Development of a radioligand, [3H]LY2119620, to probe the human M2 and M4 muscarinic receptor allosteric binding sites

Molecular Pharmacology

Volumn 86, Issue 1, 2014, Pages 116-123

  Schober, Douglas A ^a   Croy, Carrie H ^a   Xiao, Hongling ^a   Christopoulos, Arthur ^b   Felder, Christian C ^a  

^a ELI LILLY AND COMPANY   (United States)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

17 BETA HYDROXY 17 ALPHA ETHYNYL DELTA 4 ANDROSTANO[3,2 B]PYRIMIDO[1,2 A]BENZIMIDAZOLE; 3 AMINO 5 CHLORO 6 METHOXY 4 METHYLTHIENO(2,3 B)PYRIDINE 2 CARBOXYLIC ACID CYCLOPROPYLAMI; 3 AMINO 5 CHLORO N CYCLOPROPYL 4 METHYL 6 [2 (4 METHYLPIPERAZIN 1 YL) 2 OXOETHOXY]THIENO[2,3 B]PYRIDINE 2 CARBOXAMIDE H 3; 3 AMINO N (4 METHOXYBENZYL) 4,6 DIMETHYLTHIENO[2,3 B]PYRIDINE CARBOXAMIDE; GALLAMINE; GUANINE NUCLEOTIDE BINDING PROTEIN; METHYLSCOPOLAMINE; MUSCARINIC AGENT; MUSCARINIC M2 RECEPTOR; MUSCARINIC M4 RECEPTOR; RADIOLIGAND; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; LIGAND;

ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING COMPETITION; CONTROLLED STUDY; DISSOCIATION; DRUG BINDING SITE; DRUG RECEPTOR BINDING; KINETIC PARAMETERS; LIGAND BINDING; MACACA FASCICULARIS; MALE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; ANIMAL; BINDING SITE; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG POTENTIATION; HUMAN; KINETICS; METABOLISM; METHODOLOGY; MOLECULAR PROBE; PHYSIOLOGY; RADIOASSAY;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ANIMALS; CHO CELLS; CRICETULUS; GTP-BINDING PROTEINS; HUMANS; KINETICS; LIGANDS; MOLECULAR PROBES; MUSCARINIC AGONISTS; RADIOLIGAND ASSAY; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M4; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84903556600     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.114.091785     Document Type: Article

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