Major genetic susceptibility for venous thromboembolism in men: A study of Danish twins

Epidemiology

Volumn 14, Issue 3, 2003, Pages 328-332

  Larsen, Torben Bjerregaard ^a,b   Sørensen, Henrik Toft ^a,b   Skytthe, Axel ^c   Johnsen, Søren Paaske ^a,d   Vaupel, James W ^c   Christensen, Kaare ^c  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AALBORG UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d AARHUS UNIVERSITY   (Denmark)

Author keywords

Epidemiology; Genes; Genetics; Thrombophilia; Twins; Venous thromboembolism

Indexed keywords

ARTICLE; CHILD; DENMARK; DNA POLYMORPHISM; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HEREDITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TWINS; VENOUS THROMBOEMBOLISM; DIZYGOTIC TWINS; GENETIC PREDISPOSITION; GENETICS; LUNG EMBOLISM; MONOZYGOTIC TWINS; REGISTER; RISK FACTOR; STATISTICS; VEIN THROMBOSIS;

DENMARK; DISEASES IN TWINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; PULMONARY EMBOLISM; REGISTRIES; RISK FACTORS; TWIN STUDIES; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC; VENOUS THROMBOSIS;

EID: 0037996290     PISSN: 10443983     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001648-200305000-00013     Document Type: Article

References (33)

1. Anderson FA, Wheeler HB, Goldberg RJ, Hosmer DW, Forcier A. The prevalence of risk factors for venous thromboembolism among hospital patients. Arch Intern Med 1992;152:1660-1664.
2. Nordstrom M, Lindblad B, Bergqvist D, Kjellstrom T. A prospective study of the incidence of deep-vein thrombosis within a defined urban population. J Intern Med 1992;232:155-160.
3. Egeberg O. Inherited antithrombin deficiency causing thrombophilia. Thromb Diath Haemorrh 1965;13:516-530.
4. Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest 1981;68:1370-1373.
5. Bertina RM, Ploos van Amstel HK, van Wijngaarden A, et al. Heerlen polymorphism of protein S, an immunologic polymorphism due to dimorphism of residue 460. Blood 1990;76:538-548.
6. Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Nat Acad Sci USA 1993;90:1004-1008.
7. Bertina RM, Koeleman BP, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:64-67.
8. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996;88:3698-3703.
9. Koster T, Rosendaal FR, de Ronde H, Briet E, Vandenbroucke JP, Bettina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia study. Lancet 1993;342:1503-1506.
10. Ridker PM, Hennekens CH, Lindpaintner K, Stampfer MJ, Eisenberg PR, Miletich JP. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med 1995;332:912-917.
11. Rodeghiero F, Tosetto A. Activated protein C resistance and factor V Leiden mutation are independent risk factors for venous thromboembolism. Ann Intern Med 1999;130:643-650.
12. Svensson PJ, Dahlbäck B. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 1994;330:517-522.
13. Zöller B, Dahlbäck B. Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis. Lancet 1994;343:1536-1538.
14. Beauchamp NJ, Daly ME, Hampton KK, Cooper PC, Preston FE, Peake IR. High prevalence of a mutation in the factor V gene within the U.K. population: relationship to activated protein C resistance and familial thrombosis. Br J Haematol 1994;88:219-222.
15. Kyvik KO, Christensen K, Skytthe A, Harvald B, Holm NV. The Danish twin register. Dan Med Bull 1996;43:467-470.
16. Hauge M. The Danish twin register. In Mednick SA, ed. Prospective Longitudinal Research. Oxford: Oxford Medical, 1981;217-221.
17. McGue M. When assessing twin concordance, use the proband-wise not the pairwise rate. Schizophr Bull 1992;18:171-176.
18. Ramakrishnan V, Goldberg J, Henderson WG, et al. Elementary methods for the analysis of dichotomous outcomes in unselected samples of twins. Genet Epidemiol 1992;9:273-287.
19. Cornfield J. A statisitical problem arising from retrospective studies. In: Neymen A, ed. Proceedings of the 3rd Berkeley Symposium, Vol. 4. Berkeley, CA: University of California Press, 1956;135-148.
20. Falconer DS. The inheritance of liability to certain diseases, estimated from the incidence among relatives. Ann Hum Genet 1965;29:51-76.
21. Neale MC. Mx: Statistical Modeling. 2nd edition. Richmond, VA: Department of Psychiatry, 1994.
22. Neale MC, Cardon LR. Methodology for Genetic Studies of Twins and Families. Dordrecht: Kluwer Academic Publishers, 1992.
23. Lindsey JK, Jones B. Choosing among generalized linear models applied to medical data. Stat Med 1998;17:59-68.
24. Samama MM. An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients: the Sirius study. Arch Intern Med 2000;160:3415-3420.
25. Sørensen HT, Mellemkjær L, Steffensen FH, Olsen JH, Nielsen GL. The risk of a diagnosis of cancer after primary deep venous thrombosis or pulmonary embolism. N Engl J Med 1998;338:1169-1173.
26. Stunkard AJ, Sørensen TI, Hanis C, et al. An adoption study of human obesity. N Engl J Med 1986;314:193-198.
27. Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000;343:78-85.
28. Maes HH, Neale MC, Eaves LJ. Genetic and environmental factors in relative body weight and human adiposity. Behav Genet 1997;27:325-351.
29. Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet 1999;353:1167-1173.
30. Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med 2001;344:1222-1231.
31. Kyrle PA, Minar E, Hirschl M, et al. High plasma levels of factor VIII and the risk of recurrent venous thromboembolism. N Engl J Med 2000;343:457-462.
32. van Hylckama Vlieg A, van der Linden I, Bertina RM, Rosendaal FR. High levels of factor IX increase the risk of venous thrombosis. Blood 2000;95:3678-3682.
33. Kamphuisen PW, Lensen R, Houwing-Duistermaat JJ, et al. Heritability of elevated factor VIII antigen levels in factor V Leiden families with thrombophilia. Br J Haematol 2000;109:519-522.