Deuterohemin-AlaHisLys mitigates the symptoms of rats with non-insulin dependent diabetes mellitus by scavenging reactive oxygen species and activating the PI3-K/AKT signal transduction pathway

Chemico-Biological Interactions

Volumn 220, Issue , 2014, Pages 64-74

  Lei, Liyan ^a   Zhang, Guangji ^a   Li, Pengfei ^b   Zhang, Yuan ^a   Guo, Youming ^a   Zhang, Wenqi ^a   Zhang, Wenbo ^a   Hu, Bing ^a   Wang, Liping ^a  

^a JILIN UNIVERSITY   (China)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Deuterohemin AlaHisLys; Non insulin dependent diabetes mellitus; PI3 K AKT pathway; ROS

Indexed keywords

ANTIDIABETIC AGENT; DEUTEROHEMIN ALANYLHISTIDYLLYSINE; MALONALDEHYDE; METFORMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; DEUTEROHEMIN-ALAHISLYS; METALLOPORPHYRIN; OLIGOPEPTIDE; ONCOPROTEIN; GLUCOSE; PEROXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; HYPERGLYCEMIA; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PANCREAS ISLET; RAT; SIGNAL TRANSDUCTION; SYMPTOM; UPREGULATION; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; METABOLISM; PANCREAS; WESTERN BLOTTING; AMINO ACID COMPOSITION; DOSE RESPONSE; DRUG EFFICACY; GLUCOSE BLOOD LEVEL; PANCREAS ISLET DISEASE; TISSUE LEVEL;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; MALE; METALLOPORPHYRINS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; ONCOGENE PROTEIN V-AKT; PANCREAS; PHOSPHATIDYLINOSITOL 3-KINASES; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84903610844     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.05.008     Document Type: Article

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