Familial transmission of venous thromboembolism a cohort study of 80 214 swedish adoptees linked to their biological and adoptive parents

Circulation: Cardiovascular Genetics

Volumn 7, Issue 3, 2014, Pages 296-303

  Zöller, Bengt ^a   Li, Xinjun ^a   Sundquist, Jan ^a,b   Sundquist, Kristina ^a,b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Epidemiology; Pulmonary embolism; Venous thromboembolism; Venous thrombosis

Indexed keywords

ADOPTIVE PARENT; ADULT; ARTICLE; DISEASE TRANSMISSION; ENVIRONMENTAL FACTOR; FEMALE; HEREDITY; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PARENT; PRIORITY JOURNAL; RISK FACTOR; STANDARDIZED INCIDENCE RATIO; VENOUS THROMBOEMBOLISM; ADOLESCENT; ADOPTION; AGED; CHILD; COHORT ANALYSIS; FAMILY; GENETICS; INCIDENCE; MIDDLE AGED; SWEDEN; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADOPTION; ADULT; AGED; AGED, 80 AND OVER; CHILD; COHORT STUDIES; FAMILY; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PARENTS; RISK FACTORS; SWEDEN; VENOUS THROMBOEMBOLISM; YOUNG ADULT;

EID: 84903607405     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.113.000341     Document Type: Article

References (50)

