Spontaneous Brugada electrocardiogram patterns are rare in the German general population: Results from the KORA study

Europace

Volumn 11, Issue 10, 2009, Pages 1338-1344

  Sinner, Moritz F ^a   Pfeufer, Arne ^b,c   Perz, Siegfried ^c   Schulze Bahr, Eric ^d   Mönnig, Gerold ^d   Eckardt, Lars ^d   Beckmann, Britt Maria ^a   Wichmann, H Erich ^c   Breithardt, Günter ^d   Steinbeck, Gerhard ^a   Fabritz, Larissa ^d   Kääb, Stefan ^a   Kirchhof, Paulus ^d  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Brugada Syndrome; Computer analysis; Electrocardiogram; General population; Prevalence

Indexed keywords

ADULT; AGED; ARTICLE; BRUGADA SYNDROME; COMPUTER ANALYSIS; CONTROLLED STUDY; ELECTROCARDIOGRAM; FEMALE; HEART ATRIUM FIBRILLATION; HEART LEFT VENTRICLE HYPERTROPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; P WAVE; PREVALENCE; PRIORITY JOURNAL; QRS COMPLEX; T WAVE;

ADULT; AGED; BRUGADA SYNDROME; ELECTROCARDIOGRAPHY; FEMALE; GERMANY; HUMANS; INCIDENCE; MALE; MIDDLE AGED; RARE DISEASES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SURVIVAL ANALYSIS; SURVIVAL RATE;

EID: 70349480802     PISSN: 10995129     EISSN: 15322092     Source Type: Journal    
DOI: 10.1093/europace/eup205     Document Type: Article

References (28)

1. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol 1992;20:1391-1396
2. Benito B, Brugada R, Brugada J, Brugada P. Brugada syndrome. Progress Cardiovasc Diseases 2008;51:1-22.
3. Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature 1998;392: 293-296
4. Watanabe H, Koopmann TT, Le Scouarnec S, Yang T, Ingram C, Schott JJ et al. Sodium channel beta1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. J Clin Invest 2008;118:2260-2268
5. London B, Michalec M, Mehdi H, Zhu X, Kerchner L, Sanyal S et al. Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias. Circulation 2007;116:2260-2268
6. Weiss R, Barmada MM, Nguyen T, Seibel JS, Cavlovich D, Kornblit CA et al. Clinical and molecular heterogeneity in the Brugada syndrome: a novel gene locus on chromosome 3. Circulation 2002;105:707-713
7. Antzelevitch C, Pollevick GD, Cordeiro JM, Casis O, Sanguinetti MC, Aizawa Y et al. Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation 2007;115:442-449
8. Junttila MJ, Raatikainen MJ, Karjalainen J, Kauma H, Kesäniemi YA, Huikuri HV. Prevalence and prognosis of subjects with Brugada-type ECG pattern in a young and middle-aged Finnish population. Eur Heart J 2004;25:874-878
9. Giustetto C, Drago S, Demarchi PG, Dalmasso P, Bianchi F, Masi AS et al. Risk stratification of the patients with Brugada type electrocardiogram: a community-based prospective study. Europace 2009;11:507-513
10. Letsas KP, Gavrielatos G, Efremidis M, Kounas SP, Filippatos GS, Sideris A et al. Prevalence of Brugada sign in a Greek tertiary hospital population. Europace 2007;9:1077-1080
11. Gallagher MM, Forleo GB, Behr ER, Magliano G, De Luca L, Morgia V et al. Prevalence and significance of Brugada-type ECG in 12,012 apparently healthy European subjects. Int J Cardiol 2007;130:44-48
12. Bozkurt A, Yas D, Seydaoglu G, Acartürk E. Frequency of Brugada-type ECG pattern (Brugada sign) in Southern Turkey. Int Heart J 2006;47:541-547
13. Gervacio-Domingo G, Isidro J, Tirona J, Gabriel E, David G, Amarillo ML et al. The Brugada type 1 electrocardiographic pattern is common among Filipinos. J Clin Epidemiol 2008;61:1067-1072
14. Hermida JS, Lemoine JL, Aoun FB, Jarry G, Rey JL, Quiret JC. Prevalence of the brugada syndrome in an apparently healthy population. Am J Cardiol 2000;86: 91-94
15. Matsuo K, Akahoshi M, Nakashima E, Suyama A, Seto S, Hayano M et al. The prevalence, incidence and prognostic value of the Brugada-type electrocardiogram: a population-based study of four decades. J Am Coll Cardiol 2001;38:765-770
16. Tsuji H, Sato T, Morisaki K, Iwasaka T. Prognosis of subjects with Brugada-type electrocardiogram in a population of middle-aged Japanese diagnosed during a health examination. Am J Cardiol 2008;102:584-587
17. Junttila MJ, Raatikainen MJ, Perkiömäki JS, Hong K, Brugada R, Huikuri HV. Familial clustering of lone atrial fibrillation in patients with saddleback-type ST-segment elevation in right precordial leads. Eur Heart J 2007;28:463-468
18. Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 2005;111:659-670
19. Wilde AA, Antzelevitch C, Borggrefe M, Brugada J, Brugada R, Brugada P et al. Proposed diagnostic criteria for the Brugada syndrome. Eur Heart J 2002;23: 1648-1654
20. Holle R, Happich M, Löwel H, Wichmann HE. KORA-a research platform for population based health research. Gesundheitswesen 2005;67:S19-25.
21. Rautaharju PM, Wolf HK, Eifler WJ, Blackburn H. A simple procedure for positioning precordial ECG and VCG electrodes using an electrode locator. J Electrocardiol 1976;9:35-40.
22. Zywietz C, Borovsky D, Götsch G, Joseph G. Methodology of ECG interpretation in the Hannover program. Methods Inf Med 1990;29:375-385
23. Willems JL, Abreu-Lima C, Arnaud P, van Bemmel JH, Brohet C, Degani R et al. The diagnostic performance of computer programs for the interpretation of electrocardiograms. N Engl J Med 1991;325:1767-1773
24. Antzelevitch C. Brugada syndrome. PACE 2006;29:1130-1159
25. Sangwatanaroj S, Prechawat S, Sunsaneewitayakul B, Sitthisook S, Tosukhowong P, Tungsanga K. New electrocardiographic leads and the procainamide test for the detection of the Brugada sign in sudden unexplained death syndrome survivors and their relatives. Eur Heart J 2001;22:2290-2296 (Pubitemid 34000985)
26. Nakazawa K, Sakurai T, Takagi A, Kishi R, Osada K, Miyazu O et al. Clinical signifi-cance of electrocardiography recordings from a higher intercostal space for detection of the brugada sign. Circ J 2004;68:1018-1022
27. Perz S, Küfner R, Holle R. Monitoring der Qualität von EKG-Registrierungen in bevölkerungsbasierten Untersuchungen. Proceedings Biosignalverarbeitung, PTB Braunschweig und Berlin 2008;168-171
28. Veltmann C, Schimpf R, Echternach C, Eckardt L, Kuschyk J, Streitner F et al. A prospective study on spontaneous fluctuations between diagnostic and non-diagnostic ECGs in Brugada syndrome: implications for correct phenotyping and risk stratification. Eur Heart J 2006;27:2544-2552