Toxic effects of chronic low-dose exposure of thioacetamide on rats based on NMR metabolic profiling

Journal of Pharmaceutical and Biomedical Analysis

Volumn 98, Issue , 2014, Pages 334-338

  Wei, Dan Dan ^a   Wang, Jun Song ^b   Wang, Peng Ran ^a   Li, Ming Hui ^a   Yang, Ming Hua ^a   Kong, Ling Yi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Liver fibrosis; Metabolic pathway analysis (MetPA); Metabolomics; Orthogonal partial least squares discriminant analysis (OPLS DA)

Indexed keywords

2 HYDROXY 4 METHYLTHIOBUTYRIC ACID; 3 HYDROXYBUTYRIC ACID; ADIPIC ACID; CHOLINE; DIMETHYLGLYCINE; GLYCOPROTEIN; THIOACETAMIDE; TRICARBOXYLIC ACID; BIOLOGICAL MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; BLOOD BRAIN BARRIER; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; ENERGY METABOLISM; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE UTILIZATION; GLYCOLYSIS; HISTOPATHOLOGY; INSULIN RELEASE; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER INJURY; MALE; NEPHROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE METABOLIC PROFILING; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; SUCROSE METABOLISM; ANIMAL; BLOOD; CHEMISTRY; DISCRIMINANT ANALYSIS; LIVER; METABOLISM; METABOLOME; METABOLOMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; PROCEDURES; SERUM; SIGNAL TRANSDUCTION; URINE;

ANIMALS; BIOLOGICAL MARKERS; DISCRIMINANT ANALYSIS; LIVER; LIVER CIRRHOSIS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOME; METABOLOMICS; RATS; SERUM; SIGNAL TRANSDUCTION; THIOACETAMIDE; URINE;

EID: 84903582618     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.05.035     Document Type: Article

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