1. Anderson FA, Jr., Wheeler HB, Goldberg RJ, Hosmer DW, Forcier A. The prevalence of risk factors for venous thromboembolism among hospital patients. Arch Intern Med. 1992;152:1660-1664.
2. Nordström M, Lindblad B, Bergqvist D, Kjellström T. A prospective study of the incidence of deep-vein thrombosis within a defined urban population. J Intern Med. 1992;232:155-160.
3. Silverstein MD, Heit JA, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ 3rd. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med. 1998;158:585-593.
4. Briggs JB. Recurring phlebitis of obscure origins. Johns Hopkins Hosp Bull. 1905:16;228.
5. Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet. 1999;353: 1167-1173.
6. Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A. 1993;90:1004-1008.
7. Briët E, van der Meer FJ, Rosendaal FR, Houwing-Duistermaat JJ, van Houwelingen HC. The family history and inherited thrombophilia. Br J Haematol. 1994;87:348-352.
8. Cosmi B, Legnani C, Bernardi F, Coccheri S, Palareti G. Value of family history in identifying women at risk of venous thromboembolism during oral contraception: observational study. BMJ. 2001;322:1024-1025.
9. Aznar J, Mira Y, Vayá A, Ferrando F, Villa P. Is family history sufficient to identify women with risk of venous thromboembolism before commencing the contraceptive pill? Clin Appl Thromb Hemost. 2002;8:139-141.
10. van Sluis GL, Söhne M, El Kheir DY, Tanck MW, Gerdes VE, Büller HR. Family history and inherited thrombophilia. J Thromb Haemost. 2006;4:2182-2187.
11. Dietrich JE, Hertweck SP, Perlman SE. Efficacy of family history in determining thrombophilia risk. J Pediatr Adolesc Gynecol. 2007;20:221-224.
12. Bezemer ID, van der Meer FJ, Eikenboom JC, Rosendaal FR, Doggen CJ. The value of family history as a risk indicator for venous thrombosis. Arch Intern Med. 2009;169:610-615.
13. Burton PR, Tobin MD, Hopper JL. Key concepts in genetic epidemiology. Lancet. 2005;366:941-951.
14. Noboa S, Le Gal G, Lacut K, Mercier B, Leroyer C, Nowak E, et al; EDITH Collaborative Study Group. Family history as a risk factor for venous thromboembolism. Thromb Res. 2008;122:624-629.
15. Dowling NF, Austin H, Dilley A, Whitsett C, Evatt BL, Hooper WC. The epidemiology of venous thromboembolism in Caucasians and African-Americans: the GATE Study. J Thromb Haemost. 2003;1:80-87.
16. Couturaud F, Leroyer C, Julian JA, Kahn SR, Ginsberg JS, Wells PS, et al. Factors that predict risk of thrombosis in relatives of patients with unprovoked venous thromboembolism. Chest. 2009;136:1537-1545.
17. Zöller B, Li X, Sundquist J, Sundquist K. Parental history and venous thromboembolism: a nationwide study of age and sex-specific familial risks in Sweden. J Thromb Haemost. 2011; 9:64-70.
18. Zöller B, Li X, Sundquist J, Sundquist K. Familial risks of unusual forms of venous thrombosis: a nationwide epidemiological study in Sweden. J Intern Med. 2011;270:158-165.
19. Sørensen HT, Riis AH, Diaz LJ, Andersen EW, Baron JA, Andersen PK. Familial risk of venous thromboembolism: a nationwide cohort study. J Thromb Haemost. 2011;9:320-324.
20. Rosendaal FR, Reitsma PH. Genetics of venous thrombosis. J Thromb Haemost. 2009;7(suppl 1):301-304.
21. Trégouët DA, Heath S, Saut N, Biron-Andreani C, Schved JF, Pernod G, et al. Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. Blood. 2009;113:5298-5303.
22. Bezemer ID, Bare LA, Doggen CJ, Arellano AR, Tong C, Rowland CM, et al. Gene variants associated with deep vein thrombosis. JAMA. 2008;299:1306-1314.
23. Gohil R, Peck G, Sharma P. The genetics of venous thromboembolism. A meta-Analysis involving 120,000 cases and 180,000 controls. Thromb Haemost. 2009;102:360-370.
24. Buil A, Trégouët DA, Souto JC, Saut N, Germain M, Rotival M, et al. C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies. Blood. 2010;115:4644-4650.
25. Morange PE, Bezemer I, Saut N, Bare L, Burgos G, Brocheton J, et al. A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1. Am J Hum Genet. 2010;86:592-595.
26. Bezemer ID, Bare LA, Arellano AR, Reitsma PH, Rosendaal FR. Updated analysis of gene variants associated with deep vein thrombosis. JAMA. 2010;303:421-422.
27. Hemminki K, Bermejo JL. Constraints for genetic association studies imposed by attributable fraction and familial risk. Carcinogenesis. 2007;28:648-656.
28. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, et al. Finding the missing heritability of complex diseases. Nature. 2009;461:747-753.
29. Risch N. The genetic epidemiology of cancer: interpreting family and twin studies and their implications for molecular genetic approaches. Cancer Epidemiol Biomarkers Prev. 2001;10:733-741.
30. Rosen M, Hakulinen T. Use of disease registers. In: Ahrens W, Pigeot I, eds. Handbook of Epidemiology. Berlin, Germany: Springer-Verlag; 2005:231-252.
31. Ekbom A. The Swedish Multi-generation Register. Methods Mol Biol. 2011;675:215-220.
32. Sundquist K, Winkleby M, Li X, Ji J, Hemminki K, Sundquist J. Familial [corrected] transmission of coronary heart disease: a cohort study of 80,214 Swedish adoptees linked to their biological and adoptive parents. Am Heart J. 2011;162:317-323.
33. Ludvigsson JF, Andersson E, Ekbom A, Feychting M, Kim JL, Reuterwall C, et al. External review and validation of the Swedish national inpatient register. BMC Public Health. 2011;11:450.
34. Nordlöf B. Svenska Adoptioner i Stockholm 1918-1973 [Swedish Adoptions in Stockholm 1918-1973]. FoU-rapport 2001:8. Stockholm: Socialtjänstförvaltningen, Forsknings-och utvecklingsenheten; 2001.
35. Bohman M. Adopted Children and Their Families -A Follow-Up Study of Adopted Children, Their Background, Environment and Adjustment. Stockholm, Sweden: Proprius; 1970.
36. von Borczyskowski A, Lindblad F, Vinnerljung B, Reintjes R, Hjern A. Familial factors and suicide: an adoption study in a Swedish National Cohort. Psychol Med. 2011;41:749-758.
37. Souto JC, Almasy L, Borrell M, Blanco-Vaca F, Mateo J, Soria JM, et al. Genetic susceptibility to thrombosis and its relationship to physiological risk factors: the GAIT study. Am J Hum Genet. 2000;67:1452-1459.
38. Rosengren A, Fredén M, Hansson PO, Wilhelmsen L, Wedel H, Eriksson H. Psychosocial factors and venous thromboembolism: a long-term follow-up study of Swedish men. J Thromb Haemost. 2008;6:558-564.
39. Breslow NE, Day NE. Statistical methods in cancer research. Volume II -The design and analysis of cohort studies. IARC Sci Publ. 1987;82:1-406.
40. Zöller B, Ohlsson H, Sundquist J, Sundquist K. Familial risk of venous thromboembolism in first-, second-And third-degree relatives: a nationwide family study in Sweden. Thromb Haemost. 2013;109:458-463.
41. Zöller B, Li X, Sundquist J, Sundquist K. Age-And gender-specific familial risks for venous thromboembolism: a nationwide epidemiological study based on hospitalizations in Sweden. Circulation. 2011;124:1012-1020.
42. Zöller B, Li X, Sundquist J, Sundquist K. Determination of age-specific and sex-specific familial risks for the different manifestations of venous thromboembolism: a nationwide family study in Sweden. Thromb Haemost. 2011;106:102-112.
43. Zöller B, Li X, Sundquist J, Sundquist K. Shared familial aggregation of susceptibility to different manifestations of venous thromboembolism: a nationwide family study in Sweden. Br J Haematol. 2012;157:146-148.
44. Zöller B, Li X, Sundquist J, Sundquist K. A nationwide family study of pulmonary embolism: identification of high risk families with increased risk of hospitalized and fatal pulmonary embolism. Thromb Res. 2012;130:178-182.
45. Larsen TB, Sørensen HT, Skytthe A, Johnsen SP, Vaupel JW, Christensen K. Major genetic susceptibility for venous thromboembolism in men: a study of Danish twins. Epidemiology. 2003;14:328-332.
46. Borch KH, Hansen-Krone I, Braekkan SK, Mathiesen EB, Njolstad I, Wilsgaard T, et al. Physical activity and risk of venous thromboembolism. The Tromso study. Haematologica. 2010;95:2088-2094.
47. Kabrhel C, Varraso R, Goldhaber SZ, Rimm E, Camargo CA, Jr. Physical inactivity and idiopathic pulmonary embolism in women: prospective study. BMJ. 2011;343:d3867.
48. Varraso R, Kabrhel C, Goldhaber SZ, Rimm EB, Camargo CA Jr. Prospective study of diet and venous thromboembolism in US women and men. Am J Epidemiol. 2012;175:114-126.
49. Zöller B, Li X, Sundquist J, Sundquist K. Socioeconomic and occupational risk factors for venous thromboembolism in Sweden: a nationwide epidemiological study. Thromb Res. 2012;129:577-582.
50. Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology. 1990;1:43-46.