A mutation causing brugada syndrome identifies a mechanism for altered autonomic and oxidant regulation of cardiac sodium currents

Circulation: Cardiovascular Genetics

Volumn 7, Issue 3, 2014, Pages 249-256

  Aiba, Takeshi ^a   Farinelli, Federica ^a   Kostecki, Geran ^b   Hesketh, Geoffrey G ^a   Edwards, David ^a   Biswas, Subrata ^a   Tung, Leslie ^b   Tomaselli, Gordon F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Johns Hopkins University   (United States)

Author keywords

Cardiac; Death; Ion channel; Mutation; Reactive oxygen species; Sudden

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; OXIDIZING AGENT; REACTIVE OXYGEN METABOLITE; SCN5A PROTEIN, HUMAN; SODIUM; SODIUM CHANNEL NAV1.5;

ADULT; ANIMAL CELL; ARTICLE; BRUGADA SYNDROME; CASE REPORT; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE; GENE MUTATION; HUMAN; MALE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA GENE; SODIUM CURRENT; STEADY STATE; ANIMAL; ELECTROCARDIOGRAPHY; ENZYMOLOGY; GENETICS; HEART; METABOLISM; MISSENSE MUTATION; MUSCLE CELL; PATHOPHYSIOLOGY; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ADULT; ANIMALS; BRUGADA SYNDROME; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ELECTROCARDIOGRAPHY; HEART; HUMANS; MALE; MUSCLE CELLS; MUTATION, MISSENSE; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; OXIDANTS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SODIUM;

EID: 84903598796     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.113.000480     Document Type: Article

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