Calcium-mediated dual-mode regulation of cardiac sodium channel gating

Circulation Research

Volumn 104, Issue 7, 2009, Pages 870-878

  Biswas, Subrata ^a   Disilvestre, Deborah ^a   Tian, Yanli ^a   Halperin, Victoria L ^a   Tomaselli, Gordon F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calmodulin; EF hand motif; FRET; Gated sodium channel; IQ motif; Voltage

Indexed keywords

CALCIUM; CALMODULIN; CARBOXYL GROUP; CYAN FLUORESCENT PROTEIN; SODIUM CHANNEL; HYBRID PROTEIN;

ARRHYTHMOGENESIS; ARTICLE; CALCIUM CELL LEVEL; CHANNEL GATING; COMPARATIVE STUDY; CONTROLLED STUDY; ELECTRIC POTENTIAL; EMBRYO; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEART; HEART VENTRICLE ARRHYTHMIA; HUMAN; HUMAN CELL; KINETICS; MODULATION; MUTATION; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MOTIF; REGULATORY MECHANISM; STEADY STATE; WILD TYPE; CELL LINE; CELL MEMBRANE POTENTIAL; GENETIC TRANSFECTION; GENETICS; HEART ARRHYTHMIA; HEART MUSCLE CELL; METABOLISM; SITE DIRECTED MUTAGENESIS;

ARRHYTHMIAS, CARDIAC; CALCIUM; CALMODULIN; CELL LINE; EF HAND MOTIFS; HUMANS; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; MUTATION; MYOCYTES, CARDIAC; RECOMBINANT FUSION PROTEINS; SODIUM CHANNELS; TRANSFECTION;

EID: 65249104663     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.193565     Document Type: Article

References (18)

1. Keating MT, Sanguinetti MC. Molecular and cellular mechanisms of cardiac arrhythmias. Cell. 2001;104:569-580.
2. Deschênes I, Baroudi G, Berthet M, Barde I, Chalvidan T, Denjoy I, Guicheney P, Chahine M. Electrophysiological characterization of SCN5A mutations causing long QT (E1784K) and Brugada (R1512W and R1432G) syndromes. Cardiovasc Res. 2000;46:55-65.
3. Deschênes I, Trottier E, Chahine M. Implication of the C-terminal region of the alpha-subunit of voltage-gated sodium channels in fast inactivation. J Membr Biol. 2001;183:103-114.
4. Mantegazza M, Yu FH, Catterall WA, Scheuer T. Role of the C-terminal domain in inactivation of brain and cardiac sodium channels. Proc Natl Acad Sci U S A. 2001;98:15348-15353.
5. + channel inactivation gate is a molecular complex: a novel role of the COOH-terminal domain. J Gen Physiol. 2004;123:155-165.
6. + channels by calmodulin. Circ Res. 2002;90:E49 -57.
7. 2+ sensitivity of sodium channels. J Biol Chem. 2004;279:45004-45012.
8. Shah VN, Wingo TL, Weiss KL, Williams CK, Balser JR, Chazin WJ. Calcium-dependent regulation of the voltage-gated sodium channel hH1: intrinsic and extrinsic sensors use a common molecular switch. Proc Natl Acad Sci U S A. 2006;103:3592-3597.
9. Wingo TL, Shah VN, Anderson ME, Lybrand TP, Chazin WJ, Balser JR An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability. Nat Struct Mol Biol. 2004;11:219-225.
10. V1.4 current: role of binding to the carboxyl terminus. J Gen Physiol. 2008;131:197-209.
11. Veldkamp MW, Viswanathan PC, Bezzina C, Baartscheer A, Wilde AA, Balser JR. Two distinct congenital arrhythmias evoked by a multi dysfunctional Na(+) channel. Circ Res. 2000;86:e91-e97.
12. Bezzina C, Veldkamp MW, van Den Berg MP, Postma AV, Rook MB, Viersma JW, van Langen IM, Tan-Sindhunata G, Bink-Boelkens MT, van Der Hout AH, Mannens MM, Wilde AA. A single Na(+) channel mutation causing both long-QT and Brugada syndromes. Circ Res. 1999;85:1206-1213.
13. Rivolta I, Abriel H, Tateyama M, Liu H, Memmi M, Vardas P, Napolitano C, Priori SG, Kass RS. Inherited Brugada and long QT-3 syndrome mutations of a single residue of the cardiac sodium channel confer distinct channel and clinical phenotypes. J Biol Chem. 2001;276:30623-30630.
14. Cormier JW, Rivolta I, Tateyama M, Yang AS, Kass RS. Secondary structure of the human cardiac Na+ channel C terminus: evidence for a role of helical structures in modulation of channel inactivation. J Biol Chem. 2002;277:9233-9241.
15. An RH, Wang XL, Kerem B, Benhorin J, Medina A, Goldmit M, Kass RS. Novel LQT-3 mutation affects Na+ channel activity through interactions between alpha- and beta1-subunits. Circ Res. 1998;83:141-146.
16. Herzog RI, Liu C, Waxman SG, Cummins TR. Calmodulin binds to the C terminus of sodium channels Nav1.4 and Nav1.6 and differentially modulates their functional properties. J Neurosci. 2003;23:8261-8270.
17. Tan HL, Kupershmidt S, Zhang R, Stepanovic S, Roden DM. Wilde AA, Anderson ME, Balser JR. A calcium sensor in the sodium channel modulates cardiac excitability. Nature. 2002;415:442-447.
18. Drake SK, Zimmer MA, Miller CL, Falke JJ. Optimizing the metal binding parameters of an EF-hand-like calcium chelation loop: coordinating side chains play a more important tuning role than chelation loop flexibility. Biochemistry. 1997;36:9917-9926.