryological mechanisms of congenital heart diseases. Arch Cardiovasc Dis 102: 59-63.
3. Besnard P, Niot I, Poirier H, Clement L, Bernard A,. 2002. New insights into the fatty acid-binding protein (FABP) family in the small intestine. Mol Cell Biochem 239: 139-147.
4. Bishopric NH, Andreka P, Slepak T, Webster KA,. 2001. Molecular mechanisms of apoptosis in the cardiac myocyte. Curr Opin Pharmacol 1: 141-150.
5. Brown GC,. 1992. Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem J 284 (Pt 1): 1-13.
6. Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG,. 2001. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 106: 709-721.
7. Choksi KB, Boylston WH, Rabek JP, Widger WR, Papaconstantinou J,. 2004. Oxidatively damaged proteins of heart mitochondrial electron transport complexes. Biochim Biophys Acta 1688: 95-101.
8. Crow MT, Mani K, Nam YJ, Kitsis RN,. 2004. The mitochondrial death pathway and cardiac myocyte apoptosis. Circ Res 95: 957-970.
9. Fisher SA, Langille BL, Srivastava D,. 2000. Apoptosis during cardiovascular development. Circ Res 87: 856-864.
10. Hoye AT, Davoren JE, Wipf P, Fink MP, Kagan VE,. 2008. Targeting mitochondria. Acc Chem Res 41: 87-97.
11. Kaaman M, Sparks LM, van Harmelen V, Smith SR, Sjolin E, Dahlman I, Arner P,. 2007. Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue. Diabetologia 50: 2526-2533.
12. Katakam PV, Jordan JE, Snipes JA, Tulbert CD, Miller AW, Busija DW,. 2007. Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance. Am J Physiol Regul Integr Comp Physiol 292: R920-R926.
13. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X,. 1997. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489.
14. Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RP,. 1993. Nkx-2.5: A novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119: 419-431.
15. Mannella CA,. 2006. Structure and dynamics of the mitochondrial inner membrane cristae. Biochim Biophys Acta 1763: 542-548.
16. Maxwell DP, Wang Y, McIntosh L,. 1999. The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells. Proc Natl Acad Sci USA 96: 8271-8276.
17. Nemer M,. 2008. Genetic insights into normal and abnormal heart development. Cardiovasc Pathol 17: 48-54.
18. Oh H, Schneider MD,. 2002. The emerging role of telomerase in cardiac muscle cell growth and survival. J Mol Cell Cardiol 34: 717-724.
19. Olson EN,. 2006. Gene regulatory networks in the evolution and development of the heart. Science 313: 1922-1927.
20. Poelmann RE, Gittenberger-de GA,. 2005. Apoptosis as an instrument in cardiovascular development. Birth Defects Res C Embryo Today 75: 305-313.
21. Qian Q, Kuo L, Yu YT, Rottman JN,. 1999. A concise promoter region of the heart fatty acid-binding protein gene dictates tissue-appropriate expression. Circ Res 84: 276-289.
22. Robin ED, Wong R,. 1988. Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells. J Cell Physiol 136: 507-513.
23. Singh MK, Li Y, Li S, Cobb RM, Zhou D, Lu MM, Epstein JA, Morrisey EE, Gruber PJ,. 2010. Gata4 and Gata5 cooperatively regulate cardiac myocyte proliferation in mice. J Biol Chem 285: 1765-1772.
24. Skulachev VP,. 1999. Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms. Mol Aspects Med 20: 139-184.
25. Tanaka T, Hosoi F, Yamaguchi-Iwai Y, Nakamura H, Masutani H, Ueda S, Nishiyama A, Takeda S, Wada H, Spyrou G, Yodoi J,. 2002. Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. EMBO J 21: 1695-1703.
26. Tang MK, Kindler PM, Cai DQ, Chow PH, Li M, Lee KK,. 2004. Heart-type fatty acid binding proteins are upregulated during terminal differentiation of mouse cardiomyocytes, as revealed by proteomic analysis. Cell Tissue Res 316: 339-347.
27. Thompson CB,. 1995. Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462.
28. van der Heyden MA, van Kempen MJ, Tsuji Y, Rook MB, Jongsma HJ, Opthof T,. 2003. P19 embryonal carcinoma cells: A suitable model system for cardiac electrophysiological differentiation at the molecular and functional level. Cardiovasc Res 58: 410-422.
29. Yu T, Robotham JL, Yoon Y,. 2006. Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci USA 103: 2653-2658.
30. Zhang H, Zhou L, Yang R, Sheng Y, Sun W, Kong X, Cao K,. 2006. Identification of differentially expressed genes in human heart with ventricular septal defect using suppression subtractive hybridization. Biochem Biophys Res Commun 342: 135-144.
31. Zhu C, Hu DL, Liu YQ, Zhang QJ, Chen FK, Kong XQ, Cao KJ, Zhang JS, Qian LM,. 2011. Fabp3 inhibits proliferation and promotes apoptosis of embryonic myocardial cells. Cell Biochem Biophys 60: 259-266.