Biopsy or biomarkers: Is there a gold standard for diagnosis of liver fibrosis?

Clinical Chemistry

Volumn 50, Issue 8, 2004, Pages 1299-1300

  Afdhal, Nezam H ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; COLLAGEN;

EDITORIAL; EXTRACELLULAR MATRIX; FIBROGENESIS; HUMAN; LIVER BIOPSY; LIVER DISEASE; LIVER FIBROSIS; STANDARD;

BIOLOGICAL MARKERS; BIOPSY; HUMANS; LIVER CIRRHOSIS;

EID: 3242778600     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2004.035899     Document Type: Editorial

References (8)

1. Afdhal NH. Diagnosing fibrosis in hepatitis C: is the pendulum swinging from biopsy to blood tests? Hepatology 2003;37:972-4.
2. Poynard T, Munteanu M, Imbert-Bismut F, Charlotte F, Thabut D, Le Calvez S, et al. Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C. Clin Chem 2004;50:1344-55.
3. Bedossa P, Dargere D, Paradis V. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology 2003;38:1449-57.
4. Regev A, Berho M, Jeffers LJ, Milikowski C, Molina EG, Pyrsopoulos NT, et al. Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol 2002;97:2614-8.
5. Poynard T, McHutchison J, Manns M, Myers RP, Albrecht J. Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin. Hepatology 2003;38:481-92.
6. Imbert-Bismut F, Ratziu V, Pieroni L, Charlotte F, Benhamou Y, Poynard T. Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Lancet 2001;357:1069-75.
7. Imbert-Bismut F, Messous D, Thibaut V, Myers RB, Piton A, Tnabut D, et al. Intra-laboratory analytical variability of biochemical markers of fibrosis (Fibrotest) and activity (Actitest) and reference ranges in healthy blood donors. Clin Chem Lab Med 2004;42:323-33.
8. Afdhal NH, Nunes DN. Evaluation of liver fibrosis: a concise review. Am J Gastroenterol 2004; in press.