Nickel(II) complex of polyhydroxybenzaldehyde N4-thiosemicarbazone exhibits anti-inflammatory activity by inhibiting NF-κB transactivation

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Shawish, Hana Bashir ^a   Wong, Wan Ying ^b   Wong, Yi Li ^a   Loh, Sheng Wei ^b   Looi, Chung Yeng ^a   Hassandarvish, Pouya ^a   Phan, Alicia Yi Ling ^a   Wong, Won Fen ^a   Wang, Hao ^a,c   Paterson, Ian C ^a   Ea, Chee Kwee ^b   Mustafa, Mohd Rais ^a   Maah, Mohd Jamil ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

^c NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; DEXAMETHASONE; I KAPPA B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; NICKEL COMPLEX; THIOSEMICARBAZONE DERIVATIVE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; CARRAGEENAN; COORDINATION COMPOUND; I KAPPA B KINASE; LIPOPOLYSACCHARIDE; NICKEL; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY TEST; DOWN REGULATION; DRUG BINDING; DRUG DETERMINATION; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GENE TARGETING; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MALE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PAW EDEMA; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SUBSTITUTION REACTION; TRANSACTIVATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; CHEMICALLY INDUCED; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENETICS; HELA CELL LINE; METABOLISM; PATHOLOGY; PROTEIN TRANSPORT; SECRETION (PROCESS); SYNTHESIS; TRANSCRIPTION INITIATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CELL LINE; COORDINATION COMPLEXES; HELA CELLS; HUMANS; I-KAPPA B KINASE; INFLAMMATION; INTERFERON-BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE, INBRED C57BL; MOLECULAR DOCKING SIMULATION; NF-KAPPA B; NICKEL; PROTEIN TRANSPORT; THIOSEMICARBAZONES; TRANSCRIPTIONAL ACTIVATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84903592221     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100933     Document Type: Article

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